2-methyl indole

indole, 2-methyl- 2- methyl-1H-indole 2- methylindole PubMed: 2-Methylindole as an indicative nucleophile for developing a three-component reaction of aldehyde with two different nucleophiles. PubMed: Functionalization of benzylic C(sp(3))-H bonds of heteroaryl aldehydes through N-heterocyclic carbene organocatalysis. PubMed: Rh(III)-catalyzed tandem C-H allylation and oxidative cyclization of anilides: a new entry to indoles. PubMed: Biochemical and pharmacological characterization of AZD1981, an orally available selective DP2 antagonist in clinical development for asthma. PubMed: An efficient one pot syntheses of aryl-3,3'-bis(indolyl)methanes and studies on their spectral characteristics, DPPH radical scavenging-, antimicrobial-, cytotoxicity-, and antituberculosis activity. PubMed: 3-(1,2-Di-p-tolyl-vin-yl)-2-methyl-1H-indole. PubMed: 1-(4-Meth-oxy-phen-yl)-2-methyl-1H-indole-3-carbonitrile. PubMed: 1-(4-Bromo-phen-yl)-2-methyl-1H-indole-3-carbonitrile. PubMed: Synthesis under microwave irradiation of [1,2,4]triazolo[3,4-b] [1,3,4]thiadiazoles and other diazoles bearing indole moieties and their antimicrobial evaluation. PubMed: 1-(2-Chloro-phenyl)-6-fluoro-2-methyl-1H-indole-3-carbonitrile. PubMed: Discovery of selective indole-based prostaglandin D₂ receptor antagonist. PubMed: Real-time reaction monitoring using ion mobility-mass spectrometry. PubMed: Synthetic studies on indolocarbazoles: total synthesis of staurosporine aglycon. PubMed: Free radical-scavenging activity and DNA damaging potential of auxins IAA and 2-methyl-IAA evaluated in human neutrophils by the alkaline comet assay. PubMed: A platform of high-density INDEL/CAPS markers for map-based cloning in Arabidopsis. PubMed: Bioactivation of a novel 2-methylindole-containing dual chemoattractant receptor-homologous molecule expressed on T-helper type-2 cells/D-prostanoid receptor antagonist leads to mechanism-based CYP3A inactivation: glutathione adduct characterization and prediction of in vivo drug-drug interaction. PubMed: tert-Butyl 3-(8-bromo-4H,10H-1,2-oxazolo[4,3-c][1]benzoxepin-10-yl)-2-methyl-1H-indole-1-carboxyl-ate. PubMed: The relevance of the collaborative effect in determining the performances of photorefractive polymer materials. PubMed: Azolyacetones as precursors to indoles and naphthofurans facilitated by microwave irradiation with simultaneous cooling. PubMed: Carbon nucleophilicities of indoles in S(N)Ar substitutions of superelectrophilic 7-chloro-4,6-dinitrobenzofuroxan and -benzofurazan. PubMed: tert-Butyl 3-[2,2-bis-(ethoxy-carbon-yl)-vinyl]-2-methyl-1H-indole-1-carboxyl-ate. PubMed: Unconditionally stable indole-derived glass blends having very high photorefractive gain: the role of intermolecular interactions. PubMed: Novel multicomponent reactions involving isoquinoline or phenanthridine and activated acetylenic ester in the presence of heterocyclic NH or 1,3-dicarbonyl compounds. PubMed: Chemically induced dimerization of human nonpancreatic secretory phospholipase A2 by bis-indole derivatives. PubMed: Synthesis and pharmacological evaluation of peptide-mimetic protease-activated receptor-1 antagonists containing novel heterocyclic scaffolds. PubMed: Development and validation of a method for simultaneous analysis of the boar taint compounds indole, skatole and androstenone in pig fat using liquid chromatography-multiple mass spectrometry. PubMed: Isolation and identification of a major impurity in a new bulk drug candidate by preparative LC, ESI-MS(n), LC-MS-MS, and NMR. PubMed: Indole ring oxidation by activated leukocytes prevents the production of hypochlorous acid. PubMed: Effect of indole-3-acetic acid derivatives on neuroepithelium in rat embryos. PubMed: Development of a prostaglandin D2 receptor antagonist: discovery of a new chemical lead. PubMed: Identification of indole derivatives exclusively interfering with a G protein-independent signaling pathway of the prostaglandin D2 receptor CRTH2. PubMed: Identification of natural dyes used in works of art by pyrolysis-gas chromatography/mass spectrometry combined with in situ trimethylsilylation. PubMed: 2- and 3-[(aryl)(azolyl)methyl]indoles as potential non-steroidal aromatase inhibitors. PubMed: The reaction of indole with the aminoacrylate intermediate of Salmonella typhimurium tryptophan synthase: observation of a primary kinetic isotope effect with 3-[(2)H]indole. PubMed: Discovery of a new class of potent, selective, and orally active prostaglandin D2 receptor antagonists. PubMed: Development of prostaglandin D2 receptor antagonist: discovery of highly potent antagonists. PubMed: Discovery of new chemical leads for prostaglandin D2 receptor antagonists. PubMed: Discovery of orally active prostaglandin D2 receptor antagonists. PubMed: Adsorption of indole and 2-methylindole on ligand-exchange matrix. PubMed: Primary electron-transfer dynamics in 2-phenylindole-9-cyanoanthracene system. A comparative study with 2-methylindole. PubMed: Endothelium-dependent noradrenergic hyperresponsiveness induced by thapsigargin in human saphenous veins: role of thromboxane and calcium. PubMed: XAFS studies of anti-inflammatory dinuclear and mononuclear Zn(II) complexes of indomethacin. PubMed: Novel reversible indole-3-carboxylate decarboxylase catalyzing nonoxidative decarboxylation. PubMed: Isolation and characterization of anaerobic indole- and skatole-degrading bacteria from composting animal wastes. PubMed: Relationship between structures of substituted indolic compounds and their degradation by marine anaerobic microorganisms. PubMed: Fructooligosaccharides and Lactobacillus acidophilus modify bowel function and protein catabolites excreted by healthy humans. PubMed: Nature of non-radiative processes involved in the excited state of 9-cyanoanthracene in presence of 2-methylindole/2-methylindoline quenchers. A laser flash photolysis study to reveal the medium effects. PubMed: Unsymmetrical methylene derivatives of indoles as antiproliferative agents. PubMed: Anti-Inflammatory Dinuclear Copper(II) Complexes with Indomethacin. Synthesis, Magnetism and EPR Spectroscopy. Crystal Structure of the N,N-Dimethylformamide Adduct. PubMed: The oxidation of indole derivatives catalyzed by horseradish peroxidase is highly chemiluminescent. PubMed: Determination of the structures of antiinflammatory copper(II) dimers of indomethacin by multiple-scattering analyses of X-ray absorption fine structure data. PubMed: Syntheses and characterization of anti-inflammatory dinuclear and mononuclear zinc indomethacin complexes. Crystal structures of [Zn2(indomethacin)4(L)2] (L = N,N-dimethylacetamide, pyridine, 1-methyl-2-pyrrolidinone) and [Zn(indomethacin)2(L1)2] (L1 = ethanol, methanol). PubMed: Nitric oxide accelerates the ascorbic acid-induced osteoblastic differentiation of mouse stromal ST2 cells by stimulating the production of prostaglandin E(2). PubMed: Identification of binding sites of bopindolol and its two metabolites with beta1-adrenoceptors by molecular modeling: comparison with beta2 adrenoceptors. PubMed: Induction of apoptotic DNA fragmentation by nonsteroidal anti-inflammatory drugs in cultured rat gastric mucosal cells. PubMed: Anti-inflammatory drugs interacting with Zn(II), Cd(II) and Pt(II) metal ions. PubMed: Endothelium-mediated and N omega-nitro-L-arginine methyl ester-sensitive responses to cromakalim and diazoxide in the rat mesenteric bed. PubMed: Bopindolol is a slowly dissociating beta 1-adrenoceptor antagonist when compared to other beta-blockers. PubMed: 2-Methyl-L-tryptophan is a substrate of tryptophanase. PubMed: Bromoacetamido analogs of indomethacin and mefenamic acid as affinity-labeling agents and mechanistic probes for prostaglandin H2 synthase. PubMed: Solid-phase synthesis of cionin, a protochordate-derived octapeptide related to the gastrin/cholecystokinin family of peptides, and its mono-tyrosine-sulfate-containing derivatives. PubMed: Spectroscopic studies of cutaneous photosensitizing agents. XVIII. Indomethacin. PubMed: Evaluation of the final deprotection system for the solid-phase synthesis of Tyr(SO3H)-containing peptides with 9-fluorenylmethyloxycarbonyl (Fmoc)-strategy and its application to the synthesis of cholecystokinin (CCK)-12. PubMed: Development of affinity labeling agents based on nonsteroidal anti-inflammatory drugs: labeling of the nonsteroidal anti-inflammatory drug binding site of 3 alpha-hydroxysteroid dehydrogenase. PubMed: Degradation of substituted indoles by an indole-degrading methanogenic consortium. PubMed: Beta-blocking potency and selectivity of bopindolol and its two metabolites for beta 1- and beta 2-adrenergic receptors as assessed by radioligand binding assay. PubMed: Design, synthesis and antiinflammatory activity of a new indomethacin ester. 2-[N-[3-(3-(piperidinomethyl)phenoxy)propyl]carbamoylmethylthio]ethyl 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-indole-3-acetate. PubMed: Studies on antibacterial agents. II. Synthesis and antibacterial activities of substituted 1,2-dihydro-6-oxo-6H-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acids. PubMed: Effects of Bay o 2752, a hypocholesterolemic agent, on intestinal taurocholate absorption and cholesterol esterification. PubMed: Activity of melatonin and other pineal indoles on the in vitro synthesis of cortisol, cortisone, and adrenal androgens. PubMed: Influence of N,N'-(1,11-undecandiyl) bis (2,3-dihydro-2-methyl-1H-indole-1-carboxamide) (BAY 02752) on gallstone formation and regression in hamsters. PubMed: Inhibition of thromboxane formation in vivo and ex vivo: implications for therapy with platelet inhibitory drugs. PubMed: Mutagenicities of indole and 30 derivatives after nitrite treatment. PubMed: Synthesis of some indole derivatives with potential antiinflammatory activity. PubMed: Inhibition of thromboxane synthetase by the imidazole derivative 3-(1H-imidazol-1-yl-methyl)-2-methyl-1H-indole-1-propanoic acid as a novel therapeutic approach to experimental myocardial ischemia. PubMed: [Retard effect of acemetacin from a commercial preparation--kinetics in humans following single and multiple administration]. PubMed: Pharmacological profiles of 2-carboxyphenyl-1-(4-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetate and 2-[(2-carboxyphenoxy)-carbonyl]phenyl-1-(4-chlorobenzoyl)-5-meth oxy-2- methylindole-3-acetate, new antiinflammatory agents. PubMed: Selective thromboxane synthetase inhibitors. 2. 3-(1H-imidazol-1-ylmethyl)-2-methyl-1H-indole-1-propanoic acid and analogues. PubMed: Nitrosatable precursors of mutagens in vegetables and soy sauce. PubMed: Effect of inhibitors of the lipoxygenase pathway on mouse myoblast fusion. PubMed: Effect of TEI-4120 (3-benzoyl-N-beta-ethoxyisopropyl-2-methlindole) on carrageenan induced disseminated intravascular coagulation (DIC) in rats. PubMed: New synthetic inhibitors of chymotrypsin. PubMed: Indomethacin inhibition of glutathione S-transferases. PubMed: [2-Methylindoles substituted in the 1st, 3d and 5th positions and the diffuse neuroendocrine APUD system]. PubMed: Modification of the AOAC gas-liquid chromatographic method for indole in shrimp: collaborative study. PubMed: Determination of thiabendazole and 5-hydroxythiabendazole in human serum by fluorescence-detected high-performance liquid chromatography. PubMed: Free-radical damage to lipids, amino acids, carbohydrates and nucleic acids determined by thiobarbituric acid reactivity. PubMed: High-pressure liquid chromatographic determination of ibuprofen in plasma. PubMed: Clinical Pharmacokinetics of indomethacin. PubMed: Ultraviolet detection procedure for liquid chromatographic determination of indole in shrimp. PubMed: High pressure liquid chromatographic method for indole in shrimp: development of method and collaborative study. PubMed: Oxygenation of indoles by a copper(I) chloride pyridine complex. A new tryptophan 2,3-dioxygenase model system. PubMed: Structure of Cu2(indomethacin)4 and the reaction with superoxide in aprotic systems. PubMed: Glycerides as prodrugs. 3. Synthesis and antiinflammatory activity of [1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetyl]glycerides (indomethacin glycerides). PubMed: Binding sites for melatonin in bovine pineal gland. PubMed: [Therapy of acute attacks of gout using acemetacin (author's transl)]. PubMed: [Controlled double blind study on the effectiveness and adverse effects of acemetacin and indomethacin in the treatment of psoriatic arthritis]. PubMed: [Controlled, double blind study of a possible interaction between acemetacin and a concomitant anticoagulant therapy]. PubMed: [Influence of acemetacin on DNA repair and DNA synthesis in vitro and in vivo (author's transl)]. PubMed: [Toxicology of acemetacin]. PubMed: [Metabolism and pharmacokinetics of acemetacin in man (author's transl)]. PubMed: [Comparative metabolic studies on [14C]-labelled acemetacin and indometacin in rats (author's transl)]. PubMed: [Anti-inflammatory action of acemetacin (author's transl)]. PubMed: [Chemical structure and anti-inflammatory activity in the group of substituted indole-3-acetic acids (author's transl)]. PubMed: [On the pharmacodynamics of acemetacin (author's transl)]. PubMed: [Analytical methods and in vitro studies with acemetacin]. PubMed: Peroxide oxidation of indole to oxindole by chloroperoxidase catalysis. PubMed: Preparation, gas chromatography and mass spectrometry of methyl and trimethylsilyl esters of indomethacin. PubMed: Studies on the metabolism of 5-hydroxytryptamine (serotonin). VII. Effects of haloindoles on cerebral 5-HT in various species. PubMed: Pharmacokinetics of a new beta-adrenoceptor blocking agent, LF 17-895, in man. PubMed: [Influence of indole-3-alkanecarboxylic acids on glucose utilization in rats]. PubMed: The therapeutic activity of 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid monohydrate glucosamide in rheumatoid arthritis (double blind trial). PubMed: Substituted anilides of 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-indole-3-acetic acid. PubMed: Crystal and molecular structure of an antiinflammatory agent, indomethacin, 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid. PubMed: Physiologic disposition and metabolic fate of indomethacin analogs. II. 1-(p-chlorobenzoyl)-5-dimethylamino-2-methylindole-3-acetic acid. PubMed: Isomeric Mannich bases derived from ethyl 5-hydroxy-2-methylindole-3-carboxylate. PubMed: [On the pharmacology of 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole acetic acid, a new antiphlogistic agent]. PubMed: ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITIES OF INDOMETHACIN, 1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID. PubMed: Effects on amine oxidase of substances which antagonize 5-hydroxytryptamine more than tryptamine on the rat fundus strip. PubMed: Actions of some analogues of tryptamine on the isolated rat uterus and on the isolated rat fundus strip preparations.