2-nitro-p-phenylenediamine
1,4-benzenediamine, 2-nitro-
Identification
| Name | 2-nitro-p-phenylenediamine |
| CAS Number | 5307-14-2 |
| EINECS | 226-164-5 |
| FDA UNII | PV83F3C01Q |
| Molecular Formula | C6 H7 N3 O2 |
| Molecular Weight | 153.14119000 |
| MDL Number | MFCD00007903 |
| Nikkaji Number | J3.720F |
| Beilstein | 2210195 |
| XlogP3 | 0.50 (est) |
Regulatory
Physical Properties
| Appearance | almost black needles (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 137.00 °C. @ 760.00 mm Hg |
| Boiling Point | 385.40 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 5.600000 mmHg @ 25.00 °C. (est) |
| Flash Point | 368.00 °F. TCC ( 186.90 °C. ) (est) |
| logP (o/w) | 0.530 |
| Soluble in | water, 2.592e+004 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | hair dyeing agents |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intraperitoneal-mouse LD50 214 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | hair dyeing agents |
| Recommendation for 2-nitro-p-phenylenediamine usage levels up to | not for fragrance use. |
| Recommendation for 2-nitro-p-phenylenediamine flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
1,4-
benzenediamine, 2-nitro-
c.i. 76070
C.I. oxidation base 22
ci 76070
1,4-
diamino-2-nitrobenzene
du rafur brown
durafur brown
durafur brown 2R
fouramine 2R
fourrine 36
fourrine brown 2R
glycidyl-4-nitrophenyl ether
2-
nitro-1,4-benzenediamine
2-
nitro-1,4-diaminobenzene
2-
nitro-1,4-phenylene diamine
2-
nitro-1,4-phenylenediamine
2-
nitro-4-aminoaniline
2-
nitro-4-phenylenediamine
2-
nitro-p-phenylendiamine
2-
nitro-para-phenylendiamine
2-
nitro-para-phenylene diamine
2-
nitro-para-phenylenediamine
2-
nitrobenzene-1,4-diamine
2-
nitrol-p-phenylenediamine
2-
nitrol-para-phenylenediamine
p-
phenylenediamine, 2-nitro-
ursol brown RR
zoba brown RR
PubMed:
Single strand dna breaks in human lymphocytes exposed to para-phenylenediamine and its derivatives.
PubMed:
Differences in gene expression profiles in the liver between carcinogenic and non-carcinogenic isomers of compounds given to rats in a 28-day repeat-dose toxicity study.
PubMed:
Percutaneous penetration and metabolism of 2-nitro-p-phenylenediamine in human and fuzzy rat skin.
PubMed:
Comparison of the mutagenic specificity induced by four nitro-group-containing aromatic amines in Salmonella typhimurium his genes.
PubMed:
Mutagenicity and antimutagenicity studies of tannic acid and its related compounds.
PubMed:
Base-pair mutation caused by four nitro-group containing aromatic amines in Salmonella typhimurium TA100, TA104, TA4001 and TA4006.
PubMed:
Evaluation of the in vivo genotoxic potential of three carcinogenic aromatic amines using the Big Blue transgenic mouse mutation assay.
PubMed:
Effects of the nitro-group on the mutagenicity and toxicity of some benzamines.
PubMed:
Mutagenicity and toxicity studies of p-phenylenediamine and its derivatives.
PubMed:
Mutagenicity of selected aniline derivatives to Salmonella following plant activation and mammalian hepatic activation.
PubMed:
Percutaneous absorption of hair dyes: correlation with partition coefficients.
PubMed:
Assessment of sister chromatid exchange in spermatogonia and intestinal epithelium in Chinese hamsters.
PubMed:
Percutaneous absorption of 2-nitro-p-phenylenediamine.
PubMed:
Chemically-induced sister-chromatid exchange in vivo in bone marrow of Chinese hamsters. An evaluation of 24 compounds.
PubMed:
Distribution, excretion, and metabolism of nitro-p-phenylenediamine in rats.
PubMed:
Teratogenic evaluation of 2-nitro-p-phenylenediamine, 4-nitro-o-phenylenediamine, and 2,5-toluenediamine sulfate in the mouse.
PubMed:
In vivo skin penetration studies of 2,4-toluenediamine, 2,4-diaminoanisole, 2-nitro-p-phenylenediamine, p-dioxane and N-nitrosodiethanolamine in cosmetics.
PubMed:
Induction of mitotic recombination by certain hair-dye chemicals in Saccharomyces cerevisiae.
PubMed:
Carcinogenicity of the hair-dye component 2-nitro-p-phenylenediamine: induction of eosinophilic hepatocellular neoplasms in female B6C3F1 mice.
PubMed:
Dominant lethal assay of some hair-dye components in random-bred male rats.
PubMed:
Bioassay of 2-nitro-p-phenylenediamine for possible carcinogenicity.
PubMed:
The mutagenic assay of some hair dye components, using the thymidine kinase locus of L5178Y mouse lymphoma cells.
PubMed:
Testing of known carcinogens and noncarcinogens for their ability to induce unscheduled DNA synthesis in HeLa cells.
PubMed:
Dominant lethal mutagenicity study on hair dyes.
PubMed:
Hair dyes are mutagenic: identification of a variety of mutagenic ingredients.