3-amino-1H-1,2,4-triazole

CAS: 61-82-5 C2 H4 N4 MW: 84.08188000

Identification

Nameamitrole
CAS Number61-82-5
EINECS200-521-5
FDA UNIIZF80H5GXUF
Molecular FormulaC2 H4 N4
Molecular Weight84.08188000
MDL NumberMFCD00005230
Nikkaji NumberJ2.345K
Beilstein107687

Regulatory

Physical Properties

Appearance white powder (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 159.00 °C. @ 760.00 mm Hg
Boiling Point 347.20 °C. @ 760.00 mm Hg (est)
Vapor Pressure 4.400000 mmHg @ 25.00 °C. (est)
Flash Point 375.00 °F. TCC ( 190.70 °C. ) (est)
logP (o/w) -0.860
Soluble in water, 2.80E+05 mg/L @ 25 °C (exp)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintraperitoneal-mouse LD50 200 mg/kg
Dermal Toxicityskin-rat LD50 > 10000 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryherbicides / pesticides
Recommendation for amitrole usage levels up tonot for fragrance use.
Recommendation for amitrole flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

3- amino-1,2,4-triazole 2- amino-1,3,4-triazole 3- amino-1H-1,2,4-triazole 2- aminotriazole amitrol amizol D cytrole diurol 5030 emisol 50 fenavar herbidal total herbizole kleer-lot orga-414 radoxone TL ramizol simazol 1H-1,2,4- triazol-3-ylamine 1H-1,2,4- triazol-5-amine vorox AA weedar ADS weedazin weedazol weedazol T weedoclor x-all liquid PubMed: Rapid detection of pesticides not amenable to multi-residue methods by flow injection-tandem mass spectrometry. PubMed: Aminotriazole attenuated carbon tetrachloride-induced oxidative liver injury in mice. PubMed: β-ODAP accumulation could be related to low levels of superoxide anion and hydrogen peroxide in Lathyrus sativus L. PubMed: Protective mechanism of quercetin and rutin using glutathione metabolism on HO-induced oxidative stress in HepG2 cells. PubMed: Determination of amitrole in environmental water samples with precolumn derivatization by high-performance liquid chromatography. PubMed: Oxidative alterations induced by D-aspartic acid in prepubertal rat testis in vitro: a mechanistic study. PubMed: [Effects of amitrole on thyroid hormone-associated gene transcription in FRTL-5 cells]. PubMed: Autism: transient in utero hypothyroxinemia related to maternal flavonoid ingestion during pregnancy and to other environmental antithyroid agents. PubMed: Thyroid status regulates CART but not AgRP mRNA levels in the rat hypothalamus. PubMed: Acetylation of 5-amino-1H-[1,2,4]triazole revisited. PubMed: Prepro-orexin mRNA levels in the rat hypothalamus, and orexin receptors mRNA levels in the rat hypothalamus and adrenal gland are not influenced by the thyroid status. PubMed: Butylated hydroxyanisole and its metabolite tert-butylhydroquinone differentially regulate mitogen-activated protein kinases. The role of oxidative stress in the activation of mitogen-activated protein kinases by phenolic antioxidants. PubMed: Pentachlorophenol-induced oxidative DNA damage in mouse liver and protective effect of antioxidants. PubMed: Effects of aminotriazole on ethanol, water, and food intake and on brain catalase in UChA and UChB rats. PubMed: A role for thyroid hormones in cold-induced elevation of blood pressure and cardiac hypertrophy. PubMed: Production of β-damascenone precursors in cell cultures of Vitis labruscana cv Concord grapes. PubMed: Effects of 3-amino-1,2,4-triazole on brain catalase in the mediation of ethanol consumption in mice. PubMed: Origin of reactive oxygen species in erythrocytes infected with Plasmodium falciparum. PubMed: Response of the medullary thick ascending limb to hypothyroidism in the rat. PubMed: Kidney structure in hypothyroidism. PubMed: Reversal by theophylline of some changes characteristically accompanying hypothyroidism in rats. PubMed: Potential carcinogenicity of food additives and contaminants. PubMed: Absorption of herbicides by wheat as influenced by the phenoxy compound. PubMed: Insecticide inhibition of herbicide metabolism in leaf tissues. PubMed: Extraction of 3-amino-1,2,4-triazole (amitrole) and 2,6-dichloro-4-nitroaniline (DCNA) from soils.