2-chloroacetophenone
phenacylchloride
Identification
| Name | 2-chloroacetophenone |
| IUPAC | 2-chloro-1-phenylethanone |
| CAS Number | 532-27-4 |
| EINECS | 208-531-1 |
| FDA UNII | 88B5039IQG |
| Molecular Formula | C8 H7 Cl O |
| Molecular Weight | 154.59499000 |
| MDL Number | MFCD00000933 |
| Nikkaji Number | J2.629H |
| Beilstein | 0507950 |
| XlogP3 | 2.30 (est) |
Regulatory
Physical Properties
| Appearance | white crystalline solid (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 1.32400 @ 25.00 °C. |
| Melting Point | 56.50 °C. @ 760.00 mm Hg |
| Boiling Point | 247.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 0.005400 mmHg @ 20.00 °C. (est) |
| Vapor Density | 5.32 ( Air = 1 ) |
| Flash Point | 221.00 °F. TCC ( 104.80 °C. ) (est) |
| logP (o/w) | 1.724 (est) |
| Soluble in | alcohol |
| Insoluble in | water |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intraperitoneal-guinea pig LD50 17 mg/kg |
| Dermal Toxicity | skin-guinea pig LD50 > 1000 mg/kg |
| Inhalation Toxicity | inhalation-guinea pig LCLo 490 mg/m3/30M |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | herbicides / pesticides |
| Recommendation for 2-chloroacetophenone usage levels up to | not for fragrance use. |
| Recommendation for 2-chloroacetophenone flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
agent CNB
agent CNC
CAF
CaP
(2-
chloro-1-oxoethyl)benzene
2-
chloro-1-phenyl-ethanone
2-
chloro-1-phenylethan-1-one
2-
chloro-1-phenylethanone
2-
chloroacetonephenone
chloromethyl phenyl ketone
ethanone, 2-chloro-1-phenyl-
phenacyl chloride
phenacylchloride
PubMed:
Riot control agents: the tear gases CN, CS and OC--a medical review.
PubMed:
Synthesis, Characterization, and Bioactivity of Schiff Bases and Their Cd(2+), Zn(2+), Cu(2+), and Ni(2+) Complexes Derived from Chloroacetophenone Isomers with S-Benzyldithiocarbazate and the X-Ray Crystal Structure of S-Benzyl- β -N-(4-chlorophenyl)methylenedithiocarbazate.
PubMed:
Analysis of trace amount of bank dye and lachrymators from exploding bank devices by solid-phase microextraction and gas chromatography-mass spectrometry.
PubMed:
[Preparation of chiral alcohol by stereoselective reduction of acetophenone and chloroacetophenone with yeast cells].
PubMed:
[Saccharomyces cerevisiae B5 efficiently and stereoselectively reduces 2'-chloroacetophenone to R-2'-chloro-1-phenylethanol in the presence of 5% ethanol].
PubMed:
Diversity of contaminant reduction reactions by zerovalent iron: role of the reductate.
PubMed:
An evaluation of the relative potential public health concern for the self-defense spray active ingredients oleoresin capsicum, o-chlorobenzylidene malononitrile, and 2-chloroacetophenone.
PubMed:
Synthesis and hypnotic activities of 4-thio analogues of N3-substituted uridines.
PubMed:
Catalytic Meerwein-Pondorf-Verley reduction by simple aluminum complexes.
PubMed:
Regulated workplace ketones and their interference in the PFBHA method for aldehydes.
PubMed:
2-Chloroacetophenone is an effective glutathione depletor in isolated rat hepatocytes.
PubMed:
NTP Toxicology and Carcinogenesis Studies of 2-Chloroacetophenone (CAS No. 532-27-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies).
PubMed:
Examination of mouse exorbital lacrimal gland after exposure to 2-chloroacetophenone vapor.
PubMed:
[Contact dermatitis caused by 2-chloroacetophenone following tear gas exposure].
PubMed:
Spectral differentiation and gas chromatographic/mass spectrometric analysis of the lacrimators 2-chloroacetophenone and o-chlorobenzylidene malononitrile.
PubMed:
Inhibition of aldehyde dehydrogenase by 2-chloroacetophenone and the resultant effects on the catabolism of norepinephrine in brain.