12-hydroxystearic acid

octadecanoic acid, 12-hydroxy-

CAS: 106-14-9 C18 H36 O3 MW: 300.48252000

Identification

Name12-hydroxystearic acid
IUPAC12-hydroxyoctadecanoic acid
CAS Number106-14-9
EINECS203-366-1
FDA UNII933ANU3H2S
Molecular FormulaC18 H36 O3
Molecular Weight300.48252000
MDL NumberMFCD00004592
Nikkaji NumberJ48.641H
Beilstein1726730
XlogP36.50 (est)

Regulatory

DG SANTE Food Contact Materials12-hydroxystearic acid
FDA Mainterm (IAUFC)106-14-9 ; 12-HYDROXYSTEARIC ACID

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 82.00 °C. @ 760.00 mm Hg (est)
Boiling Point 436.28 °C. @ 760.00 mm Hg (est)
Vapor Pressure 1.940000 mmHg @ 25.00 °C. (est)
Flash Point 449.00 °F. TCC ( 231.80 °C. ) (est)
logP (o/w) 5.767 (est)
Soluble in water, 0.3315 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usescleansing agents

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic agents
Recommendation for 12-hydroxystearic acid usage levels up tonot for fragrance use.
Recommendation for 12-hydroxystearic acid flavor usage levels up tonot for flavor use.

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Potential Uses

emulsifying agents

Natural Occurrence

not found in nature

Synonyms

harwax A hydrofol acid 200 12- hydroxy stearic acid DL-12- hydroxy stearic acid 12- hydroxy-octadecanoic acid 12- hydroxyoctadecanoic acid hydroxystearic acid DL-12- hydroxystearic acid loxiol G 21 octadecanoic acid, 12-hydroxy- stearic acid, 12-hydroxy- PubMed: Allergic contact dermatitis from 12-hydroxystearic Acid and hydrogenated castor oil. PubMed: Synthesis of new sugar-based surfactants and evaluation of their hemolytic activities. PubMed: Long chain oxoaldehydes and oxoalcohols from esters as major constituents of the surface lipids of Manduca sexta pupae in diapause. PubMed: Occurrence of fatty acid chlorohydrins in jellyfish lipids. PubMed: Aqueous dispersions of organogel nanoparticles - potential systems for cosmetic and dermo-cosmetic applications. PubMed: Yielding and flow of solutions of thermoresponsive surfactant tubes: tuning macroscopic rheology by supramolecular assemblies. PubMed: Interaction between surfactants and colloidal latexes in nonpolar solvents studied using contrast-variation small-angle neutron scattering. PubMed: Poly(dimethylsiloxane)-stabilized polymer particles from radical dispersion polymerization in nonpolar solvent:influence of stabilizer properties and monomer type [corrected]. PubMed: Increased production of γ-lactones from hydroxy fatty acids by whole Waltomyces lipofer cells induced with oleic acid. PubMed: Cooling rate effects on the microstructure, solid content, and rheological properties of organogels of amides derived from stearic and (R)-12-hydroxystearic acid in vegetable oil. PubMed: Gelled oil particles: a new approach to encapsulate a hydrophobic metallophthalocyanine. PubMed: Phase-selective sorbent xerogels as reclamation agents for oil spills. PubMed: Lipid-based microtubes for topical delivery of amphotericin B. PubMed: Thermoreversible luminescent organogels doped with Eu(TTA)3phen complex. PubMed: Nanoincorporation of layered double hydroxides into a miscible blend system of cellulose acetate with poly(acryloyl morpholine). PubMed: Solvation effects with a photoresponsive two-component 12-hydroxystearic acid-azobenzene additive organogel. PubMed: CriticalSorb: a novel efficient nasal delivery system for human growth hormone based on Solutol HS15. PubMed: A structural study of an organogel investigated by small-angle neutron scattering and synchrotron small-angle X-ray scattering. PubMed: Allergic contact dermatitis caused by bis-diglycerylpolyacyladipate-2 (Softisan® 649) owing to its 12-hydroxystearic acid content. PubMed: Multiscale structural characterizations of fatty acid multilayered tubes with a temperature-tunable diameter. PubMed: Revisiting the synthesis of a well-known comb-graft copolymer stabilizer and its application to the dispersion polymerization of poly(methyl methacrylate) in organic media. PubMed: Pair interaction potentials of colloids by extrapolation of confocal microscopy measurements of collective suspension structure. PubMed: Structural relationships in 2,3-bis-n-decyloxyanthracene and 12-hydroxystearic acid molecular gels and aerogels processed in supercritical CO(2). PubMed: Preparation and evaluation of microporous organogel scaffolds for cell viability and proliferation. PubMed: Characterization of organogel as a novel oral controlled release formulation for lipophilic compounds. PubMed: Allergic contact dermatitis from 12-hydroxystearic Acid and hydrogenated castor oil. PubMed: 12-Hydroxystearic acid lipid tubes under various experimental conditions. PubMed: Rheological characterization of a new type of colloidal dispersion based on nanoparticles of gelled oil. PubMed: Solvent-modulated nucleation and crystallization kinetics of 12-hydroxystearic acid: a nonisothermal approach. PubMed: Nanoengineering of a biocompatible organogel by thermal processing. PubMed: Robust organogels from nitrogen-containing derivatives of (R)-12-hydroxystearic acid as gelators: comparisons with gels from stearic acid derivatives. PubMed: Low molecular mass organogelator based gel electrolyte with effective charge transport property for long-term stable quasi-solid-state dye-sensitized solar cells. PubMed: Detailed structural elucidation of polyesters and acrylates using Fourier transform mass spectrometry. PubMed: Electrostatic charging of nonpolar colloids by reverse micelles. PubMed: Synthesis of new sugar-based surfactants and evaluation of their hemolytic activities. PubMed: Preparation of monodisperse, fluorescent PMMA-latex colloids by dispersion polymerization. PubMed: Production of gamma-lactones by the brown-rot basidiomycete Piptoporus soloniensis. PubMed: Effect of fatty acids on the membrane potential of an alkaliphilic bacillus. PubMed: How hard is a colloidal "hard-sphere" interaction? PubMed: Ricinoleic acid-based biopolymers. PubMed: The phosphatidyl-myo-inositol anchor of the lipoarabinomannans from Mycobacterium bovis bacillus Calmette Guérin. Heterogeneity, structure, and role in the regulation of cytokine secretion. PubMed: Selective inhibition of cyclic AMP-dependent protein kinase by amphiphilic triterpenoids and related compounds. PubMed: Solutol HS 15, nontoxic polyoxyethylene esters of 12-hydroxystearic acid, reverses multidrug resistance. PubMed: Isolation of mast cells from rabbit lung and liver: comparison of histamine release induced by the hypnotics Althesin and propanidid. PubMed: Comparison of the histamine-releasing activity of cremophor E1 and some of its derivatives in two experimental models: the in vivo anaesthetized dog and in vitro rat peritoneal mast cells. PubMed: Long chain oxoaldehydes and oxoalcohols from esters as major constituents of the surface lipids of Manduca sexta pupae in diapause. PubMed: The active part of the [6]-gingerol molecule in mutagenesis. PubMed: Histamine release and hypotensive reactions in dogs by solubilizing agents and fatty acids: analysis of various components in cremophor El and development of a compound with reduced toxicity. PubMed: Occurrence of fatty acid chlorohydrins in jellyfish lipids.