1-naphthol

1-naphthol

CAS: 90-15-3 C10 H8 O MW: 144.17296000

Identification

Name1-naphthol
IUPACnaphthalen-1-ol
CAS Number90-15-3
EINECS201-969-4
FDA UNII2A71EAQ389
Molecular FormulaC10 H8 O
Molecular Weight144.17296000
MDL NumberMFCD00003930
Nikkaji NumberJ3.911J
Beilstein1817321
XlogP32.80 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 94.00 to 95.00 °C. @ 760.00 mm Hg
Boiling Point 279.00 to 280.00 °C. @ 760.00 mm Hg, 142.00 to 143.00 °C. @ 10.00 mm Hg
Vapor Pressure 0.001000 mmHg @ 25.00 °C. (est)
Flash Point 291.00 °F. TCC ( 144.00 °C. ) (est)
logP (o/w) 2.850
Soluble in water, 866 mg/L @ 24C (exp)

Cosmetic Information

CosIngcosmetic data
Cosmetic Useshair dyeing agents

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-cat LD50 134 mg/kg
Dermal Toxicityskin-rabbit LD50 880 mg/kg
Inhalation Toxicityinhalation-rat LC50 > 420 mg/m3/1H

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic agents
Recommendation for 1-naphthol usage levels up tonot for fragrance use.
Recommendation for 1-naphthol flavor usage levels up tonot for flavor use.

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Potential Uses

hair dyeing agents

Natural Occurrence

not found in nature walnut black walnut oil

Synonyms

C.I. oxidation base 33 CI oxidation base 33 durafur developer D fouramine ERN fourrine 99 fourrine ERN furro ER a- hydroxynaphthalene alpha- hydroxynaphthalene molisch's reagent nako TRB naphthalen-1-ol 1- naphthalenol a- naphthol alpha- naphthol a- naphthyl alcohol tertral ERN ursol ERN zoba ERN PubMed: HCR-stimulated formation of DNAzyme concatamers on gold nanoparticle for ultrasensitive impedimetric immunoassay. PubMed: Tyramine-based enzymatic conjugate repeats for ultrasensitive immunoassay accompanying tyramine signal amplification with enzymatic biocatalytic precipitation. PubMed: Metabolism of chamaechromone in vitro with human liver microsomes and recombinant human drug-metabolizing enzymes. PubMed: DNAzyme-functionalized gold-palladium hybrid nanostructures for triple signal amplification of impedimetric immunosensor. PubMed: Graphene oxide-labeled sandwich-type impedimetric immunoassay with sensitive enhancement based on enzymatic 4-chloro-1-naphthol oxidation. PubMed: Characterization of modified high-amylose maize starch-α-naphthol complexes and their influence on rheological properties of wheat starch. PubMed: Rapid determination of nitrites in food using a diffuse UV-visible reflectance method. PubMed: Excretion profiles and half-lives of ten urinary polycyclic aromatic hydrocarbon metabolites after dietary exposure. PubMed: Ionic liquid-based dispersive liquid-liquid microextraction with back-extraction coupled with capillary electrophoresis to determine phenolic compounds. PubMed: Inhibitory effects of naphthols on the activity of mushroom tyrosinase. PubMed: Assessment of polyaromatic hydrocarbon degradation by potentially pathogenic environmental Vibrio parahaemolyticus isolates from coastal Louisiana, USA. PubMed: Identification of the human UDP-glucuronosyltransferases involved in the glucuronidation of combretastatin A-4. PubMed: Multi-enzyme inhibition assay for the detection of insecticidal organophosphates and carbamates by high-performance thin-layer chromatography applied to determine enzyme inhibition factors and residues in juice and water samples. PubMed: [Effect of naphthalene and its derivatives on Candida pseudotropicalis 44 PK sensitivity to trichothecene mycotoxins]. PubMed: Speciation and separation of Cr(VI) and Cr(III) using coprecipitation with Ni2+/2-Nitroso-1-naphthol-4-sulfonic acid and determination by FAAS in water and food samples. PubMed: Surfactant effects on the affinity of plant cuticles with organic pollutants. PubMed: Pomegranate juice inhibits sulfoconjugation in Caco-2 human colon carcinoma cells. PubMed: [Determination of aniline in water by flow injection spectrophotometry]. PubMed: Effect of breed upon cytochromes P450 and phase II enzyme expression in cattle liver. PubMed: SULT1C3, an orphan sequence of the human genome, encodes an enzyme activating various promutagens. PubMed: Disposable electrochemical genosensor for the simultaneous analysis of different bacterial food contaminants. PubMed: Liquid chromatographic determination of N-methyl carbamate pesticide residues at low parts-per-billion levels in eggs. PubMed: Comparison of hydrolytic and conjugative biotransformation pathways in horse, cattle, pig, broiler chick, rabbit and rat liver subcellullar fractions. PubMed: Hydrolysis of carbaryl by carbonate impurities in reference clay SWy-2. PubMed: Application of micellar electrokinetic capillary chromatography to the analysis of uncharged pesticides of environmental impact. PubMed: Oligonucleotide-modified screen-printed gold electrodes for enzyme-amplified sensing of nucleic acids. PubMed: A colony blot immunoassay for the rapid identification of Bacillus cereus. PubMed: An analytical device for on-site immunoassay. Demonstration of its applicability in semiquantitative detection of aflatoxin B1 in a batch of samples with ultrahigh sensitivity. PubMed: A simple method for the determination of carbaryl and 1-naphthol in fruit juices by high-performance liquid chromatography-diode-array detection. PubMed: Naphthalene--an environmental and occupational toxicant. PubMed: Nuclear receptor, pregname X receptor, is required for induction of UDP-glucuronosyltranferases in mouse liver by pregnenolone-16 alpha-carbonitrile. PubMed: Investigation of the relation between self-reported food consumption and household chemical exposures with urinary levels of selected nonpersistent pesticides. PubMed: Oxidation of carbaryl in aqueous solution by membrane anodic fenton treatment. PubMed: Purification and characterization of acetyl esterase from Candida guilliermondii. PubMed: Kuwait's total diet study: dietary intake of organochlorine, carbamate, benzimidazole and phenylurea pesticide residues. PubMed: A study for the proper application of urinary naphthols, new biomarkers for airborne polycyclic aromatic hydrocarbons. PubMed: Spectrophotometric determination of carbaryl pesticide and its hydrolysis product in soil and strawberry samples. PubMed: A simple colony-blot method for identification of Listeria in food samples. PubMed: Detection of exo-beta-1,3-glucanase activity in polyacrylamide gels after electrophoresis under denaturing or nondenaturing conditions. PubMed: Effects of 1-isothiocyanato-3-(methylsulfinyl)-propane on xenobiotic metabolizing enzymes in rats. PubMed: Evidence for an NIH shift in oxidation of naphthalene by the marine cyanobacterium Oscillatoria sp. strain JCM. PubMed: Degradation of carbaryl in natural waters: enhanced hydrolysis rate in micellar solution. PubMed: Disposition of 1-naphthol in the channel catfish (Ictalurus punctatus). PubMed: Identification of [14C]carmoisine metabolites in bacterial suspension of rat faeces. PubMed: Mechanisms of anti-carcinogenesis by indole-3-carbinol. Studies of enzyme induction, electrophile-scavenging, and inhibition of aflatoxin B1 activation. PubMed: 1-Naphthol--single and repeated dose (30-day) oral toxicity studies in the mouse. PubMed: Effects of the fungicide prochloraz on xenobiotic metabolism in rainbow trout: in vivo induction. PubMed: Multigeneration reproduction and carcinogenicity studies in Sprague-Dawley rats exposed topically to oxidative hair-colouring formulations containing p-phenylenediamine and other aromatic amines. PubMed: Effects of dietary zinc deficiency on the activity of enzymes associated with phase I and II of drug metabolism in Fischer-344 rats: activities of drug metabolising enzymes in zinc deficiency. PubMed: Metabolic disposition of 14C-labelled carmoisine in the rat, mouse and guinea-pig. PubMed: Metabolism of zearalenone by sow intestinal mucosa in vitro. PubMed: Glucuronidation of morphine and six beta 2-sympathomimetics in isolated rat intestinal epithelial cells. PubMed: Effects of semisynthetic diets on xenobiotic metabolizing enzyme activity and morphology of small intestinal mucosa in humans. PubMed: Glucuronidation in the reindeer: dietary modification in the UDP-glucuronosyltransferase activity with 4-nitrophenol, 1-naphthol and phenolphthalein as acceptors. PubMed: Preparative separation of alpha- and beta-naphthols catalyzed by immobilized sulfatase. PubMed: Bacterial metabolism of 1-naphthol. PubMed: Automated steam distillation and fluorometry for screening for carbaryl as 1-naphthol in fruits and vegetables. PubMed: Degradation of 1-naphthol in sea water. PubMed: [Determination of residual amounts of sevin and 1-naphthol in the blood and milk of cows].