phloretic acid

4-hydroxybenzenepropanoic acid

CAS: 501-97-3 C9 H10 O3 MW: 166.17630000

Identification

Namephloretic acid
CAS Number501-97-3
EINECS207-931-3
FDA UNII6QNC6P18SR
Molecular FormulaC9 H10 O3
Molecular Weight166.17630000
MDL NumberMFCD00002778
Nikkaji NumberJ1.565B
Beilstein2209841
XlogP31.20 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 352.40 °C. @ 760.00 mm Hg (est)
Flash Point 358.00 °F. TCC ( 181.10 °C. ) (est)
logP (o/w) 1.100 (est)
Soluble in water, 6.182e+004 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintravenous-mouse LD50 1809 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for phloretic acid usage levels up tonot for fragrance use.
Recommendation for phloretic acid flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

arrowroot leaf avocado peanut plant

Synonyms

dihydro-p-coumaric acid hydro-p-coumaric acid 4- hydroxybenzenepropanoic acid 3-(4- hydroxyphenyl) propionic acid 3-(4- hydroxyphenyl)propanoic acid 3-(4- hydroxyphenyl)propionic acid 3-(p- hydroxyphenyl)propionic acid beta-(p- hydroxyphenyl)propionic acid PubMed: Cytotoxic and Anti-metastatic Activities of Phenolic Compounds from Dendrobium ellipsophyllum. PubMed: Human intestinal microbial metabolism of naringin. PubMed: In vivo evolution of metabolic pathways by homeologous recombination in mitotic cells. PubMed: Simple ligand exchange reactions enabling excellent dispersibility and stability of magnetic nanoparticles in polar organic, aromatic, and protic solvents. PubMed: Fecal microbial metabolism of polyphenols and its effects on human gut microbiota. PubMed: Influence of physically crosslinked gelatins on the vasculature in the avian chorioallantoic membrane. 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PubMed: Optimization of ultrasound-accelerated synthesis of enzymatic octyl hydroxyphenylpropionate by response surface methodology. PubMed: Profiling of phenols in human fecal water after raspberry supplementation. PubMed: Use of 3-(4-hydroxyphenyl)propionic acid as electron donating compound in a potentiometric aflatoxin M1-immunosensor. PubMed: Proanthocyanidin metabolites associated with dietary fibre from in vitro colonic fermentation and proanthocyanidin metabolites in human plasma. PubMed: Quantitative analysis of plasma caffeic and ferulic acid equivalents by liquid chromatography tandem mass spectrometry. PubMed: Sensitive fluorescent probes for determination of hydrogen peroxide and glucose based on enzyme-immobilized magnetite/silica nanoparticles. PubMed: The bioavailability of apigenin-7-glucoside is influenced by human intestinal microbiota in rats. PubMed: Injectable chitosan-based hydrogels for cartilage tissue engineering. 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PubMed: Isolation, structure elucidation and antioxidant potential of the major phenolic and flavonoid compounds in brined olive drupes. PubMed: Singlet oxygen-mediated protein oxidation: evidence for the formation of reactive side chain peroxides on tyrosine residues. PubMed: Synthesis and antiproliferative activity of a new compound containing an alpha-methylene-gamma-lactone group. PubMed: Molecularly imprinted polymer using-p-hydroxybenzoic acid, p-hydroxyphenylacetic acid and p-hydroxyphenylpropionic acid as templates. PubMed: Phenylpropanoid interconversion in Anigozanthos preissii observed by high-performance liquid chromatography-nuclear magnetic resonance spectroscopy. PubMed: Kinetic model for phenolic compound oxidation by Fenton's reagent. PubMed: Eosinophils are a major source of nitric oxide-derived oxidants in severe asthma: characterization of pathways available to eosinophils for generating reactive nitrogen species. PubMed: 3-hydroxy-3-phenylpropanoic acid is an intermediate in the biosynthesis of benzoic acid and salicylic acid but benzaldehyde is not. PubMed: A sandwich enzyme immunoassay for pulmonary surfactant protein D and measurement of its blood levels in drowning victims. PubMed: Urinary metabolites of 4-n-nonylphenol in rainbow trout (Oncorhynchus mykiss). PubMed: A sandwich enzyme immunoassay for human muscle-specific beta-enolase and its application for the determination of skeletal muscle injury. PubMed: Characterization of biliary metabolites of 4-n-nonylphenol in rainbow trout (Oncorhynchus mykiss). PubMed: A sandwich enzyme immunoassay for brain S-100 protein and its forensic application. PubMed: Radical scavenger activity of three flavonoid metabolites studied by inhibition of chemiluminescence in human PMNs. PubMed: Effects of glycine and bovine serum albumin on inhibition of propionate metabolism in ovine hepatocytes caused by reduced phenolic monomers. PubMed: Portal and hepatic fluxes in sheep and concentrations in cattle ruminal fluid of 3-(4-hydroxyphenyl)propionic, benzoic, 3-phenylpropionic, and trans-cinnamic acids. PubMed: (Z)-3-(4-bromophenyl)-3-(3-pyridyl)allylamine as substrate for studies of myeloperoxidase activity. PubMed: Effects of reduced phenolic acids on metabolism of propionate and palmitate in bovine liver tissue in vitro. PubMed: A highly sensitive sandwich enzyme immunoassay for human liver-specific antigen (LSA) and its forensic application. PubMed: Receptor-mediated endocytosis of retinol-binding protein by liver parenchymal cells: interference by radioactive iodination. PubMed: Impairment of macrophage function in Mongolian gerbils. PubMed: A sensitive sandwich enzyme immunoassay for gamma-seminoprotein and its application to sex discrimination of blood and bloodstains. PubMed: A comparison of the sensitivity and specificity of enzyme immunoassays and time-resolved fluoroimmunoassay. PubMed: 3-p-hydroxyphenylpropionic acid--a sensitive fluorogenic substrate for automated fluorometric enzyme immunoassays. PubMed: Hydra head activator-like immunoreactivity in human brain astrocytomas grade III-IV and the surrounding brain tissue. PubMed: Pharmacokinetics of dermatan sulfate in the rabbit after intravenous injection. PubMed: Sensitive sandwich enzyme immunoassay of human growth hormone (hGH) in serum and urine using monoclonal antibody-coated polystyrene balls. PubMed: A highly specific and sensitive sandwich enzyme immunoassay for human hemoglobin A. PubMed: Sandwich enzyme immunoassay for human interleukin-1 beta (hIL-1 beta) in urine. PubMed: Crystal structure of phlorizin and the iodothyronine deiodinase inhibitory activity of phloretin analogues. PubMed: [Pharmacokinetic and pharmacological studies on cetraxate, an anti-ulcer agent]. PubMed: Dihydrochalcone metabolism in the rat: phloretin. PubMed: 3-(p-hydroxyphenyl)propionic acid as a new fluorogenic reagent for amine oxidase assays. PubMed: Radioimmunoassay of delta sleep-inducing peptide using an iodinated p-hydroxyphenylpropionic acid derivative as tracer. PubMed: Influence of plant phenolic acids on growth and cellulolytic activity of rumen bacteria. PubMed: Enzyme immunoassay of cyclazocine using peroxidase as label. PubMed: Structural specificity in the renal tubular transport of tyrosine. PubMed: Production of p-hydroxyhydrocinnamic acid from tyrosine by Peptostreptococcus anaerobius. PubMed: A new rearrangement reaction in tyrosine metabolism. PubMed: Hormone-receptor studies with avidin and biotinylinsulin-avidin complexes. PubMed: Production of indole-3-propanoic acid and 3-(p-hydroxyphenyl)propanoic acid by Clostridium sporogenes: a convenient thin-layer chromatography detection system. PubMed: NH2-terminal monoiodination of hexadecapeptide gastrin: a simple procedure for preparation of 125I-gastrin for radioimmunoassays and receptors studies. PubMed: The genome-linked protein of picornaviruses. VI. The 5'-terminal protein of poliovirus type 2RNA is covalently linked to a nonanucleotide identical to that of poliovirus type 1 RNA. PubMed: O4-(5'-uridylyl)tyrosine is the bond between the genome-linked protein and the RNA of poliovirus. PubMed: Neocarzinostatin: effect of modification of side chain amino and carboxyl groups on chemical and biological properties. PubMed: Preparation of 125I-labeled oligosaccharide derivatives with the aid of 3-(4-hydroxyphenyl)propionic acid N-hydroxysuccinimide ester. PubMed: A radioimmunoassay for human serum myoglobin: method development and normal values. PubMed: Solubilization of nerve growth factor receptors of rabbit superior cervical ganglia. PubMed: Some properties of p-coumarate decarboxylase from Cladosporium phlei. PubMed: Radioimmunoassay of sisomicin. PubMed: Radioimmunoassay of iodinated gentamicin. PubMed: The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. PubMed: Isolation of phloretic acid from plant material. PubMed: An inducible hydrolase from Aspergillus niger, acting on carbon-carbon bonds, for phlorrhizin and other C-acylated phenols. PubMed: Metabolism of phloridzin by Erwinia herbicola: nature of the degradation products, and the purification and properties of phloretin hydrolase. PubMed: DL-2-Hydrazino-3-(4-hydroxyphenyl)propionic acid. PubMed: Chromatographic degradation of phloridzin. PubMed: Phloretic acid and phlorin as products of degradation of phloridzin during chromatography in systems containing ammonia.