glycol salicylate
2-hydroxybenzoic acid, 2-hydroxyethyl ester
Identification
| Name | glycol salicylate |
| IUPAC | 2-hydroxyethyl 2-hydroxybenzoate |
| CAS Number | 87-28-5 |
| EINECS | 201-737-2 |
| FDA UNII | 3I1VBB7AXH |
| Molecular Formula | C9 H10 O4 |
| Molecular Weight | 182.17550000 |
| MDL Number | MFCD00002862 |
| Nikkaji Number | J55.649A |
| Beilstein | 2255685 |
| XlogP3 | 1.90 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 1.24400 @ 25.00 °C. |
| Melting Point | 37.00 °C. @ 760.00 mm Hg |
| Boiling Point | 294.00 to 295.00 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 0.001000 mmHg @ 25.00 °C. (est) |
| Flash Point | 263.00 °F. TCC ( 128.30 °C. ) (est) |
| logP (o/w) | 1.519 (est) |
| Soluble in | alcohol |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | uv absorbers |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic UV absorber |
| Recommendation for glycol salicylate usage levels up to | not for fragrance use. |
| Recommendation for glycol salicylate flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
benzoic acid, 2-hydroxy-, 2-hydroxyethyl ester
ethylene glycol monosalicylate
1,2-
ethylene glycol monosalicylate
ethylene glycol salicylate
glycol monosalicylate
mono
glycol salicylate
2-
hydroxybenzoic acid 2-hydroxyethyl ester
2-
hydroxybenzoic acid, 2-hydroxyethyl ester
2-
hydroxyethyl 2-hydroxybenzoate
2-
hydroxyethyl salicylate
rheumacyl
salicylic acid 2-hydroxyethyl ester
salicylic acid ethylene glycol ester
salicylic acid, 2-hydroxyethyl ester
sarocol
spirosal
traumasenex
PubMed:
Optimization and validation of liquid chromatography and headspace-gas chromatography based methods for the quantitative determination of capsaicinoids, salicylic acid, glycol monosalicylate, methyl salicylate, ethyl salicylate, camphor and l-menthol in a topical formulation.
PubMed:
Allergic contact dermatitis from a veterinary antiinflammatory gel containing 2-hydroxyethyl salicylate.
PubMed:
Contact dermatitis due to topical drugs.
PubMed:
Synergetic analgesic effect of the combination of arnica and hydroxyethyl salicylate in ethanolic solution following cutaneous application by transcutaneous electrostimulation.
PubMed:
Contact dermatitis from anti-inflammatory gel containing hydroxyethyl salicylate.
PubMed:
Topical penetration of commercial salicylate esters and salts using human isolated skin and clinical microdialysis studies.
PubMed:
Contact dermatitis from hydroxyethyl salicylate.
PubMed:
[Therapy of rheumatic disease with a hydroxyethylsalicylate gel. Results of 2 clinical studies of effectiveness and bioavailability].
PubMed:
Reduced vasoactive responses in port wine stains.
PubMed:
Thermodynamics of distribution of salicylates in semi-solid ointment bases.
PubMed:
[On interactions of drugs on and in the skin/comparative studies on the mutual influences of ethyleneglycol-monosalicylate and benzylnicotinate (author's transl)].
PubMed:
[Influence of the excipient on the absorption of glycol salicylate administered in ointments by cutaneous and rectal routes].