2-chloroacetophenone

phenacylchloride

CAS: 532-27-4 C8 H7 Cl O MW: 154.59499000

Identification

Name2-chloroacetophenone
IUPAC2-chloro-1-phenylethanone
CAS Number532-27-4
EINECS208-531-1
FDA UNII88B5039IQG
Molecular FormulaC8 H7 Cl O
Molecular Weight154.59499000
MDL NumberMFCD00000933
Nikkaji NumberJ2.629H
Beilstein0507950
XlogP32.30 (est)

Regulatory

Physical Properties

Appearance white crystalline solid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.32400 @ 25.00 °C.
Melting Point 56.50 °C. @ 760.00 mm Hg
Boiling Point 247.00 °C. @ 760.00 mm Hg
Vapor Pressure 0.005400 mmHg @ 20.00 °C. (est)
Vapor Density 5.32 ( Air = 1 )
Flash Point 221.00 °F. TCC ( 104.80 °C. ) (est)
logP (o/w) 1.724 (est)
Soluble in alcohol
Insoluble in water

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintraperitoneal-guinea pig LD50 17 mg/kg
Dermal Toxicityskin-guinea pig LD50 > 1000 mg/kg
Inhalation Toxicityinhalation-guinea pig LCLo 490 mg/m3/30M

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryherbicides / pesticides
Recommendation for 2-chloroacetophenone usage levels up tonot for fragrance use.
Recommendation for 2-chloroacetophenone flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

agent CNB agent CNC CAF CaP (2- chloro-1-oxoethyl)benzene 2- chloro-1-phenyl-ethanone 2- chloro-1-phenylethan-1-one 2- chloro-1-phenylethanone 2- chloroacetonephenone chloromethyl phenyl ketone ethanone, 2-chloro-1-phenyl- phenacyl chloride phenacylchloride PubMed: Riot control agents: the tear gases CN, CS and OC--a medical review. PubMed: Synthesis, Characterization, and Bioactivity of Schiff Bases and Their Cd(2+), Zn(2+), Cu(2+), and Ni(2+) Complexes Derived from Chloroacetophenone Isomers with S-Benzyldithiocarbazate and the X-Ray Crystal Structure of S-Benzyl- β -N-(4-chlorophenyl)methylenedithiocarbazate. PubMed: Analysis of trace amount of bank dye and lachrymators from exploding bank devices by solid-phase microextraction and gas chromatography-mass spectrometry. PubMed: [Preparation of chiral alcohol by stereoselective reduction of acetophenone and chloroacetophenone with yeast cells]. PubMed: [Saccharomyces cerevisiae B5 efficiently and stereoselectively reduces 2'-chloroacetophenone to R-2'-chloro-1-phenylethanol in the presence of 5% ethanol]. PubMed: Diversity of contaminant reduction reactions by zerovalent iron: role of the reductate. PubMed: An evaluation of the relative potential public health concern for the self-defense spray active ingredients oleoresin capsicum, o-chlorobenzylidene malononitrile, and 2-chloroacetophenone. PubMed: Synthesis and hypnotic activities of 4-thio analogues of N3-substituted uridines. PubMed: Catalytic Meerwein-Pondorf-Verley reduction by simple aluminum complexes. PubMed: Regulated workplace ketones and their interference in the PFBHA method for aldehydes. PubMed: 2-Chloroacetophenone is an effective glutathione depletor in isolated rat hepatocytes. PubMed: NTP Toxicology and Carcinogenesis Studies of 2-Chloroacetophenone (CAS No. 532-27-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). PubMed: Examination of mouse exorbital lacrimal gland after exposure to 2-chloroacetophenone vapor. PubMed: [Contact dermatitis caused by 2-chloroacetophenone following tear gas exposure]. PubMed: Spectral differentiation and gas chromatographic/mass spectrometric analysis of the lacrimators 2-chloroacetophenone and o-chlorobenzylidene malononitrile. PubMed: Inhibition of aldehyde dehydrogenase by 2-chloroacetophenone and the resultant effects on the catabolism of norepinephrine in brain.