(+)-cinchonine

(9S)- cinchonan-9-ol cinchonan-9-ol, (9S)- (8R,9S)- cinchonine D- cinchonine [(5R)-5- ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-quinolin-4-ylmethanol (S)- quinolin-4-yl((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol quinolin-4-yl((2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol alpha-(5- vinyl-2-quinuclidinyl)-4-quinolinemethanol PubMed: Asymmetric domino multicatalysis for the synthesis of 3-substituted phthalides: cinchonine/NHC cooperative system. PubMed: Ovarian cancer stem cell-specific gene expression profiling and targeted drug prescreening. PubMed: Stereoselective inhibition of serotonin transporters by antimalarial compounds. PubMed: One-pot fluorescent labeling protocol for complex hydroxylated bioactive natural products. PubMed: Cinchonine and thiourea. PubMed: Antiparasitic hybrids of Cinchona alkaloids and bile acids. PubMed: Asymmetric 5-endo chloroetherification of homoallylic alcohols toward the synthesis of chiral β-chlorotetrahydrofurans. PubMed: A theoretical investigation on the Strecker reaction catalyzed by a Ti(IV)-complex catalyst generated from a cinchona alkaloid, achiral substituted 2,2'-biphenol, and tetraisopropyl titanate. PubMed: Platelet-activating factor (PAF)-antagonists of natural origin. PubMed: Evaluation of antibacterial and anti-biofilm activities of cinchona alkaloid derivatives against Staphylococcus aureus. PubMed: Capillary electrophoresis methods for the analysis of antimalarials. Part I. Chiral separation methods. PubMed: Extraction of alkaloids for NMR-based profiling: exploratory analysis of an archaic Cinchona bark collection. PubMed: Asymmetric organocatalytic decarboxylative Mannich reaction using β-keto acids: A new protocol for the synthesis of chiral β-amino ketones. PubMed: New insights into cinchonine-aluminium complexes and their application as chiral building blocks: unprecedented ligand-exchange processes in the presence of ZnR2 compounds. PubMed: Crystal structure of quinine: the effects of vinyl and methoxy groups on molecular assemblies of Cinchona alkaloids cannot be ignored. PubMed: Development of a generic micellar electrokinetic chromatography method for the separation of 15 antimalarial drugs as a tool to detect medicine counterfeiting. PubMed: Mutation in the Plasmodium falciparum CRT protein determines the stereospecific activity of antimalarial cinchona alkaloids. PubMed: Bioproduction of Cinchona alkaloids by the endophytic fungus Diaporthe sp. associated with Cinchona ledgeriana. PubMed: Synthesis of 3-(1-alkyl/aminoalkyl-3-vinyl-piperidin-4-yl)-1-(quinolin-4-yl)-propan-1-ones and their 2-methylene derivatives as potential spermicidal and microbicidal agents. PubMed: Cinchonine Prevents High-Fat-Diet-Induced Obesity through Downregulation of Adipogenesis and Adipose Inflammation. PubMed: Copolymer-supported heterogeneous organocatalyst for asymmetric aldol addition in aqueous medium. PubMed: Organocatalytic asymmetric conjugate addition of 3-monosubstituted oxindoles to (E)-1,4-diaryl-2-buten-1,4-diones: a strategy for the indirect enantioselective furanylation and pyrrolylation of 3-alkyloxindoles. PubMed: Rapid and Green Analytical Method for the Determination of Quinoline Alkaloids from Cinchona succirubra Based on Microwave-Integrated Extraction and Leaching (MIEL) Prior to High Performance Liquid Chromatography. PubMed: Silicon-based Lewis acid assisted cinchona alkaloid catalysis: highly enantioselective aza-Michael reaction under solvent-free conditions. PubMed: The role of weak hydrogen bonds in chiral recognition. PubMed: Desymmetrization of cyclohexadienones via asymmetric Michael reaction catalyzed by cinchonine-derived urea. PubMed: Organocatalytic asymmetric aldol reaction of hydroxyacetone with β,γ-unsaturated α-keto esters: facile access to chiral tertiary alcohols. PubMed: Tosyl esters of cinchonidine and cinchonine alkaloids: the structure-reactivity relationship in the hydrolysis to 9-epibases. PubMed: Cinchona alkaloids are also produced by an endophytic filamentous fungus living in cinchona plant. PubMed: Novel molecularly imprinted microsphere using a single chiral monomer and chirality-matching (S)-ketoprofen template. PubMed: Facile synthesis of enantioenriched Cγ-tetrasubstituted α-amino acid derivatives via an asymmetric nucleophilic addition/protonation cascade. PubMed: Organocatalytic aza-Michael/retro-aza-Michael reaction: pronounced chirality amplification in aza-Michael reaction and racemization via retro-aza-Michael reaction. PubMed: Organocatalyzed enantioselective michael addition of 2-hydroxy-1,4-naphthoquinone to β,γ-unsaturated α-ketophosphonatesθ. PubMed: Development of chiral N,N-ditopic metalloligands based on a Cinchona alkaloids' backbone for constructing homochiral coordination polymers. PubMed: Enantioselective radical addition to ketimines: a synthetic route towards α,α-disubstituted α-amino acids. PubMed: Primary amine/(+)-CSA salt-promoted organocatalytic conjugate addition of nitro esters to enones. PubMed: Determination of cinchona alkaloids by non-aqueous CE with MS detection. PubMed: Hydrocinchonine, cinchonine, and quinidine potentiate paclitaxel-induced cytotoxicity and apoptosis via multidrug resistance reversal in MES-SA/DX5 uterine sarcoma cells. PubMed: Monodispersed, molecularly imprinted polymers for cinchonidine by precipitation polymerization. PubMed: Channel-like crystal structure of cinchoninium L-O-phosphoserine salt dihydrate. PubMed: Self-association promoted conformational transition of (3R,4S,8R,9R)-9-[(3,5-bis(trifluoromethyl)phenyl))-thiourea](9-deoxy)-epi-cinchonine. PubMed: Influence of peripheral groups on the physical and chemical behavior of cinchona alkaloids. PubMed: Resolution of (+)-cinchonine and (-)-cinchonidine by phase-modulation fluorescence spectroscopy. PubMed: Metal complexes of cinchonine as chiral building blocks: a strategy for the construction of nanotubular architectures and helical coordination polymers. PubMed: Separation of Cinchona alkaloids on a novel strong cation-exchange-type chiral stationary phase-comparison with commercially available strong cation exchanger and reversed-phase packing materials. PubMed: Highly enantioselective radical addition to N-benzoyl hydrazones using chiral ammonium salts. PubMed: Chiral squaramide derivatives are excellent hydrogen bond donor catalysts. PubMed: Homochiral crystallization of microporous framework materials from achiral precursors by chiral catalysis. PubMed: Performance of electrospun nanofibers for SPE of drugs from aqueous solutions. PubMed: A combined NMR, DFT, and X-ray investigation of some cinchona alkaloid O-ethers. PubMed: Ylide-initiated michael addition-cyclization reactions beyond cyclopropanes. PubMed: Highly enantioselective synthesis of isoxazoline N-oxides. PubMed: Capillary electrophoretic chiral separation of Cinchona alkaloids using a cyclodextrin selector. PubMed: Asymmetric Mannich reaction of dicarbonyl compounds with alpha-amido sulfones catalyzed by cinchona alkaloids and synthesis of chiral dihydropyrimidones. PubMed: Factors controlling adsorption equilibria from solution onto solid surfaces: the uptake of cinchona alkaloids on platinum surfaces. PubMed: Synthesis and optical resolution of an allenoic acid by diastereomeric salt formation induced by chiral alkaloids. PubMed: An improved synthesis of 10,11-didehydro Cinchona alkaloids. PubMed: Asymmetric activation of tropos 2,2'-biphenol with cinchonine generates an effective catalyst for the asymmetric strecker reaction of N-tosyl-protected aldimines and ketoimines. PubMed: Highly enantioselective direct aldol reaction catalyzed by cinchona derived primary amines. PubMed: Temperature-dependent time-resolved fluorescence study of cinchonine alkaloid dication. PubMed: Increased uptake of quinine into the brain by inhibition of P-glycoprotein. PubMed: Organocatalytic enantioselective indole alkylations of alpha,beta-unsaturated ketones. PubMed: Resolution and stereochemistry of tert-butylphenylphosphinous acid-borane. PubMed: Competitive chemisorption between pairs of cinchona alkaloids and related compounds from solution onto platinum surfaces. PubMed: Crystal and molecular structures of trichloro-cobalt(II) complexes of epiquinine, epiquinidine, and epidihydrocinchonine. PubMed: Time-lapse STM studies of diastereomeric cinchona alkaloids on platinum metals. PubMed: Liquid chromatographic analysis of cinchona alkaloids in beverages. PubMed: Role of the solvent in the adsorption-desorption equilibrium of cinchona alkaloids between solution and a platinum surface: correlations among solvent polarity, cinchona solubility, and catalytic performance. PubMed: Stimulation of choline/Mg2+ antiport in rat erythrocytes by mefloquine. PubMed: Pharmacological strategies for overcoming multidrug resistance. PubMed: Highly enantioselective cyanation of aldehydes catalyzed by a multicomponent titanium complex. PubMed: Michael addition of thiols to alpha-enones in ionic liquids with and without organocatalysts. PubMed: Direct enantio- and diastereoselective Mannich reactions of malonate and beta-keto esters with N-Boc and N-Cbz aldimines catalysed by a bifunctional cinchonine derivative. PubMed: [Preparation of molecularly imprinted chiral monolithic column and its applications for separation of diastereomers]. PubMed: Enantioselective organocatalytic Michael addition of malonate esters to nitro olefins using bifunctional cinchonine derivatives. PubMed: Asymmetric Mannich reactions of beta-keto esters with acyl imines catalyzed by cinchona alkaloids. PubMed: Direct STM investigation of cinchona alkaloid adsorption on Cu(III). PubMed: Evaluation of magnesium fluxes in rat erythrocytes using a stable isotope of magnesium. PubMed: Bioactive cinchona alkaloids from Remijia peruviana. PubMed: Carbon nanotubes as adsorbent of solid-phase extraction and matrix for laser desorption/ionization mass spectrometry. PubMed: In-vitro response of Plasmodium falciparum to the main alkaloids of Cinchona in northwestern Thailand. PubMed: Dose-dependent resorption of quinine after intrarectal administration to children with moderate Plasmodium falciparum malaria. PubMed: Five new alkaloids from the leaves of Remijia peruviana. PubMed: Enantioselective alkylation of beta-keto esters by phase-transfer catalysis using chiral quaternary ammonium salts. PubMed: Evidence for the 2:1 molecular recognition and inclusion behaviour between beta- and gamma-cyclodextrins and cinchonine. PubMed: Synthetic cinchonidine receptors obtained by cross-linking linear poly(methacrylic acid) derivatives as an alternative molecular imprinting technique. PubMed: Short columns with molecularly imprinted monolithic stationary phases for rapid separation of diastereomers and enantiomers. PubMed: Spectrophotometric method for estimation of alkaloids precipitable with Dragendorff's reagent in plant materials. PubMed: Hydrogenation of cinchona alkaloids over supported Pt catalyst. PubMed: Pharmacokinetics of idarubicin in the isolated perfused rat lung: effect of cinchonine and rutin. PubMed: Conformational spaces of Cinchona alkaloids. PubMed: Preparation of enantiopure 1-azabicyclo[3.2.2]nonanes functionalized at carbon C3, from cinchonine and cinchonidine. stereoselective solvolysis and an easily enolizable ketone. PubMed: Selective binding of chiral molecules of cinchona alkaloid by beta- and gamma-cyclodextrins and organoselenium-bridged bis(beta-cyclodextrin)s. PubMed: New crystalline complex of quinine and quinidine. PubMed: Cobalt complex of cinchonine: intermolecular interactions in two crystalline modifications. PubMed: The characterisation of supported platinum nanoparticles on carbon used for enantioselective hydrogenation: a combined electrochemical-STM approach. PubMed: Acyclic stereoselective boron alkylation reactions for the asymmetric synthesis of beta-substituted alpha-amino acid derivatives. PubMed: Highly stereoselective, uniformly sized molecularly imprinted polymers for cinchona alkaloids in hydro-organic mobile phases. PubMed: [Beaded molecule imprinted polymer for stereo isomer separation]. PubMed: Transformation of Cinchona alkaloids into 1-N-oxide derivatives by endophytic Xylaria sp isolated from Cinchona pubescens. PubMed: Practical enantioselective synthesis of endothelin antagonist S-1255 by dynamic resolution of 4-methoxychromene-3-carboxylic acid intermediate. PubMed: Highly enantioselective reformatsky reaction of ketones: chelation-assisted enantioface discrimination. PubMed: The enantioselective synthesis of alpha-amino acid derivatives via organoboranes. PubMed: Unexpected change of the sense of the enantioselective hydrogenation of ethyl pyruvate catalyzed by a Pt-alumina-cinchona alkaloid system. PubMed: Role of the choline exchanger in Na(+)-independent Mg(2+) efflux from rat erythrocytes. PubMed: Catalytic enantioselective fluorination of beta-keto esters by phase-transfer catalysis using chiral quaternary ammonium salts. PubMed: A selective PVC membrane for di- or trinitrophenol based on N,N-dibenzyl-3,3',5,5'-tetramethylbenzidine. PubMed: Asymmetric Weitz-Scheffer epoxidation of isoflavones with hydroperoxides mediated by optically active phase-transfer catalysts. PubMed: Cinchoninium L-tartrate tetrahydrate. PubMed: In vitro effect of alkaloids on bloodstream forms of Trypanosoma brucei and T. congolense. PubMed: Flexibility of CuCl4-tetrahedra in bis[cinchoninium tetrachlorocuprate(II)]trihydrate single crystals. X-ray diffraction and EPR studies. PubMed: Apoptosis induced by doxorubicin and cinchonine in P388 multidrug-resistant cells. PubMed: HPTLC method for the estimation of alkaloids of Cinchona officinalis stem bark and its marketed formulations. PubMed: Picric acid sensitive optode based on a fluorescence carrier covalently bound to membrane. PubMed: Phase I study of cinchonine, a multidrug resistance reversing agent, combined with the CHVP regimen in relapsed and refractory lymphoproliferative syndromes. PubMed: Non-aqueous capillary electrophoretic enantioseparation of N-derivatized amino acids using cinchona alkaloids and derivatives as chiral counter-ions. PubMed: Atomic emission spectrometric determination of ephedrine, cinchonine, chlorpheniramine, atropine and diphenhydramine based on formation of ion associates with ammonium reineckate. PubMed: Conformation of epicinchonine and cinchonine in view of their antimalarial activity: x-ray and theoretical studies. PubMed: Quinine disposition in globally malnourished children with cerebral malaria. PubMed: Comparison of kinetic properties of amine oxidases from sainfoin and lentil and immunochemical characterization of copper/quinoprotein amine oxidases. PubMed: Novel chiral recognition elements for molecularly imprinted polymer preparation. PubMed: An open randomized clinical study of intrarectal versus infused Quinimax for the treatment of childhood cerebral malaria in Niger. PubMed: Dual effects of nimesulide, a COX-2 inhibitor, in human platelets. PubMed: The inhibitory effect of cinchonine on human platelet aggregation due to blockade of calcium influx. PubMed: Comparison of 3, 5 and 7 days' treatment with Quinimax for falciparum malaria in Guinea-Bissau. PubMed: Optosensor for cinchona alkaloids with C18 silica gel as a substrate. PubMed: The separation and determination of quinine in bitter drinks by micellar electrokinetic capillary chromatography. PubMed: Reducing the oral quinine-quinidine-cinchonin (Quinimax) treatment of uncomplicated malaria to three days does not increase the recurrence of attacks among children living in a highly endemic area of Senegal. PubMed: Lambda-carrageenan: a novel chiral selector for capillary electrophoresis. PubMed: Intrarectal Quinimax (an association of Cinchona alkaloids) for the treatment of Plasmodium falciparum malaria in children in Niger: efficacy and pharmacokinetics. PubMed: The chemical and immunoglobulin structural features necessary for reactions of quinine-dependent antibodies to neutrophils. PubMed: Cinchonine per os: efficient circumvention of P-glycoprotein-mediated multidrug resistance. PubMed: Comparative effects of quinine and cinchonine in reversing multidrug resistance on human leukemic cell line K562/ADM. PubMed: Comparative in vitro renal damage due to stereoisomeric cinchona alkaloids. PubMed: Inhibition of the multidrug resistance efflux pump. PubMed: Effect of Cinchona bark alkaloids and chloroquine on phospholipid synthesis. K+ channel blockers specifically enhance the activity of the serine base exchange enzyme system in Jurkat T cells. PubMed: Pharmacokinetics of quinine, quinidine and Cinchonine when given as combination. PubMed: Role of guinea pig and rabbit hepatic aldehyde oxidase in oxidative in vitro metabolism of cinchona antimalarials. PubMed: Cinchonine, a potent efflux inhibitor to circumvent anthracycline resistance in vivo. PubMed: Molecular properties of Cinchona alkaloids: a theoretical approach. PubMed: Spectrophotometric determination of ephedrine HCl, cinchonine HCl, chlorpheniramine maleate, atropine sulphate and diphenhydramine HCl by solvent extraction of reineckate complexes. PubMed: Enhanced choline and Rb+ transport in human erythrocytes infected with the malaria parasite Plasmodium falciparum. PubMed: Quinidine-induced inhibition of the fast transient outward K+ current in rat melanotrophs. PubMed: Red cell and plasma concentrations of combined quinine-quinidine and quinine in falciparum malaria. PubMed: Comparison of coupling subsites and inhibition effects of piperidine alkaloids and aminoketones on plant amine oxidases. PubMed: Simultaneous measurement of quinine and quinidine in human plasma, whole blood, and erythrocytes by high-performance liquid chromatography with fluorescence detection. PubMed: Combination of quinine, quinidine and cinchonine for the treatment of acute falciparum malaria: correlation with the susceptibility of Plasmodium falciparum to the cinchona alkaloids in vitro. PubMed: A comparison of the antimalarial activity of the cinchona alkaloids against Plasmodium falciparum in vitro. PubMed: Effect of quinine and cinchonine on human neutrophils functions in vitro. PubMed: [Combinations of borotungstic acid with nitrogenous compounds]. PubMed: Efficacy of a 3-day oral regimen of a quinine-quinidine-cinchonine association (Quinimax) for treatment of falciparum malaria in Madagascar. PubMed: A combination of quinine, quinidine and cinchonine (LA 40221) in the treatment of chloroquine resistant falciparum malaria in Thailand: two double-blind trials. PubMed: Effect of Precursors on Growth and Alkaloid Production in Chinchona ledgeriana Leaf-Shoot Organ Cultures. PubMed: Activity of a combination of three cinchona bark alkaloids against Plasmodium falciparum in vitro. PubMed: Toxicity of quinoline alkaloids to cultured Cinchona ledgeriana cells. PubMed: Treatment of chloroquine-resistant falciparum malaria with a combination of quinine, quinidine and cinchonine (LA40221) in adults by oral and intravenous administration. PubMed: Analysis of Cinchona alkaloids by high-performance liquid chromatography. Application to the analysis of quinidine gluconate and quinidine sulfate and their dosage forms. PubMed: Quinoline alkaloids from Anthocephalus chinensis. PubMed: Comparative disposition kinetics of two diastereomeric pairs of cinchona alkaloids in the dog. PubMed: Competitive inhibition of sparteine oxidation in human liver by beta-adrenoceptor antagonists and other cardiovascular drugs. PubMed: [Synthesis of O-(beta-diethylaminoethyl)cinchoninaldoxime with local anesthetic activity]. PubMed: Rapid high-pressure liquid chromatographic determination of quinidine and dihydroquinidine in plasma samples. PubMed: Colorimetric assay of quinine and quinidine in raw materials, formulations, and biological fluids. PubMed: GLC determination of quinidines in human plasma. PubMed: Ligand-exchange chromatography of alkaloids. PubMed: Nitrogen photochemistry. V. A new photochemical reduction of the cinchona alkaloids, quinine, quinidine, cinchonidine, cinchonine. PubMed: Separation of alkyl gallates as complexes with cinchonine and strychnine. PubMed: [Determination of quinine, quinidine, cinchonine, cinchonidine and sparteine by means of Reinecke's salt]. PubMed: Paper chromatographic determination of quinine and cinchonine. PubMed: Immunoreactions involving platelets. III. Quantitative aspects of platelet agglutination, inhibition of clot retraction, and other reactions caused by the antibody of quinidine purpura. PubMed: [Synthesis of cinchona alkaloid derivatives. XXVII. Derivation of dihydrocinchonamine from cinchonine]. PubMed: Action of sheep liver homogenates on quinine, quinidine, cinchonine and cinchonidine. PubMed: Solubility of cinchonine and cinchonidine in alcohol-water mixtures. PubMed: The metabolism of cinchonine in dogs and in man. PubMed: Studies on the chemotherapy of the human malarias the metabolism of cinchonine in relation to its antimalarial activity. PubMed: STUDIES ON THE CHEMOTHERAPY OF THE HUMAN MALARIAS. IV. THE METABOLISM OF CINCHONINE IN RELATION TO ITS ANTIMALARIAL ACTIVITY. PubMed: Quinine and cinchonine effects on growth, differentiation and lethal temperature of Drosophila melanogaster. PubMed: Constitution of strychnine and its relation to cinchonine. PubMed: Cinchonine in the treatment of malaria. PubMed: Metabolism of cinchonine in dogs and man. PubMed: Cinchona alkaloids; physiological disposition of cinchonine metabolic products in man. PubMed: My experience with cinchonine. PubMed: Cinchona alkaloids; suppressive antimalarial activity of cinchonine carbostyril. PubMed: [Qualitative determination of atophan and cinchonine]. PubMed: QUININE IDIOSYNCRASY AND CINCHONINE. PubMed: THE ADVANTAGES OF INTRAMUSCULAR INJECTIONS OF SOLUBLE CINCHONINE SALTS IN SEVERE MALARIAL INFECTIONS. PubMed: An Experimental Investigation OF THE SUITABILITY OF THE MORE SOLUBLE SALTS OF QUININE AND CINCHONINE FOR INTRAVENOUS INJECTION.