lobeline hydrochloride
ethanone, 2-((2R,6S)-6-((2S)-2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl)-1-phenyl-, hydrochloride
Identification
| Name | lobeline hydrochloride |
| IUPAC | 2-[(2R,6S)-6-[(2R)-2-hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl]-1-phenylethanone;hydrochloride |
| CAS Number | 134-63-4 |
| EINECS | 205-150-2 |
| FDA UNII | 96J834CB88 |
| Molecular Formula | C22 H28 Cl N O2 |
| Molecular Weight | 373.92256000 |
| MDL Number | MFCD00082455 |
| Beilstein | 3920196 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 510.50 °C. @ 760.00 mm Hg (est) |
| Flash Point | 505.00 °F. TCC ( 262.50 °C. ) (est) |
| logP (o/w) | 3.610 (est) |
| Soluble in | water, 659.5 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | parenteral-frog LDLo 150 mg/kg |
| Dermal Toxicity | subcutaneous-mouse LD50 87500 ug/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE\nBEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD']
Safety in Use
| Category | information only not used for fragrances or flavors |
| Recommendation for lobeline hydrochloride usage levels up to | not for fragrance use. |
| Recommendation for lobeline hydrochloride flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
acetophenone, 2-(6-(beta-hydroxyphenethyl)-1-methyl-2-piperidyl)-, hydrochloride, (-)-
ethanone, 2-((2R,6S)-6-((2S)-2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl)-1-phenyl-, hydrochloride
2-[(2R,6S)-6-[(2R)-2-
hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl]-1-phenylethanone;hydrochloride
2-{(2R,6S)-6-[(2R)-2-
hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl}-1-phenylethanone hydrochloride (1:1)
lobeline HCl
(-)-
lobeline hydrochloride
alpha-
lobeline hydrochloride
PubMed:
Evaluation of mutagenic and genotoxic activities of lobeline and its modulation on genomic instability induced by ethanol.
PubMed:
Surface plasmon resonance based biosensors for exploring the influence of alkaloids on aggregation of amyloid-β peptide.
PubMed:
Endoscopic scoring of the tracheal septum in horses and its clinical relevance for the evaluation of lower airway health in horses.
PubMed:
Effects of tension of the girth strap on respiratory system mechanics in horses at rest and during hyperpnea induced by administration of lobeline hydrochloride.
PubMed:
Influence of breathing pattern and lung inflation on impulse oscillometry measurements in horses.
PubMed:
Ultrasound spirometry in the horse: a preliminary report on the method and the effects of xylazine and lobeline hydrochloride medication.
PubMed:
Relations between structure and nicotine-like activity: X-ray crystal structure analysis of (-)-cytisine and (-)-lobeline hydrochloride and a comparison with (-)-nicotine and other nicotine-like compounds.
PubMed:
[Effect of various analeptics on the outcome of acute microwave lesion in mice].
PubMed:
[Stability of injectable lobeline hydrochloride to sterilization with steam and lobeline hydrochloride assay in solutions].
PubMed:
[Effects of lobeline hydrochloride on the heart of the frog in situ].
PubMed:
[Action of lobeline hydrochloride on apnea of reoxygenation in anoxemic animals anesthetized with nitrous oxide].