3,5-lutidine
pyridine, 3,5-dimethyl-
Identification
| Name | 3,5-lutidine |
| IUPAC | 3,5-dimethylpyridine |
| CAS Number | 591-22-0 |
| EINECS | 209-708-6 |
| FDA UNII | 6Q4YPZ045V |
| Molecular Formula | C7 H9 N |
| Molecular Weight | 107.15573000 |
| MDL Number | MFCD00006404 |
| Nikkaji Number | J6.756C |
| Beilstein | 0105682 |
| CoE Number | 11382 |
| XlogP3 | 1.80 (est) |
Regulatory
| DG SANTE Food Flavourings | 14.106 3,5-dimethylpyridine |
| FDA Mainterm (IAUFC) | 591-22-0 ; 3,5-DIMETHYLPYRIDINE |
Physical Properties
| Appearance | colorless to pale yellow clear liquid (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 0.93900 to 0.94500 @ 25.00 °C. |
| Pounds per Gallon - (est). | 7.813 to 7.863 |
| Refractive Index | 1.50000 to 1.50600 @ 20.00 °C. |
| Melting Point | -9.00 °C. @ 760.00 mm Hg |
| Boiling Point | 170.00 to 172.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 1.924000 mmHg @ 25.00 °C. (est) |
| Flash Point | 128.00 °F. TCC ( 53.33 °C. ) |
| logP (o/w) | 1.780 |
| Soluble in | alcohol |
No sensory data available
Safety Information
| Preferred SDS | View |
| European information | Most important hazard(s): |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | flavoring agents |
| Recommendation for 3,5-lutidine usage levels up to | not for fragrance use. |
| Maximised Survey-derived Daily Intakes (MSDI-EU) | 0.073 (μg/capita/day) |
| Modified Theoretical Added Maximum Daily Intake (mTAMDI) | 400 (μg/person/day) |
| Threshold of Concern | 540 (μg/person/day) |
| Structure Class | II |
| Dairy products, excluding products of category 02.0 (01.0) | 0.40000 |
| Fats and oils, and fat emulsions (type water-in-oil) (02.0) | 0.10000 |
| Edible ices, including sherbet and sorbet (03.0) | 0.40000 |
| Processed fruit (04.1) | 0.40000 |
| Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2) | - |
| Confectionery (05.0) | 1.00000 |
| Chewing gum (05.3) | - |
| Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0) | 0.20000 |
| Bakery wares (07.0) | 2.00000 |
| Meat and meat products, including poultry and game (08.0) | 0.20000 |
| Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0) | 0.20000 |
| Eggs and egg products (10.0) | - |
| Sweeteners, including honey (11.0) | - |
| Salts, spices, soups, sauces, salads, protein products, etc. (12.0) | 0.10000 |
| Foodstuffs intended for particular nutritional uses (13.0) | 0.20000 |
| Non-alcoholic ("soft") beverages, excl. dairy products (14.1) | 0.20000 |
| Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2) | - |
| Ready-to-eat savouries (15.0) | 1.00000 |
| Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0) | 0.20000 |
Lluch Essence S.L.
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Penta International Corporation
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Potential Uses
Natural Occurrence
Synonyms
3,5-
dimethyl pyridine
3,5-
dimethylpyridine
pyridine, 3,5-dimethyl-
US Patents:
3,931,166 - Certain 2,5-dimethyl-3-thiopyrazines
PubMed:
PET imaging shows loss of striatal PDE10A in patients with Huntington disease.
US Patents:
Flavoring agent
PubMed:
Utilizing proton transfer to produce molecular salts in bromanilic acid substituted-pyridine molecular complexes - predictable synthons?
PubMed:
Synthesis, characterization and X-ray structure of the adducts of bis(O-butyldithiocarbonato)nickel(II) with substituted pyridines.
PubMed:
Quantification of 18F-JNJ-42259152, a novel phosphodiesterase 10A PET tracer: kinetic modeling and test-retest study in human brain.
PubMed:
Excited-state characteristics of tetracyanidonitridorhenium(V) and -technetium(V) complexes with N-heteroaromatic ligands.
PubMed:
Preclinical evaluation of [(18)F]JNJ42259152 as a PET tracer for PDE10A.
PubMed:
Human biodistribution and dosimetry of 18F-JNJ42259152, a radioligand for phosphodiesterase 10A imaging.
PubMed:
[C7H10N][In3Se5]: a layered selenide with two indium coordination environments.
PubMed:
New Ï-arene ruthenium(II) piano-stool complexes with nitrogen ligands.
PubMed:
Molybdenum(VI) complexes of a 2,2'-biphenyl-bridged bis(amidophenoxide): competition between metal-ligand and metal-amidophenoxide Ï bonding.
PubMed:
Substitution reactions in dinuclear Ru-Hbpp complexes: an evaluation of through-space interactions.
PubMed:
Magnesium hydrides and the dearomatisation of pyridine and quinoline derivatives.
PubMed:
Synthesis, in vivo occupancy, and radiolabeling of potent phosphodiesterase subtype-10 inhibitors as candidates for positron emission tomography imaging.
PubMed:
Stable heteroleptic complexes of divalent lanthanides with bulky pyrazolylborate ligands--iodides, hydrocarbyls and triethylborohydrides.
PubMed:
Structural correlations for (1)H, (13)C and (15)N NMR coordination shifts in Au(III), Pd(II) and Pt(II) chloride complexes with lutidines and collidine.
PubMed:
A new spin crossover heterometallic Fe(II)Ag(I) coordination polymer with the [Ag(2)(CN)(3)](-) unit: crystallographic and magnetic study.
PubMed:
Reactions of 'pincer' pyridine dicarbene complexes of Fe(0) with silanes.
PubMed:
Factors dictating the nuclearity/aggregation and acetate coordination modes of lutidine-coordinated zinc(II) acetate complexes.
PubMed:
Photomagnetism of a series of dinuclear Iron(II) complexes.
PubMed:
Theoretical studies on the molecular structure and vibrational spectra of some dimethyl substituted pyridine derivatives.
PubMed:
'Pincer' pyridine dicarbene complexes of nickel and their derivatives. Unusual ring opening of a coordinated imidazol-2-ylidene.
PubMed:
A three-dimensional open-framework indium selenide: [C(7)H(10)N][In(9)Se(14)].
PubMed:
Mononuclear and polynuclear copper(I) complexes with a new N,N',S-donor ligand and with structural analogies to the copper thionein core.
PubMed:
trans-Dichloridotetrakis(3,5-dimethylpyridine)copper(II).
PubMed:
Reaction of bis[bis(tri-tert-butoxysilanethiolato) cadmium(II)] with 3,5-dimethylpyridine - 113Cd NMR solution study.
PubMed:
The insertion reaction of acetonitrile on aryl nickel complexes stabilized by bidentate N,N'-chelating ligands.
PubMed:
2,6-Dibromo-3,5-dimethylpyridine and 2,6-diiodo-3,5-dimethylpyridine.
PubMed:
Characterization of ZnE (E = S, Se, or Te) materials synthesized using silylated chalcogen reagents in mesoporous MCM-41.
PubMed:
Sensitive quantification of omeprazole and its metabolites in human plasma by liquid chromatography-mass spectrometry.
PubMed:
Global kinetic model: a case study on the N-oxidation of alkylpyridines.
PubMed:
Rhenium oxo compounds containing eta2-pyrazolate ligands.
PubMed:
Kinetics and mechanisms of the electron transfer reactions of oxo-centred carboxylate bridged complexes, [Fe3(mu3-O)(O2CR)6L3]ClO4, with verdazyl radicals in acetonitrile solution.
PubMed:
Lanthanide(III)/actinide(III) differentiation in coordination of azine molecules to tris(cyclopentadienyl) complexes of cerium and uranium.
PubMed:
Simple synthesis of a weak nucleophilic base (4-ethyl-2,6-diisopropyl-3,5-dimethylpyridine) evidencing a double Janus group effect.
PubMed:
[Study on adductive reaction of Ni[(C4H9O)2PS2]2 with nitrogen base by spectrographic method].
PubMed:
Photoinduced axial ligation and deligation dynamics of nonplanar nickel dodecaarylporphyrins.
PubMed:
Mixed Chloride/Amine Complexes of Dimolybdenum(II,II). 4. Rotational Isomers of Mo(2)Cl(4)(R-py)(4) (R-py = 4-Picoline, 3,5-Lutidine, and 4-tert-Butylpyridine).
PubMed:
Synthesis and Structural Characterization of (1,4-Dihydropyrid-1-yl)aluminum Complexes.
PubMed:
Synthesis and Structure of Pd(II) Complexes Containing the C,C-Chelating Bis-Ylide Ligand [Ph(3)P=C(H)](2)CO. X-ray Crystal Structure of {Pd(&mgr;-Cl){[C(H)PPh(3)](2)CO}}(2)(ClO(4))(2).CH(2)Cl(2).
PubMed:
Monomeric Three- and Four-Coordinate Magnesium Amides.
PubMed:
Theoretical characterization of photoisomerization channels of dimethylpyridines on the singlet and triplet potential energy surfaces.
PubMed:
Understanding the orientation and dynamic motion of planar heterocyclic N-donor ligands by exploiting the symmetry properties of mixed-ligand mu-oxorhenium(V) dinuclear complexes.
PubMed:
Synthesis, Characterization, and Reactivity of Group 12 Metal Thiocarboxylates, M(SOCR)(2)Lut(2) [M = Cd, Zn; R = CH(3), C(CH(3))(3); Lut = 3,5-Dimethylpyridine (Lutidine)].
PubMed:
Structural, Spectroscopic, and Magnetochemical Characterization of the Trinuclear Vanadium(III) Carboxylates [V(3)O(O(2)CR)(6)L(3)](ClO(4)) (R = Various Groups; L = Pyridine, 4-Picoline, 3,5-Lutidine).
PubMed:
Comparative Kinetic Analysis of Reversible Intermolecular Electron-Transfer Reactions between a Series of Pentaammineruthenium Complexes and Cytochrome c.
PubMed:
Use of borinium ions as probes of steric effects in gas-phase ion-molecule complexes.
PubMed:
Buffer dependence of CO2 hydration catalyzed by human carbonic anhydrase I.