cytisine
(1R,9S)-7,11-diazatricyclo[7.3.1.02,7]trideca-2,4-dien-6-on
Identification
| Name | cytisine |
| CAS Number | 485-35-8 |
| EINECS | 207-616-0 |
| FDA UNII | 53S5U404NU |
| Molecular Formula | C11 H14 N2 O |
| Molecular Weight | 190.24578000 |
| MDL Number | MFCD00136048 |
| Nikkaji Number | J9.571K |
| Beilstein | 0083882 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 152.50 °C. @ 760.00 mm Hg |
| Boiling Point | 413.04 °C. @ 760.00 mm Hg (est) |
| Flash Point | 398.00 °F. TCC ( 203.60 °C. ) (est) |
| logP (o/w) | 0.172 (est) |
| Soluble in | water, 1.511e+004 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intravenous-cat LD50 400 ug/kg |
| Dermal Toxicity | subcutaneous-guinea pig LDLo 40 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for cytisine usage levels up to | not for fragrance use. |
| Recommendation for cytisine flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
baptitoxin
baptitoxine
cytiton
cytitone
(1R,9S)-7,11-
diazatricyclo[7.3.1.02,7]trideca-2,4-dien-6-on
(1R,9S)-7,11-
diazatricyclo[7.3.1.02,7]trideca-2,4-dien-6-one
(1R-5S)-1,2,3,4,5,6-
hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one
(1R,5S)-1,2,3,4,5,6-
hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one
(1R,5S)-1,2,3,4,5,6-
hexahydro-1,5-methano-pyrido[1,2-a][1,5]diazocin-8-one
(1R,5S)-1,2,3,4,5,6-
hexahydro-8H-1,5-methanopyrido[1,2-a][1,5]diazocin-8-one
laburnin
1,5-
methano-8H-pyrido(1,2-a)(1,5)diazocin-8-one, 1,2,3,4,5,6-hexahydro-, (1R,5S)-
1,5-
methano-8H-pyrido[1,2-a][1,5]diazocin-8-one, 1,2,3,4,5,6-hexahydro-, (1R,5S)-
tabax
(1R,5S)-3,4,5,6-
tetrahydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-8(2H)-one
tsitafat
tsitizin
ulexin
ulexine
PubMed:
The effects of noncontingent and self-administered cytisine on body weight and meal patterns in male Sprague-Dawley rats.
PubMed:
Nicotine decreases food intake through activation of POMC neurons.
PubMed:
The effects of nicotine, varenicline, and cytisine on schedule-controlled responding in mice: differences in α4β2 nicotinic receptor activation.
PubMed:
Lobeline and cytisine reduce voluntary ethanol drinking behavior in male C57BL/6J mice.
PubMed:
Nicotinic receptor ligands reduce ethanol intake by high alcohol-drinking HAD-2 rats.
PubMed:
Partial nicotinic acetylcholine (alpha4beta2) agonists as promising new medications for smoking cessation.
PubMed:
Simultaneous determination of thirteen plant alkaloids in a human specimen by SPE and HPLC.
PubMed:
Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptors.
PubMed:
Chemical composition, nutritive value, and toxicology evaluation of Mexican wild lupins.
PubMed:
Discriminative stimulus properties of the nicotinic agonist cytisine.
PubMed:
Clozapine attenuates the discriminative stimulus properties of (-)-nicotine.
PubMed:
Behavioural and pharmacokinetic studies on nicotine, cytisine and lobeline.
PubMed:
Role of training dose in discrimination of nicotine and related compounds by rats.
PubMed:
Nicotine cue in rats analysed with drugs acting on cholinergic and 5-hydroxytryptamine mechanisms.
PubMed:
Discriminative stimulus properties of nicotine: further evidence for mediation at a cholinergic receptor.