3,4-lutidine
pyridine, 3,4-dimethyl-
Identification
| Name | 3,4-lutidine |
| IUPAC | 3,4-dimethylpyridine |
| CAS Number | 583-58-4 |
| EINECS | 209-511-5 |
| FDA UNII | FCU895KJ7H |
| Molecular Formula | C7 H9 N |
| Molecular Weight | 107.15573000 |
| MDL Number | MFCD00006403 |
| Nikkaji Number | J7.443H |
| Beilstein | 0106583 |
Regulatory
| DG SANTE Food Flavourings | 14.105 3,4-dimethylpyridine |
| FDA Mainterm (IAUFC) | 583-58-4 ; 3,4-DIMETHYLPYRIDINE |
Physical Properties
| Appearance | colorless to pale yellow clear liquid (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 0.95400 to 0.96000 @ 25.00 °C. |
| Pounds per Gallon - (est). | 7.938 to 7.988 |
| Refractive Index | 1.50700 to 1.51300 @ 20.00 °C. |
| Melting Point | -12.00 °C. @ 760.00 mm Hg |
| Boiling Point | 176.00 to 178.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 2.694000 mmHg @ 25.00 °C. (est) |
| Flash Point | 129.00 °F. TCC ( 53.89 °C. ) |
| logP (o/w) | 1.749 (est) |
| Soluble in | alcohol |
Organoleptic Properties
| Taste Description | green |
Safety Information
| Preferred SDS | View |
| European information | Most important hazard(s): |
| Oral/Parenteral Toxicity | oral-rat LD50 710 uL/kg |
| Dermal Toxicity | skin-rabbit LD50 140 uL/kg |
| Inhalation Toxicity | inhalation-rat TCLo 500 ppm/4H |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | flavoring agents |
| Recommendation for 3,4-lutidine usage levels up to | not for fragrance use. |
| Maximised Survey-derived Daily Intakes (MSDI-EU) | 0.13 (μg/capita/day) |
| Modified Theoretical Added Maximum Daily Intake (mTAMDI) | 400 (μg/person/day) |
| Threshold of Concern | 540 (μg/person/day) |
| Structure Class | II |
| Dairy products, excluding products of category 02.0 (01.0) | 0.40000 |
| Fats and oils, and fat emulsions (type water-in-oil) (02.0) | 0.10000 |
| Edible ices, including sherbet and sorbet (03.0) | 0.40000 |
| Processed fruit (04.1) | 0.40000 |
| Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2) | - |
| Confectionery (05.0) | 1.00000 |
| Chewing gum (05.3) | - |
| Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0) | 0.20000 |
| Bakery wares (07.0) | 2.00000 |
| Meat and meat products, including poultry and game (08.0) | 0.20000 |
| Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0) | 0.20000 |
| Eggs and egg products (10.0) | - |
| Sweeteners, including honey (11.0) | - |
| Salts, spices, soups, sauces, salads, protein products, etc. (12.0) | 0.10000 |
| Foodstuffs intended for particular nutritional uses (13.0) | 0.20000 |
| Non-alcoholic ("soft") beverages, excl. dairy products (14.1) | 0.20000 |
| Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2) | - |
| Ready-to-eat savouries (15.0) | 1.00000 |
| Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0) | 0.20000 |
Potential Uses
Natural Occurrence
Synonyms
3,4-
dimethyl pyridine
3,4-
dimethylpyridine
pyridine, 3,4-dimethyl-
US Patents:
3,931,166 - Certain 2,5-dimethyl-3-thiopyrazines
PubMed:
New Ï-arene ruthenium(II) piano-stool complexes with nitrogen ligands.
US Patents:
Flavoring agent
PubMed:
Factors dictating the nuclearity/aggregation and acetate coordination modes of lutidine-coordinated zinc(II) acetate complexes.
PubMed:
Theoretical studies on the molecular structure and vibrational spectra of some dimethyl substituted pyridine derivatives.
PubMed:
Aerobic biodegradation of 4-methylpyridine and 4-ethylpyridine by newly isolated Pseudonocardia sp. strain M43.
PubMed:
Topological ferrimagnetic behavior of two new [Mn(L)2(N3)2]n chains with the new AF/AF/F alternating sequence (L = 3-methylpyridine or 3,4-dimethylpyridine).
PubMed:
Use of borinium ions as probes of steric effects in gas-phase ion-molecule complexes.
PubMed:
[Effectiveness of new quarternary ammonium chloride compounds against selected bacteria and fungi. XXI. Synthesis of alkoxymethyl-3,4-dimethyl- pyridine and 1-ethyloxymethyl-3-alkylthiomethylimidazole chlorides].
PubMed:
In vitro drug delivery mediated by ecto-NAD+-glycohydrolase ligand-targeted liposomes.
PubMed:
Targeting of liposomes by covalent coupling with ecto-NAD+-glycohydrolase ligands.