alpha-naphthyl butyrate

butyric acid, 1-naphthyl ester

CAS: 3121-70-8 C14 H14 O2 MW: 214.26398000

Identification

Namealpha-naphthyl butyrate
IUPACnaphthalen-1-yl butanoate
CAS Number3121-70-8
EINECS221-500-7
FDA UNII9UZL9U0CIK
Molecular FormulaC14 H14 O2
Molecular Weight214.26398000
MDL NumberMFCD00003923
Nikkaji NumberJ208.090G
Beilstein2558646
XlogP33.60 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.09100 to 1.09400 @ 20.00 °C.
Pounds per Gallon - (est). 9.089 to 9.114
Refractive Index 1.57000 to 1.57300 @ 20.00 °C.
Boiling Point 182.00 °C. @ 18.00 mm Hg, 320.00 to 321.00 °C. @ 760.00 mm Hg (est)
Flash Point 243.00 °F. TCC ( 117.20 °C. ) (est)
logP (o/w) 3.856 (est)
Soluble in alcohol
Insoluble in water

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryinformation only not used for fragrances or flavors
Recommendation for alpha-naphthyl butyrate usage levels up tonot for fragrance use.
Recommendation for alpha-naphthyl butyrate flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

butanoic acid 1-naphthyl ester butanoic acid, 1-naphthalenyl ester butyric acid 1-naphthyl ester butyric acid, 1-naphthyl ester naphthalen-1-yl butanoate 1- naphthyl butyrate 1- naphthylbutyrate PubMed: Characterization of a novel lipolytic enzyme from Aspergillus oryzae. PubMed: Esterase isoenzymes and insecticide resistance in Frankliniella occidentalis populations from the south-east region of Spain. PubMed: A peculiar case of acute myeloid leukemia mimicking plasmacytoid dendritic precursor cell leukemia. PubMed: N-linked oligosaccharides of Aspergillus awamori feruloyl esterase are important for thermostability and catalysis. PubMed: Identification of esterases expressed in Caco-2 cells and effects of their hydrolyzing activity in predicting human intestinal absorption. PubMed: Myeloid enzymes profile related to the immunophenotypic characteristics of blast cells from patients with acute myeloid leukemia (AML) at diagnosis. PubMed: Mutational analysis of a feruloyl esterase from Aspergillus awamori involved in substrate discrimination and pH dependence. PubMed: Relative contributions of enzyme cytochemistry and flow cytometric immunophenotyping to the evaluation of acute myeloid leukemias with a monocytic component and of flow cytometric immunophenotyping to the evaluation of absolute monocytoses. PubMed: Monocytes with altered phenotypes in posttrauma patients. PubMed: The professional phagocytes of sea bass (Dicentrarchus labrax L.): cytochemical characterisation of neutrophils and macrophages in the normal and inflamed peritoneal cavity. PubMed: Acute monoblastic leukemia with t(8;16): a distinct clinicopathologic entity; report of a case and review of the literature. PubMed: Reliability and limitations of cytochemistry in diagnosis of acute myeloid leukemia. Minireview. PubMed: [Effect of the cholinesterase reactivator dipyroxime in various models of delayed hypersensitivity during acute intoxication by acrylonitrile]. PubMed: Establishment and characterization of an arsenic-sensitive monoblastic leukaemia cell line (SigM5). PubMed: Differential cytochemical staining characteristics of channel catfish leukocytes identify cell populations in lymphoid organs. PubMed: Cytochemical staining characteristics of leukocytes of the common brushtail possum (Trichosurus vulpecula). PubMed: The effects of hormone replacement therapy on hypothalamic neuropeptide gene expression in a primate model of menopause. PubMed: Comprehensive review of adult acute myelogenous leukemia: cytomorphological, enzyme cytochemical, flow cytometric immunophenotypic, and cytogenetic findings. PubMed: Neutrophil and macrophage responses to inflammation in the peritoneal cavity of rainbow trout Oncorhynchus mykiss. A light and electron microscopic cytochemical study. PubMed: Proanthocyanidins from barley bran potentiate retinoic acid-induced granulocytic and sodium butyrate-induced monocytic differentiation of HL60 cells. PubMed: Three cases of near-tetraploid acute myeloid leukemias originating in pluripotent myeloid progenitors. PubMed: Establishment and characterization of a novel human promonocytic cell line from peripheral blood of a patient with psoriasis. PubMed: Abnormalities of esterase and glycogen in developing macrophages in non-Hodgkin's lymphoma: a quantitative cytochemical study. PubMed: Establishment and characterization of an immature human megakaryoblastic cell line, MEG-A2. PubMed: Dexamethasone alters the subpopulation make-up of rat bone marrow stromal cell cultures. PubMed: Minimally differentiated acute myeloid leukaemia (AML-M0): cytochemical, immunophenotypic and cytogenetic analysis of 19 cases. PubMed: Primary splenic lymphoma in a horse. PubMed: [CD14-positive and nonspecific esterase-positive neutrophils in a patient with refractory anemia with excess of blasts in transformation]. PubMed: Disordered macrophage development in Hodgkin's disease shown by quantitative cytochemistry. PubMed: Quantitative enzyme cytochemistry during human macrophage development. PubMed: Isolation and functional studies on feline bone marrow derived macrophages. PubMed: EDTA induces differentiation and suppresses proliferation of promyelocytic leukemia cell line HL-60--possible participation of zinc. PubMed: Histochemical and immunohistochemical study of the mucosal lymphoid system in swine. PubMed: [Philadelphia chromosome (Ph1) positive acute myelomonocytic leukemia with esophageal cancer: a case report]. PubMed: alpha-Naphthyl butyrate carboxylesterase activity in human and rat nasal tissue. PubMed: Cytotoxicity in feline leukemia virus subgroup-C infected fibroblasts is mediated by adherent bone marrow mononuclear cells. PubMed: Characterization of glycoprotein IIb/IIIa-positive cells in human umbilical cord blood: their potential usefulness as megakaryocyte progenitors. PubMed: Monocytic differentiation induction of HL-60 cells by MC 903, a novel vitamin D analogue. PubMed: Cytochemical study of activated peritoneal macrophages in normal and tumor-bearing rats. PubMed: Human c-fgr induces a monocyte-specific enzyme in NIH 3T3 cells. PubMed: Dendritic accessory cells derived from rat bone marrow precursors under chemically defined conditions in vitro belong to the myeloid lineage. PubMed: [Esterase activity of neutrophils and monocytes in patients with stenocardia and myocardial infarction]. PubMed: Human monoblastoid cell line U-937 cultured in protein-free medium: immunophenotype, cytochemical and biochemical markers. PubMed: Cytochemical and immunocytochemical characterization of Yoshida ascites sarcoma cells. PubMed: Establishment of a macrophagelike cell line derived from U-937, human histiocytic lymphoma, grown serum-free. PubMed: Temperature regulation of microtiter plates for enzyme assays. PubMed: Sex dependence of naphthyl butyrate esterase activity in rat serum. PubMed: Differentiation of human myeloid leukemia cell line ML-1 induced by retinoic acid and 1,25-dihydroxyvitamin D3. PubMed: [Acute myelomonocytic leukemia with inv (16) (p13 q22) disappeared abnormal karyotype during complete remission]. PubMed: Cooperative effects of gamma-interferon and 1 alpha, 25-dihydroxyvitamin D3 on in vitro differentiation of the blast cells of RAEB and RAEB-T. PubMed: Quinidine-induced inhibition of leukocyte esterases. PubMed: Quinidine-induced decrease of intracellular esterase activity in a hepatoma cell line. PubMed: Pitfalls in ecto-5'-nucleotidase enzyme cytochemistry as demonstrated by the immunogold-labelling technique on macrophages. PubMed: A case of acute promyelocytic leukaemia with 'faggot cells' exhibiting strong alpha-naphthylbutyrate esterase activity. PubMed: [Cytochemical findings in acute promyelocytic leukemias]. PubMed: [Modifications of immunoenzymatic aspects of B-cell chronic lymphocytic leukemia lymphocytes incubated in vitro with polyclonal B-cell activators and alpha-interferon]. PubMed: Novel monocyte-like properties of microglial/astroglial cells. Constitutive secretion of lysozyme and cystatin-C. PubMed: Cytochemical profile of megakaryoblastic leukaemia: a study with cytochemical methods, monoclonal antibodies, and ultrastructural cytochemistry. PubMed: Enzyme histochemistry of the rat nasal mucosa embedded in cold glycol methacrylate. PubMed: Enzymatic histochemistry of mouse kidney in plastic. PubMed: Eosinophilia in children. Cytochemical and immunological analysis of increased eosinophils. PubMed: [alpha-Naphthylbutyrate esterase as a marker of immunologic variants of lymphocytes]. PubMed: Enzyme histochemistry of hepatocellular neoplasms. PubMed: Hereditary monocyte esterase deficiency. PubMed: [An acute monocytic leukemia with no POX, alpha-NBE activity of blast cells and normal lysozyme level]. PubMed: Characterization of rabbit stromal fibroblasts derived from red and yellow bone marrow. PubMed: Acute myelomonocytic leukemia: an unusual variant with both granulocytic and monocytic esterases in the leukemic cells. PubMed: [Activity of alpha-naphthylbutyrate esterase in the peripheral blood cells of healthy subjects]. PubMed: [Cytochemical activity of bone marrow and blood esterases in healthy subjects and in leukemia]. PubMed: Heterogeneity and prognostic significance of macrophages in human colonic carcinomas. PubMed: Cytochemical characterization of leukemic cells from 20 dogs. PubMed: Ultrastructural patterns of the alpha-naphthyl butyrate esterase activity in normal and leukaemic peripheral blood leucocytes. PubMed: [Cytochemical studies of T- and B-lymphocyte subpopulations in normal conditions and in malignant lymphoproliferative diseases]. PubMed: Enzyme histochemistry of normal and neoplastic transitional epithelium. PubMed: [Studies on monocytes in acute leukemia. Changes in absolute counts and in staining with alpha-naphthyl butyrate esterase]. PubMed: Morphologic, cytochemical, and functional studies of peripheral blood cells of young healthy American alligators (Alligator mississippiensis). PubMed: Liver endothelium and not hepatocytes or Kupffer cells have transferrin receptors. PubMed: [Suitability of the alpha-naphthyl-butyrate-esterase reaction for the demonstration of monocytes in peripheral cell smears and cell concentrates]. PubMed: Esterase cytochemistry in primary myelodysplastic syndromes and megaloblastic anaemias: demonstration of abnormal staining patterns associated with dysmyelopoiesis. PubMed: Alpha-naphthyl butyrate esterase (a selective cytochemical monocyte marker). PubMed: Identification and distribution of immunocompetent cells in inflamed gingiva of human chronic periodontitis. PubMed: Evaluation of tissue preparation methods and paired immunofluorescence staining for immunocytochemistry of lymphomas. PubMed: A lymphoblastoid cell line with high phagocytic activity established from peripheral blood of a patient with chronic myelocytic leukemia in blast crisis. PubMed: Macrophages and infertility: oviductal macrophages as potential mediators of infertility. PubMed: Esterase staining in monocytes. PubMed: Lidocaine effects on immunocompetent cells. Implications for studies of cells obtained by bronchoalveolar lavage. PubMed: Characterization of mononuclear phagocytes from the mouse, guinea pig, rat, and man. PubMed: Enzymatic deficiency in monocytes from patients with chronic granulomatous disease. PubMed: Blastic transformation of a well-differentiated monocytic leukemia: changes in cytochemical and cell surface markers. PubMed: Cytochemical study in human lymphocyte subpopulations as defined by Fc receptors. PubMed: Differentiation of macrophages from Lewis lung carcinoma tumour cells in tissue sections by their alpha-naphthyl butyrate esterase activity. PubMed: An ultraviolet spectrophotometric assay for alpha-naphthyl acetate and alpha-naphthyl butyrate esterases. PubMed: Enzyme histochemistry and immunohistochemistry on biopsy specimens of pathologic human bone marrow. PubMed: Identification of alpha-naphthyl butyrate esterase as a plasma membrane ectoenzyme of monocytes and as a discrete intracellular membrane-bounded organelle in lymphocytes. PubMed: Monocyte alpha-naphtyl esterase deficiency in chronic granulomatous disease. PubMed: Chronic myelomonocytic leukemia in childhood. PubMed: Cytochemical reactions in resting and activated T-lymphocytes. PubMed: Enzyme histochemistry on bone marrow biopsies: reactions useful in the differential diagnosis of leukemia and lymphoma applied to 2-micron plastic sections. PubMed: Characterization of blast cells in acute nonlymphoid leukemias by consecutive cytochemical reactions.