laudanosine

(1)-1-((3,4- dimethoxyphenyl)methyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinoline 1-[(3,4- dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline (±)- laudanosine iso quinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-veratryl-, (+-)- 1,2,3,4- tetrahydro-6,7-dimethoxy-2-methyl-1-veratrylisoquinoline PubMed: [Determination of atracurium and laudanosine in dog plasma during cardiopulmonary bypass by high performance liquid chromatography with fluorometric detection]. PubMed: Synthesis of 1-substituted tetrahydroisoquinolines by lithiation and electrophilic quenching guided by in situ IR and NMR spectroscopy and application to the synthesis of salsolidine, carnegine and laudanosine. PubMed: Synthesis of alkaloids by Stevens rearrangement of nitrile-stabilized ammonium ylides: (±)-laudanosine, (±)-laudanidine, (±)-armepavine, (±)-7-methoxycryptopleurine, and (±)-xylopinine. PubMed: Laudanosine has no effects on respiratory activity but induces non-respiratory excitement activity in isolated brainstem-spinal cord preparation of neonatal rats. PubMed: Methyl-laudanosine: a new pharmacological tool to investigate the function of small-conductance Ca(2+)-activated K(+) channels. PubMed: Modulation of rat brain synaptosomal plasma membrane achieved by atracurium and its metabolite laudanosine. PubMed: Laudanosine and atracurium concentrations in a patient receiving long-term atracurium infusion. PubMed: Mechanism of the cardiovascular activity of laudanosine: comparison with papaverine and other benzylisoquinolines. PubMed: Interactions between laudanosine, GABA, and opioid subtype receptors: implication for laudanosine seizure activity. PubMed: Convulsive effects and pharmacokinetics of laudanosine in the rat. PubMed: Pharmacology of laudanosine in dogs. PubMed: Laudanosine (a metabolite of atracurium) increases the minimum alveolar concentration of halothane in rabbits. PubMed: Suicide with cisatracurium and thiopental: forensic and analytical aspects. PubMed: Pharmacokinetic modelling of a parent drug and its metabolite. Atracurium and laudanosine. PubMed: Atracurium decay and the formation of laudanosine in humans. PubMed: Cardiovascular and neurological effects of laudanosine. Studies in mice and rats, and in conscious and anaesthetized dogs. PubMed: Electrophysiological characterization of the SK channel blockers methyl-laudanosine and methyl-noscapine in cell lines and rat brain slices. PubMed: Effect of atracurium and laudanosine on the release of 3H-noradrenaline. PubMed: [Effect of laudanosine on catecholamine release in dogs]. PubMed: Cardiovascular and electroencephalographic effects of laudanosine in "nephrectomized" cats. PubMed: Cerebrospinal fluid concentrations of atracurium, laudanosine and vecuronium following clinical subarachnoid hemorrhage. PubMed: Pharmacodynamics and atracurium and laudanosine concentrations during a fixed continuous infusion of atracurium in mechanically ventilated patients with acute respiratory distress syndrome. PubMed: Laudanosine, an atracurium and cisatracurium metabolite. PubMed: Cerebrospinal fluid concentrations of laudanosine after administration of atracurium. PubMed: Electroencephalographic effects of laudanosine in an animal model of epilepsy. PubMed: Modification by drugs used in anaesthesia of CNS stimulation induced in mice by laudanosine and strychnine. PubMed: Clearance of atracurium and laudanosine in the urine and by continuous venovenous haemofiltration. PubMed: Concentrations of atracurium and laudanosine in cerebrospinal fluid and plasma during intracranial surgery. PubMed: Laudanosine does not displace receptor-specific ligands from the benzodiazepinergic or muscarinic receptors. PubMed: Blockade and activation of the human neuronal nicotinic acetylcholine receptors by atracurium and laudanosine. PubMed: Plasma laudanosine levels in patients given atracurium during liver transplantation. PubMed: Concentrations of atracurium and laudanosine in cerebrospinal fluid and plasma in three intensive care patients. PubMed: Pharmacokinetics of atracurium and laudanosine in the elderly. PubMed: Disposition of infusions of atracurium and its metabolite, laudanosine, in patients in renal and respiratory failure in an ITU. PubMed: Synthesis and biological evaluation of N-methyl-laudanosine iodide analogues as potential SK channel blockers. PubMed: Plasma concentrations of laudanosine, but not of atracurium, are increased during the anhepatic phase of orthotopic liver transplantation in pigs. PubMed: The distribution of laudanosine in tissues after death from atracurium injection. PubMed: High-performance liquid chromatographic method for the determination of atracurium and laudanosine in human plasma. Application to pharmacokinetics. PubMed: Transplacental distribution of atracurium, laudanosine and monoquaternary alcohol during elective caesarean section. PubMed: High-performance liquid chromatographic assay for laudanosine in biological fluids and tissue for neurotoxic studies in rats. PubMed: Modification of central nervous system effects of laudanosine by inhalation anaesthetics. PubMed: Pharmacokinetics of atracurium and laudanosine in patients with hepatic cirrhosis. PubMed: The metabolic disposition of laudanosine in dog, rabbit, and man. PubMed: [Absorption of papaverine, laudanosine and cepharanthine across human intestine by using human Caco-2 cells monolayers model]. PubMed: Nitrous oxide antagonizes CNS stimulation by laudanosine in mice. PubMed: Production of laudanosine following infusion of atracurium in man and its effects on awakening. PubMed: Effect of renal failure on laudanosine excretion in man. PubMed: Pharmacokinetics of 1R-cis 1'R-cis atracurium besylate (51W89) and plasma laudanosine concentrations in health and chronic renal failure. PubMed: Synthesis and radioligand binding studies of C-5- and C-8-substituted 1-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinoliniums as SK channel blockers related to N-methyl-laudanosine and N-methyl-noscapine. PubMed: Clinical experience and plasma laudanosine concentrations during the infusion of atracurium in the intensive therapy unit. PubMed: Simultaneous determination of atracurium and its metabolite laudanosine in post-mortem fluids by liquid chromatography/multiple-stage mass spectrometry on an ion trap. PubMed: Chiral separation of norlaudanosoline, laudanosoline, laudanosine, chlorthalidone, and three benzoin derivatives using amino acid based molecular micelles. PubMed: Identification of laudanosine, an atracurium metabolite, following a fatal drug-related shooting. PubMed: Hepatotoxicity testing of atracurium and laudanosine in the isolated, perfused rat liver. PubMed: Determination of atracurium and laudanosine in human plasma by high-performance liquid chromatography. PubMed: The microbial oxygenation of the benzylisoquinoline alkaloid laudanosine. PubMed: Atracurium and laudanosine pharmacokinetics in acute renal failure. PubMed: Simplified method for the determination of atracurium and laudanosine in pig plasma by high-performance liquid chromatography and fluorimetric detection. PubMed: The possible neuroprotective effect of laudanosine, an atracurium and cisatracurium metabolite. PubMed: High-dose laudanosine enhances liver cell activity and bile flow during reperfusion of the liver. PubMed: Determination of atracurium, laudanosine and related compounds in plasma by high-performance liquid chromatography. PubMed: The use of cisatracurium in critical care: A review of the literature. PubMed: Investigation of chondroitin sulfate D and chondroitin sulfate E as novel chiral selectors in capillary electrophoresis. PubMed: [DEHYDRATION OF TERTIARY AMINES WITH HG(II)-EDTA. 8. ON THE CONFIGURATION OF 1-BENZYL-N-TERT-BUTYL-1,2,3,4-TETRAHYDROISOQUINOLINE AND LAUDANOSINE]. PubMed: [Dehydration of tertiary amines by mercuric acetate in the presence of ethylenediaminetetraacetic acid. 1. The configuration of laudanosine]. PubMed: Microbial transformations of natural antitumor agents. 2. Studies with d-tetrandrine and laudanosine. PubMed: [DEHYDROGENATION OF TERTIARY AMINES WITH HG(II)-EDTA. 6. FURTHER STUDIES ON THE PROCESS OF AROMATIZATION OF LAUDANOSINE WITH HG(III)-EDTA]. PubMed: [Dehydration of tertiary amines with Hg(II)-EDTA. 4. On the course of aromatization of laudanosine with Hg(II)-EDTA]. PubMed: Characterization of three O-methyltransferases involved in noscapine biosynthesis in opium poppy. PubMed: Synthesis and radioligand binding studies of bis-(8-isopropyl-isoquinolinium) derivatives as ligands for apamin-sensitive sites on cloned SK2 and SK3 channels. PubMed: Atracurium infusions in patients with fulminant hepatic failure awaiting liver transplantation. PubMed: Anesthesiologist suicide with atracurium. PubMed: The in vitro degradation of cisatracurium, the R, cis-R'-isomer of atracurium, in human and rat plasma. PubMed: The biosynthesis of papaverine proceeds via (S)-reticuline. PubMed: Enantioselective synthesis of tetrahydroprotoberberines and bisbenzylisoquinoline alkaloids from a deprotonated α-aminonitrile. PubMed: Identification and quantitation of six non-depolarizing neuromuscular blocking agents by LC-MS in biological fluids. PubMed: Pharmacokinetics and dynamics of atracurium infusions after paediatric orthotopic liver transplantation. PubMed: Determination of atracurium, cisatracurium and mivacurium with their impurities in pharmaceutical preparations by liquid chromatography with charged aerosol detection. PubMed: Perinatal neuroprotection by muscle relaxants against hypoxic-ischemic lesions: is it a possible hypothesis? PubMed: Evaluation of the enantioselectivity of glycogen-based dual chiral selector systems towards basic drugs in capillary electrophoresis. PubMed: Comparison of the pharmacodynamics and pharmacokinetics of an infusion of cis-atracurium (51W89) or atracurium in critically ill patients undergoing mechanical ventilation in an intensive therapy unit. PubMed: In vitro degradation of atracurium in human plasma. PubMed: The pharmacokinetics of cisatracurium in patients with acute respiratory distress syndrome. PubMed: Effects of neuromuscular blocking agents on excitatory transmission and gamma-aminobutyric acidA-mediated inhibition in the rat hippocampal slice. PubMed: Pharmacokinetics of cisatracurium in patients receiving nitrous oxide/opioid/barbiturate anesthesia. PubMed: The prolonged use of atracurium in a patient with tetanus. PubMed: Pharmacokinetics of atracurium and its metabolites in patients with normal renal function, and in patients in renal failure. PubMed: Pharmacophore modelling of structurally unusual diltiazem mimics at L-type calcium channels. PubMed: A comparison of the infusion pharmacokinetics and pharmacodynamics of cisatracurium, the 1R-cis 1'R-cis isomer of atracurium, with atracurium besylate in healthy patients. PubMed: A pharmacokinetic-pharmacodynamic model for a muscle relaxant: atracurium. PubMed: Pharmacokinetics of 51W89: preliminary data. PubMed: Atracurium-induced neuromuscular block in the isolated arm. PubMed: Pharmacokinetics and neuromuscular blocking effects of atracurium besylate and two of its metabolites in patients with normal and impaired renal function. PubMed: The pharmacokinetics and pharmacodynamics of atracurium in patients with and without renal failure. PubMed: Synthesis of carbon-11 labeled 1-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinolinium derivatives as new potential PET SKCa channel imaging agents. PubMed: Bis-tetrahydroisoquinoline derivatives: AG525E1, a new step in the search for non-quaternary non-peptidic small conductance Ca(2+)-activated K(+) channel blockers. PubMed: Risk-based approach for the transfer of quantitative methods: bioanalytical applications. PubMed: SK channels control the firing pattern of midbrain dopaminergic neurons in vivo. PubMed: Studies of polymerized sodium N-undecylenyl-L-valinate in chiral micellar electrokinetic capillary chromatography of neutral, acidic, and basic compounds. PubMed: Pharmacokinetics and pharmacodynamics of cisatracurium in patients with end-stage liver disease undergoing liver transplantation. PubMed: Lambda-carrageenan: a novel chiral selector for capillary electrophoresis. PubMed: Influence of extreme obesity on the body disposition and neuromuscular blocking effect of atracurium. PubMed: Prolonged infusion of atracurium in an infant. PubMed: Atracurium overdose in a small infant. PubMed: Generation of reactive metabolites during spontaneous degradation of atracurium in vitro. PubMed: Pharmacokinetics of atracurium in anaesthetized infants and children. PubMed: Relationships between structure and vascular activity in a series of benzylisoquinolines. PubMed: Activation of brain acetylcholine receptors by neuromuscular blocking drugs. A possible mechanism of neurotoxicity. PubMed: Influence of incubated atracurium on rat liver function. PubMed: Residual curarization in the neonate after caesarean section. PubMed: Pharmacokinetics and pharmacodynamics of atracurium obtained with arterial and venous blood samples. PubMed: Anaesthesia for the treatment of a giant cerebral aneurysm under hypothermic circulatory arrest. PubMed: Synthesis and radioligand binding studies of methoxylated 1,2,3,4-tetrahydroisoquinolinium derivatives as ligands of the apamin-sensitive Ca2+-activated K+ channels. PubMed: The efficient synthesis of morphinandienone alkaloids by using a combination of hypervalent iodine(III) reagent and heteropoly acid. PubMed: Inhibitory effects of ethaverine, a homologue of papaverine, on monoamine oxidase activity in mouse brain. PubMed: Effect of dopamine, dimethoxyphenylethylamine, papaverine, and related compounds on mitochondrial respiration and complex I activity. PubMed: Identification of urinary and biliary conjugated metabolites of the neuromuscular blocker 51W89 by liquid chromatography/mass spectrometry. PubMed: Selective inhibition of calcium entry induced by benzylisoquinolines in rat smooth muscle. PubMed: The cardiovascular effects of atracurium and it's metabolite. PubMed: Pharmacological action of breakdown products of atracurium and related substances. PubMed: Cisatracurium infusion for neuromuscular blockade in the pediatric intensive care unit: A dose-finding study. PubMed: Applicability of ultra-performance liquid chromatography-tandem mass spectrometry for heroin profiling. PubMed: Bioactive constituents of the roots of Polyalthia cerasoides. PubMed: Evaluation of benzyltetrahydroisoquinolines as ligands for neuronal nicotinic acetylcholine receptors. PubMed: Transformation of opium poppy (Papaver somniferum L.) with antisense berberine bridge enzyme gene (anti-bbe) via somatic embryogenesis results in an altered ratio of alkaloids in latex but not in roots. PubMed: The GC-MS detection and characterization of reticuline as a marker of opium use. PubMed: Instability of pancuronium in postmortem blood and liver taken after a fatal intramuscular Pavulon injection. PubMed: The GC-MS detection and characterization of reticuline as a marker of opium use. PubMed: Aporphine alkaloids from Guatteria spp. with leishmanicidal activity. PubMed: Modulation of small conductance calcium-activated potassium (SK) channels: a new challenge in medicinal chemistry. PubMed: Colominic acid: a novel chiral selector for capillary electrophoresis of basic drugs. PubMed: Pharmacokinetic-pharmacodynamic modeling of atracurium in intensive care patients. PubMed: Approaching a million-fold sensitivity increase in capillary electrophoresis with direct ultraviolet detection: cation-selective exhaustive injection and sweeping PubMed: Comparative evaluation of capillary electrophoresis and high-performance liquid chromatography for the separation of cis-cis, cis-trans, and trans-trans isomers of atracurium besylate. PubMed: [Cisatracurium]. PubMed: [The clinical pharmacology of new benzylisoquinoline-diester compounds, with special consideration of cisatracurium and mivacurium]. PubMed: [New muscle relaxants]. PubMed: Approaches to short-acting neuromuscular blocking agents: nonsymmetrical bis-tetrahydroisoquinolinium mono- and diesters. PubMed: Simple high-performance liquid chromatographic method for the analysis of the non-depolarizing neuromuscular blocking drugs in clinical anaesthesia. PubMed: Pharmacokinetics of atracurium metabolites. PubMed: Review of atracurium by continuous i.v. infusion. PubMed: High pressure liquid chromatographic determination of the five major alkaloids in Papaver somniferum L. and thebaine in Papaver bracteatum Lindl. capsular tissue. PubMed: Hofmann elimination with diazomethane on curare bases and selected quaternary tetrahydroisoquinoline alkaloids. PubMed: A relatively simple differential screening test for GABA or glycine antagonists using rat electroretinography. PubMed: Alkaloids of Hernandia voyronii: chloroquine-potentiating activity and structure elucidation of herveline D. PubMed: Neutral heroin impurities from tetrahydrobenzylisoquinoline alkaloids. PubMed: The roles of latex and the vascular bundle in morphine biosynthesis in the opium poppy, Papaver somniferum. PubMed: The insulin pump as murder weapon: a case report. PubMed: Does ester hydrolysis change the in vitro degradation rate of cisatracurium and atracurium? PubMed: Concentration-effect relationship of cisatracurium at three different dose levels in the anesthetized patient. PubMed: [Effects of priming technique on onset profile of cisatracurium]. PubMed: In vitro degradation of atracurium and cisatracurium at pH 7.4 and 37 degrees C depends on the composition of the incubating solutions. PubMed: Importance of the organ-independent elimination of cisatracurium. PubMed: Simultaneous determination of dextrorphan and guaifenesin in human plasma by liquid chromatography with fluorescence detection. PubMed: Is 51W89 an improvement compared with atracurium? PubMed: Inhibition of purine nucleobase transport in human erythrocytes and cell lines by papaverine. Investigation of structure-activity relationship. PubMed: Simple and rapid high-performance liquid chromatography method for the determination of alcuronium in human plasma and urine. PubMed: Inhibition of hepatic microsomal drug metabolism by atracurium administration in the rat. PubMed: Separation of eight alkaloids and meconic acid and quantitation of five principal alkaloids in gum opium by gradient reversed-phase high-performance liquid chromatography. PubMed: Effects of atracurium, vecuronium or pancuronium pretreatment on lignocaine seizure thresholds in cats. PubMed: Preponderance of hydrolysis in inactivation of atracurium: questions remain. PubMed: Status epilepticus following enflurane anaesthesia. PubMed: Atracurium infusions in patients with renal failure on an ITU. PubMed: Pharmacokinetics of atracurium and its metabolites. PubMed: Atracurium: an overview. PubMed: The cerebral effects of pancuronium and atracurium in halothane-anesthetized dogs. PubMed: Magic bullets, science, and medicine. PubMed: [Metabolism and pharmacokinetics of atracurium]. PubMed: Stereochemical preferences for curarimimetic neuromuscular junction blockade IV: Monoquaternary ammonium probes possessing carbon and nitrogen asymmetry. PubMed: Stereochemical preferences for curarimimetic neuromuscular junction blockade I: enantiomeric monoquaternary amines as probes.