2-pyridine carboxaldehyde

2-nicotinaldehyde

CAS: 1121-60-4 C6 H5 N O MW: 107.11205000 caramellic

Identification

Name2-pyridine carboxaldehyde
IUPACpyridine-2-carbaldehyde
CAS Number1121-60-4
EINECS214-333-6
FDA UNIISearch
Molecular FormulaC6 H5 N O
Molecular Weight107.11205000
MDL NumberMFCD00006290
Nikkaji NumberJ28.014C
Beilstein0105341
XlogP30.40 (est)

Regulatory

Physical Properties

Appearance colorless to pale yellow clear liquid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.12600 @ 25.00 °C.
Melting Point -21.00 °C. @ 760.00 mm Hg
Boiling Point 180.00 °C. @ 760.00 mm Hg
Vapor Pressure 0.906000 mmHg @ 25.00 °C. (est)
Flash Point 130.00 °F. TCC ( 54.44 °C. )
logP (o/w) 0.440
Soluble in water, 4.681e+004 mg/L @ 25 °C (est)

Organoleptic Properties

Taste Description caramellic fatty

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryinformation only not used for fragrances or flavors
Recommendation for 2-pyridine carboxaldehyde usage levels up tonot for fragrance use.
Recommendation for 2-pyridine carboxaldehyde flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

2- formyl pyridine 2- formylpyridine 2- nicotinaldehyde o- nicotinaldehyde 2- picolinaldehyde 2- picolinealdehyde 2- pyridaldehyde pyridine-2-aldehyde pyridine-2-carbaldehyde 2- pyridinecarbaldehyde 2- pyridinecarboxaldehyde 2- pyridylaldehyde 2- pyridylcarboxaldehyde US Patents: 3,952,024 - Furfurylthioacetone PubMed: Synthesis, characterization and biological activity of some unsymmetrical Schiff base transition metal complexes. US Patents: Certain 2,5-dimethyl-3-thiopyrazines PubMed: DNA-catalyzed Henry reaction in pure water and the striking influence of organic buffer systems. PubMed: Synthesis, characterization, fluorescence and catalytic activity of some new complexes of unsymmetrical Schiff base of 2-pyridinecarboxaldehyde with 2,6-diaminopyridine. PubMed: Trithiocyanurate complexes of iron, manganese and nickel and their anticholinesterase activity. PubMed: Exclusive selectivity of multidentate ligands independent on the oxidation state of cobalt: influence of steric hindrance on dioxygen binding and phenoxazinone synthase activity. PubMed: Tetratopic pyrimidine-hydrazone ligands modified with terminal hydroxymethyl and acryloyl arms and their Pb(II), Zn(II), Cu(II) and Ag(I) complexes. PubMed: Determination of rare earth elements in waters by inductively coupled plasma optical emission spectrometry after preconcentration with 6-(2-thienyl)-2-pyridinecarboxaldehyde functionalized Amberlite XAD-4 resin. PubMed: Aldehyde stress-mediated novel modification of proteins: epimerization of the N-terminal amino acid. PubMed: Use of polymer-bound Schiff base as a new liquid binding agent of diffusive gradients in thin-films for the measurement of labile Cu²⁺, Cd²⁺ and Pb²⁺. PubMed: Metal-Arene Complexes with Indolo[3,2-c]-quinolines: Effects of Ruthenium vs Osmium and Modifications of the Lactam Unit on Intermolecular Interactions, Anticancer Activity, Cell Cycle, and Cellular Accumulation. PubMed: Influence of terminal acryloyl arms on the coordination chemistry of a ditopic pyrimidine-hydrazone ligand: comparison of Pb(II), Zn(II), Cu(II), and Ag(I) complexes. PubMed: Discrimination of fluorescence light-up effects induced by pH and metal ion chelation on a spirocyclic derivative of rhodamine B. PubMed: Hydroformylation of 1-octene using low-generation Rh(I) metallodendritic catalysts based on a tris-2-(2-pyridyliminoethyl)amine scaffold. PubMed: Synthesis of New VO(II), Co(II), Ni(II) and Cu(II) Complexes with Isatin-3-Chloro-4-Floroaniline and 2-Pyridinecarboxylidene-4-Aminoantipyrine and their Antimicrobial Studies. PubMed: Methemoglobin formation by triapine, di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT), and other anticancer thiosemicarbazones: identification of novel thiosemicarbazones and therapeutics that prevent this effect. PubMed: Origins of stereoselectivity in optically pure phenylethaniminopyridine tris-chelates M(NN')3(n+) (M = Mn, Fe, Co, Ni and Zn). PubMed: Configurational and constitutional information storage: multiple dynamics in systems based on pyridyl and acyl hydrazones. PubMed: Cyclic Acetal Formation Between 2-Pyridinecarboxaldehyde and gamma-Hydroxy-alpha,beta-Acetylenic Esters. PubMed: Coordinative trends of a tridentate thiosemicarbazone ligand: synthesis, characterization, luminescence studies and desulfurization processes. PubMed: Isoreticular metalation of metal-organic frameworks. PubMed: Selective complexation of 3d metal(II) ions with multidentate and chiral isomers derived from condensation of 2-pyridinecarboxaldehyde with triethylenetetramine. PubMed: Synthesis and spectroscopic studies on complexes of N,N'-bis-(2-pyridinecarboxaldimine)-1,8-diaminonaphthalene (L); DNA binding studies on Cu(II) complex. PubMed: DFT studies on the mechanism of the diboration of aldehydes catalyzed by copper(I) boryl complexes. PubMed: Characterization and crystal structure of Escherichia coli KDPGal aldolase. PubMed: Spectroscopic and biological approach of Ni(II) and Cu(II) complexes of 2-pyridinecarboxaldehyde thiosemicarbazone. PubMed: Magnetic properties of a manganese(II) trinuclear complex involving a tridentate Schiff-Base ligand. PubMed: Enantioselective reductive coupling of 1,3-enynes to heterocyclic aromatic aldehydes and ketones via rhodium-catalyzed asymmetric hydrogenation: mechanistic insight into the role of Brønsted acid additives. PubMed: Asymmetric synthesis of 2-(2-pyridyl)aziridines from 2-pyridineimines bearing stereogenic N-alkyl substituents and regioselective opening of the aziridine ring. PubMed: High performance liquid chromatographic determination of isoniazid, pyrazinamide and rifampicin in pharmaceutical preparations. PubMed: Complexation to Fe(II), Ni(II), and Zn(II) of multidentate ligands resulting from condensation of 2-pyridinecarboxaldehyde with alpha,omega-triamines: selective imidazolidine/hexahydropyrimidine ring opening revisited. PubMed: Phosphine-free hydrazone-Pd complex as the catalyst precursor for a Suzuki-Miyaura reaction under mild aerobic conditions. PubMed: Organometallic reactions in aqueous media: indium-promoted additions to 2-pyridyl and glyoxylic acid oxime ethers. PubMed: Effects on Mycobacterium avium replication in normal human macrophages by deferiprone (L1) and other iron chelators. Possible implications on toxicity. PubMed: Synthesis and Characterization of Dimeric Mutually Coordinated Magnesium meso-2-Pyridylporphyrins. PubMed: A chloro(2-pyridinecarboxaldehyde)(2,2':6',2"-terpyridine)ruthenium(II) complex. PubMed: Chloroform-soluble schiff-base Zn(II) or Cd(II) complexes from a dynamic combinatorial library. PubMed: Helical-chain copper(II) complexes and a cyclic tetranuclear copper(II) complex with single syn-anti carboxylate bridges and ferromagnetic exchange interactions. PubMed: Selective imidazolidine ring opening during complex formation of iron(III), copper(II), and zinc(II) with a multidentate ligand obtained from 2-pyridinecarboxaldehyde N-oxide and triethylenetetramine. PubMed: Synthesis, rotamer orientation, and calcium channel modulation activities of alkyl and 2-phenethyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(3- or 6-substituted-2-pyridyl)-5-pyridinecarboxylates. PubMed: Abiotic transformations and decomposition kinetics of 4-carbamoyl-2'-[(hydroxyimino)methyl]-1,1'-(oxydimethylene)-bis(pyridin ium chloride) in aqueous phosphate buffers. PubMed: Synthesis and calcium channel antagonist activity of nifedipine analogues containing 1-oxido-2-pyridyl in place of the 2-nitrophenyl moiety. PubMed: Separation of some transition-metal ions on silica-immobilized 2-pyridinecarboxaldehyde phenylhydrazone. PubMed: Mechanism of action of arenesulfonylhydrazones of 2-pyridinecarboxaldehyde 1-oxide in L1210 cells. PubMed: Relationship of spontaneous chemical transformation of arylsulfonylhydrazones of 2-pyridinecarboxaldehyde 1-oxide to anticancer activity. PubMed: In vivo and in vitro activity by diverse chelators against Trypanosoma brucei brucei. PubMed: Synthesis and antineoplastic activity of phenyl-substituted benzenesulfonylhydrazones of 2-pyridinecarboxyaldehyde 1-oxide.