3-chloro-1,2-propane diol
3-chloro-1,2-propanediol
Identification
| Name | 3-chloro-1,2-propane diol |
| CAS Number | 96-24-2 |
| EINECS | 202-492-4 |
| FDA UNII | QGS78A3T6P |
| Molecular Formula | C3 H7 Cl O2 |
| Molecular Weight | 110.53919000 |
| MDL Number | MFCD00004712 |
| Nikkaji Number | J3.965I |
| Beilstein | 0635684 |
Regulatory
Physical Properties
| Appearance | colorless to pale yellow clear liquid (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 1.32200 @ 25.00 °C. |
| Boiling Point | 213.00 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 0.200000 mmHg @ 20.00 °C. (est) |
| Flash Point | > 230.00 °F. TCC ( > 110.00 °C. ) |
| logP (o/w) | -0.760 (est) |
| Soluble in | water, 1.00E+06 mg/L @ 20 °C (exp) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-bird - wild LD50 23700 ug/kg |
| Dermal Toxicity | skin-rabbit LD50 800 uL/kg |
| Inhalation Toxicity | inhalation-mouse LC50 > 90 ppm/4H |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | herbicides / pesticides |
| Recommendation for 3-chloro-1,2-propane diol usage levels up to | not for fragrance use. |
| Recommendation for 3-chloro-1,2-propane diol flavor usage levels up to | not for flavor use. |
Potential Uses
Natural Occurrence
Synonyms
1-
chloro-1-deoxyglycerol
3-
chloro-1,2-dihydroxypropane
(±)-3-
chloro-1,2-propanediol
3-
chloro-1,2-propanediol
3-
chloro-1,2-propylene glycol
1-
chloro-2,3-dihydroxypropane
1-
chloro-2,3-propanediol
a-
chlorohydrin
a-mono
chlorohydrin
a-
chlorohydrine
3-
chloropropane-1,2-diol
3-mono
chloropropane-1,2-diol
1-
chloropropane-2,3-diol
3-
chloropropylene glycol
3-
chlorpropan-1,2-diol
(±)-2,3-
dihydroxychloropropane
2,3-
dihydroxypropyl chloride
glycerin a-monochlorhydrin
glycerin epichlorohydrin
glycerine a-monochlorohydrin
glycerol 3-chlorohydrin
glycerol a-monochlorohydrin
glycerol a-monochlorohydrin [UN2689] [Keep away from food]
glycerol chlorohydrin
a-
glycerol chlorohydrin
glyceryl a-chlorohydrin
glyceryl-a-chlorohydrin
1,2-
propanediol, 3-chloro-
PubMed:
A novel approach of periodate oxidation coupled with HPLC-FLD for the quantitative determination of 3-chloro-1,2-propanediol in water and vegetable oil.
PubMed:
Metabonomic analysis of urine from rats after low-dose exposure to 3-chloro-1,2-propanediol using UPLC-MS.
PubMed:
A new, direct analytical method using LC-MS/MS for fatty acid esters of 3-chloro-1,2-propanediol (3-MCPD esters) in edible oils.
PubMed:
Absorption and metabolism of the food contaminant 3-chloro-1,2-propanediol (3-MCPD) and its fatty acid esters by human intestinal Caco-2 cells.
PubMed:
Migration studies of 3-chloro-1,2-propanediol (3-MCPD) in polyethylene extrusion-coated paperboard food packaging.
PubMed:
Carcinogenicity study of 3-monochloropropane-1, 2-diol (3-MCPD) administered by drinking water to B6C3F1 mice showed no carcinogenic potential.
PubMed:
Novel biomarkers of 3-chloro-1,2-propanediol exposure by ultra performance liquid chromatography/mass spectrometry based metabonomic analysis of rat urine.
PubMed:
Mixed sorbent phases for thick film open tubular traps.
PubMed:
Hydrolysis and H2O2-assisted UV photolysis of 3-chloro-1,2-propanediol.
PubMed:
Rational design of solid catalysts for the selective use of glycerol as a natural organic building block.
PubMed:
Occurrence of 3-MCPD fatty acid esters in human breast milk.
PubMed:
Esters of 3-chloro-1,2-propanediol (3-MCPD) in vegetable oils: significance in the formation of 3-MCPD.
PubMed:
A reinvestigation of the synthesis of arsonolipids (2,3-diacyloxypropylarsonic acids).
PubMed:
Evaluation of certain food additives and contaminants.
PubMed:
The selective neurotoxicity produced by 3-chloropropanediol in the rat is not a result of energy deprivation.
PubMed:
[Study on elimination of 3-chloro-1,2-propanediol in hydrolyzed vegetable protein by capillary electrophoresis with electrochemical detection].
PubMed:
Removal of 1,3-dichloro2-propanol and 3-chloro1,2-propanediol by the whole cell system of pseudomonas putida DSM 437.
PubMed:
Determination of rate constants and activation energy of 3-chloro-1,2-propanediol hydrolysis by capillary electrophoresis with electrochemical detection.
PubMed:
Biodegradation of 3-chloro-1,2-propanediol with Saccharomyces cerevisiae.
PubMed:
Model studies on the formation of monochloropropanediols in the presence of lipase.
PubMed:
[Study on the toxicological effect of chloropropanols on rats].
PubMed:
Evaluation of certain food additives and contaminants.
PubMed:
Determination of 3-chloro-1,2-propanediol in foods and food ingredients by gas chromatography with mass spectrometric detection: collaborative study.
PubMed:
Conformational features of reduced and disulfide intact forms of hen egg white lysozyme in aqueous solution in presence of 3-chloro-1, 2-propanediol and dioxane: implications for protein folding intermediates.
PubMed:
Determination of halogenated mono-alcohols and diols in water by gas chromatography with electron-capture detection.
PubMed:
Analytical methods for the determination of 3-chloro-1,2-propandiol and 2-chloro-1,3-propandiol in hydrolysed vegetable protein, seasonings and food products using gas chromatography/ion trap tandem mass spectrometry.
PubMed:
Biochemical characterization of a haloalcohol dehalogenase from Arthrobacter erithii H10a.
PubMed:
The vicinal chloroalcohols 1,3-dichloro-2-propanol (DC2P), 3-chloro-1,2-propanediol (3CPD) and 2-chloro-1,3-propanediol (2CPD) are not genotoxic in vivo in the wing spot test of Drosophila melanogaster.
PubMed:
Antifertility potential of ornidazole analogues in rats.
PubMed:
Toxicity to transferred rat embryos after aspirin treatment during preimplantation stage in vivo.
PubMed:
Purification and Characterization of Two Epoxide Hydrolases from Corynebacterium sp. Strain N-1074.
PubMed:
Utilization of a short-term male reproductive toxicity study design to examine effects of alpha-chlorohydrin (3-chloro-1,2-propanediol).
PubMed:
Production of (R)-3-Chloro-1,2-Propanediol from Prochiral 1,3-Dichloro-2-Propanol by Corynebacterium sp. Strain N-1074.
PubMed:
Resolution and some properties of enzymes involved in enantioselective transformation of 1,3-dichloro-2-propanol to (R)-3-chloro-1,2-propanediol by Corynebacterium sp. strain N-1074.
PubMed:
Identification and quantitative analysis of urinary metabolites of dichloropropanols in rats.
PubMed:
Purification and characterization of haloalcohol dehalogenase from Arthrobacter sp. strain AD2.
PubMed:
Malignant transformation of mouse M2-fibroblasts by glycerol chlorohydrines contained in protein hydrolysates and commercial food.
PubMed:
NTP Toxicology and Carcinogenesis Studies of Glycidol (CAS No. 556-52-5) In F344/N Rats and B6C3F1 Mice (Gavage Studies).
PubMed:
Genotoxicity, metabolism and blood kinetics of epichlorohydrin in mice.
PubMed:
The comparative effects of 1,2-dibromo-3-chloropropane (DBCP) and its metabolites, 3-chloro-1,2-propaneoxide (epichlorohydrin), 3-chloro-1,2-propanediol (alphachlorohydrin), and oxalic acid, on the urogenital system of male rats.
PubMed:
Mutagenicity of glycerol chlorohydrines and of their esters with higher fatty acids present in protein hydrolysates.
PubMed:
Measurement of Metabolites Associated with Nonaqueously Isolated Starch Granules from Immature Zea mays L. Endosperm.
PubMed:
A Nonaqueous Procedure for Isolating Starch Granules with Associated Metabolites from Maize (Zea mays L.) Endosperm.
PubMed:
Antifertility activity of alpha-chlorohydrin (3-chloro-1, 2 propanediol, U-5897) on the female rats.
PubMed:
Effect of alpha-chlorohydrin on the male reproductive organs of the Indian langur.
PubMed:
DNA synthesis in HeLa cell nuclei isolated in a non-aqueous medium.
PubMed:
Chemical sterilization: effects of a single high dose of 3-chloro-1,2-propanediol on the testes and epididymides of dog.
PubMed:
Biochemical changes in the female genital tract of the hedgehog following 3-chloro-1,2-propanediol administration.
PubMed:
Observations of the effects of 3-chloro-1,2-propanediol on the female reproductive tract and pituitary gonadotrophs of the gerbil (Meriones hurrianae).
PubMed:
Studies on the male anti-fertility drug 3-chloro-1,2-propanediol.
PubMed:
[Effect of 3-chloro-1,2-propanediol on the tests and seminal vesicles in rats. Histochemical study].
PubMed:
New developments in contraceptive agents.
PubMed:
Bulk isolation in nonaqueous media of nuclei from lyophilized cells.
PubMed:
Antifertility activity of 3-chloro-1, 2-propanediol (U-5897) on male rats.
PubMed:
Nature and site of action of 3-chloro-1,2-propanediol--an oral antifertility agent for the male.
PubMed:
Possible mechanism of posttesticular antifertility action of 3-chloro-1,2-propanediol.