2-methoxypyridine

pyridine, 2-methoxy-

CAS: 1628-89-3 C6 H7 N O MW: 109.12799000 burnt

Identification

Name2-methoxypyridine
IUPAC2-methoxypyridine
CAS Number1628-89-3
EINECS216-623-8
FDA UNIIGEB38J8108
Molecular FormulaC6 H7 N O
Molecular Weight109.12799000
MDL NumberMFCD00006262
Nikkaji NumberJ7.535C
Beilstein0108189
XlogP31.40 (est)

Regulatory

JECFA Food Flavoring2156 2-methoxypyridine
FEMA Number4639
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)1628-89-3 ; 2-METHOXYPYRIDINE

Physical Properties

Appearance colorless to pale yellow clear liquid (est)
Assay 96.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.04400 to 1.05000 @ 20.00 °C.
Pounds per Gallon - (est). 8.697 to 8.747
Refractive Index 1.50100 to 1.50700 @ 20.00 °C.
Boiling Point 142.00 to 144.00 °C. @ 760.00 mm Hg
Vapor Pressure 7.114000 mmHg @ 25.00 °C. (est)
Flash Point 89.00 °F. TCC ( 31.67 °C. )
logP (o/w) 1.340
Soluble in alcohol
Insoluble in water

Organoleptic Properties

Odor Description at 0.10 % in propylene glycol.
Taste Description burnt, mustard-like

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavoring agents
Recommendation for 2-methoxypyridine usage levels up tonot for fragrance use.
baked goods-
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings0.20000
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea0.10000
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces0.20000

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

2- methoxy pyridine methyl 2-pyridyl ether pyridine, 2-methoxy- US Patents: 3,952,024 - Furfurylthioacetone PubMed: Highly linear selective cobalt-catalyzed addition of aryl imines to styrenes: reversing intrinsic regioselectivity by ligand elaboration. US Patents: Certain 2,5-dimethyl-3-thiopyrazines PubMed: Triflic anhydride mediated synthesis of imidazo[1,5-a]azines. PubMed: HIV-1 associated Topoisomerase IIβ kinase: a potential pharmacological target for viral replication. PubMed: Development of new carbon-11 labelled radiotracers for imaging GABAA- and GABAB-benzodiazepine receptors. PubMed: Preparation of THP-ester-derived pyridinium-type salts and their reactions with various nucleophiles. PubMed: Deprotonative metalation of aromatic compounds by using an amino-based lithium cuprate. PubMed: Characterization of two hydroxytrichloropicolinic acids: application of the one-bond chlorine-isotope effect in 13C NMR. PubMed: In search of conformationally chiral square-planar complexes: dichloridobis(2-methoxypyridine-kappaN)copper(II). PubMed: Electron-transfer oxidation of coenzyme B12 model compounds and facile cleavage of the cobalt(IV)-carbon bond via charge-transfer complexes with bases. A negative temperature dependence of the rates. PubMed: Influence of two insecticides, chlorpyrifos and quinalphos, on arginine ammonification and mineralizable nitrogen in two tropical soil types. PubMed: Dissipation of chlorpyrifos in two soil environments of semi-arid India. PubMed: Lithiation of 2-chloro- and 2-methoxypyridine with lithium dialkylamides: initial ortho-direction or subsequent lithium ortho-stabilization? PubMed: Acid-base equilibria in nonpolar media. 2.(1) Self-consistent basicity scale in THF solution ranging from 2-methoxypyridine to EtP(1)(pyrr) phosphazene. PubMed: Lithiation of 2-heterosubstituted pyridines with BuLi-LiDMAE: evidence for regiospecificity at C-6. PubMed: A pyridone analogue of traditional cannabinoids. A new class of selective ligands for the CB(2) receptor. PubMed: Ethyl 6-amino-2-methoxypyridine-3-carboxylate, interplay of molecular and supramolecular structure. PubMed: Studies of the synthesis and thermochemistry of coordinatively unsaturated chelate complexes (eta 5-C5Me5)IrL2 (L2 = TsNCH2CH2NTs, TsNCH2CO2, CO2CO2). PubMed: An efficient synthesis of 5-bromo-2-methoxy-6-methylaminopyridine-3carboxylic acid. PubMed: cis-Dichloro(dimethyl sulfoxide-S)(2-methoxypyridine-N)platinum(II). PubMed: Synthesis and antiinflammatory activity of 6-oxo-1-(beta-D-ribofuranosyl)nocotinic acid and related derivatives.