1,4-butane diol

1,4-butanediol

CAS: 110-63-4 C4 H10 O2 MW: 90.12210000

Identification

Name1,4-butane diol
IUPACbutane-1,4-diol
CAS Number110-63-4
EINECS203-786-5
FDA UNII7XOO2LE6G3
Molecular FormulaC4 H10 O2
Molecular Weight90.12210000
MDL NumberMFCD00002968
Nikkaji NumberJ5.097K
Beilstein1633445
XlogP3-0.80 (est)

Regulatory

DG SANTE Food Contact Materials1,4-butanediol
FDA Mainterm (IAUFC)110-63-4 ; 1,4-BUTYLENE GLYCOL
FDA RegulationFDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS

Physical Properties

Appearance colorless clear oily liquid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.01700 @ 25.00 °C.
Melting Point 20.40 °C. @ 760.00 mm Hg
Boiling Point 235.00 °C. @ 760.00 mm Hg
Vapor Pressure 0.010500 mmHg @ 25.00 °C.
Vapor Density 3.1 ( Air = 1 )
Flash Point > 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w) -0.830
Soluble in water, 1.00E+06 mg/L @ 20 °C (exp)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usessolvents

No sensory data available

Safety Information

Oral/Parenteral Toxicityoral-rat LD50 1525 mg/kg
Dermal ToxicityNot determined
Inhalation Toxicityinhalation-rat LCLo 15000 mg/m3/4H

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)\nBLOOD: OTHER CHANGES\nBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)', 'BLOOD: OTHER CHANGES\nBEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)\nBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)', 'BLOOD: OTHER CHANGES\nBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)\nBEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)', 'BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)\nBLOOD: OTHER CHANGES\nBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)']

Safety in Use

Categorysolvents
Recommendation for 1,4-butane diol usage levels up tonot for fragrance use.
Recommendation for 1,4-butane diol flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

agrisynth B1D 1,4- butandiol butane-1,4-diol 1,4- butanediol 1,4- butylene glycol 1,4- dihydroxybutane tetramethylene glycol 1,4- tetramethylene glycol PubMed: Physical dependence on gamma-hydroxybutrate (GHB) prodrug 1,4-butanediol (1,4-BD): time course and severity of withdrawal in baboons. PubMed: Comparative study of equimolar doses of gamma-hydroxybutyrate (GHB), 1,4-butanediol (1,4-BD) and gamma-butyrolactone (GBL) on catalepsy after acute and chronic administration. PubMed: Self-administration of gamma-hydroxybutyric acid (GHB) precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) in baboons. PubMed: Thermal behavior and gelling interactions of Mesona Blumes gum and rice starch mixture. PubMed: Cloning, expression and characterization of meso-2,3-butanediol dehydrogenase from Klebsiella pneumoniae. PubMed: Monolithic column based on a poly(glycidyl methacrylate-co-4-vinylphenylboronic acid-co-ethylene dimethacrylate) copolymer for capillary liquid chromatography of small molecules and proteins. PubMed: Determination of polyadipates migrating from lid gaskets of glass jars. Hydrolysis to adipic acid and measurement by LC-MS/MS. PubMed: Electrochromatographic characterization of methacrylate ester-based monolith and capillary electrochromatography separation of flavonoids. PubMed: Preparation of a neutral porous monolith and its evaluation in pressurized capillary electrochromatography with neutral and charged solutes. PubMed: Xyloglucan xyloglucosyl transferases from barley (Hordeum vulgare L.) bind oligomeric and polymeric xyloglucan molecules in their acceptor binding sites. PubMed: Preparation and evaluation of the highly cross-linked poly(1-hexadecane-co-trimethylolpropane trimethacrylate) monolithic column for capillary electrochromatography. PubMed: Behavioral effects and pharmacokinetics of gamma-hydroxybutyrate (GHB) precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) in baboons. PubMed: Rapid determination of sterols in vegetable oils by CEC using methacrylate ester-based monolithic columns. PubMed: Numerical and genetic analysis of polycyclic aromatic hydrocarbon-degrading mycobacteria. PubMed: Discriminative stimulus effects of gamma-hydroxybutyrate (GHB) and its metabolic precursor, gamma-butyrolactone (GBL) in rats. PubMed: Interaction between 1,4-butanediol and ethanol on operant responding and the cardiovascular system. PubMed: Influence of reinforcer type and route of administration on gamma-hydroxybutyrate discrimination in rats. PubMed: Chronic 1,4-butanediol treatment in rats: cross-tolerance to gamma-hydroxybutyrate and (+/-)-baclofen. PubMed: Effects of gamma-hydroxybutyrate (GHB) on schedule-controlled responding in rats: role of GHB and GABAB receptors. PubMed: The role of GABAB receptors in the discriminative stimulus effects of gamma-hydroxybutyrate in rats: time course and antagonism studies. PubMed: NTP Toxicology and Carcinogenesis Studies of Tetrahydrofuran (CAS No. 109-99-9) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). PubMed: Pretreatment of CD-1 mice with 4-methylpyrazole blocks toxicity from the gamma-hydroxybutyrate precursor, 1,4-butanediol. PubMed: Gamma-hydroxybutyrate, gamma-butyrolactone, and 1,4-butanediol: a case report and review of the literature. PubMed: Coma and respiratory depression following the ingestion of GHB and its precursors: three cases. PubMed: Development of immunoassays for tyramine and tryptamine toxins of Phalaris aquatica L. PubMed: Subacute oral toxicity of 1,4-butanediol in rats. PubMed: Separation of immunoglobulin and transferrin from blood serum and plasma by metal chelate interaction chromatography. PubMed: Separation of immunoglobulins and lactoferrin from cheese whey by chelating chromatography.