2-methyl-3-butyn-2-ol

3-butyn-2-ol, 2-methyl-

CAS: 115-19-5 C5 H8 O MW: 84.11796000

Identification

Name2-methyl-3-butyn-2-ol
IUPAC2-methylbut-3-yn-2-ol
CAS Number115-19-5
EINECS204-070-5
FDA UNIIEHB904XHKH
Molecular FormulaC5 H8 O
Molecular Weight84.11796000
MDL NumberMFCD00004467
Nikkaji NumberJ38.146B
Beilstein0635746
XlogP30.30 (est)

Regulatory

Physical Properties

Appearance colorless to pale yellow clear liquid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 0.86100 to 0.86400 @ 20.00 °C.
Pounds per Gallon - (est). 7.173 to 7.198
Refractive Index 1.42000 to 1.42300 @ 20.00 °C.
Melting Point 2.00 to 4.00 °C. @ 760.00 mm Hg
Boiling Point 102.00 to 105.00 °C. @ 760.00 mm Hg
Vapor Pressure 17.184000 mmHg @ 25.00 °C. (est)
Flash Point 77.00 °F. TCC ( 25.00 °C. )
logP (o/w) 0.280
Soluble in alcohol

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-rat LD50 1950 mg/kg
Dermal Toxicitysubcutaneous-mouse LD50 1161 mg/kg
Inhalation Toxicityinhalation-mouse LC50 2000 mg/m3

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryinformation only not used for fragrances or flavors
Recommendation for 2-methyl-3-butyn-2-ol usage levels up tonot for fragrance use.
Recommendation for 2-methyl-3-butyn-2-ol flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

but-3-yn-2-ol, 2-methyl- 3- butyn-2-ol, 2-methyl- dimethyl acetylenyl carbinol dimethyl ethynyl carbinol 1,1- dimethyl propargyl alcohol dimethylacetylenylcarbinol dimethylethynylcarbinol 1,1- dimethylpropargyl alcohol 2,2- dimethylpropargyl alcohol 2- hydroxy-2-methyl-3-butyne 3- methyl butynol 3- methyl-1-butyn-3-ol 2- methyl-2-butynol 3- methyl-3-hydroxy-1-butyne 2- methyl-but-3-yn-2-ol 2- methylbut-3-yn-2-ol 3- methylbutynol PubMed: Novel synthesis of thick wall coatings of titania supported Bi poisoned Pd catalysts and application in selective hydrogenation of acetylene alcohols in capillary microreactors. PubMed: Fabrication of magnetically recoverable catalysts based on mixtures of Pd and iron oxide nanoparticles for hydrogenation of alkyne alcohols. PubMed: Reactivity of Cl atom with triple-bonded molecules. An experimental and theoretical study with alcohols. PubMed: Practical synthesis of aryl-2-methyl-3-butyn-2-ols from aryl bromides via conventional and decarboxylative copper-free Sonogashira coupling reactions. PubMed: Influence of natural adsorbates of magnesium oxide on its reactivity in basic catalysis. PubMed: An easily removable stereo-dictating group for enantioselective synthesis of propargylic amines. PubMed: Detection of estrus in Indian blackbuck: behavioural, hormonal and urinary volatiles evaluation. PubMed: 4,4'-(4,5-dimethyl-1,2-phenylene)bis(2-methylbut-3-yn-2-ol): structural variation in vicinal dialkynols. PubMed: A computational study on the role of chiral N-oxides in enantioselective Pauson-Khand reactions. PubMed: Structure sensitivity of alkynol hydrogenation on shape- and size-controlled palladium nanocrystals: which sites are most active and selective? PubMed: A rapid and efficient synthetic route to terminal arylacetylenes by tetrabutylammonium hydroxide- and methanol-catalyzed cleavage of 4-aryl-2-methyl-3-butyn-2-ols. PubMed: Synthesis of a novel restricted access chiral stationary phase based on atom transfer radical polymerization and click chemistry for the analysis of chiral drugs in biological matrices. PubMed: Basic reactivity of CaO: investigating active sites under operating conditions. PubMed: Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. PubMed: Ligand accelerated indium(III)-catalyzed asymmetric alkynylation of aldehydes with 2-methyl-3-butyn-2-ol as an ethyne equivalent donor. PubMed: Synthesis and cytotoxic activity of benzo[a]pyrano[3,2-h] and [2,3-i]xanthone analogues of psorospermine, acronycine, and benzo[a]acronycine. PubMed: Hydride-alkenylcarbyne to alkenylcarbene transformation in bisphosphine-osmium complexes. PubMed: Tandem Sonogashira coupling: an efficient tool for the synthesis of diarylalkynes. PubMed: Regioselective synthesis of 6-alkyl- and 6-prenylpolyhydroxyisoflavones and 6-alkylcoumaronochromone derivatives. PubMed: One step Pd(0)-catalyzed synthesis, X-ray analysis, and photophysical properties of cyclopent[hi]aceanthrylene: fullerene-like properties in a nonalternant cyclopentafused aromatic hydrocarbon. PubMed: Synthesis and cytotoxic activity of benzopyranoxanthone analogues of benz. PubMed: Enantioselective addition of 2-methyl-3-butyn-2-ol to aldehydes: preparation of 3-hydroxy-1-butynes PubMed: Methylbutynol effectively replaces methylbutenol, a pheromone component ofIps typographus (L.) (Coleoptera: Scolytidae). PubMed: 2-Methyl-3-butyn-2-ol as an acetylene precursor in the Mannich reaction. A new synthesis of suicide inactivators of monoamine oxidase.