3-chloro-1,2-propane diol

3-chloro-1,2-propanediol

CAS: 96-24-2 C3 H7 Cl O2 MW: 110.53919000

Identification

Name3-chloro-1,2-propane diol
CAS Number96-24-2
EINECS202-492-4
FDA UNIIQGS78A3T6P
Molecular FormulaC3 H7 Cl O2
Molecular Weight110.53919000
MDL NumberMFCD00004712
Nikkaji NumberJ3.965I
Beilstein0635684

Regulatory

Physical Properties

Appearance colorless to pale yellow clear liquid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.32200 @ 25.00 °C.
Boiling Point 213.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure 0.200000 mmHg @ 20.00 °C. (est)
Flash Point > 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w) -0.760 (est)
Soluble in water, 1.00E+06 mg/L @ 20 °C (exp)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-bird - wild LD50 23700 ug/kg
Dermal Toxicityskin-rabbit LD50 800 uL/kg
Inhalation Toxicityinhalation-mouse LC50 > 90 ppm/4H

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryherbicides / pesticides
Recommendation for 3-chloro-1,2-propane diol usage levels up tonot for fragrance use.
Recommendation for 3-chloro-1,2-propane diol flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

1- chloro-1-deoxyglycerol 3- chloro-1,2-dihydroxypropane (±)-3- chloro-1,2-propanediol 3- chloro-1,2-propanediol 3- chloro-1,2-propylene glycol 1- chloro-2,3-dihydroxypropane 1- chloro-2,3-propanediol a- chlorohydrin a-mono chlorohydrin a- chlorohydrine 3- chloropropane-1,2-diol 3-mono chloropropane-1,2-diol 1- chloropropane-2,3-diol 3- chloropropylene glycol 3- chlorpropan-1,2-diol (±)-2,3- dihydroxychloropropane 2,3- dihydroxypropyl chloride glycerin a-monochlorhydrin glycerin epichlorohydrin glycerine a-monochlorohydrin glycerol 3-chlorohydrin glycerol a-monochlorohydrin glycerol a-monochlorohydrin [UN2689] [Keep away from food] glycerol chlorohydrin a- glycerol chlorohydrin glyceryl a-chlorohydrin glyceryl-a-chlorohydrin 1,2- propanediol, 3-chloro- PubMed: A novel approach of periodate oxidation coupled with HPLC-FLD for the quantitative determination of 3-chloro-1,2-propanediol in water and vegetable oil. PubMed: Metabonomic analysis of urine from rats after low-dose exposure to 3-chloro-1,2-propanediol using UPLC-MS. PubMed: A new, direct analytical method using LC-MS/MS for fatty acid esters of 3-chloro-1,2-propanediol (3-MCPD esters) in edible oils. PubMed: Absorption and metabolism of the food contaminant 3-chloro-1,2-propanediol (3-MCPD) and its fatty acid esters by human intestinal Caco-2 cells. PubMed: Migration studies of 3-chloro-1,2-propanediol (3-MCPD) in polyethylene extrusion-coated paperboard food packaging. PubMed: Carcinogenicity study of 3-monochloropropane-1, 2-diol (3-MCPD) administered by drinking water to B6C3F1 mice showed no carcinogenic potential. PubMed: Novel biomarkers of 3-chloro-1,2-propanediol exposure by ultra performance liquid chromatography/mass spectrometry based metabonomic analysis of rat urine. PubMed: Mixed sorbent phases for thick film open tubular traps. PubMed: Hydrolysis and H2O2-assisted UV photolysis of 3-chloro-1,2-propanediol. PubMed: Rational design of solid catalysts for the selective use of glycerol as a natural organic building block. PubMed: Occurrence of 3-MCPD fatty acid esters in human breast milk. PubMed: Esters of 3-chloro-1,2-propanediol (3-MCPD) in vegetable oils: significance in the formation of 3-MCPD. PubMed: A reinvestigation of the synthesis of arsonolipids (2,3-diacyloxypropylarsonic acids). PubMed: Evaluation of certain food additives and contaminants. PubMed: The selective neurotoxicity produced by 3-chloropropanediol in the rat is not a result of energy deprivation. PubMed: [Study on elimination of 3-chloro-1,2-propanediol in hydrolyzed vegetable protein by capillary electrophoresis with electrochemical detection]. PubMed: Removal of 1,3-dichloro2-propanol and 3-chloro1,2-propanediol by the whole cell system of pseudomonas putida DSM 437. PubMed: Determination of rate constants and activation energy of 3-chloro-1,2-propanediol hydrolysis by capillary electrophoresis with electrochemical detection. PubMed: Biodegradation of 3-chloro-1,2-propanediol with Saccharomyces cerevisiae. PubMed: Model studies on the formation of monochloropropanediols in the presence of lipase. PubMed: [Study on the toxicological effect of chloropropanols on rats]. PubMed: Evaluation of certain food additives and contaminants. PubMed: Determination of 3-chloro-1,2-propanediol in foods and food ingredients by gas chromatography with mass spectrometric detection: collaborative study. PubMed: Conformational features of reduced and disulfide intact forms of hen egg white lysozyme in aqueous solution in presence of 3-chloro-1, 2-propanediol and dioxane: implications for protein folding intermediates. PubMed: Determination of halogenated mono-alcohols and diols in water by gas chromatography with electron-capture detection. PubMed: Analytical methods for the determination of 3-chloro-1,2-propandiol and 2-chloro-1,3-propandiol in hydrolysed vegetable protein, seasonings and food products using gas chromatography/ion trap tandem mass spectrometry. PubMed: Biochemical characterization of a haloalcohol dehalogenase from Arthrobacter erithii H10a. PubMed: The vicinal chloroalcohols 1,3-dichloro-2-propanol (DC2P), 3-chloro-1,2-propanediol (3CPD) and 2-chloro-1,3-propanediol (2CPD) are not genotoxic in vivo in the wing spot test of Drosophila melanogaster. PubMed: Antifertility potential of ornidazole analogues in rats. PubMed: Toxicity to transferred rat embryos after aspirin treatment during preimplantation stage in vivo. PubMed: Purification and Characterization of Two Epoxide Hydrolases from Corynebacterium sp. Strain N-1074. PubMed: Utilization of a short-term male reproductive toxicity study design to examine effects of alpha-chlorohydrin (3-chloro-1,2-propanediol). PubMed: Production of (R)-3-Chloro-1,2-Propanediol from Prochiral 1,3-Dichloro-2-Propanol by Corynebacterium sp. Strain N-1074. PubMed: Resolution and some properties of enzymes involved in enantioselective transformation of 1,3-dichloro-2-propanol to (R)-3-chloro-1,2-propanediol by Corynebacterium sp. strain N-1074. PubMed: Identification and quantitative analysis of urinary metabolites of dichloropropanols in rats. PubMed: Purification and characterization of haloalcohol dehalogenase from Arthrobacter sp. strain AD2. PubMed: Malignant transformation of mouse M2-fibroblasts by glycerol chlorohydrines contained in protein hydrolysates and commercial food. PubMed: NTP Toxicology and Carcinogenesis Studies of Glycidol (CAS No. 556-52-5) In F344/N Rats and B6C3F1 Mice (Gavage Studies). PubMed: Genotoxicity, metabolism and blood kinetics of epichlorohydrin in mice. PubMed: The comparative effects of 1,2-dibromo-3-chloropropane (DBCP) and its metabolites, 3-chloro-1,2-propaneoxide (epichlorohydrin), 3-chloro-1,2-propanediol (alphachlorohydrin), and oxalic acid, on the urogenital system of male rats. PubMed: Mutagenicity of glycerol chlorohydrines and of their esters with higher fatty acids present in protein hydrolysates. PubMed: Measurement of Metabolites Associated with Nonaqueously Isolated Starch Granules from Immature Zea mays L. Endosperm. PubMed: A Nonaqueous Procedure for Isolating Starch Granules with Associated Metabolites from Maize (Zea mays L.) Endosperm. PubMed: Antifertility activity of alpha-chlorohydrin (3-chloro-1, 2 propanediol, U-5897) on the female rats. PubMed: Effect of alpha-chlorohydrin on the male reproductive organs of the Indian langur. PubMed: DNA synthesis in HeLa cell nuclei isolated in a non-aqueous medium. PubMed: Chemical sterilization: effects of a single high dose of 3-chloro-1,2-propanediol on the testes and epididymides of dog. PubMed: Biochemical changes in the female genital tract of the hedgehog following 3-chloro-1,2-propanediol administration. PubMed: Observations of the effects of 3-chloro-1,2-propanediol on the female reproductive tract and pituitary gonadotrophs of the gerbil (Meriones hurrianae). PubMed: Studies on the male anti-fertility drug 3-chloro-1,2-propanediol. PubMed: [Effect of 3-chloro-1,2-propanediol on the tests and seminal vesicles in rats. Histochemical study]. PubMed: New developments in contraceptive agents. PubMed: Bulk isolation in nonaqueous media of nuclei from lyophilized cells. PubMed: Antifertility activity of 3-chloro-1, 2-propanediol (U-5897) on male rats. PubMed: Nature and site of action of 3-chloro-1,2-propanediol--an oral antifertility agent for the male. PubMed: Possible mechanism of posttesticular antifertility action of 3-chloro-1,2-propanediol.