1,5-pentane diol
pentamethylene glycol
Identification
| Name | 1,5-pentane diol |
| IUPAC | pentane-1,5-diol |
| CAS Number | 111-29-5 |
| EINECS | 203-854-4 |
| FDA UNII | 07UXZ0SCST |
| Molecular Formula | C5 H12 O2 |
| Molecular Weight | 104.14904000 |
| MDL Number | MFCD00002978 |
| Nikkaji Number | J5.107A |
| Beilstein | 1560130 |
Regulatory
Physical Properties
| Appearance | colorless clear viscous liquid (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 0.99400 @ 25.00 °C. |
| Refractive Index | 1.45000 @ 20.00 °C. |
| Melting Point | -16.00 °C. @ 760.00 mm Hg |
| Boiling Point | 238.00 to 239.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 0.003900 mmHg @ 25.00 °C. |
| Flash Point | 265.00 °F. TCC ( 129.44 °C. ) |
| logP (o/w) | -0.599 (est) |
| Soluble in | alcohol |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | solvents |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-rabbit LD50 6300 mg/kg |
| Dermal Toxicity | skin-rabbit LD50 > 20 ml/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | solvents |
| Recommendation for 1,5-pentane diol usage levels up to | not for fragrance use. |
| Recommendation for 1,5-pentane diol flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
1,5-
dihydroxypentane
pentamethylene glycol
1,5-
pentamethylene glycol
alpha,omega-
pentane diol
pentane-1,5-diol
1,5-
pentanediol
alpha,omega-
pentanediol
1,5-
pentylene glycol
PubMed:
Contribution of liver alcohol dehydrogenase to metabolism of alcohols in rats.
PubMed:
Excess enthalpies of mixing, effect of temperature and composition on the density, and viscosity and thermodynamic properties of binary systems of {ammonium-based ionic liquid + alkanediol}.
PubMed:
Enzymatic production of 5-aminovalerate from L-lysine using L-lysine monooxygenase and 5-aminovaleramide amidohydrolase.
PubMed:
Tetrabutylammonium bromide (TBABr)-based deep eutectic solvents (DESs) and their physical properties.
PubMed:
A comparative ultrasonic relaxation study of lower vicinal and terminal alkanediols at 298.15 K in relation to their molecular structure and hydrogen bonding.
PubMed:
1,3,5-Tri-p-tolyl-pentane-1,5-diol.
PubMed:
Preliminary crystallographic analysis of a cruciferin protein from seeds of Moringa oleifera.
PubMed:
Isolation, structure determination, and antiaging effects of 2,3-pentanediol from endophytic fungus of Curcuma amada and docking studies.
PubMed:
Molybdenum-catalyzed deoxydehydration of vicinal diols.
PubMed:
Aqueous phase hydrogenation of levulinic acid to 1,4-pentanediol.
PubMed:
Safety assessment and biological effects of a new cold processed SilEmulsion for dermatological purpose.
PubMed:
Phase-diagram-guided method for growth of a large crystal of glycoside hydrolase family 45 inverting cellulase suitable for neutron structural analysis.
PubMed:
Cubic and sponge phases in ether lipid-solvent-water ternary systems: phase behavior and NMR characterization.
PubMed:
Controlled synthesis of ultrathin lamellar Eu(2)O(3) nanocrystals: self-assembly of 1D nanowires to 2D nanosheets.
PubMed:
In vivo study of an instantly formed lipid-water cubic phase formulation for efficient topical delivery of aminolevulinic acid and methyl-aminolevulinate.
PubMed:
Metabolic engineering of Escherichia coli for the production of 5-aminovalerate and glutarate as C5 platform chemicals.
PubMed:
Catalyst-controlled reversal of chemoselectivity in acylation of 2-aminopentane-1,5-diol derivatives.
PubMed:
Highly crosslinked polymeric monoliths for reversed-phase capillary liquid chromatography of small molecules.
PubMed:
Synthesis of high molecular weight polyesters via in vacuo dehydrogenation polymerization of diols.
PubMed:
Theoretical calculation of the OH vibrational overtone spectra of 1,5-pentanediol and 1,6-hexanediol.
PubMed:
A Fast Degrading Odd-Odd Aliphatic Polyester-5,7 Made by Condensation Polymerization for Biomedical Applications.
PubMed:
The preparation of 3-substituted-1,5-dibromopentanes as precursors to heteracyclohexanes.
PubMed:
Direct catalytic conversion of furfural to 1,5-pentanediol by hydrogenolysis of the furan ring under mild conditions over Pt/Co2AlO4 catalyst.
PubMed:
The size control of silver nanocrystals with different polyols and its application to low-reflection coating materials.
PubMed:
Influence of polyols on the formation of iron oxide nanoparticles in solvothermal system.
PubMed:
A practical total synthesis of (+)-spirolaxine methyl ether.
PubMed:
Internally protected amino sugar equivalents from enantiopure 1,2-oxazines: synthesis of variably configured carbohydrates with C-branched amino sugar units.
PubMed:
Allergic contact dermatitis to propyl gallate and pentylene glycol in an emollient cream.
PubMed:
Lipase-catalyzed regioselective monoacetylation of unsymmetrical 1,5-primary diols.
PubMed:
Improved synthesis of three methyl-branched pheromone components produced by the female lichen moth.
PubMed:
Bridged oligonucleotides as molecular probes for investigation of enzyme-substrate interaction and allele-specific analysis of DNA.
PubMed:
Reactivity of poly-alcohols towards OH, NO3 and SO4- in aqueous solution.
PubMed:
In vitro activity of chlorhexidine and pentane-1,5-diol and their combination on Candida albicans, Staphylococcus aureus and Propionibacterium acnes.
PubMed:
1,4-Butanediol content of aqua dots children's craft toy beads.
PubMed:
Therapeutic effect of 1,5-pentanediol for herpes simplex labialis: a randomized, double-blind, placebo-controlled clinical trial.
PubMed:
The shape evolution of gold seeds and gold@silver core-shell nanostructures.
PubMed:
Experimental stroke protection induced by 4-hydroxybenzyl alcohol is cancelled by bacitracin.
PubMed:
Transferable force field for alcohols and polyalcohols.
PubMed:
Chemoselective hydrogenolysis of tetrahydrofurfuryl alcohol to 1,5-pentanediol.
PubMed:
Effect of pentane-1,5-diol and propane-1,2-diol on percutaneous absorption of terbinafine.
PubMed:
Enantioselective syntheses of both enantiomers of noranabasamine.
PubMed:
Thermal properties and mixing state of diol-water mixtures studied by calorimetry, large-angle X-ray scattering, and NMR relaxation.
PubMed:
A comparison of pentane-1,5-diol to other diols for use in dermatology.
PubMed:
Synthesis of phosphate monomers and bonding to dentin: esterification methods and use of phosphorus pentoxide.
PubMed:
Allergic contact dermatitis to pentylene glycol in a cosmetic cream.
PubMed:
[Spectral studies on liquid crystal photoalignment film of photosensitive monomer with fluorinated groups].
PubMed:
Polyhedral gold nanocrystals with O h symmetry: from octahedra to cubes.
PubMed:
Treatment of atopic dermatitis with 1% hydrocortisone and 25% pentane-1,5-diol: effect on Staphylococcus aureus.
PubMed:
Thermotropic properties of organic nanocrystals embedded in ultrasmall crystallization chambers.
PubMed:
MD simulations of the binding of alcohols and diols by a calixarene in water: connections between microscopic and macroscopic properties.
PubMed:
Pentane-1,5-diol as a percutaneous absorption enhancer.
PubMed:
Total synthesis of the epoxy isoprostane phospholipids PEIPC and PECPC.
PubMed:
The in vitro activity of pentane-1,5-diol against aerobic bacteria. A new antimicrobial agent for topical usage?
PubMed:
Removal of lipopolysaccharides from protein-lipopolysaccharide complexes by nonflammable solvents.
PubMed:
Characterization of European wine glycerol: stable carbon isotope approach.
PubMed:
Improved assay for determination of busulfan by liquid chromatography using postcolumn photolysis.
PubMed:
Simple synthesis of beta-D-glycopyranosides using beta-glycosidase from almonds.
PubMed:
Allergic contact dermatitis from pentylene glycol in an emollient cream, with possible co-sensitization to resveratrol.
PubMed:
Continuous monitoring of prostatic acid phosphatase using self-indicating substrates.
PubMed:
Effects of aldehydes and methods of cross-linking on properties of calcium alginate microspheres prepared by emulsification.
PubMed:
Stereocontrolled total synthesis of the Stemona alkaloid (-)-stenine.
PubMed:
Volumes of aqueous alcohols, ethers, and ketones to T = 523 K and p = 28 MPa.
PubMed:
Aerobic and anaerobic metabolism of glutaraldehyde in a river water-sediment system.
PubMed:
New synthesis of serricornin, the female sex pheromone of the cigarette beetle.
PubMed:
Ecotoxicology of glutaraldehyde: review of environmental fate and effects studies.
PubMed:
Determination of leachable components from four commercial dental composites by gas and liquid chromatography/mass spectrometry.
PubMed:
On protein solubility in organic solvent.
PubMed:
The effect of pH and temperature on the stability and enzymatic activity of prostatic acid phosphatase. Studies on the optimization of a continuous monitored determination of acid phosphatase, II.
PubMed:
Effect of ascorbic acid on the metabolism of N-nitrosopiperidine.
PubMed:
Protection of CGS 10078B against ouabain-induced arrhythmia in the cat.
PubMed:
[Synthesis of propenol and pentanediol derivatives].
PubMed:
Synthesis and antitumor effect of new biological alkylating agents, isethionic acid esters.
PubMed:
Mutagenicity and alpha-hydroxylation of N-nitrosopyrrolidine and N-nitrosopiperidine: a possible correlation.
PubMed:
The antimycotic activity in vitro of five diols.
PubMed:
Permeability of dog lung endothelium to sodium, diols, amides, and water.
PubMed:
Inhibition of bovine hepatic fructose-1,6-diphosphatase by substrate analogs.
PubMed:
Action of gamma radiation on liquid 1,5-pentanediol.
PubMed:
Preparation of dihydropyran delta-hydroxyvaleraldehyde and 1,5-pentanediol from tetrahydrofurfuryl alcohol.