cymarin
stropheantin K
Identification
| Name | cymarin |
| CAS Number | 508-77-0 |
| EINECS | 208-087-9 |
| FDA UNII | UK3LS8435E |
| Molecular Formula | C30 H44 O9 |
| Molecular Weight | 548.67348000 |
| MDL Number | MFCD00003669 |
| Beilstein | 0101370 |
| XlogP3 | 0.80 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 148.00 °C. @ 760.00 mm Hg |
| Boiling Point | 722.10 °C. @ 760.00 mm Hg (est) |
| Flash Point | 451.00 °F. TCC ( 232.70 °C. ) (est) |
| logP (o/w) | 0.640 |
| Soluble in | water, 98.71 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intravenous-cat LD50 95 ug/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | pharmaceuticals / chemical synthisis |
| Recommendation for cymarin usage levels up to | not for fragrance use. |
| Recommendation for cymarin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
cymarine
5-beta-
card-20(22)-enolide, 3-beta-(beta-d-cymarosyloxy)-5,14-dihydroxy-19-oxo-
alvonal MR
K-
strophanthin-alpha
strofantidina cimaroside
strophanthidin-D-cymarosid
stropheantin K
PubMed:
Convallatoxin: A new P-glycoprotein substrate.
PubMed:
Treatment of human embryonic stem cells with different combinations of priming and inducing factors toward definitive endoderm.
PubMed:
Interaction of digitalis-like compounds with p-glycoprotein.
PubMed:
Cardiotonic effect of Apocynum venetum L. extracts on isolated guinea pig atrium.
PubMed:
LC-ESI-MS/MS characterization of strophanthin-K.
PubMed:
Inhibitory effect of Adonis amurensis components on tube-like formation of human umbilical venous cells.
PubMed:
Cardenolides as oviposition deterrents to twoPieris species: Structure-activity relationships.
PubMed:
Properties of palytoxin-induced whole cell current in single rat ventricular myocytes.
PubMed:
Vesicular uptake system for the cation lucigenin in the rat hepatocyte.
PubMed:
Chemical constituents ofErysimum cheiranthoides deterring oviposition by the cabbage butterfly,Pieris rapae.
PubMed:
Palytoxin-induced K+ efflux from ileal longitudinal smooth muscle of the guinea-pig.
PubMed:
Preparation and evaluation of technetium-99m labeled cardiac glycoside derivatives as potential myocardial imaging agent.
PubMed:
Palytoxin induces a relatively non-selective cation permeability in frog sciatic nerve which can be inhibited by cardiac glycosides.
PubMed:
Human cell mutants affected in the interaction of the 12 beta-OH group of cardiac glycosides with the digitalis receptor.
PubMed:
Absorption, metabolism and elimination of strophanthus glycosides in man.
PubMed:
Fast atom bombardment and tandem mass spectrometry for structure determination of steroid and flavonoid glycosides.
PubMed:
Interaction of palytoxin and cardiac glycosides on erythrocyte membrane and (Na+ + K+) ATPase.
PubMed:
Involvement of the sugar moiety in the inhibitory action of the cardiac glycosides on the palytoxin-induced responses in vascular smooth muscles.
PubMed:
Photoaffinity labeling of (Na+K+)-ATPase with [125I]iodoazidocymarin.
PubMed:
Sugar moiety of cardiac glycosides is essential for the inhibitory action on the palytoxin-induced K+ release from red blood cells.
PubMed:
[Effect of plant glycosides on resistance and capacitance vessels].
PubMed:
Cytotoxic principles of Parquetina nigrescens (Afzel.) Bullock (Asclepiadaceae).
PubMed:
Cardenolides of Trachomitum sarmatiense Woodson.
PubMed:
Photoaffinity labeling of the ouabain-binding site on (Na+ plus K+) adenosinetriphosphatase.
PubMed:
Isolation of cymarin from Adonis aestivalis.
PubMed:
[Our experiences with Cymarin (C 197) in the oral therapy of heart insufficiency].
PubMed:
[The inhibitory effect of cardiac glycosides on 86 Rb-uptake of erythrocytes. I. Studies on the determination of cymarin (k-strophantin-a) and digitoxin].
PubMed:
[The inhibitory effects of cardiac glycosides on 86 Rb uptake of erythrocytes. 3. The influence of different substances on the inhibitory effect of cymarin on 86 Rb-uptake of erythrocytes].
PubMed:
[The inhibitory effect of cardiac glycosides on 86 Rb-uptake of erythrocytes. II. Specificity of the inhibitory effect with special attention to cymarin (k-strophantin-a) and its derivatives].
PubMed:
[Clinical quantitative studies on cardio-active glycosides. A review with special reference to the studies on rapid fibrillation using cymarin].
PubMed:
Structure-activity relationships of several cardiotonic steroids with respect to inhibition of ion transport in frog muscle.
PubMed:
[On the quantitative effectiveness of k-strophanthin-alpha (Cymarin) in intravenous and oral administration].
PubMed:
[The effect of strophanthin, corelborin and cymarin on the cardiovascular system in patients with circulatory insufficiency following heart surgery].
PubMed:
[Experimental studies of cardiac glycosides corelborin P and cymarin].
PubMed:
[Standardization of an Apocynum extract with pure cymarin].
PubMed:
[Comparison of the effect of Digitalis lanata standard drug with digoxin and cymarin on guinea pigs].
PubMed:
[Oral therapy of cardiac insufficiency with cymarin (Alvonal MR)].
PubMed:
[Effect of corelborine P, cymarin and strophanthin K on cardiovascular system of dogs with symptoms of cardiac insufficiency].
PubMed:
[The extracardial effect of cymarin on the smooth muscles of the intestine].
PubMed:
[Experience with cymarin in the practice].
PubMed:
Distribution, excretion and metabolism of cymarin in the rat.
PubMed:
[COMPARATIVE STUDIES ON THE EFFECT OF STROPHANTHIN AND CYMARIN IN PATIENTS WITH PREDOMINANTLY LEFT CARDIAC INSUFFICIENCY].
PubMed:
[COMPARATIVE BIOLOGICAL EFFECTS OF STROPHANTHIN-K, CORELBORIN-P, CYMARIN AND PERIPLOCIN ON THE CAT HEART IN LESIONS INDUCED WITH ZINC HYDROXIDE].
PubMed:
TUMOR INHIBITORS. IV. APOCANNOSIDE AND CYMARIN, THE CYTOTOXIC PRINCIPLES OF APOCYNUM CANNABINUM L.
PubMed:
The isolation of cymarin and periplocymarin from the seeds of Castilloa elastica Cerv.
PubMed:
[Cymarin, an orally effective k-strophanthin].
PubMed:
[On the characteristics of the action of strophanthin and cymarin in experimental myocardial infarct].
PubMed:
[Data on comparative studies of the activity of crystalline cymarin and standard liquid Adonis preparation on R. temporaria].
PubMed:
[Examination of hexahydroscillaren A & allocymarin as possible antagonists of scillaren A & cymarin on isolated heart].
PubMed:
[Comparative therapeutic effects of strophanthin and cymarin in experimental myocarditis].
PubMed:
[Some new drugs with cardio-vascular action].
PubMed:
[Not Available].
PubMed:
[Not Available].