1,4-dimethyl naphthalene

naphthalene, 1,4-dimethyl-

CAS: 571-58-4 C12 H12 MW: 156.22764000 moldy

Identification

Name1,4-dimethyl naphthalene
IUPAC1,4-dimethylnaphthalene
CAS Number571-58-4
EINECS209-335-9
FDA UNIIBQH3S1I0SO
Molecular FormulaC12 H12
Molecular Weight156.22764000
MDL NumberMFCD00004037
Nikkaji NumberJ116.786C
Beilstein2039842
XlogP34.40 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.01600 @ 25.00 °C.
Refractive Index 1.61300 @ 20.00 °C.
Melting Point 7.60 °C. @ 760.00 mm Hg
Boiling Point 268.00 °C. @ 760.00 mm Hg, 267.00 to 268.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure 0.013000 mmHg @ 25.00 °C. (est)
Flash Point > 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w) 4.370
Soluble in alcohol
Insoluble in water

Organoleptic Properties

Taste Description mouldy tarry

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryinformation only not used for fragrances or flavors
Recommendation for 1,4-dimethyl naphthalene usage levels up tonot for fragrance use.
Recommendation for 1,4-dimethyl naphthalene flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

artemisia variabilis flower oil italy @ 0.50% Data

Synonyms

1,4- dimethyl-naphthalene 1,4- dimethylnaphthalene 1,4- DMN naphthalene, 1,4-dimethyl- US Patents: 3,931,166 - Certain 2,5-dimethyl-3-thiopyrazines PubMed: The Paleobiosphere: a novel device for the in vivo testing of hydrocarbon producing-utilizing microorganisms. US Patents: 3,961,095 - Flavoring agent PubMed: Triplet excited state behavior of naphthalene-based pseudopeptides in the presence of energy donors. PubMed: Functionalized derivatives of 1,4-dimethylnaphthalene as precursors for biomedical applications: synthesis, structures, spectroscopy and photochemical activation in the presence of dioxygen. PubMed: The sprout inhibitor 1,4-dimethylnaphthalene induces the expression of the cell cycle inhibitors KRP1 and KRP2 in potatoes. PubMed: Ralstonia sp. U2 naphthalene dioxygenase and Comamonas sp. JS765 nitrobenzene dioxygenase show differences in activity towards methylated naphthalenes. PubMed: Liquid phase separation of polyaromatics on [Cu2(BDC)2(dabco)]. PubMed: Electron donor-acceptor interaction of 3,4-dimethylaniline with 2,3-dicyano-1,4-naphthoquinone. PubMed: Dexmedetomidine induces both relaxations and contractions, via different {alpha}2-adrenoceptor subtypes, in the isolated mesenteric artery and aorta of the rat. PubMed: Analogues of (3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic). Synthesis and in vitro and in vivo opioid receptor antagonist activity. PubMed: Steric effects on the control of endo/exo-selectivity in the asymmetric cycloaddition reaction of 3,4-dimethyl-1-phenylarsole. PubMed: The sprout inhibitors chlorpropham and 1,4-dimethylnaphthalene elicit different transcriptional profiles and do not suppress growth through a prolongation of the dormant state. PubMed: (1R*,2R*)-1-(4-Chloro-phen-yl)-4-dimethyl-amino-1-(3-meth-oxy-2-naphth-yl)-2-(1-naphth-yl)butan-2-ol. PubMed: (1R*,2R*)-1-(7-Bromo-3-methoxy-naphthalen-2-yl)-4-(dimethyl-amino)-2-(naphthalen-1-yl)-1-phenyl-butan-2-ol. PubMed: Yields of glyoxal and ring-cleavage co-products from the OH radical-initiated reactions of naphthalene and selected alkylnaphthalenes. PubMed: Metal-organic frameworks as high-potential adsorbents for liquid-phase separations of olefins, alkylnaphthalenes and dichlorobenzenes. PubMed: Generation of cholesterol carboxyaldehyde by the reaction of singlet molecular oxygen [O2 (1Delta(g))] as well as ozone with cholesterol. PubMed: Soft-hydrothermal processing of red cedar bedding reduces its induction of cytochrome P450 in mouse liver. PubMed: The pH effect on the naphthoquinone-photosensitized oxidation of 5-methylcytosine. PubMed: Multidimensional gas chromatography with capillary flow technology and LTM-GC. PubMed: Selective oxidation and reduction of trinuclear titanium(II) hexaazatrinaphthylene complexes-synthesis, structure, and electrochemical investigations. PubMed: On the effect of 1,4-diazabicyclo[2.2.2]octane on the singlet-oxygen dimol emission: chemical generation of 1O2)2 in peroxide reactions. PubMed: A widely used retinoic acid receptor antagonist induces peroxisome proliferator-activated receptor-gamma activity. PubMed: Disorder-to-order transition of 1,4-dimethylnaphthalene: Formation of molecular complex with water and p-xylene on Al2O3 (0001). PubMed: Volatile biomarkers of pulmonary tuberculosis in the breath. PubMed: Oximetry of oxygen supersaturated solutions using nitroxides as EPR probe. PubMed: Effects of 9,10-dihydroxy-4,4-dimethyl-5,8-dihydro-1(4H)-anthracenone derivatives on tumor cell respiration. PubMed: Enantioselective addition of vinylzinc reagents to aldehydes catalyzed by modular ligands derived from amino acids. PubMed: Synthesis and antidepressant activity of some 1,3,5-triphenyl-2-pyrazolines and 3-(2''-hydroxy naphthalen-1''-yl)-1,5-diphenyl-2-pyrazolines. PubMed: A redox active and electrochemiluminescent threading bis-intercalator and its applications in DNA assays. PubMed: Application of cyclodextrin-mediated capillary electrophoresis to determine the apparent binding constants and thermodynamic parameters of the alkylnaphthalene derivatives. PubMed: Characterization of Sphingomonas aldehyde dehydrogenase catalyzing the conversion of various aromatic aldehydes to their carboxylic acids. PubMed: Estimates of internal energies of vaporisation of some room temperature ionic liquids. PubMed: Identification of a new scaffold for opioid receptor antagonism based on the 2-amino-1,1-dimethyl-7-hydroxytetralin pharmacophore. PubMed: Synthesis, antiprotozoal and cytotoxic activities of new N-(3,4-dimethyl-5-isoxazolyl)-1,2-naphthoquinone-4-amino derivatives. PubMed: A retinoid-related molecule that does not bind to classical retinoid receptors potently induces apoptosis in human prostate cancer cells through rapid caspase activation. PubMed: Synthesis of conformationally stable 1,8-diarylnaphthalenes: development of new photoluminescent sensors for ion-selective recognition. PubMed: Chemical composition of the essential oils of two Chinese endemic Meconopsis species. PubMed: Singlet molecular oxygen generated from lipid hydroperoxides by the russell mechanism: studies using 18(O)-labeled linoleic acid hydroperoxide and monomol light emission measurements. PubMed: Direct evidence of singlet molecular oxygen [O2(1Deltag)] production in the reaction of linoleic acid hydroperoxide with peroxynitrite. PubMed: Effects of hydroxypropyl-beta-cyclodextrin on the chemical stability of a naphthoquinone in aqueous solutions. PubMed: Sensitized photoxygenation of piroxicam in neat solvents and solvent mixtures. PubMed: Differential effects of U46619 on renal regional hemodynamics in the rat: involvement of endothelin. PubMed: Disposition and metabolism of 1,4-dimethylnaphthalene in rat. PubMed: Effect of experimental diabetes on the fatty acid composition, molecular species of phosphatidyl-choline and physical properties of hepatic microsomal membranes. PubMed: Effect of hydroxypropyl-beta-cyclodextrin on the solubility of an antibacterial isoxazolyl-naphthoquinone. PubMed: Cytochrome P450 omega/omega-1 hydroxylase-derived eicosanoids contribute to endothelin(A) and endothelin(B) receptor-mediated vasoconstriction to endothelin-1 in the rat preglomerular arteriole. PubMed: Mechanism of antibacterial and degradation behavior of a chlorinated isoxazolylnaphthoquinone. PubMed: Antimutagenic effects and possible mechanisms of action of vitamins and related compounds against genotoxic heterocyclic amines from cooked food. PubMed: An aqueous concentration model for riverine spills. PubMed: Effects of endothelin-1 on capsaicin-induced nociception in mice. PubMed: Inactivation of enveloped viruses by singlet oxygen thermally generated from a polymeric naphthalene derivative. PubMed: Oxidative stress in Staphylococcus aureus associated to the cleavage of an isoxazolylnaphthoquinoneimine with antibacterial capacity. PubMed: An "in vitro" system simulates in membranes the antibacterial mechanism postulated for the action of isoxazolylnaphtoquinoneimine in Staphylococcus aureus. PubMed: Activation of 5-HT1A receptors potentiates the clonidine inhibitory effect in the locus coeruleus. PubMed: Singlet Oxygen and the Production of Sulfur Oxygenates of Nickel(II) and Palladium(II) Thiolates. PubMed: New non-peptide endothelin-A receptor antagonists: synthesis, biological properties, and structure-activity relationships of 5-(dimethylamino)-N-pyridyl-,-N-pyrimidinyl-,-N-pyridazinyl-, and -N-pyrazinyl-1-naphthalenesulfonamides. PubMed: Antibacterial effect of 2-hydroxy-N-(3,4-dimethyl-5-isoxazolyl)-1, 4-naphthoquinone-4-imine on Staphylococcus aureus. PubMed: Formation of singlet oxygen in the thermal decomposition of 3-hydroxymethyl-3,4,4-trimethyl-1,2-dioxetane, a chemical source of triplet-excited ketones. PubMed: A role for endothelin ETA receptors in regulation of renal function in spontaneously hypertensive rats. PubMed: Glucocorticoid receptor-mediated inhibition by corticosterone of 5-HT1A autoreceptor functioning in the rat dorsal raphe nucleus. PubMed: Mutagenic activity of isoxazolylnaphthoquinoneimines assayed by micronucleus bone marrow test. PubMed: Diurnal rhythm of beta-carotene in photosynthetic alga Gonyaulax polyedra. PubMed: Discovery and structure-activity relationships of sulfonamide ETA-selective antagonists. PubMed: Antibiotic activity of isoxazolylnaphthoquinone imines on mice infected with Staphylococcus aureus. PubMed: BMS-182874 is a selective, nonpeptide endothelin ETA receptor antagonist. PubMed: Stability determination of 3-bromo-2-hydroxy-N-(3,4-dimethyl-5-isoxazolyl)- 1,4-naphthoquinon-4-imine in ethanol by first-derivative spectrophotometry. PubMed: Isoxazoles. 8. Preformulation studies of an isoxazolylnaphthoquinone derivative. PubMed: Synthesis and some physiochemical properties of 2-hydroxy-N-(3,4-dimethyl-5-isoxazolyl)-1,4-naphthoquinone 4-imine derivatives. PubMed: The discovery of sulfonamide endothelin antagonists and the development of the orally active ETA antagonist 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulf onamide. PubMed: Energy-transfer measurements of the Cys35-Cys84 distance in bovine cardiac troponin C. PubMed: Effect of Plumbagin on some glucose metabolising enzymes studied in rats in experimental hepatoma. PubMed: [In vitro antibacterial activity of isoxazolyl++ naphthoquinones. I]. PubMed: The in vitro and in vivo cytotoxicity of menadione (vitamin K3) against rat transplantable hepatoma induced by 3'-methyl-4-dimethyl-aminoazobenzene. PubMed: Isoxazolylnaphthoquinone effects on the growth of Trypanosoma cruzi. PubMed: Isoxazoles. VI: Aspects of the chemical stability of a new naphthoquinone-amine in acidic aqueous solution. PubMed: Substrate interactions during aerobic biodegradation of benzene. PubMed: [Effect of naphthoquinone-imines on the production of hydrogen peroxide by Crithidia fasciculata and Leptomonas seymouri]. PubMed: Palladium(0)-assisted synthesis of C-glycopyranosyl compounds. PubMed: Structure-activity relationships among DNA gyrase inhibitors. Synthesis and biological evaluation of 1,2-dihydro-4, 4-dimethyl-1-oxo-2-naphthalenecarboxylic acids as 1-carba bioisosteres of oxolinic acid. PubMed: High-dose chemotherapy and autologous bone marrow transplantation for the treatment of small cell lung carcinoma. PubMed: Different protein-lipid interaction in human red blood cell membrane of Rh positive and Rh negative blood compared with Rhnull. PubMed: Inhibition of DMBA carcinogenesis of hamster buccal pouch by phenanthrene and dimethylnaphthalene. PubMed: Treatment of malignant gliomas and brain metastases in adults using a combination of adriamycine, VM 26, and CCNU. Results of a type II trial. PubMed: Treatment of malignant gliomas and brain metastases in adults with a combination of adriamycin, VM 26, and CCNU. Results of a phase II trail. PubMed: [Trial treatment of glioblastomas in adults and cerebral metastais by adriamycin, VM 26 and CCNU combination. Result of a type II trial]. PubMed: The cardioactive and related properties of N-methyl-N-( -phenylethyl)-1,2,3,4-tetrahydro-6-methoxy-4,4-dimethyl-2-naphthylamine hydrochloride (2-AT-1). PubMed: Microbial hydrocarbon co-oxidation. I. Oxidation of mono- and dicyclic hydrocarbons by soil isolates of the genus Nocardia.