mercaptopropyltrimethoxysilane
1-propanethiol, 3-(trimethoxysilyl)-
Identification
| Name | mercaptopropyltrimethoxysilane |
| IUPAC | 3-trimethoxysilylpropane-1-thiol |
| CAS Number | 4420-74-0 |
| EINECS | 224-588-5 |
| FDA UNII | 8CB1M08OIW |
| Molecular Formula | C6 H16 O3 S Si |
| Molecular Weight | 196.34142000 |
| MDL Number | MFCD00004901 |
| Nikkaji Number | J8.721A |
| Beilstein | 2038119 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 1.03900 @ 25.00 °C. |
| Boiling Point | 198.00 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 0.500000 mmHg @ 25.00 °C. (est) |
| Flash Point | 120.00 °F. TCC ( 48.89 °C. ) |
| logP (o/w) | 1.090 (est) |
| Soluble in | water, 2.77e+004 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | nail conditioning |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intraperitoneal-mouse LD50 633 mg/kg |
| Dermal Toxicity | skin-rabbit LD50 2140 uL/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | nail conditioning agents |
| Recommendation for mercaptopropyltrimethoxysilane usage levels up to | not for fragrance use. |
| Recommendation for mercaptopropyltrimethoxysilane flavor usage levels up to | not for flavor use. |
Potential Uses
Natural Occurrence
Synonyms
GF 70
KBE 803
KBM 803
M 8500
(3-
mercaptopropyl) trimethoxysilane
(3-
mercaptopropyl)trimethoxysilane
(gamma-
mercaptopropyl)trimethoxysilane
3-
mercaptopropyltrimethoxysilane
gamma-
mercaptopropyltrimethoxysilane
MPS-M
NUCA 189
1-
propanethiol, 3-(trimethoxysilyl)-
prosil 196
SH 6062
sila-ace S 810
silane A 189
silane, 3-mercaptopropyltrimethoxy-
silquest A 189
3-(
sulfanylpropyl)trimethoxysilane
(3-
thiopropyl)trimethoxysilane
3-(
trimethoxysilyl)propanethiol
3-(
trimethoxysilyl)propyl mercaptan
3-
trimethoxysilylpropane-1-thiol
union carbide A-189
PubMed:
Facile preparation of an immobilized surfactant-free palladium nanocatalyst for metal hydride trapping: a novel sensing platform for TXRF analysis.
PubMed:
A novel hierarchical nanobiocomposite of graphene oxide-magnetic chitosan grafted with mercapto as a solid phase extraction sorbent for the determination of mercury ions in environmental water samples.
PubMed:
Coating of magnetite with mercapto modified rice hull ash silica in a one-pot process.
PubMed:
β-Cyclodextrin/thermosensitive containing polymer brushes grafted onto magnetite nano-particles for extraction and determination of venlafaxine in biological and pharmaceutical samples.
PubMed:
Polymer brushes containing thermosensitive and functional groups grafted onto magnetic nano-particles for interaction and extraction of famotidine in biological samples.
PubMed:
Effect of surface charge and electrode material on the size-dependent oxidation of surface-attached metal nanoparticles.
PubMed:
Synthesis of nanospheres-on-microsphere silica with tunable shell morphology and mesoporosity for improved HPLC.
PubMed:
Shaped platinum nanoparticles directly synthesized inside mesoporous silica supports.
PubMed:
Investigation of the interfacial effects of small chemical-modified TiO2 nanotubes on 3T3 fibroblast responses.
PubMed:
Preparation of a sulfo-group-containing rod-like polysilsesquioxane with a hexagonally stacked structure and its proton conductivity.
PubMed:
Synthesis and characterization of poly[N-isopropylacrylamide-co-1-(N,N-bis-carboxymethyl)amino-3-allylglycerol] grafted to magnetic nano-particles for the extraction and determination of fluvoxamine in biological and pharmaceutical samples.
PubMed:
DNA hybridization detection with 100 zM sensitivity using piezoelectric plate sensors with an improved noise-reduction algorithm.
PubMed:
Magnetic and noble metallic nanoparticles deposited on silica spheres via silanization.
PubMed:
The regulation of sepiolite surface free energy and its impact on the thermal insulation property of coating.
PubMed:
Nanostructured optical photonic crystal biosensor for HIV viral load measurement.
PubMed:
Self-assembled monolayers of gold nanostars: a convenient tool for near-IR photothermal biofilm eradication.
PubMed:
Adsorption of cadmium ions on thiol or sulfonic-functionalized poly(dimethylsiloxane) networks.
PubMed:
Stir bar sorptive extraction combined with high performance liquid chromatography-ultraviolet/inductively coupled plasma mass spectrometry for analysis of thyroxine in urine samples.
PubMed:
Preparation of saline-stable, silica-coated triangular silver nanoplates of use for optical sensing.
PubMed:
Synthesis and characterization of poly[1-(N,N-bis-carboxymethyl)amino-3-allylglycerol-co-dimethylacrylamide] grafted to magnetic nano-particles for extraction and determination of letrozole in biological and pharmaceutical samples.
PubMed:
Establishment of a derivatization method to quantify thiol function in sulfur-containing plasma polymer films.
PubMed:
[Preparation of organic-inorganic hybrid boronate affinity monolith via thiol-ene click reaction for specific capture of glycoproteins].
PubMed:
Magnetic materials as sorbents for metal/metalloid preconcentration and/or separation. A review.
PubMed:
Fabrication of SiO2 beads with high concentrated hydrophobic CdSe/Cd(x)Zn(1-x)S quantum dots using functional alkoxides.
PubMed:
Silanization effect on the photoluminescence characteristics of crystalline and amorphous silicon nanoparticles.
PubMed:
Biofunctionalization of silica microspheres for protein separation.
PubMed:
Cage-like silica nanoparticles-functionalized silica hybrid monolith for high performance capillary electrochromatography via "one-pot" process.
PubMed:
Facile preparation of organic-silica hybrid monolith for capillary hydrophilic liquid chromatography based on "thiol-ene" click chemistry.
PubMed:
Improvement of adhesive strength of segmented polyurethane on Ti-29Nb-13Ta-4.6Zr alloy through HâOâ treatment for biomedical applications.
PubMed:
Real-time, in situ DNA hybridization detection with attomolar sensitivity without amplification using (pb(Mg1/3Nb2/3)O3)0.65-(PbTiO3)0.35 piezoelectric plate sensors.
PubMed:
Polymeric ionic liquid modified stainless steel wire as a novel fiber for solid-phase microextraction.
PubMed:
Grafting 3-mercaptopropyl trimethoxysilane on multi-walled carbon nanotubes surface for improving on-line cadmium(II) preconcentration from water samples.
PubMed:
Growth kinetics of MPS-capped CdS quantum dots in self-assembled thin films.
PubMed:
One-pot synthesis of spheres-on-sphere silica particles from a single precursor for fast HPLC with low back pressure.
PubMed:
Label-free Growth Receptor-2 Detection and Dissociation Constant Assessment in Diluted Human Serum Using a Longitudinal Extension Mode of a Piezoelectric Microcantilever Sensor.
PubMed:
A new imidazolium-embedded C18 stationary phase with enhanced performance in reversed-phase liquid chromatography.
PubMed:
Nanowire transistor-based ultrasensitive virus detection with reversible surface functionalization.
PubMed:
Selectivity enhancement for the separation of tocopherols and steroids by integration of highly ordered weak interaction sites along the polymer main chain.
PubMed:
Influence of interface layers on Ag thin film growth.
PubMed:
Screening and determinations of tissue polypeptide antigen by label-free optical immunosensing method.
PubMed:
Cadmium (II) imprinted 3-mercaptopropyltrimethoxysilane coated stir bar for selective extraction of trace cadmium from environmental water samples followed by inductively coupled plasma mass spectrometry detection.
PubMed:
Flower-like self-assembly of gold nanoparticles for highly sensitive electrochemical detection of chromium(VI).
PubMed:
Facile fabrication of gold nanoparticles-poly(vinyl alcohol) electrospun water-stable nanofibrous mats: efficient substrate materials for biosensors.
PubMed:
Chemical functionalization of diatom silica microparticles for adsorption of gold (III) ions.
PubMed:
Probing quenched dye fluorescence of Cy3-DNA-Au-nanoparticle hybrid conjugates using solution and array platforms.
PubMed:
Optical method for predicting the composition of self-assembled monolayers of mixed thiols on surfaces coated with silver nanoparticles.
PubMed:
Molecular-shape selective high-performance liquid chromatography: stabilization effect of polymer main chain by alternating copolymerization.
PubMed:
Polymeric ionic liquid modified organic-silica hybrid monolithic column for capillary electrochromatography.
PubMed:
Synthesis, characterization and catalytic behavior of functionalized mesoporous SBA-15 with various organo-silanes.
PubMed:
Photoluminescent properties of novel rare earth organic-inorganic nanocomposite with TiO2 modified silica via double crosslinking units.
PubMed:
Investigation of folate-conjugated fluorescent silica nanoparticles for targeting delivery to folate receptor-positive tumors and their internalization mechanism.
PubMed:
Nanostructures of functionalized gold nanoparticles prepared by particle lithography with organosilanes.
PubMed:
Effect of surface chemical composition on the work function of silicon substrates modified by binary self-assembled monolayers.
PubMed:
Adsorption characteristics of haloacetonitriles on functionalized silica-based porous materials in aqueous solution.
PubMed:
Thiolated mucoadhesive and PEGylated nonmucoadhesive organosilica nanoparticles from 3-mercaptopropyltrimethoxysilane.
PubMed:
New solid-phase-nanoscavenger for the analytical enrichment of mercury from water.
PubMed:
Back-surface gold mirrors for vibrationally resonant sum-frequency (VR-SFG) spectroscopy using 3-mercaptopropyltrimethoxysilane as an adhesion promoter.
PubMed:
Preparation and characterization of silica monolith modified with bovine serum albumin-gold nanoparticles conjugates and its use as chiral stationary phases for capillary electrochromatography.
PubMed:
Synthesis and solid-state NMR characterization of cubic mesoporous silica SBA-1 functionalized with sulfonic acid groups.
PubMed:
Preparation of nanoporous carbons via a grafting method for the application to electrochemical double layer capacitors.
PubMed:
Novel photofunctional multicomponent rare earth (Eu3+, Tb3+, Sm3+ and Dy3+) hybrids with double cross-linking siloxane covalently bonding SiO2/ZnS nanocomposite.
PubMed:
Formation mechanism and size control in one-pot synthesis of mercapto-silica colloidal spheres.
PubMed:
Effect of surface chemical composition on the surface potential and iso-electric point of silicon substrates modified with self-assembled monolayers.
PubMed:
Polyoxometalate (POM)-based, multi-functional, inorganic-organic, hybrid compounds: syntheses and molecular structures of silanol- and/or siloxane bond-containing species grafted on mono- and tri-lacunary Keggin POMs.
PubMed:
Enzyme integrated silicate-Pt nanoparticle architecture: a versatile biosensing platform.
PubMed:
Synthesis of silica-coated AgI nanoparticles and immobilization of proteins on them.
PubMed:
Capillary electrophoresis with immobilized quantum dot fluorescence detection for rapid determination of organophosphorus pesticides in vegetables.
PubMed:
Label free detection of white spot syndrome virus using lead magnesium niobate-lead titanate piezoelectric microcantilever sensors.
PubMed:
Comparison of adsorption of mercaptopropyltrimethoxysilane on amphiphilic TiO2 and hydroxylated SiO2.
PubMed:
Elaborate control over the morphology and structure of mercapto-functionalized mesoporous silicas as multipurpose carriers.
PubMed:
Potential-controlled electrochemical seed-mediated growth of gold nanorods directly on electrode surfaces.
PubMed:
Grafting of poly[1-(N,N-bis-carboxymethyl)amino-3-allylglycerol-co-dimethylacrylamide] copolymer onto siliceous support for preconcentration and determination of lead (II) in human plasma and environmental samples.
PubMed:
Photophysical properties of a novel organic-inorganic hybrid material: Eu(III)-β-diketone complex covalently bonded to SiO(2) /ZnO composite matrix.
PubMed:
Rapid approach to biobased telechelics through two one-pot thiol-ene click reactions.
PubMed:
Preparation and characterization of silica coated iron oxide magnetic nano-particles.
PubMed:
Size-controlled synthesis, surface functionalization, and biological applications of thiol-organosilica particles.
PubMed:
Preparation of organic-inorganic hybrid silica monolith with octyl and sulfonic acid groups for capillary electrochromatograhpy and application in determination of theophylline and caffeine in beverage.
PubMed:
Copper pattern on self-assembled monolayer through microcontact printing.
PubMed:
A reusable liposome array and its application to assay of growth-hormone-related peptides.
PubMed:
Improvement of cytotoxicity of titanocene-functionalized mesoporous materials by the increase of the titanium content.
PubMed:
Screening platelet-surface interactions using negative surface charge gradients.
PubMed:
Size-tunable highly luminescent SiO2 particles impregnated with number-adjusted CdTe nanocrystals.
PubMed:
Fabrication of micro- and nano-scale gold patterns on glass by transfer printing.
PubMed:
Influence of organosiloxanes on the properties of mesoporous materials.
PubMed:
Alumina nanofibers grafted with functional groups: a new design in efficient sorbents for removal of toxic contaminants from water.
PubMed:
New synthesis strategies for effective functionalization of kaolinite and saponite with silylating agents.
PubMed:
Hybrid organic-inorganic silica monolith with hydrophobic/strong cation-exchange functional groups as a sorbent for micro-solid phase extraction.
PubMed:
Silver nanoparticles self assembly as SERS substrates with near single molecule detection limit.
PubMed:
One-step synthesis of functional chiral porous silica nanorods using an achiral surfactant.
PubMed:
Convective assembly and dry transfer of nanoparticles using hydrophobic/hydrophilic monolayer templates.
PubMed:
Factors affecting the reactivity of thiol-functionalized mesoporous silica adsorbents toward mercury(II).
PubMed:
Colorimetric sensing of pyrophosphate in aqueous media using bis-functionalised silica surfaces.
PubMed:
Nitric oxide-releasing S-nitrosothiol-modified xerogels.
PubMed:
Stepwise formation approach to improve ellipsometric biosensor response.
PubMed:
Photochemical shape control of cadmium sulfide nanorods coated with an amorphous silica thin layer.
PubMed:
Modifications induced by pretreatments on Au/SBA-15 and their influence on the catalytic activity for low temperature CO oxidation.
PubMed:
Spectroscopic evaluation of surface functionalization efficiency in the preparation of mercaptopropyltrimethoxysilane self-assembled monolayers on glass.
PubMed:
Transfection of aqueous CdS quantum dots using polyethylenimine.
PubMed:
Preparation of poly(lactic acid)/siloxane/calcium carbonate composite membranes with antibacterial activity.
PubMed:
Solution chemistry approach to fabricate vertically aligned carbon nanotubes on gold wires: towards vertically integrated electronics.
PubMed:
A palm-sized surface plasmon resonance sensor with microchip flow cell.
PubMed:
Bifunctionalized mesoporous silicas for Cr(VI) reduction and concomitant Cr(III) immobilization.
PubMed:
Synthesis and assessment of molecular recognizability by RP-HPLC of an N-alkyl-beta-Ala-L: -Phe-derived organic phase with self-assembling ability.
PubMed:
Label-free, all-electrical, in situ human epidermal growth receptor 2 detection.
PubMed:
Preparation, telomerization, immobilization and application of N-alkyl L-phenylalanine-derived polymerizable organogelator for reversed-phase high-performance liquid chromatography.
PubMed:
[Preparation and characterization of poly(N-isopropylacrylamide) bonded silica gel stationary phase].
PubMed:
Enhancement of retentivity and selectivity for PAHs in NP-HPLC by high-density immobilization of poly(4-vinylpyridine) as an organic phase on silica.
PubMed:
Design of novel hybrid organic-inorganic nanostructured biomaterials for immunoassay applications.
PubMed:
Sorption of methylene blue on an organoclay bearing thiol groups and application to electrochemical sensing of the dye.
PubMed:
Speciation of inorganic tellurium from seawater by ICP-MS following magnetic SPE separation and preconcentration.
PubMed:
Ni(II) removal from aqueous effluents by silylated clays.
PubMed:
MPTS-silica coated capillary microextraction on line hyphenated with inductively coupled plasma atomic emission spectrometry for the determination of Cu, Hg and Pb in biological samples.
PubMed:
Synthesis and alignment of silver nanorods and nanowires and the formation of Pt, Pd, and core/shell structures by galvanic exchange directly on surfaces.
PubMed:
Fabrication and self-assembly of hydrophobic gold nanorods.
PubMed:
Ultrasonic-assisted synthesis of highly dispersed MoO3 nanospheres using 3-mercaptopropyltrimethoxysilane.
PubMed:
3-mercaptopropyltrimethoxysilane as insulating coating and surface for protein immobilization for piezoelectric microcantilever sensors.
PubMed:
Pilot evaluation of resin composite cement adhesion to zirconia using a novel silane system.
PubMed:
Adsorption of trimethoxysilane and of 3-mercaptopropyltrimethoxysilane on silica and on silicon wafers from vapor phase: an IR study.
PubMed:
Manipulation of the growth of gold and silver nanomaterials on glass by seeding approach.
PubMed:
A tunnel current in self-assembled monolayers of 3-mercaptopropyltrimethoxysilane.
PubMed:
Studies of thiol additions of silane coupling agents by vibrational spectroscopy.
PubMed:
The effect of five silane coupling agents on the bond strength of a luting cement to a silica-coated titanium.
PubMed:
Physicochemically modified silicon as a substrate for protein microarrays.
PubMed:
Factors affecting the preparation and properties of electrodeposited silica thin films functionalized with amine or thiol groups.
PubMed:
A novel and simplified procedure for patterning hydrophobic and hydrophilic SAMs for microfluidic devices by using UV photolithography.
PubMed:
Structural relation properties of hydrothermally stable functionalized mesoporous organosilicas and catalysis.
PubMed:
Silver-nanoparticle-attached indium tin oxide surfaces fabricated by a seed-mediated growth approach.
PubMed:
Immobilization of DNA onto poly(dimethylsiloxane) surfaces and application to a microelectrochemical enzyme-amplified DNA hybridization assay.
PubMed:
Micropatterning of copper on a poly(ethylene terephthalate) substrate modified with a self-assembled monolayer.
PubMed:
[Preparation of polymer modified stationary phases through surface radical chain transfer reaction].
PubMed:
Negatively charged sol-gel column with stable electroosmotic flow for online preconcentration of zwitterionic biomolecules in capillary electromigration separations.
PubMed:
Two independent routes to synthesize identical silicas by grafting ethylenimine or 2-aminoethanethiol, their cation adsorbing abilities, and thermodynamic data.
PubMed:
Functionalized organosilica microspheres via a novel emulsion-based route.
PubMed:
Vibrational spectroscopic studies of (3-mercaptopropyl)trimethoxylsilane sol-gel and its coating.
PubMed:
Highly photoluminescent multilayer QD-glass films prepared by LbL self-assembly.
PubMed:
Growth and reactions of SiOx/Si nanostructures on surface-templated molecule corrals.
PubMed:
[Microchip capillary electrophoresis-electrochemical detection of nitrite using a modified carbon paste electrode].
PubMed:
Microstructuring of phospholipid bilayers on gold surfaces by micromolding in capillaries.
PubMed:
Preparation of monolithic silica column with strong cation-exchange stationary phase for capillary electrochromatography.
PubMed:
Biomaterial with chemically engineered surface for protein immobilization.
PubMed:
Electrochemical impedance behavior of DNA biosensor based on colloidal Ag and bilayer two-dimensional sol-gel as matrices.
PubMed:
Novel potentiometric immunosensor for determination of diphtheria antigen based on compound nanoparticles and bilayer two-dimensional sol-gel as matrices.
PubMed:
Preparation of a sulfonated fused-silica capillary and its application in capillary electrophoresis and electrochromatography.
PubMed:
Novel polymeric chelating fibers for selective removal of mercury and cesium from water.
PubMed:
High surface density immobilization of oligonucleotide on silicon.
PubMed:
Ethyleneimine Anchored on Thiol-Modified Silica Gel Surface-Adsorption of Divalent Cations and Calorimetric Data.
PubMed:
Effects of mixed silane coupling agent on porcelain tooth material and various dental alloys.
PubMed:
[Effect of 3-mercaptopropyltrimethoxysilane coupling agent on stainless steel and silica surface].
PubMed:
Affinity fibre--a new support for rapid enzyme purification by high-performance liquid affinity chromatography.
PubMed:
[Properties of urease immobilized on silochrome by means of disulfide bonds].