p-dioxane-2,5-dione, 3,6-dimethyl- (8CI)

CAS: 95-96-5 C6 H8 O4 MW: 144.12656000

Identification

Namelactide
CAS Number95-96-5
EINECS202-468-3
FDA UNII7EH08MWO6M
Molecular FormulaC6 H8 O4
Molecular Weight144.12656000
MDL NumberMFCD00011685
Nikkaji NumberJ4.715E

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 285.50 °C. @ 760.00 mm Hg (est)
Flash Point 303.00 °F. TCC ( 150.60 °C. ) (est)
logP (o/w) -1.450 (est)
Soluble in water, 3165 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesabrasives

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-rat LD50 > 5000 mg/kg
Dermal Toxicityskin-rabbit LD50 > 2000 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryabrasives, skin conditioning
Recommendation for lactide usage levels up tonot for fragrance use.
Recommendation for lactide flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

dilactide 3,6- dimethyl-1,4-dioxane-2,5-dione 3,6- dimethyl-2,5-dioxo-1,4-dioxane 1,4- dioxane-2,5-dione, 3,6-dimethyl- p- dioxane-2,5-dione, 3,6-dimethyl- (8CI) lactic acid, bimol. cyclic ester propanoic acid, 2-hydroxy-, bimol. cyclic ester PubMed: Biodegradable polylactide microspheres enhance specific immune response induced by Hepatitis B surface antigen. PubMed: Docetaxel Loaded PEG-PLGA Nanoparticles: Optimized Drug Loading, In-vitro Cytotoxicity and In-vivo Antitumor Effect. PubMed: Creep loading during degradation attenuates mechanical property loss in PLGA. PubMed: Delivery of phytochemicals of tropical fruit by-products using poly (DL-lactide-co-glycolide) (PLGA) nanoparticles: synthesis, characterization, and antimicrobial activity. PubMed: Biodegradable polylactide microspheres enhance specific immune response induced by Hepatitis B surface antigen. PubMed: Detection of PLGA-based nanoparticles at a single-cell level by synchrotron radiation FTIR spectromicroscopy and correlation with X-ray fluorescence microscopy. PubMed: Properties of poly(lactide)-whey protein isolate laminated films. PubMed: Physicochemical features and transfection properties of chitosan/poloxamer 188/poly(D,L-lactide-co-glycolide) nanoplexes. PubMed: Effects of N-octyl lactate as plasticizer on the thermal and functional properties of extruded PLA-based films. PubMed: Development of Yersinia pestis F1 antigen-loaded microspheres vaccine against plague. PubMed: Tumor Antigen-Derived Peptides Delivery for Cancer Immunotherapy. PubMed: Stereolithography in tissue engineering. PubMed: Preparation and physicochemical characteristics of polylactide microspheres of emamectin benzoate by modified solvent evaporation/extraction method. PubMed: Interactions of flavoured oil in-water emulsions with polylactide. PubMed: Characterization of load dependent creep behavior in medically relevant absorbable polymers. PubMed: Advances in nanomedicines for malaria treatment. PubMed: Bioactive lipids in pathological retinopathy. PubMed: Effect of chain-extenders on the properties and hydrolytic degradation behavior of the poly(lactide)/poly(butylene adipate-co-terephthalate) blends. PubMed: Preparation and characterization of poly(L-lactide)-co-poly(trimethylene carbonate)/talc film. PubMed: In vitro and in vivo study of sustained nitric oxide release coating using diazeniumdiolate-oped poly(vinyl chloride) matrix with poly(lactide-co-glycolide) additive. PubMed: Curcumin protects neuronal-like cells against acrolein by restoring Akt and redox signaling pathways. PubMed: Biodegradable poly([D,L]-lactide-co-glycolide) nanofibers for the sustainable delivery of lidocaine into the epidural space after laminectomy. PubMed: PLGA nanoparticle entrapped killed porcine reproductive and respiratory syndrome virus vaccine helps in viral clearance in pigs. PubMed: Local demixion in plasticized polylactide probed by electron spin resonance. PubMed: Effect of composition ratio on the thermal and physical properties of semicrystalline PLA/PHB-HHx composites. PubMed: Antimicrobial efficacy of poly (DL-lactide-co-glycolide) (PLGA) nanoparticles with entrapped cinnamon bark extract against Listeria monocytogenes and Salmonella typhimurium. PubMed: Three-month subchronic intramuscular toxicity study of rotigotine-loaded microspheres in SD rats. PubMed: Evaluation of silver-infused polylactide films for inactivation of Salmonella and feline calicivirus in vitro and on fresh-cut vegetables. PubMed: Local and systemic immune responses in mice to intranasal delivery of peptides representing bovine respiratory syncytial virus epitopes encapsulated in poly (DL-lactide-co-glycolide) microparticles. PubMed: Biodegradable nanoparticle-entrapped vaccine induces cross-protective immune response against a virulent heterologous respiratory viral infection in pigs. PubMed: Three-month subchronic intramuscular toxicity study of rotigotine-loaded microspheres in Cynomolgus monkeys. PubMed: A biocompatible tissue scaffold produced by supercritical fluid processing for cartilage tissue engineering. PubMed: A novel radiopaque biodegradable stent for pancreatobiliary applications--the first human phase I trial in the pancreas. PubMed: Self-assembly and paclitaxel loading capacity of cellulose-graft-poly(lactide) nanomicelles. PubMed: Use of mid- and near-infrared spectroscopy to track degradation of bio-based eating utensils during composting. PubMed: Transparent films based on PLA and montmorillonite with tunable oxygen barrier properties. PubMed: The use of poly-L-lactic acid filler in facial aesthetics. PubMed: Can leptin-derived sequence-modified nanoparticles be suitable tools for brain delivery? PubMed: Design of an inhalable dry powder formulation of DOTAP-modified PLGA nanoparticles loaded with siRNA. PubMed: A toxicological and dermatological assessment of macrocyclic lactone and lactide derivatives when used as fragrance ingredients. PubMed: Fragrance material review on ethylene dodecanedioate. PubMed: Fragrance material review on ω-6-hexadecenlactone. PubMed: Fragrance material review on 16-hydroxy-7-hexadecenoic acid lactone. PubMed: Fragrance material review on hexadecanolide. PubMed: Fragrance material review on ω-pentadecalactone. PubMed: Fragrance material review on 10-oxahexadecanolide. PubMed: Fragrance material review on oxacyclohexadecane-2,13-dione. PubMed: Fragrance material review on oxacycloheptadec-10-ene-2-one. PubMed: Fragrance material review on 12-oxahexadecanolide. PubMed: Fragrance material review on 11-oxahexadecanolide. PubMed: Fragrance material review on E- and Z-oxacyclohexadec-12(+13)-en-2-one. PubMed: Fragrance material review on ethylene brassylate. PubMed: Effects of poly-(lactide-co-glycolide) nanoparticles on electrophysiological properties of enteroendocrine cells. PubMed: Poly (DL-lactide-co-glycolide) (PLGA) nanoparticles with entrapped trans-cinnamaldehyde and eugenol for antimicrobial delivery applications. PubMed: Thermal and rheological properties of L-polylactide/polyethylene glycol/silicate nanocomposites films. PubMed: Induction of nicotinamide-adenine dinucleotide phosphate oxidase and apoptosis by biodegradable polymers in macrophages: implications for stents. PubMed: Endostar-loaded PEG-PLGA nanoparticles: in vitro and in vivo evaluation. PubMed: Adipose-derived stem cells and BMP2: part 1. BMP2-treated adipose-derived stem cells do not improve repair of segmental femoral defects. PubMed: Preparation of fish gelatin and fish gelatin/poly(L-lactide) nanofibers by electrospinning. PubMed: Migration of antimicrobial silver from composites of polylactide with silver zeolites. PubMed: Rheological and thermal properties of polylactide/silicate nanocomposites films. PubMed: Equivalence randomized controlled trial of bioresorbable versus titanium miniplates in treatment of mandibular fracture: a pilot study. PubMed: Spectral and spatial characterization of protein loaded PLGA nanoparticles. PubMed: Pharmacokinetics and efficacy of a biweekly dosage formulation of exenatide in Zucker diabetic fatty (ZDF) rats. PubMed: Ammonolysis-based microencapsulation technique using isopropyl formate as dispersed solvent. PubMed: Preparation of antimicrobial membranes: coextrusion of poly(lactic acid) and Nisaplin in the presence of Plasticizers. PubMed: Properties of poly(lactide)-coated paperboard for the use of 1-way paper cup. PubMed: Activation of lactoperoxidase system in milk by glucose oxidase immobilized in electrospun polylactide microfibers. PubMed: Migration of lactic acid, lactide and oligomers from polylactide food-contact materials. PubMed: Effect of filler content and size on transport properties of water vapor in PLA/calcium sulfate composites. PubMed: [Preparation of biodegradable and sustained release gel of tinidazole]. PubMed: PLGA 90/10 and caprolactone biodegradable nerve guides for the reconstruction of the rat sciatic nerve. PubMed: Microencapsulation of insulin into biodegradable microcapsules by the high voltage field method. PubMed: Poly(D,L-lactide-co-glycolide acid) nanoparticles for DNA delivery: waiving preparation complexity and increasing efficiency. PubMed: Electrospray encapsulation of water-soluble protein with polylactide. I. Effects of formulations and process on morphology and particle size. PubMed: Electrospray encapsulation of water-soluble protein with polylactide. Effects of formulations on morphology, encapsulation efficiency and release profile of particles. PubMed: Indications and limitations in resorbable P(L70/30DL)LA osteosyntheses of displaced mandibular fractures in 4.5-year follow-up. PubMed: An overview of polylactides as packaging materials. PubMed: Biodegradable microparticles for the mucosal delivery of antibacterial and dietary antigens. PubMed: Rapid endo-lysosomal escape of poly(DL-lactide-co-glycolide) nanoparticles: implications for drug and gene delivery. PubMed: Alternative methods of terminal sterilization for biologically active macromolecules. PubMed: The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. PubMed: Oral tolerance elicited in mice by beta-lactoglobulin entrapped in biodegradable microspheres. PubMed: Toxicity of lactide in dogs after 2 and 13 weeks of daily oral dosing. PubMed: Biocompatibility of a biodegradable in situ forming implant system in rhesus monkeys. PubMed: Controlled drug delivery by biodegradable poly(ester) devices: different preparative approaches. PubMed: Adjuvanticity and protective immunity elicited by Bordetella pertussis antigens encapsulated in poly(DL-lactide-co-glycolide) microspheres. PubMed: Safety assessment of polylactide (PLA) for use as a food-contact polymer. PubMed: Medical devices; reclassification and codification of absorbable poly(glycolide/L-lactide) surgical suture--FDA. Final rule.