1,3-propane diol
1,3-propanediol
Identification
| Name | 1,3-propane diol |
| IUPAC | propane-1,3-diol |
| CAS Number | 504-63-2 |
| EINECS | 207-997-3 |
| FDA UNII | 5965N8W85T |
| Molecular Formula | C3 H8 O2 |
| Molecular Weight | 76.09516000 |
| MDL Number | MFCD00002949 |
| Nikkaji Number | J2.606I |
| Beilstein | 0969155 |
| XlogP3 | -1.00 (est) |
Regulatory
| FDA/DG SANTE Petitions, Reviews, Notices | GRN 302 |
| DG SANTE Food Contact Materials | 1,3-propanediol |
| FEMA Number | 4753 |
| FDA | No longer provide for the use of these seven synthetic flavoring substances |
Physical Properties
| Appearance | colorless clear liquid (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 1.05300 to 1.05600 @ 20.00 °C. |
| Pounds per Gallon - (est). | 8.772 to 8.797 |
| Refractive Index | 1.43800 to 1.44100 @ 20.00 °C. |
| Boiling Point | 214.00 to 215.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 0.034000 mmHg @ 25.00 °C. (est) |
| Flash Point | 175.00 °F. TCC ( 79.44 °C. ) |
| logP (o/w) | -1.040 (est) |
| Soluble in | alcohol |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | solvents |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intraperitoneal-mouse LD50 4780 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | solvents |
| Recommendation for 1,3-propane diol usage levels up to | not for fragrance use. |
| baked goods | 1300.00000 |
| beverages(nonalcoholic) | 690.00000 |
| beverages(alcoholic) | 690.00000 |
| breakfast cereal | - |
| cheese | - |
| chewing gum | 1800.00000 |
| condiments / relishes | 20.00000 |
| confectionery froastings | - |
| egg products | - |
| fats / oils | - |
| fish products | - |
| frozen dairy | 810.00000 |
| fruit ices | 810.00000 |
| gelatins / puddings | 250.00000 |
| granulated sugar | - |
| gravies | - |
| hard candy | 1300.00000 |
| imitation dairy | - |
| instant coffee / tea | - |
| jams / jellies | - |
| meat products | - |
| milk products | - |
| nut products | - |
| other grains | - |
| poultry | - |
| processed fruits | 300.00000 |
| processed vegetables | - |
| reconstituted vegetables | - |
| seasonings / flavors | - |
| snack foods | - |
| soft candy | 1300.00000 |
| soups | 20.00000 |
| sugar substitutes | - |
| sweet sauces | 7000.00000 |
BOC Sciences
Best of Chemicals Supplier
Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...
ECSA Chemicals
Human Chemistry
ECSA Chemicals has been active since 1913 in the trading and international commerce of raw materials. With an organisation divided into industrial segments managed by specialists, it has become one of...
Penta International Corporation
Chemistry innovation
At Penta, our products and services help businesses do business better.
Potential Uses
Natural Occurrence
Synonyms
2-
deoxyglycerol
1,3-
dihydroxypropane
2-(
hydroxymethyl)ethanol
propan-1,3-diol
1,3-
propandiol
1,3-
propane diol
propane-1,3-diol
1,3-
propanediol
1,3-
propylene glycol
beta-
propylene glycol
1,3-
propylenediol
trimethylene glycol
PubMed:
Effect of 1,3-propanediol, organic acids, and ethanol on growth and metabolism of Clostridium butyricum DSP1.
PubMed:
Biotechnological potential of Clostridium butyricum bacteria.
PubMed:
Hypothetical glycerol pathways of newly isolated strains capable of 1,3-propanediol production.
PubMed:
Fully glycerol-independent microbial production of 1, 3-propanediol via non-natural pathway: Paving the way to success with synthetic tiles.
PubMed:
2-Chloro-1,3-propanediol (2-MCPD) and its fatty acid esters: cytotoxicity, metabolism, and transport by human intestinal Caco-2 cells.
PubMed:
Metabolic Engineering of a Glycerol-Oxidative Pathway in Lactobacillus panis PM1 for Utilization of Bioethanol Thin Stillage: Potential To Produce Platform Chemicals from Glycerol.
PubMed:
Impurities of crude glycerol and their effect on metabolite production.
PubMed:
Identification of a new angiotensin-converting enzyme (ACE) inhibitor from Thai edible plants.
PubMed:
Conversion of glycerol to 1,3-propanediol by Citrobacter freundii and Hafnia alvei - newly isolated strains from the Enterobacteriaceae.
PubMed:
Biorefinery development through utilization of biodiesel industry by-products as sole fermentation feedstock for 1,3-propanediol production.
PubMed:
Transcriptional repressor role of PocR on the 1,3-propanediol biosynthetic pathway by Lactobacillus panis PM1.
PubMed:
Scale-up of anaerobic 1,3-propanediol production by Clostridium butyricum DSP1 from crude glycerol.
PubMed:
Biosynthesis of 1,3-propanediol from glycerol with Lactobacillus reuteri: effect of operating variables.
PubMed:
Bioconversion of glycerol to 1,3-propanediol in thin stillage-based media by engineered Lactobacillus panis PM1.
PubMed:
Enhanced production of 3-hydroxypropionic acid from glycerol by modulation of glycerol metabolism in recombinant Escherichia coli.
PubMed:
[Construction of polyhydroxybutyrate pathway in Klebsiella pneumoniae].
PubMed:
Microbial purification of postfermentation medium after 1,3-PD production from raw glycerol.
PubMed:
Denitrification of industrial wastewater: Influence of glycerol addition on metabolic activity and community shifts in a microbial consortium.
PubMed:
Biodegradation of glycerol using bacterial isolates from soil under aerobic conditions.
PubMed:
FTY720 for cancer therapy (Review).
PubMed:
Volatile components of essential oil from cultivated Myrica gale var. tomentosa and its antioxidant and antimicrobial activities.
PubMed:
Glycerol and environmental factors: effects on 1,3-propanediol production and NAD(+) regeneration in Lactobacillus panis PM1.
PubMed:
Toxicology, occurrence and risk characterisation of the chloropropanols in food: 2-monochloro-1,3-propanediol, 1,3-dichloro-2-propanol and 2,3-dichloro-1-propanol.
PubMed:
Alkaline conditions stimulate the production of 1,3-propanediol in Lactobacillus panis PM1 through shifting metabolic pathways.
PubMed:
Influence of oxygen on NADH recycling and oxidative stress resistance systems in Lactobacillus panis PM1.
PubMed:
Enhanced 1,3-propanediol production by a newly isolated Citrobacter freundii strain cultivated on biodiesel-derived waste glycerol through sterile and non-sterile bioprocesses.
PubMed:
Isolation and characterization of novel 1,3-propanediol-producing Lactobacillus panis PM1 from bioethanol thin stillage.
PubMed:
Picea mariana bark: a new source of trans-resveratrol and other bioactive polyphenols.
PubMed:
Molecular cloning, co-expression, and characterization of glycerol dehydratase and 1,3-propanediol dehydrogenase from Citrobacter freundii.
PubMed:
Isolation, identification and characterization of human intestinal bacteria with the ability to utilize chloramphenicol as the sole source of carbon and energy.
PubMed:
Adaptation dynamics of Clostridium butyricum in high 1,3-propanediol content media.
PubMed:
Isolation process of industrially useful Clostridium bifermentans from natural samples.
PubMed:
Furan induction of DNA cross-linking and strand breaks in turkey fetal liver in comparison to 1,3-propanediol.
PubMed:
Enhancement of pH stability and activity of glycerol dehydratase from Klebsiella pneumoniae by rational design.
PubMed:
Klebsiella spp as a 1, 3-propanediol producer: the metabolic engineering approach.
PubMed:
Impact of anaerobiosis strategy and bioreactor geometry on the biochemical response of Clostridium butyricum VPI 1718 during 1,3-propanediol fermentation.
PubMed:
Microbial utilization of crude glycerol for the production of value-added products.
PubMed:
Rapid NMR method for the quantification of organic compounds in thin stillage.
PubMed:
Microbiological and chemical characterisation of ting, a sorghum-based sourdough product from Botswana.
PubMed:
1,3-Propanediol dehydrogenases in Lactobacillus reuteri: impact on central metabolism and 3-hydroxypropionaldehyde production.
PubMed:
Further investigation into maple syrup yields 3 new lignans, a new phenylpropanoid, and 26 other phytochemicals.
PubMed:
Production of 1,3-propanediol by Clostridium butyricum growing on biodiesel-derived crude glycerol through a non-sterilized fermentation process.
PubMed:
Effect of biodiesel-derived waste glycerol impurities on biomass and 1,3-propanediol production of Clostridium butyricum VPI 1718.
PubMed:
Debottlenecking the 1,3-propanediol pathway by metabolic engineering.
PubMed:
Influence of environmental parameters on production of the acrolein precursor 3-hydroxypropionaldehyde by Lactobacillus reuteri DSMZ 20016 and its accumulation by wine lactobacilli.
PubMed:
Industrial biotechnology: tools and applications.
PubMed:
Novel metabolites from cereal-associated lactobacilli - novel functionalities for cereal products?
PubMed:
Sugar-glycerol cofermentations by Lactobacillus hilgardii isolated from wine.
PubMed:
Glycerol metabolism and bitterness producing lactic acid bacteria in cidermaking.
PubMed:
Crystallization and phase behavior of fatty acid esters of 1,3 propanediol III: 1,3 propanediol dicaprylate/1,3 propanediol distearate (CC/SS) and 1,3 propanediol dicaprylate/1,3 propanediol dipalmitate (CC/PP) binary systems.
PubMed:
Glycerol induces reuterin production and decreases Escherichia coli population in an in vitro model of colonic fermentation with immobilized human feces.
PubMed:
Significant lability of guaiacylglycerol beta-phenacyl ether under alkaline conditions.
PubMed:
Crystallization and phase behavior of 1,3-propanediol esters II. 1,3-propanediol distearate/1,3-propanediol dipalmitate (SS/PP) and 1,3-propanediol distearate/1,3-propanediol dimyristate (SS/MM) binary systems.
PubMed:
Crystallization and phase behavior of fatty acid esters of 1,3-propanediol I: pure systems.
PubMed:
Thermal behavior of beta-1 subunits in lignin: pyrolysis of 1,2-diarylpropane-1,3-diol-type lignin model compounds.
PubMed:
Biogenic amines in natural ciders.
PubMed:
Stability and comparative metabolism of selected felbamate metabolites and postulated fluorofelbamate metabolites by postmitochondrial suspensions.
PubMed:
Eicosapentaenoic acid modulates the immune response but has no effect on a mimic of antigen-specific responses.
PubMed:
Constituents of the leaves of Peucedanum japonicum Thunb. and their biological activity.
PubMed:
Development of a new method, based on a bioreactor coupled with an L-lactate biosensor, toward the determination of a nonspecific inhibition of L-lactic acid production during milk fermentation.
PubMed:
3-hydroxypropionaldehyde: applications and perspectives of biotechnological production.
PubMed:
Purification and structural characterization of 3-hydroxypropionaldehyde and its derivatives.
PubMed:
Effect of glucose on glycerol bioconversion by Lactobacillus reuteri.
PubMed:
Production of 1,3-propanediol by Klebsiella pneumoniae.
PubMed:
Effect of water activity and immobilization on fatty acid selectivity for esterification reactions mediated by lipases.
PubMed:
Metabolism and distribution of [2,3-(14)C]acrolein in laying hens.
PubMed:
Glycosides and phenylpropanoid glycerol in vitis vinifera cv. Gewurztraminer wine.
PubMed:
Biodegradable films from isolate of sunflower (Helianthus annuus) proteins.
PubMed:
Comparative fatty acid selectivity of lipases in esterification reactions with glycerol and diol analogues in organic media.
PubMed:
Selectivity of celite-immobilized patatin (lipid acyl hydrolase) from potato (Solanum tuberosum L.) tubers in esterification reactions As influenced by water activity and glycerol analogues as alcohol acceptors.
PubMed:
Chemicals from biotechnology: molecular plant genetics will challenge the chemical and the fermentation industry.
PubMed:
Acute, subchronic, and chronic toxicity studies with felbamate, 2-phenyl-1,3-propanediol dicarbamate.
PubMed:
Cross-linking of starch with bifunctional precursors of nitroalkenes.
PubMed:
The vicinal chloroalcohols 1,3-dichloro-2-propanol (DC2P), 3-chloro-1,2-propanediol (3CPD) and 2-chloro-1,3-propanediol (2CPD) are not genotoxic in vivo in the wing spot test of Drosophila melanogaster.
PubMed:
Determination of 2-ethylhexyl 4-(N-methyl-N-nitrosamino) benzoate in commercial sunscreens and cosmetic products.
PubMed:
Felbamate pharmacology and use in epilepsy.