2-nitro-p-phenylenediamine

1,4-benzenediamine, 2-nitro-

CAS: 5307-14-2 C6 H7 N3 O2 MW: 153.14119000

Identification

Name2-nitro-p-phenylenediamine
CAS Number5307-14-2
EINECS226-164-5
FDA UNIIPV83F3C01Q
Molecular FormulaC6 H7 N3 O2
Molecular Weight153.14119000
MDL NumberMFCD00007903
Nikkaji NumberJ3.720F
Beilstein2210195
XlogP30.50 (est)

Regulatory

Physical Properties

Appearance almost black needles (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 137.00 °C. @ 760.00 mm Hg
Boiling Point 385.40 °C. @ 760.00 mm Hg (est)
Vapor Pressure 5.600000 mmHg @ 25.00 °C. (est)
Flash Point 368.00 °F. TCC ( 186.90 °C. ) (est)
logP (o/w) 0.530
Soluble in water, 2.592e+004 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Useshair dyeing agents

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintraperitoneal-mouse LD50 214 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryhair dyeing agents
Recommendation for 2-nitro-p-phenylenediamine usage levels up tonot for fragrance use.
Recommendation for 2-nitro-p-phenylenediamine flavor usage levels up tonot for flavor use.

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Potential Uses

hair dyeing agents

Natural Occurrence

not found in nature

Synonyms

1,4- benzenediamine, 2-nitro- c.i. 76070 C.I. oxidation base 22 ci 76070 1,4- diamino-2-nitrobenzene du rafur brown durafur brown durafur brown 2R fouramine 2R fourrine 36 fourrine brown 2R glycidyl-4-nitrophenyl ether 2- nitro-1,4-benzenediamine 2- nitro-1,4-diaminobenzene 2- nitro-1,4-phenylene diamine 2- nitro-1,4-phenylenediamine 2- nitro-4-aminoaniline 2- nitro-4-phenylenediamine 2- nitro-p-phenylendiamine 2- nitro-para-phenylendiamine 2- nitro-para-phenylene diamine 2- nitro-para-phenylenediamine 2- nitrobenzene-1,4-diamine 2- nitrol-p-phenylenediamine 2- nitrol-para-phenylenediamine p- phenylenediamine, 2-nitro- ursol brown RR zoba brown RR PubMed: Single strand dna breaks in human lymphocytes exposed to para-phenylenediamine and its derivatives. PubMed: Differences in gene expression profiles in the liver between carcinogenic and non-carcinogenic isomers of compounds given to rats in a 28-day repeat-dose toxicity study. PubMed: Percutaneous penetration and metabolism of 2-nitro-p-phenylenediamine in human and fuzzy rat skin. PubMed: Comparison of the mutagenic specificity induced by four nitro-group-containing aromatic amines in Salmonella typhimurium his genes. PubMed: Mutagenicity and antimutagenicity studies of tannic acid and its related compounds. PubMed: Base-pair mutation caused by four nitro-group containing aromatic amines in Salmonella typhimurium TA100, TA104, TA4001 and TA4006. PubMed: Evaluation of the in vivo genotoxic potential of three carcinogenic aromatic amines using the Big Blue transgenic mouse mutation assay. PubMed: Effects of the nitro-group on the mutagenicity and toxicity of some benzamines. PubMed: Mutagenicity and toxicity studies of p-phenylenediamine and its derivatives. PubMed: Mutagenicity of selected aniline derivatives to Salmonella following plant activation and mammalian hepatic activation. PubMed: Percutaneous absorption of hair dyes: correlation with partition coefficients. PubMed: Assessment of sister chromatid exchange in spermatogonia and intestinal epithelium in Chinese hamsters. PubMed: Percutaneous absorption of 2-nitro-p-phenylenediamine. PubMed: Chemically-induced sister-chromatid exchange in vivo in bone marrow of Chinese hamsters. An evaluation of 24 compounds. PubMed: Distribution, excretion, and metabolism of nitro-p-phenylenediamine in rats. PubMed: Teratogenic evaluation of 2-nitro-p-phenylenediamine, 4-nitro-o-phenylenediamine, and 2,5-toluenediamine sulfate in the mouse. PubMed: In vivo skin penetration studies of 2,4-toluenediamine, 2,4-diaminoanisole, 2-nitro-p-phenylenediamine, p-dioxane and N-nitrosodiethanolamine in cosmetics. PubMed: Induction of mitotic recombination by certain hair-dye chemicals in Saccharomyces cerevisiae. PubMed: Carcinogenicity of the hair-dye component 2-nitro-p-phenylenediamine: induction of eosinophilic hepatocellular neoplasms in female B6C3F1 mice. PubMed: Dominant lethal assay of some hair-dye components in random-bred male rats. PubMed: Bioassay of 2-nitro-p-phenylenediamine for possible carcinogenicity. PubMed: The mutagenic assay of some hair dye components, using the thymidine kinase locus of L5178Y mouse lymphoma cells. PubMed: Testing of known carcinogens and noncarcinogens for their ability to induce unscheduled DNA synthesis in HeLa cells. PubMed: Dominant lethal mutagenicity study on hair dyes. PubMed: Hair dyes are mutagenic: identification of a variety of mutagenic ingredients.