3,5-lutidine

pyridine, 3,5-dimethyl-

CAS: 591-22-0 C7 H9 N MW: 107.15573000 green

Identification

Name3,5-lutidine
IUPAC3,5-dimethylpyridine
CAS Number591-22-0
EINECS209-708-6
FDA UNII6Q4YPZ045V
Molecular FormulaC7 H9 N
Molecular Weight107.15573000
MDL NumberMFCD00006404
Nikkaji NumberJ6.756C
Beilstein0105682
CoE Number11382
XlogP31.80 (est)

Regulatory

DG SANTE Food Flavourings14.106 3,5-dimethylpyridine
FDA Mainterm (IAUFC)591-22-0 ; 3,5-DIMETHYLPYRIDINE

Physical Properties

Appearance colorless to pale yellow clear liquid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 0.93900 to 0.94500 @ 25.00 °C.
Pounds per Gallon - (est). 7.813 to 7.863
Refractive Index 1.50000 to 1.50600 @ 20.00 °C.
Melting Point -9.00 °C. @ 760.00 mm Hg
Boiling Point 170.00 to 172.00 °C. @ 760.00 mm Hg
Vapor Pressure 1.924000 mmHg @ 25.00 °C. (est)
Flash Point 128.00 °F. TCC ( 53.33 °C. )
logP (o/w) 1.780
Soluble in alcohol

No sensory data available

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavoring agents
Recommendation for 3,5-lutidine usage levels up tonot for fragrance use.
Maximised Survey-derived Daily Intakes (MSDI-EU)0.073 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI)400 (μg/person/day)
Threshold of Concern540 (μg/person/day)
Structure ClassII
Dairy products, excluding products of category 02.0 (01.0)0.40000
Fats and oils, and fat emulsions (type water-in-oil) (02.0)0.10000
Edible ices, including sherbet and sorbet (03.0)0.40000
Processed fruit (04.1)0.40000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2)-
Confectionery (05.0)1.00000
Chewing gum (05.3)-
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0)0.20000
Bakery wares (07.0)2.00000
Meat and meat products, including poultry and game (08.0)0.20000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0)0.20000
Eggs and egg products (10.0)-
Sweeteners, including honey (11.0)-
Salts, spices, soups, sauces, salads, protein products, etc. (12.0)0.10000
Foodstuffs intended for particular nutritional uses (13.0)0.20000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1)0.20000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2)-
Ready-to-eat savouries (15.0)1.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0)0.20000

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Potential Uses

None Found

Natural Occurrence

tea - up to 0.15 mg/kg

Synonyms

3,5- dimethyl pyridine 3,5- dimethylpyridine pyridine, 3,5-dimethyl- US Patents: 3,931,166 - Certain 2,5-dimethyl-3-thiopyrazines PubMed: PET imaging shows loss of striatal PDE10A in patients with Huntington disease. US Patents: Flavoring agent PubMed: Utilizing proton transfer to produce molecular salts in bromanilic acid substituted-pyridine molecular complexes - predictable synthons? PubMed: Synthesis, characterization and X-ray structure of the adducts of bis(O-butyldithiocarbonato)nickel(II) with substituted pyridines. PubMed: Quantification of 18F-JNJ-42259152, a novel phosphodiesterase 10A PET tracer: kinetic modeling and test-retest study in human brain. PubMed: Excited-state characteristics of tetracyanidonitridorhenium(V) and -technetium(V) complexes with N-heteroaromatic ligands. PubMed: Preclinical evaluation of [(18)F]JNJ42259152 as a PET tracer for PDE10A. PubMed: Human biodistribution and dosimetry of 18F-JNJ42259152, a radioligand for phosphodiesterase 10A imaging. PubMed: [C7H10N][In3Se5]: a layered selenide with two indium coordination environments. PubMed: New π-arene ruthenium(II) piano-stool complexes with nitrogen ligands. PubMed: Molybdenum(VI) complexes of a 2,2'-biphenyl-bridged bis(amidophenoxide): competition between metal-ligand and metal-amidophenoxide π bonding. PubMed: Substitution reactions in dinuclear Ru-Hbpp complexes: an evaluation of through-space interactions. PubMed: Magnesium hydrides and the dearomatisation of pyridine and quinoline derivatives. PubMed: Synthesis, in vivo occupancy, and radiolabeling of potent phosphodiesterase subtype-10 inhibitors as candidates for positron emission tomography imaging. PubMed: Stable heteroleptic complexes of divalent lanthanides with bulky pyrazolylborate ligands--iodides, hydrocarbyls and triethylborohydrides. PubMed: Structural correlations for (1)H, (13)C and (15)N NMR coordination shifts in Au(III), Pd(II) and Pt(II) chloride complexes with lutidines and collidine. PubMed: A new spin crossover heterometallic Fe(II)Ag(I) coordination polymer with the [Ag(2)(CN)(3)](-) unit: crystallographic and magnetic study. PubMed: Reactions of 'pincer' pyridine dicarbene complexes of Fe(0) with silanes. PubMed: Factors dictating the nuclearity/aggregation and acetate coordination modes of lutidine-coordinated zinc(II) acetate complexes. PubMed: Photomagnetism of a series of dinuclear Iron(II) complexes. PubMed: Theoretical studies on the molecular structure and vibrational spectra of some dimethyl substituted pyridine derivatives. PubMed: 'Pincer' pyridine dicarbene complexes of nickel and their derivatives. Unusual ring opening of a coordinated imidazol-2-ylidene. PubMed: A three-dimensional open-framework indium selenide: [C(7)H(10)N][In(9)Se(14)]. PubMed: Mononuclear and polynuclear copper(I) complexes with a new N,N',S-donor ligand and with structural analogies to the copper thionein core. PubMed: trans-Dichloridotetrakis(3,5-dimethylpyridine)copper(II). PubMed: Reaction of bis[bis(tri-tert-butoxysilanethiolato) cadmium(II)] with 3,5-dimethylpyridine - 113Cd NMR solution study. PubMed: The insertion reaction of acetonitrile on aryl nickel complexes stabilized by bidentate N,N'-chelating ligands. PubMed: 2,6-Dibromo-3,5-dimethylpyridine and 2,6-diiodo-3,5-dimethylpyridine. PubMed: Characterization of ZnE (E = S, Se, or Te) materials synthesized using silylated chalcogen reagents in mesoporous MCM-41. PubMed: Sensitive quantification of omeprazole and its metabolites in human plasma by liquid chromatography-mass spectrometry. PubMed: Global kinetic model: a case study on the N-oxidation of alkylpyridines. PubMed: Rhenium oxo compounds containing eta2-pyrazolate ligands. PubMed: Kinetics and mechanisms of the electron transfer reactions of oxo-centred carboxylate bridged complexes, [Fe3(mu3-O)(O2CR)6L3]ClO4, with verdazyl radicals in acetonitrile solution. PubMed: Lanthanide(III)/actinide(III) differentiation in coordination of azine molecules to tris(cyclopentadienyl) complexes of cerium and uranium. PubMed: Simple synthesis of a weak nucleophilic base (4-ethyl-2,6-diisopropyl-3,5-dimethylpyridine) evidencing a double Janus group effect. PubMed: [Study on adductive reaction of Ni[(C4H9O)2PS2]2 with nitrogen base by spectrographic method]. PubMed: Photoinduced axial ligation and deligation dynamics of nonplanar nickel dodecaarylporphyrins. PubMed: Mixed Chloride/Amine Complexes of Dimolybdenum(II,II). 4. Rotational Isomers of Mo(2)Cl(4)(R-py)(4) (R-py = 4-Picoline, 3,5-Lutidine, and 4-tert-Butylpyridine). PubMed: Synthesis and Structural Characterization of (1,4-Dihydropyrid-1-yl)aluminum Complexes. PubMed: Synthesis and Structure of Pd(II) Complexes Containing the C,C-Chelating Bis-Ylide Ligand [Ph(3)P=C(H)](2)CO. X-ray Crystal Structure of {Pd(&mgr;-Cl){[C(H)PPh(3)](2)CO}}(2)(ClO(4))(2).CH(2)Cl(2). PubMed: Monomeric Three- and Four-Coordinate Magnesium Amides. PubMed: Theoretical characterization of photoisomerization channels of dimethylpyridines on the singlet and triplet potential energy surfaces. PubMed: Understanding the orientation and dynamic motion of planar heterocyclic N-donor ligands by exploiting the symmetry properties of mixed-ligand mu-oxorhenium(V) dinuclear complexes. PubMed: Synthesis, Characterization, and Reactivity of Group 12 Metal Thiocarboxylates, M(SOCR)(2)Lut(2) [M = Cd, Zn; R = CH(3), C(CH(3))(3); Lut = 3,5-Dimethylpyridine (Lutidine)]. PubMed: Structural, Spectroscopic, and Magnetochemical Characterization of the Trinuclear Vanadium(III) Carboxylates [V(3)O(O(2)CR)(6)L(3)](ClO(4)) (R = Various Groups; L = Pyridine, 4-Picoline, 3,5-Lutidine). PubMed: Comparative Kinetic Analysis of Reversible Intermolecular Electron-Transfer Reactions between a Series of Pentaammineruthenium Complexes and Cytochrome c. PubMed: Use of borinium ions as probes of steric effects in gas-phase ion-molecule complexes. PubMed: Buffer dependence of CO2 hydration catalyzed by human carbonic anhydrase I.