stropheantin K

CAS: 508-77-0 C30 H44 O9 MW: 548.67348000

Identification

Namecymarin
CAS Number508-77-0
EINECS208-087-9
FDA UNIIUK3LS8435E
Molecular FormulaC30 H44 O9
Molecular Weight548.67348000
MDL NumberMFCD00003669
Beilstein0101370
XlogP30.80 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 148.00 °C. @ 760.00 mm Hg
Boiling Point 722.10 °C. @ 760.00 mm Hg (est)
Flash Point 451.00 °F. TCC ( 232.70 °C. ) (est)
logP (o/w) 0.640
Soluble in water, 98.71 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintravenous-cat LD50 95 ug/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for cymarin usage levels up tonot for fragrance use.
Recommendation for cymarin flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

found in nature

Synonyms

cymarine 5-beta- card-20(22)-enolide, 3-beta-(beta-d-cymarosyloxy)-5,14-dihydroxy-19-oxo- alvonal MR K- strophanthin-alpha strofantidina cimaroside strophanthidin-D-cymarosid stropheantin K PubMed: Convallatoxin: A new P-glycoprotein substrate. PubMed: Treatment of human embryonic stem cells with different combinations of priming and inducing factors toward definitive endoderm. PubMed: Interaction of digitalis-like compounds with p-glycoprotein. PubMed: Cardiotonic effect of Apocynum venetum L. extracts on isolated guinea pig atrium. PubMed: LC-ESI-MS/MS characterization of strophanthin-K. PubMed: Inhibitory effect of Adonis amurensis components on tube-like formation of human umbilical venous cells. PubMed: Cardenolides as oviposition deterrents to twoPieris species: Structure-activity relationships. PubMed: Properties of palytoxin-induced whole cell current in single rat ventricular myocytes. PubMed: Vesicular uptake system for the cation lucigenin in the rat hepatocyte. PubMed: Chemical constituents ofErysimum cheiranthoides deterring oviposition by the cabbage butterfly,Pieris rapae. PubMed: Palytoxin-induced K+ efflux from ileal longitudinal smooth muscle of the guinea-pig. PubMed: Preparation and evaluation of technetium-99m labeled cardiac glycoside derivatives as potential myocardial imaging agent. PubMed: Palytoxin induces a relatively non-selective cation permeability in frog sciatic nerve which can be inhibited by cardiac glycosides. PubMed: Human cell mutants affected in the interaction of the 12 beta-OH group of cardiac glycosides with the digitalis receptor. PubMed: Absorption, metabolism and elimination of strophanthus glycosides in man. PubMed: Fast atom bombardment and tandem mass spectrometry for structure determination of steroid and flavonoid glycosides. PubMed: Interaction of palytoxin and cardiac glycosides on erythrocyte membrane and (Na+ + K+) ATPase. PubMed: Involvement of the sugar moiety in the inhibitory action of the cardiac glycosides on the palytoxin-induced responses in vascular smooth muscles. PubMed: Photoaffinity labeling of (Na+K+)-ATPase with [125I]iodoazidocymarin. PubMed: Sugar moiety of cardiac glycosides is essential for the inhibitory action on the palytoxin-induced K+ release from red blood cells. PubMed: [Effect of plant glycosides on resistance and capacitance vessels]. PubMed: Cytotoxic principles of Parquetina nigrescens (Afzel.) Bullock (Asclepiadaceae). PubMed: Cardenolides of Trachomitum sarmatiense Woodson. PubMed: Photoaffinity labeling of the ouabain-binding site on (Na+ plus K+) adenosinetriphosphatase. PubMed: Isolation of cymarin from Adonis aestivalis. PubMed: [Our experiences with Cymarin (C 197) in the oral therapy of heart insufficiency]. PubMed: [The inhibitory effect of cardiac glycosides on 86 Rb-uptake of erythrocytes. I. Studies on the determination of cymarin (k-strophantin-a) and digitoxin]. PubMed: [The inhibitory effects of cardiac glycosides on 86 Rb uptake of erythrocytes. 3. The influence of different substances on the inhibitory effect of cymarin on 86 Rb-uptake of erythrocytes]. PubMed: [The inhibitory effect of cardiac glycosides on 86 Rb-uptake of erythrocytes. II. Specificity of the inhibitory effect with special attention to cymarin (k-strophantin-a) and its derivatives]. PubMed: [Clinical quantitative studies on cardio-active glycosides. A review with special reference to the studies on rapid fibrillation using cymarin]. PubMed: Structure-activity relationships of several cardiotonic steroids with respect to inhibition of ion transport in frog muscle. PubMed: [On the quantitative effectiveness of k-strophanthin-alpha (Cymarin) in intravenous and oral administration]. PubMed: [The effect of strophanthin, corelborin and cymarin on the cardiovascular system in patients with circulatory insufficiency following heart surgery]. PubMed: [Experimental studies of cardiac glycosides corelborin P and cymarin]. PubMed: [Standardization of an Apocynum extract with pure cymarin]. PubMed: [Comparison of the effect of Digitalis lanata standard drug with digoxin and cymarin on guinea pigs]. PubMed: [Oral therapy of cardiac insufficiency with cymarin (Alvonal MR)]. PubMed: [Effect of corelborine P, cymarin and strophanthin K on cardiovascular system of dogs with symptoms of cardiac insufficiency]. PubMed: [The extracardial effect of cymarin on the smooth muscles of the intestine]. PubMed: [Experience with cymarin in the practice]. PubMed: Distribution, excretion and metabolism of cymarin in the rat. PubMed: [COMPARATIVE STUDIES ON THE EFFECT OF STROPHANTHIN AND CYMARIN IN PATIENTS WITH PREDOMINANTLY LEFT CARDIAC INSUFFICIENCY]. PubMed: [COMPARATIVE BIOLOGICAL EFFECTS OF STROPHANTHIN-K, CORELBORIN-P, CYMARIN AND PERIPLOCIN ON THE CAT HEART IN LESIONS INDUCED WITH ZINC HYDROXIDE]. PubMed: TUMOR INHIBITORS. IV. APOCANNOSIDE AND CYMARIN, THE CYTOTOXIC PRINCIPLES OF APOCYNUM CANNABINUM L. PubMed: The isolation of cymarin and periplocymarin from the seeds of Castilloa elastica Cerv. PubMed: [Cymarin, an orally effective k-strophanthin]. PubMed: [On the characteristics of the action of strophanthin and cymarin in experimental myocardial infarct]. PubMed: [Data on comparative studies of the activity of crystalline cymarin and standard liquid Adonis preparation on R. temporaria]. PubMed: [Examination of hexahydroscillaren A & allocymarin as possible antagonists of scillaren A & cymarin on isolated heart]. PubMed: [Comparative therapeutic effects of strophanthin and cymarin in experimental myocarditis]. PubMed: [Some new drugs with cardio-vascular action]. PubMed: [Not Available]. PubMed: [Not Available].