2-methyl-3-butyn-2-ol
3-butyn-2-ol, 2-methyl-
Identification
| Name | 2-methyl-3-butyn-2-ol |
| IUPAC | 2-methylbut-3-yn-2-ol |
| CAS Number | 115-19-5 |
| EINECS | 204-070-5 |
| FDA UNII | EHB904XHKH |
| Molecular Formula | C5 H8 O |
| Molecular Weight | 84.11796000 |
| MDL Number | MFCD00004467 |
| Nikkaji Number | J38.146B |
| Beilstein | 0635746 |
| XlogP3 | 0.30 (est) |
Regulatory
Physical Properties
| Appearance | colorless to pale yellow clear liquid (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 0.86100 to 0.86400 @ 20.00 °C. |
| Pounds per Gallon - (est). | 7.173 to 7.198 |
| Refractive Index | 1.42000 to 1.42300 @ 20.00 °C. |
| Melting Point | 2.00 to 4.00 °C. @ 760.00 mm Hg |
| Boiling Point | 102.00 to 105.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 17.184000 mmHg @ 25.00 °C. (est) |
| Flash Point | 77.00 °F. TCC ( 25.00 °C. ) |
| logP (o/w) | 0.280 |
| Soluble in | alcohol |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-rat LD50 1950 mg/kg |
| Dermal Toxicity | subcutaneous-mouse LD50 1161 mg/kg |
| Inhalation Toxicity | inhalation-mouse LC50 2000 mg/m3 |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | information only not used for fragrances or flavors |
| Recommendation for 2-methyl-3-butyn-2-ol usage levels up to | not for fragrance use. |
| Recommendation for 2-methyl-3-butyn-2-ol flavor usage levels up to | not for flavor use. |
Potential Uses
Natural Occurrence
Synonyms
but-3-yn-2-ol, 2-methyl-
3-
butyn-2-ol, 2-methyl-
dimethyl acetylenyl carbinol
dimethyl ethynyl carbinol
1,1-
dimethyl propargyl alcohol
dimethylacetylenylcarbinol
dimethylethynylcarbinol
1,1-
dimethylpropargyl alcohol
2,2-
dimethylpropargyl alcohol
2-
hydroxy-2-methyl-3-butyne
3-
methyl butynol
3-
methyl-1-butyn-3-ol
2-
methyl-2-butynol
3-
methyl-3-hydroxy-1-butyne
2-
methyl-but-3-yn-2-ol
2-
methylbut-3-yn-2-ol
3-
methylbutynol
PubMed:
Novel synthesis of thick wall coatings of titania supported Bi poisoned Pd catalysts and application in selective hydrogenation of acetylene alcohols in capillary microreactors.
PubMed:
Fabrication of magnetically recoverable catalysts based on mixtures of Pd and iron oxide nanoparticles for hydrogenation of alkyne alcohols.
PubMed:
Reactivity of Cl atom with triple-bonded molecules. An experimental and theoretical study with alcohols.
PubMed:
Practical synthesis of aryl-2-methyl-3-butyn-2-ols from aryl bromides via conventional and decarboxylative copper-free Sonogashira coupling reactions.
PubMed:
Influence of natural adsorbates of magnesium oxide on its reactivity in basic catalysis.
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An easily removable stereo-dictating group for enantioselective synthesis of propargylic amines.
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Detection of estrus in Indian blackbuck: behavioural, hormonal and urinary volatiles evaluation.
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4,4'-(4,5-dimethyl-1,2-phenylene)bis(2-methylbut-3-yn-2-ol): structural variation in vicinal dialkynols.
PubMed:
A computational study on the role of chiral N-oxides in enantioselective Pauson-Khand reactions.
PubMed:
Structure sensitivity of alkynol hydrogenation on shape- and size-controlled palladium nanocrystals: which sites are most active and selective?
PubMed:
A rapid and efficient synthetic route to terminal arylacetylenes by tetrabutylammonium hydroxide- and methanol-catalyzed cleavage of 4-aryl-2-methyl-3-butyn-2-ols.
PubMed:
Synthesis of a novel restricted access chiral stationary phase based on atom transfer radical polymerization and click chemistry for the analysis of chiral drugs in biological matrices.
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Basic reactivity of CaO: investigating active sites under operating conditions.
PubMed:
Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.
PubMed:
Ligand accelerated indium(III)-catalyzed asymmetric alkynylation of aldehydes with 2-methyl-3-butyn-2-ol as an ethyne equivalent donor.
PubMed:
Synthesis and cytotoxic activity of benzo[a]pyrano[3,2-h] and [2,3-i]xanthone analogues of psorospermine, acronycine, and benzo[a]acronycine.
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Hydride-alkenylcarbyne to alkenylcarbene transformation in bisphosphine-osmium complexes.
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Tandem Sonogashira coupling: an efficient tool for the synthesis of diarylalkynes.
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Regioselective synthesis of 6-alkyl- and 6-prenylpolyhydroxyisoflavones and 6-alkylcoumaronochromone derivatives.
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One step Pd(0)-catalyzed synthesis, X-ray analysis, and photophysical properties of cyclopent[hi]aceanthrylene: fullerene-like properties in a nonalternant cyclopentafused aromatic hydrocarbon.
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Synthesis and cytotoxic activity of benzopyranoxanthone analogues of benz.
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Enantioselective addition of 2-methyl-3-butyn-2-ol to aldehydes: preparation of 3-hydroxy-1-butynes
PubMed:
Methylbutynol effectively replaces methylbutenol, a pheromone component ofIps typographus (L.) (Coleoptera: Scolytidae).
PubMed:
2-Methyl-3-butyn-2-ol as an acetylene precursor in the Mannich reaction. A new synthesis of suicide inactivators of monoamine oxidase.