(±)-ephedrine hydrochloride

2-(methylamino)-1-phenyl-1-propanol hydrochloride (1:1)

CAS: 134-71-4 C10 H16 Cl N O MW: 201.69572000

Identification

Name(±)-ephedrine hydrochloride
IUPAC2-(methylamino)-1-phenylpropan-1-ol;hydrochloride
CAS Number134-71-4
EINECS205-153-9
FDA UNII43SK4LAO7D
Molecular FormulaC10 H16 Cl N O
Molecular Weight201.69572000
MDL NumberMFCD00012626

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 255.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure 0.008650 mmHg @ 25.00 °C. (est)
Flash Point 186.00 °F. TCC ( 85.60 °C. ) (est)
logP (o/w) 1.054 (est)
Soluble in water, 1e+006 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-man TDLo 1429 ug/kg
Dermal Toxicitysubcutaneous-mouse LD50 520 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for (±)-ephedrine hydrochloride usage levels up tonot for fragrance use.
Recommendation for (±)-ephedrine hydrochloride flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

benzenemethanol, a-(1-(methylamino)ethyl)-, hydrochloride, (R*,R*)-(±)- benzenemethanol, a-[1-(methylamino)ethyl]-, hydrochloride (1:1) benzenemethanol, a-[1-(methylamino)ethyl]-, hydrochloride, S-(R,R)- benzyl alcohol, a-(1-methylaminoethyl)-, hydrochloride ephedrine hydrochloride DL- ephedrine hydrochloride ephedrine, hydrochloride, (±)- ephedrinehydrochloride 2-( methylamino)-1-phenyl-1-propanol hydrochloride (1:1) 2-( methylamino)-1-phenylpropan-1-ol hydrochloride (1:1) 2-( methylamino)-1-phenylpropan-1-ol;hydrochloride DL-a-(1-( methylamino)ethyl) benzyl alcohol hydrochloride (R*,S*)-(1)-a-(1-( methylamino)ethyl)benzyl alcohol hydrochloride DL-a(1-( methylamino)ethyl)benzyl alcohol hydrochloride (R*,S*)-a-[1-( methylamino)ethyl]benzenemethanol hydrochloride racephedrine hydrochloride PubMed: Pharmacokinetic comparisons of five ephedrine alkaloids following oral administration of four different Mahuang-Guizhi herb-pair aqueous extracts ratios in rats. PubMed: [Simultaneous determination of scopolamine hydrobromide, atropine sulfate, ephedrine hydrochloride and pseudoephedrine hydrochloride in Zhichuanling oral liquid with HPLC]. PubMed: [Simultaneous determination of ephedrine hydrochloride, D-pseudoephedrine and amygdalin in xiao'er pingchuan qutan granule by HPLC]. PubMed: Extractive determination of ephedrine hydrochloride and bromhexine hydrochloride in pure solutions, pharmaceutical dosage form and urine samples. PubMed: Ephedrine hydrochloride inhibits PGN-induced inflammatory responses by promoting IL-10 production and decreasing proinflammatory cytokine secretion via the PI3K/Akt/GSK3β pathway. PubMed: Ephedrine hydrochloride: novel use in the management of resistant non-neurogenic daytime urinary incontinence in children. PubMed: Clarification of route specific impurities found in methylamphetamine synthesised using the Birch method. PubMed: Precise, fast, and flexible determination of protein interactions by affinity capillary electrophoresis: part 1: performance. PubMed: Ephedrine hydrochloride protects mice from LPS challenge by promoting IL-10 secretion and inhibiting proinflammatory cytokines. PubMed: Simultaneous determination of six active components in traditional herbal medicine 'Oyaksungisan' by HPLC-DAD. PubMed: Pharmacokinetic determination of ephedrine in Herba Ephedrae and Wu Tou Tang decoctions in rats using ultra performance liquid chromatography tandem mass spectrometry. PubMed: [Determination of ephedrine hydrochloride, pseudoephedrine hydrochloride and methylephedrine hydrochloride in maxingshigan decoction by CE]. PubMed: [Simultaneous determination of 5 kinds of alkaloids in Kechuanning tablets by SPE-UPLC under different UV-vis wavelength]. PubMed: Labeling for bronchodilators to treat asthma; cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-the-counter human use. Final rule. PubMed: A novel accelerated oxidative stability screening method for pharmaceutical solids. PubMed: Assessment of acute and chronic pharmacological effects on energy expenditure and macronutrient oxidation in humans: responses to ephedrine. PubMed: [Concentration of biyankang extracts using multi-stage membranes separation]. PubMed: Treatment of hypothalamic obesity with caffeine and ephedrine. PubMed: Use of warm priming solution in open heart surgery: its effects on hemodynamics and acute inflammation. PubMed: Rapid nondestructive on-site screening of methylamphetamine seizures by attenuated total reflection fourier transform infrared spectroscopy. PubMed: Spinal anaesthesia with a micro-catheter in high-risk patients undergoing colorectal cancer and other major abdominal surgery. PubMed: [Direct determination of four components in compound paracetamol and diphenhydramine tablets by wide bore capillary gas chromatography]. PubMed: Flow injection-chemiluminescence determination of sulfadiazine in compound naristillae. PubMed: [Investigate into of effective constituent transference of herba Ephedrae and cortex Magnoliae officinalis in preparation course of Shujin Kechuan capsule]. PubMed: [Study on the preparation and quality standard of Ephedra sinica dispensing granules]. PubMed: Highly sensitive spectrofluorimetric determination of ephedrine hydrochloride in pharmaceutical preparations. PubMed: [Simultaneous determination of ephedrine and chlorpheniramine in human plasma by a highly sensitive liquid chromatography-tandem mass spectrometric method]. PubMed: Liquid chromatography and chemometric-assisted spectrophotometric methods for the analysis of two multicomponent mixtures containing cough suppressant drugs. PubMed: [Case of circulatory depression in an obese patient in prone position during general anesthesia]. PubMed: Single-step recovery of ephedrine hydrochloride from raw materials using expanded bed adsorption. PubMed: [Rheological and biopharmaceutical investigation of polymer drug delivery systems]. PubMed: Structure and drug release of lamellar liquid crystals containing glycerol. PubMed: [HPCE determination of trimebutine maleate in rat plasma and its pharmacokinetics]. PubMed: [Simultaneous determination of chlorpheniramine, paracetamol and pseudo-ephedrine hydrochloride in composite tablets by high performance liquid chromatography]. PubMed: Determination of theophylline and ephedrine HCL in tablets by ratio-spectra derivative spectrophotometry and LC. PubMed: [Propofol anesthesia for a patient with progressive muscular dystrophy]. PubMed: Determination of trimebutine maleate in rat plasma and tissues by using capillary zone electrophoresis. PubMed: A prospective randomised study to assess the efficacy of differenct medications for relief of post-operative nasal obstruction. PubMed: [Sources of error in the European Pharmacopoeia assay of halide salts of organic bases by titration with alkali]. PubMed: [A case of fixed drug eruption due to ephedrine hydrochloride]. PubMed: Effects of crystallization in the presence of the diastereomer on the crystal properties of (SS)-(+)-pseudoephedrine hydrochloride. PubMed: Assay of ephedrine hydrochloride and theophylline in pharmaceutical formulations by differential-derivative spectroscopy. PubMed: Simultaneous assay of ephedrine hydrochloride, theophylline, papaverine hydrochloride and hydroxyzine hydrochloride in tablets using RP-LC. PubMed: Nocturnal enuresis: pathogenesis and treatment. PubMed: Ephedrine pharmacokinetics after the ingestion of nutritional supplements containing Ephedra sinica (ma huang). PubMed: Ophthalmic drug products for over-the-counter human use; proposed amendment of final monograph--FDA. Proposed rule. PubMed: [Determination of paracetmol caffeine and ephedrine hydrochloride in likeshu capsules]. PubMed: [Toxicity of drugs on nasal mucocilia and the method of its evaluation]. PubMed: Do changes in cardiac output affect the inspiratory to end-trial oxygen difference? PubMed: Potentiometric, enantioselective sensors for alkyl and aryl ammonium ions of pharmaceutical significance, based on lipophilic cyclodextrins. PubMed: A prospective randomized study to assess the efficacy of post-operative nasal medication after endonasal surgery. PubMed: Orthostatic hypotension in patients, bed rest subjects, and astronauts. PubMed: [Influence of viscosity on drug release from ointments, creams, gels and emulsions]. PubMed: The effect of some commercially available antihistamine and decongestant intra-nasal formulations on ciliary beat frequency. PubMed: [Crystal morphological and habit investigations of crystalline drugs. II. Amobarbital, barbital and ephedrine hydrochloride]. PubMed: Potentiometric determination of ephedrine hydrochloride using plastic membrane ion-selective electrode. PubMed: Effects of chronic administration of ephedrine during very-low-calorie diets on energy expenditure, protein metabolism and hormone levels in obese subjects. PubMed: Hypertensive crisis from chronic intoxication with nasal decongestant and cough medications. PubMed: [Use of extraction-frequency metric method for the determination of microquantities of ephedrine and its application in pharmaceutical analysis]. PubMed: Release of highly water-soluble medicinal compounds from inert, heterogeneous matrixes. II: Melt. PubMed: Release of highly water-soluble medicinal compounds from inert, heterogeneous matrixes. I: Physical mixture. PubMed: Determination of chlorpheniramine maleate, dihydrocodeine bitartrate and ephedrine hydrochloride in cough mixture by derivative and differential spectrometry. PubMed: [Coronary spasm during laryngoplasty]. PubMed: A simple, effective method of treating vertigo patients. PubMed: Determination of enantiomeric purity of ephedrine and pseudoephedrine by high-performance liquid chromatography with dual optical rotation/UV absorbance detection. PubMed: [Studies on multiwavelength absorbance ratio difference spectrophotometry and its application]. PubMed: Thermal characterization of drug/polymer and excipient/polymer interactions in some film coating formulation. PubMed: A controlled trial of an oral bronchodilator preparation ('Franol') in asthma. PubMed: [Effect of ephedrine on the blood supply and oxygen regimen of the brain during motion sickness]. PubMed: Does ephedrine promote weight loss in low-energy-adapted obese women? PubMed: Use of orthogonal polynomials for unequal intervals to eliminate interference in spectrophotometric analysis. Simultaneous determination of ephedrine hydrochloride and diphenhydramine hydrochloride in two-component mixtures. PubMed: A controlled trial using ephedrine in the treatment of obesity. PubMed: [Arterial hypertension induced by an excess of mineralocorticoids caused by abuse of nasal spray. Report of a case]. PubMed: The effect of d-amphetamine and ephedrine on smoking attitude and behavior. PubMed: [Research concerning the biodisposability of ephedrine hydrochloride tablets]. PubMed: Spectrophotometric determination of ephedrine hydrochloride and phenylephrine hydrochloride. PubMed: A study of the thermic responses to a meal and to a sympathomimetic drug (ephedrine) in relation to energy balance in man. PubMed: High-pressure liquid chromatographic assay of theophylline, ephedrine hydrochloride, and phenobarbital tablets. PubMed: Simultaneous high-performance liquid chromatographic determination of theophylline, ephedrine hydrochloride, and phenobarbital in tablets. PubMed: NMR assay of ephedrine hydrochloride in tablets. PubMed: The effects upon vigilance and reaction speed of the addition of ephedrine hydrochloride to chlorpheniramine maleate. PubMed: Scopolamine alone or combined with ephedrine in seasickness: a double-blind, placebo-controlled study. PubMed: Spectrophotometric method for determination of chlorpheniramine maleate in pharmaceutical preparations in the presence of codeine phosphate and ephedrine hydrochloride. PubMed: [UV spectrophotometric method for the quantitative determination of ephedrine hydrochloride]. PubMed: [Periodatometric method for the quantitative determination of ephedrine hydrochloride in drug mixtures]. PubMed: Simple and specific electron-capture GLC assay for plasma and urine ephedrine concentrations following single doses. PubMed: [Spectrophotometric and photometric determination of ephedrine hydrochloride]. PubMed: Effect of guar gum on the dissolution rate of ephedrine hydrochloride and sulphadimidine tablets. PubMed: [Dansyl chloride as a reagent for sympathomimetic amines, II: Fluorimetric determination of ephedrine hydrochloride as its dansyl derivative in tablets (author's transl)]. PubMed: [Absorption of ephedrine hydrochloride in the presence of auxiliary high-molecular compounds in the intestines of rats]. PubMed: Structure and fragmentation mechanisms of some ions in the mass spectrum of ephedrine. PubMed: UV spectrophotometric determination of aminophylline, amobarbital, and ephedrine hydrochloride in an antiasthma capsule preparation. PubMed: [Changes in bile formation in calves under the influence of ephedrine hydrochloride]. PubMed: Comparison of stability-indicating assay methods: ultraviolet, high pressure liquid chromatography and acid dye. PubMed: The pharmacokinetics of ephedrine after oral dosage in asthmatics receiving acute and chronic treatment. PubMed: Colorimetric determinations of chlorpheniramine maleate, ephedrine hydrochloride, and guaiacolsulfonate potassium in a cough syrup. PubMed: Effects of tonicities and solutes of solutions on the lethality and the survival time after intraduodenal administration of ephedrine hydrochloride in mice. PubMed: [Analysis of a mixture of ephedrine hydrochloride and dimedrol by grid-polybuffer distribution]. PubMed: Quantitative GLC analysis of theophylline, ephedrine hydrochloride, and phenobarbital suspension. PubMed: [Extraction-photometric determination of dimedrol and ephedrine hydrochloride in drug mixtures by means of acid azo dyes]. PubMed: Variations in theophylline, ephedrine hydrochloride and phenobarbital tablets manufactured by thirteen firms. PubMed: [Titration method of determination of ephedrine hydrochloride on the basis of copper complex formation]. PubMed: Determination of aminophylline, ephedrine hydrochloride and sodium caffeinebenzoate in composed prescription drugs. PubMed: [Chromatospectrophotometric method of quantitative determination of theophylline, dimedrol and ephedrine hydrochloride in drug mixtures]. PubMed: [Determination of ephedrine hydrochloride in compound pharmaceutical preparations by means of para-toluenesulfonic acid]. PubMed: Quantitative gas chromatographic determination of methapyrilene fumarate, ephedrine hydrochloride, and codeine phosphate in syrup. PubMed: [Determination of theophylline, caffeine and ephedrine hydrochloride in the preparation Belladrinal tablet]. PubMed: [Reactions for the identification of ephedrine hydrochloride and their use in examination of drug mixtures]. PubMed: USE OF EPHEDRINE HYDROCHLORIDE IN THE PAPYROGRAPHY OF AMINO ACIDS. PubMed: [Action of adrenaline and ephedrine hydrochloride on the activity of Lebistes reticulus (Peociliidae--Cyprinodontiformes)]. PubMed: [EXPERIMENTAL CLINICAL TESTING OF N-HYDROXYETHYLPROMETHAZINE CHLORIDE (APROBIT) COMBINED WITH EPHEDRINE HYDROCHLORIDE IN THE NASAL CAVITY]. PubMed: Spectrophotometric assay of capsules of aminophylline, amobarbital, and ephedrine hydrochloride. PubMed: [Chromatographic purity test for ephedrine hydrochloride. VI. Behavior of the alkaloidal salt solution on aluminum hydroxide column]. PubMed: [Action of alkaline chlorobicarbonated water on the antidiuretic effects of ephedrine hydrochloride].