1,2,4-triazole

pyrrodiazole

CAS: 288-88-0 C2 H3 N3 MW: 69.06691000

Identification

Name1,2,4-triazole
IUPAC1H-1,2,4-triazole
CAS Number288-88-0
EINECS206-022-9
FDA UNII10MS0Y1RDI
Molecular FormulaC2 H3 N3
Molecular Weight69.06691000
MDL NumberMFCD00005228
Nikkaji NumberJ5.455K
Beilstein605619
XlogP3-0.60 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 260.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure 0.603000 mmHg (est)
Flash Point 282.00 °F. TCC ( 139.10 °C. ) (est)
logP (o/w) -0.580
Soluble in water, 4.244e+005 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-mouse LD50 1350 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for 1,2,4-triazole usage levels up tonot for fragrance use.
Recommendation for 1,2,4-triazole flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

pyrrodiazole 1H-1,2,4- triazol 1H-1,2,4- triazole PubMed: Triazole GHS-R1a antagonists JMV4208 and JMV3002 attenuate food intake, body weight, and adipose tissue mass in mice. PubMed: Access to a new class of biologically active quinoline based 1,2,4-triazoles. PubMed: Combined repeated-dose and reproductive/developmental toxicity screening test of 3-amino-5-mercapto-1,2,4-triazole in rats. PubMed: The involvement of several enzymes in methanol detoxification in Drosophila melanogaster adults. PubMed: Ghrelin-induced orexigenic effect in rats depends on the metabolic status and is counteracted by peripheral CB1 receptor antagonism. PubMed: Synthesis, fungicidal activity, and sterol 14α-demethylase binding interaction of 2-azolyl-3,4-dihydroquinazolines on Penicillium digitatum. PubMed: Synthesis, crystal structure, in vitro acetohydroxyacid synthase inhibition, in vivo herbicidal activity, and 3D-QSAR of new asymmetric aryl disulfides. PubMed: The 1,2,4-triazole as a scaffold for the design of ghrelin receptor ligands: development of JMV 2959, a potent antagonist. PubMed: Synthesis and fungicidal activity of novel 3-(substituted/unsubstituted phenylselenonyl)-1-ribosyl/deoxyribosyl-1H-1,2,4-triazole. PubMed: The involvement of cytochrome P450 monooxygenases in methanol elimination in Drosophila melanogaster larvae. PubMed: Separation and preconcentration of Cd(II), Cu(II), Ni(II), and Pb(II) in water and food samples using Amberlite XAD-2 functionalized with 3-(2-nitrophenyl)-1H-1,2,4-triazole-5(4H)-thione and determination by inductively coupled plasma-atomic emission spectrometry. PubMed: Efficient synthesis of novel 1,2,4-triazole fused acyclic and 21-28 membered macrocyclic and/or lariat macrocyclic oxaazathia crown compounds with potential antimicrobial activity. PubMed: β-ODAP accumulation could be related to low levels of superoxide anion and hydrogen peroxide in Lathyrus sativus L. PubMed: Synthesis and biological activity of some novel trifluoromethyl-substituted 1,2,4-triazole and bis(1,2,4-triazole) Mannich bases containing piperazine rings. PubMed: Synthesis, crystal structure, and biological activity of 4-methyl-1,2,3-thiadiazole-containing 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles. PubMed: The effects of buthionine sulfoximine, diethyldithiocarbamate or 3-amino-1,2,4-triazole on propyl gallate-treated HeLa cells in relation to cell growth, reactive oxygen species and glutathione. PubMed: Determination of stereoselective interaction between enantiomers of chiral gamma-aryl-1H-1,2,4-triazole derivatives and Penicillium digitatum. PubMed: Resistance to cadmium as a function of Caco-2 cell differentiation: role of reactive oxygen species in cadmium- but not zinc-induced adaptation mechanisms. PubMed: Synthesis and PET studies of [(11)C-cyano]letrozole (Femara), an aromatase inhibitor drug. PubMed: Chiral gamma-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents: Design, synthesis, structure, and in vitro fungicidal activities. PubMed: Central versus peripheral antagonism of cannabinoid CB1 receptor in obesity: effects of LH-21, a peripherally acting neutral cannabinoid receptor antagonist, in Zucker rats. PubMed: Pharmacological evaluation of LH-21, a newly discovered molecule that binds to cannabinoid CB1 receptor. PubMed: New trisubstituted 1,2,4-triazole derivatives as potent ghrelin receptor antagonists. 3. Synthesis and pharmacological in vitro and in vivo evaluations. PubMed: Toward potent ghrelin receptor ligands based on trisubstituted 1,2,4-triazole structure. 2. Synthesis and pharmacological in vitro and in vivo evaluations. PubMed: Development of potential manufacturing routes for substituted thiophenes--preparation of halogenated 2-thiophenecarboxylic acid derivatives as building blocks for a new family of 2,6-dihaloaryl 1,2,4-triazole insecticides. PubMed: First synthesis and antimicrobial activity Of N- and S-alpha-L-arabinopyranosyl-1,2,4-triazoles. PubMed: Synthesis and pharmacological in vitro and in vivo evaluations of novel triazole derivatives as ligands of the ghrelin receptor. 1. PubMed: Sterol demethylation inhibitor fungicides as disruptors of insect development and inducers of glutathione S-transferase activities in Mamestra brassicae. PubMed: Contributions of pro-oxidant and anti-oxidant conditions to the actions of 24,25-dihydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on phosphate uptake in intestinal cells. PubMed: Synthesis and herbicidal activity of N,N-diethyl-3-(arylselenonyl)-1H-1,2,4-triazole-1-carboxamide. PubMed: Efficient synthesis, structure, and antimicrobial activity of some novel N- and S-beta-D-glucosides of 5-pyridin-3-yl-1,2,4-triazoles. PubMed: Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole--LH 21. PubMed: Determination of 22 triazole compounds including parent fungicides and metabolites in apples, peaches, flour, and water by liquid chromatography/tandem mass spectrometry. PubMed: Determination of Fe(II) and Zn(II) by spectrophotometry, atomic absorption spectrometry and ions chromatography methods in Vitrum. PubMed: Kinetics and products of photo-Fenton degradation of triazophos. PubMed: Spectrophotometric determination of Fe(II) and Zn(II) in the pharmaceutical multivitamin preparations with microelements. PubMed: Comparison of three colorimetric reagents in the determination of methanol with alcohol oxidase. Application to the assay of pectin methylesterase. PubMed: Sorption behavior of triazole fungicides in Indian soils and its correlation with soil properties. PubMed: Liquid chromatographic determination of ampicillin residues in porcine muscle tissue by a multipenicillin analytical method: European Collaborative Study. PubMed: Role of acetaldehyde in the discriminative stimulus effects of ethanol. PubMed: A specific and potent inhibitor of brassinosteroid biosynthesis possessing a dioxolane ring. PubMed: Acetylation of 5-amino-1H-[1,2,4]triazole revisited. PubMed: Characterization of a catalase-peroxidase from the hyperthermophilic archaeon Archaeoglobus fulgidus. PubMed: Metabolism of [(14)C]flusilazole in the goat. PubMed: Purification and some properties of catalase from wheat germ (Triticum aestivum L.). PubMed: Multi-residue analysis of penicillin residues in porcine tissue using matrix solid phase dispersion. PubMed: Multiresidue liquid chromatographic method for determining residues of mono- and dibasic penicillins in bovine muscle tissues. PubMed: The catalase-peroxidase of Synechococcus PCC 7942: purification, nucleotide sequence analysis and expression in Escherichia coli. PubMed: Effects of 3-amino-1,2,4-triazole on brain catalase in the mediation of ethanol consumption in mice. PubMed: Analysis of penicillin G in milk by liquid chromatography. PubMed: Origin of reactive oxygen species in erythrocytes infected with Plasmodium falciparum. PubMed: Molecular mechanisms of action of ribavirin. PubMed: Extraction of 3-amino-1,2,4-triazole (amitrole) and 2,6-dichloro-4-nitroaniline (DCNA) from soils.