2-amino-4-picoline
ascensil
Identification
| Name | 2-amino-4-picoline |
| IUPAC | 4-methylpyridin-2-amine |
| CAS Number | 695-34-1 |
| EINECS | 211-780-9 |
| FDA UNII | 394N1Z644H |
| Molecular Formula | C6 H8 N2 |
| Molecular Weight | 108.14376000 |
| Nikkaji Number | J31.382C |
| Beilstein | 0107066 |
| XlogP3 | 0.60 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 3.668e+004 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for 2-amino-4-picoline usage levels up to | not for fragrance use. |
| Recommendation for 2-amino-4-picoline flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
2-
amino-4-methylpyridine
alpha-
amino-gamma-picoline
ascensil
4-
methyl pyridine amine
4-
methyl-2-aminopyridine
4-
methyl-2-pyridinamine
4-
methyl-2-pyridyl amine
methyl-4-amino-2-pyridine
4-
methylpyridin-2-amine
4-
picolyl amine
PubMed:
New carboxamide derivatives bearing benzenesulphonamide as a selective COX-II inhibitor: Design, synthesis and structure-activity relationship.
PubMed:
Sonochemical synthesis, characterization, and effects of temperature, power ultrasound and reaction time on the morphological properties of two new nanostructured mercury(II) coordination supramolecule compounds.
PubMed:
Influences of temperature, power ultrasound and reaction time on the morphological properties of two new mercury(II) coordination supramolecular compounds.
PubMed:
Tautomerization, molecular structure, transition state structure, and vibrational spectra of 2-aminopyridines: a combined computational and experimental study.
PubMed:
Spectrophotometric study on the proton transfer reaction between 2-amino-4-methylpyridine with 2,6-dichloro-4-nitrophenol in methanol, acetonitrile and the binary mixture 50% methanol+50% acetonitrile.
PubMed:
Room-temperature transition-metal-free one-pot synthesis of 3-aryl imidazo[1,2-a]pyridines via iodo-hemiaminal intermediate.
PubMed:
Oxidative regioselective amination of chromones exposes potent inhibitors of the hedgehog signaling pathway.
PubMed:
An Accessible Chiral Linker to Enhance Potency and Selectivity of Neuronal Nitric Oxide Synthase Inhibitors.
PubMed:
Synthesis, structural characterization and dielectric properties of (C6H9N2)2(Hg0.75Cd0.25)Cl4 compound.
PubMed:
¹H-MAS-NMR chemical shifts in hydrogen-bonded complexes of chlorophenols (pentachlorophenol, 2,4,6-trichlorophenol, 2,6-dichlorophenol, 3,5-dichlorophenol, and p-chlorophenol) and amine, and H/D isotope effects on ¹H-MAS-NMR spectra.
PubMed:
An amino-imino resonance study of 2-amino-4-methylpyridinium nitrate and 2-amino-5-methylpyridinium nitrate.
PubMed:
Molecular and crystal structures, vibrational studies and quantum chemical calculations of 3 and 5-nitroderivatives of 2-amino-4-methylpyridine.
PubMed:
Feasibility and dosimetry studies for 18F-NOS as a potential PET radiopharmaceutical for inducible nitric oxide synthase in humans.
PubMed:
Growth and characterization of 2-amino-4-picolinium toluene sulfonate single crystal.
PubMed:
Quantitative morphometry of respiratory tract epithelial cells as a tool for testing chemopreventive agent efficacy.
PubMed:
DNA binding ability and hydrogen peroxide induced nuclease activity of a novel Cu(II) complex with malonate as the primary ligand and protonated 2-amino-4-picoline as the counterion.
PubMed:
Supramolecular assembly of Mg(II) complexes directed by associative lone pair-pi/pi-pi/pi-anion-pi/pi-lone pair interactions.
PubMed:
Robust recognition of malonate and 2-amino-4-picolinium in conjunction with M(II) as a triad (M = Ni/Co/Mn): role of this highly stable hydrogen-bonded motif in driving supramolecular self-assembly.
PubMed:
Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fluoropropyl)-4-methyl-pyridin-2-amine as a potential PET tracer for inducible nitric oxide synthase.
PubMed:
Rhodium(I)-catalyzed one-pot synthesis of dialkyl ketones from methanol and alkenes through directed sp3 C-H bond activation of N-methylamine.
PubMed:
Decreased beta-adrenoceptor chronotropic response in selenium-deficient mice: negative crosstalk between iNOS activity and cAMP accumulation.
PubMed:
Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity.
PubMed:
The fixation of bis(2-pyridylimino)isoindolato (BPI) ligands to dendritic carbosilanes.
PubMed:
Inhibition of nitric oxide synthase aggravates cisplatin-induced nephrotoxicity: effect of 2-amino-4-methylpyridine.
PubMed:
Differential activity of NO synthase inhibitors as chemopreventive agents in a primary rat tracheal epithelial cell transformation system.
PubMed:
Synthesis of aliphatic ketones from allylic alcohols through consecutive isomerization and chelation-assisted hydroacylation by a rhodium catalyst.
PubMed:
The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes.
PubMed:
Effects of intravenous nitric oxide inhibitors on endotoxin-induced fever in prepubertal pigs.
PubMed:
Effects of 4-methyl-2-aminopyridine on [3H]-noradrenaline overflow and contractility of isolated rabbit arteries.
PubMed:
Analgesic activity of 2-amino-4-methylpyridine, a novel NO synthase inhibitor.
PubMed:
2-Amino-4-methylpyridine as a potent inhibitor of inducible NO synthase activity in vitro and in vivo.
PubMed:
[Study of the effect of analgeton on the release of beta-endorphin and its effect on chronic hyperalgesia].
PubMed:
[Baroreflex effects on systolic arterial pressure and the intersystolic period in a comparative study of aminton and phenylephrine].
PubMed:
Cholinergic effect of 4-aminopyridine and adrenergic effect of 4-methyl-2-aminopyridine in cardiac muscle.
PubMed:
Actions of 4-methyl-2-aminopyridine on neuromuscular transmission and contractility of skeletal muscle.
PubMed:
[Effect of aminton on noradrenaline and adrenaline depots in the rat heart].
PubMed:
On the mechanism of action of 2-amino-4-methylpyridine, a morphine-like analgesic.
PubMed:
[Effects of 4-methyl-2-aminopyridine on the heart and on circulation. Experimental research].
PubMed:
[Clinical trials with 4-methyl-2-aminopyridine camphorsulfonate in the shock from recent infarct].
PubMed:
[The action of 4-methyl-2-aminopyridine on the pressure of the greater and lesser circulations, on cerebral flow and on the coronary circulation].
PubMed:
[Toxicological and pharmacological characteristics of a new cardiocirculatory analeptic with prolonged action: 4-methyl-2-aminopyridine camphorsulfonate].
PubMed:
[Cardiocirculatory action of 4-methyl-2-aminopyridine camphorsulfonate].
PubMed:
Cardiac effects of 4-methyl-2-aminopyridine and some of its isomers.
PubMed:
[Circulatory effects of 2-amino-4-picoline].