2,4-xylidine
benzenamine, 2,4-dimethyl-
Identification
| Name | 2,4-xylidine |
| CAS Number | 95-68-1 |
| EINECS | 202-440-0 |
| FDA UNII | 367R1L22C9 |
| Molecular Formula | C8 H11 N |
| Molecular Weight | 121.18267000 |
| MDL Number | MFCD00007738 |
| Nikkaji Number | J358A |
| Beilstein | 0636243 |
| XlogP3 | 1.70 (est) |
Regulatory
Physical Properties
| Appearance | dark brown liquid (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 0.98000 @ 25.00 °C. |
| Melting Point | -14.30 °C. @ 760.00 mm Hg (est) |
| Boiling Point | 214.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 0.154000 mmHg @ 25.00 °C. (est) |
| Flash Point | 195.00 °F. TCC ( 90.56 °C. ) |
| logP (o/w) | 1.680 |
| Soluble in | water, 3652 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-mouse LD50 250 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | inhalation-mouse LC50 149 ppm/7H |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | pharmaceuticals / chemical synthisis |
| Recommendation for 2,4-xylidine usage levels up to | not for fragrance use. |
| Recommendation for 2,4-xylidine flavor usage levels up to | not for flavor use. |
Potential Uses
Natural Occurrence
Synonyms
4-
amino-1,3-dimethylbenzene
4-
amino-1,3-xylene
1-
amino-2,4-dimethylbenzene
aniline, 2,4-dimethyl-
benzenamine, 2,4-dimethyl-
2,4-
dimethyl aniline
2,4-
dimethyl-benzenamine
2,4-
dimethyl-phenylamine
2,4-
dimethylanilin
2,4-
dimethylaniline
2,4-
dimethylbenzenamine
2,4-
dimethylbenzene-1-amine
2,4-
dimethylbenzeneamine
2,4-
dimethylphenylamine
2-
methyl-p-toluidine
2-
methyl-para-toluidine
m-
xylidine
2,4-
xylylamine
PubMed:
Determination method for xylidines in workplace air.
PubMed:
Simultaneous determination of amitraz and its metabolite residue in food animal tissues by gas chromatography-electron capture detector and gas chromatography-mass spectrometry with accelerated solvent extraction.
PubMed:
Determination of amitraz and 2,4-dimethylaniline residues in honey by using LC with UV detection and MS/MS.
PubMed:
Separation and analysis of dimethylaniline isomers by supercritical fluid chromatography--electrospray ionization tandem mass spectrometry.
PubMed:
Determination of amitraz and its transformation products in pears by ethyl acetate extraction and liquid chromatography-tandem mass spectrometry.
PubMed:
Directed evolution of aniline dioxygenase for enhanced bioremediation of aromatic amines.
PubMed:
Anaerobic metabolism of 1-amino-2-naphthol-based azo dyes (Sudan dyes) by human intestinal microflora.
PubMed:
Probing the molecular determinants of aniline dioxygenase substrate specificity by saturation mutagenesis.
PubMed:
Identification of pesticide transformation products in food by liquid chromatography/time-of-flight mass spectrometry via "fragmentation-degradation" relationships.
PubMed:
Electrochemical monitoring of the biodegradation of 2,4-dimethylaniline.
PubMed:
Electrochemical investigation of the effect of pH and solvent on amitraz stability.
PubMed:
[Cosmetic colorants. Toxicology and regulation].
PubMed:
Oxidative degradation of 2,4-xylidine by photosensitization with 2,4,6-triphenylpyrylium: homogeneous and heterogeneous catalysis.
PubMed:
Liquid phase overtone spectral investigations of 2,6-dimethylaniline and 2,4-dimethylaniline-evidence for steric nature of the ortho effect and the consequent base weakening.
PubMed:
New insights into the mechanisms of the thermal Fenton reactions occurring using different iron(II)-complexes.
PubMed:
Ruthenium(II)-tris-bipyridine/titanium dioxide codoped zeolite Y photocatalysts: II. Photocatalyzed degradation of the model pollutant 2,4-xylidine, evidence for percolation behavior.
PubMed:
[FeII(bpy)3]2+/TiO2-codoped zeolites: synthesis, characterization, and first application in photocatalysis.
PubMed:
Teratogenic effects of amitraz, 2,4-dimethylaniline, and paraquat on developing frog (Xenopus) embryos.
PubMed:
An N,N'-dialkyl-4,4'-bipyridinium-modified titanium-dioxide photocatalyst for water remediation--observation and application of supramolecular effects in photocatalytic degradation of pi-donor organic compounds.
PubMed:
Optimal experimental design and artificial neural networks applied to the photochemically enhanced Fenton reaction.
PubMed:
Assessment of aniline derivatives-induced DNA damage in the liver cells of B6C3F1 mice using the alkaline single cell gel electrophoresis ('comet') assay.
PubMed:
Assessment of aniline derivatives-induced DNA damage in the liver cells of B6C3F1 mice using the alkaline single cell gel electrophoresis ("comet") assay.
PubMed:
An evaluation of the DNA damaging effect of selected aniline derivatives using the alkaline single cell gel electrophoresis ("comet") assay.
PubMed:
The genotoxicity of a variety of aniline derivatives in a DNA repair test with primary cultured rat hepatocytes.
PubMed:
[Various characteristics of the combined effects of chemical substances on the body after their inhalation and skin absorption].
PubMed:
Metabolic activation of 2,4-xylidine and its mutagenic metabolite.
PubMed:
Serum bile acid concentration in some experimental liver lesions of rat.
PubMed:
Testing of twenty-one environmental aromatic amines or derivatives for long-term toxicity or carcinogenicity.
PubMed:
2,4-xylidine (hydrochloride).
PubMed:
Personal air sampling for vapors of aniline compounds.
PubMed:
Proceedings: Early biochemical and morphological changes in the liver of mice after a single oral administration of 2,4-xylidine.