veratric acid

benzoic acid, 3,4-dimethoxy-

CAS: 93-07-2 C9 H10 O4 MW: 182.17550000

Identification

Nameveratric acid
CAS Number93-07-2
EINECS202-215-7
FDA UNII1YY04E7RR4
Molecular FormulaC9 H10 O4
Molecular Weight182.17550000
MDL NumberMFCD00002500
Nikkaji NumberJ10.598H
Beilstein0518285
XlogP31.60 (est)

Regulatory

Physical Properties

Appearance white to pale yellow powder (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 181.00 °C. @ 760.00 mm Hg
Boiling Point 302.00 to 303.00 °C. @ 760.00 mm Hg (est)
Flash Point 250.00 °F. TCC ( 120.90 °C. ) (est)
logP (o/w) 1.610
Soluble in alcohol

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintraperitoneal-mouse LD50 > 800 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for veratric acid usage levels up tonot for fragrance use.
Recommendation for veratric acid flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

capsicum coriander plant olive fruit sabadill PMC trollius chinensis

Synonyms

benzoic acid, 3,4-dimethoxy- 3,4- dimethoxy-benzoic acid 3,4- dimethoxybenzoic acid 3,4- dimethoxybenzoicacid 3,4- dimethyl protocatechuic acid 3,4- dimethylprotocatechuic acid (±)-m- methoxymandelic acid PubMed: Veratric acid inhibits iNOS expression through the regulation of PI3K activation and histone acetylation in LPS-stimulated RAW264.7 cells. PubMed: Studies on the Biotransformation of Veratric Acid, a Human Metabolite of Mebeverine, by Using the Incubated Hen's Egg. PubMed: Absorption properties and mechanism of trolline and veratric acid and their implication to an evaluation of the effective components of the flowers of Trollius chinensis. PubMed: Inhibitory effect of aqueous extracts from Miracle Fruit leaves on mutation and oxidative damage. PubMed: Protective effect of veratric acid on lipopolysaccharide-induced acute lung injury in mice. PubMed: Distribution of Two bioactive compounds in flowers of Trollius chinensis. PubMed: Crabgrass (Digitaria sanguinalis) allelochemicals that interfere with crop growth and the soil microbial community. PubMed: Antagonist effects of veratric acid against UVB-induced cell damages. PubMed: The regulatory effect of veratric acid on NO production in LPS-stimulated RAW264.7 macrophage cells. PubMed: Production of natural fragrance aromatic acids by coexpression of trans-anethole oxygenase and p-anisaldehyde dehydrogenase genes of Pseudomonas putida JYR-1 in Escherichia coli. PubMed: Investigation of the substrate range of CYP199A4: modification of the partition between hydroxylation and desaturation activities by substrate and protein engineering. PubMed: The wood rot ascomycete Xylaria polymorpha produces a novel GH78 glycoside hydrolase that exhibits α-L-rhamnosidase and feruloyl esterase activities and releases hydroxycinnamic acids from lignocelluloses. PubMed: Veratric acid ameliorates hyperlipidemia and oxidative stress in Wistar rats fed an atherogenic diet. PubMed: Effect of veratric acid on the cardiovascular risk of L-NAME-induced hypertensive rats. PubMed: Nonlinear changes in the activity of the oxygen-dependent demethylase system in Rhodococcus erythropolis cells in the presence of low and very low doses of formaldehyde. PubMed: Veratric acid, a phenolic acid attenuates blood pressure and oxidative stress in L-NAME induced hypertensive rats. PubMed: Synthesis of homoveratric acid-imprinted polymers and their evaluation as selective separation materials. PubMed: Photoenhanced degradation of veratraldehyde upon the heterogeneous ozone reactions. PubMed: Selective oxidative demethylation of veratric acid to vanillic acid by CYP199A4 from Rhodopseudomonas palustris HaA2. PubMed: [Spectroscopic investigation on the interaction of protocatechuic acid and veratric acid with biomacromolecules]. PubMed: Influence of very low doses of mediators on fungal laccase activity - nonlinearity beyond imagination. PubMed: Hansch analysis of veratric acid derivatives as antimicrobial agents. PubMed: Assessment of the genotoxicity of olive mill waste water (OMWW) with the Vicia faba micronucleus test. PubMed: Isolation and characterization of Streptomyces sp. NL15-2K capable of degrading lignin-related aromatic compounds. PubMed: Molecular cloning of streptomyces genes encoding vanillate demethylase. PubMed: Metabolism of isovanillate, vanillate, and veratrate by Comamonas testosteroni strain BR6020. PubMed: Investigative implications of the instability and metabolism of mebeverine. PubMed: Regulation of Laccase Gene Transcription in Trametes versicolor. PubMed: Involvement of lipid peroxidation in the degradation of a non-phenolic lignin model compound by manganese peroxidase of the litter-decomposing fungus Stropharia coronilla. PubMed: Production of laccase by immobilized cells of Agaricus sp.: induction effect of xylan and lignin derivatives. PubMed: Biotransformation of lignin polymers derived from beech wood pulping by Sporobolomyces roseus isolated from leafy material. PubMed: [Phenyl pyrazolones--novel oxidoreductase redox-mediators for degradation of xenobiotics]. PubMed: Acylated flavone C-glycosides from Trollius ledebouri. PubMed: Trollioside, a new compound from the flowers of Trollius chinensis. PubMed: Tyrosinase inhibitor from black rice bran. PubMed: Enzyme production by Mycena galopus mycelium in artificial media and in Picea sitchensis F1 horizon needle litter. PubMed: Mechanistic features of lignin peroxidase-catalyzed oxidation of substituted phenols and 1,2-dimethoxyarenes. PubMed: Relationship of demethylation processes to veratric acid concentration and cell density in cultures of Rhodococcus erythropolis. PubMed: [A study on chemical constituents in the herb of Mentha spicata]. PubMed: Lignin degradation in a compost environment by the deuteromycete Paecilomyces inflatus. PubMed: Induction of laccase activity in the edible straw mushroom, Volvariella volvacea. PubMed: Influence of aromatic compounds on biodegradation of [14C]-labeled xylan and mannan by the white-rot fungus Phlebia radiata. PubMed: Identification of mebeverine acid as the main circulating metabolite of mebeverine in man. PubMed: Kinetic model for phenolic compound oxidation by Fenton's reagent. PubMed: The antispasmodic drug mebeverine leads to positive amphetamine results by fluorescence polarization immunoassay (FPIA)--studies on the toxicological analysis of urine by FPIA and GC-MS. PubMed: Differential regulation of laccase gene expression in Pleurotus sajor-caju. PubMed: Demethylation of [14C]-labelled veratric acid and oxidation of methanol and formaldehyde by the white-rot fungus Phlebia radiata. PubMed: Multiple respiratory bursts as a response to veratrate stress in Rhodococcus erythropolis cells. PubMed: On the metabolism of the amphetamine-derived antispasmodic drug mebeverine: gas chromatography-mass spectrometry studies on rat liver microsomes and on human urine. PubMed: Relationships between demethylase activity, formaldehyde and oxygen during incubation of Rhodococcus erythropolis with veratrate. PubMed: Genetics of ferulic acid bioconversion to protocatechuic acid in plant-growth-promoting Pseudomonas putida WCS358. PubMed: Lack of bioavailability of mebeverine even after pretreatment with pyridostigmine. PubMed: Comparison of the Efficacies of Chloromethane, Methionine, and S-Adenosylmethionine as Methyl Precursors in the Biosynthesis of Veratryl Alcohol and Related Compounds in Phanerochaete chrysosporium. PubMed: Decoloration of azo dyes by three whiterot fungi: influence of carbon source. PubMed: Anisaldehyde and Veratraldehyde Acting as Redox Cycling Agents for H(2)O(2) Production by Pleurotus eryngii. PubMed: The metabolism of mebeverine in man: identification of urinary metabolites by gas chromatography/mass spectrometry. PubMed: Degradation of non-phenolic beta-o-4 lignin substructure model compounds by Acinetobacter sp. PubMed: Facile hydrolysis of mebeverine in vitro and in vivo: negligible circulating concentrations of the drug after oral administration. PubMed: Formation and Action of Lignin-Modifying Enzymes in Cultures of Phlebia radiata Supplemented with Veratric Acid. PubMed: Degradation of labelled lignins and veratrylglycerol-beta-guaiacyl ether by Acinetobacter sp. PubMed: Regulation of the production of hemicellulolytic and cellulolytic enzymes by a Streptomyces sp. growing on lignocellulose. PubMed: Metabolism of Lignin Model Compounds of the Arylglycerol-beta-Aryl Ether Type by Pseudomonas acidovorans D(3). PubMed: The action of mebeverine and metabolites on mammalian non-myelinated nerve fibres. PubMed: Antimicrobial properties of aromatic compounds of plant origin. PubMed: Variation of melatonin and serotonin content in rat pineal gland with sex and oestrous phase difference determined by high-performance liquid chromatography with fluorimetric detection. PubMed: Substrate-induction of veratric acid O-demethylase in Nocardia sp. PubMed: Aerobic and Anaerobic Catabolism of Vanillic Acid and Some Other Methoxy-Aromatic Compounds by Pseudomonas sp. Strain PN-1. PubMed: New compounds: Reissert compound studies XXXII: facile synthesis of 3-azapapaverine. PubMed: [O-Demethylation of benzoic acids in wheat seedlings]. PubMed: Degradation of methoxylated benzoic acids by a Nocardia from a lignin-rich environment: significance to lignin degradation and effect of chloro substituents. PubMed: A note on the synthesis of veratric acid. PubMed: Studies in detoxication; the metabolism of veratraldehyde and veratric acid in the rabbit. PubMed: Studies in detoxication: 14. The metabolism of veratraldehyde and veratric acid in the rabbit.