3',5,7-trihydroxy-4'-methoxyflavone-7-rutinoside

CAS: 520-27-4 C28 H32 O15 MW: 608.55104000

Identification

Namediosmin
CAS Number520-27-4
EINECS208-289-7
FDA UNII7QM776WJ5N
Molecular FormulaC28 H32 O15
Molecular Weight608.55104000
MDL NumberMFCD00009772
Nikkaji NumberJ6.600A

Regulatory

Physical Properties

Appearance white crystalline powder (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 274.00 °C. @ 760.00 mm Hg
Boiling Point 926.78 °C. @ 760.00 mm Hg (est)
Flash Point 581.00 °F. TCC ( 305.20 °C. ) (est)
logP (o/w) 0.140
Soluble in water, 407.8 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantioxidants

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryantioxidants
Recommendation for diosmin usage levels up tonot for fragrance use.
Recommendation for diosmin flavor usage levels up tonot for flavor use.

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

View All Website 1-631-485-4226 account@bocsci.com

Glentham Life Sciences Ltd

The Chemical, Biochemical & Research Essentials Supplier

Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK.

View All Website +44 (0) 1225 667798 info@glentham.com

Potential Uses

None Found

Natural Occurrence

horsemint plant hyssop leaf hyssop plant hyssop shoot lemon leaf mandarin leaf orange flower parsley petitgrain lemon petitgrain mandarin rosemary leaf spearmint leaf spearmint shoot

Synonyms

barosmin 7-[[6-O-6- deoxy-a-L-mannopyranosyl-b-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one diosmetin 7-b-rutinoside diosminum 5- hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-(O6-a-L-rhamnopyranosyl-b-D-glucopyranosyloxy)chromen-4-one 5- hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-b-rutinosyloxy-4H-chromen-4-one 3,5,7- trihydroxy-4-methoxyflavone-7-rutinoside 3',5,7- trihydroxy-4'-methoxyflavone 7-rutinoside 3',5,7- trihydroxy-4'-methoxyflavone-7-rutinoside veno-V diosmine PubMed: Hydrolysis of flavanone glycosides by β-glucosidase from Pyrococcus furiosus and its application to the production of flavanone aglycones from citrus extracts. PubMed: A review on pharmacological and analytical aspects of diosmetin: a concise report. PubMed: Confirmation of diosmetin 3-O-glucuronide as major metabolite of diosmin in humans, using micro-liquid-chromatography-mass spectrometry and ion mobility mass spectrometry. PubMed: PP2A mediates diosmin p53 activation to block HA22T cell proliferation and tumor growth in xenografted nude mice through PI3K-Akt-MDM2 signaling suppression. PubMed: Bioactive phenolics and antioxidant propensity of flavedo extracts of Mauritian citrus fruits: potential prophylactic ingredients for functional foods application. PubMed: Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity. PubMed: Effects of diosmin, a flavonoid glycoside in citrus fruits, on P-glycoprotein-mediated drug efflux in human intestinal Caco-2 cells. PubMed: Determination of flavonoids in citrus juices by micro-HPLC-ESI/MS. PubMed: Treatment of metastatic melanoma B16F10 by the flavonoids tangeretin, rutin, and diosmin. PubMed: Monograph. Diosmin. PubMed: Flavonoid distribution during the development of leaves, flowers, stems, and roots of Rosmarinus officinalis. postulation of a biosynthetic pathway. PubMed: Effect of the rootstock and interstock grafted in lemon tree (Citrus limon (L.) Burm.) on the flavonoid content of lemon juice. PubMed: Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context. PubMed: Flavonoids detection by HPLC-DAD-MS-MS in lemon juices from Sicilian cultivars. PubMed: Radioprotective effects in vivo of phenolics extracted from Olea europaea L. leaves against X-ray-induced chromosomal damage: comparative study versus several flavonoids and sulfur-containing compounds. PubMed: Selection of hybrids and edible citrus species with a high content in the diosmin functional compound. Modulating effect of plant growth regulators on contents. PubMed: In vitro inhibitory effect of some flavonoids on rotavirus infectivity. PubMed: Antioxidant activity and radioprotective effects against chromosomal damage induced in vivo by X-rays of flavan-3-ols (Procyanidins) from grape seeds (Vitis vinifera): comparative study versus other phenolic and organic compounds.