3-deazauridine

3- deazuridine 1-[(2R,3R,4S,5R)-3,4- dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxypyridin-2-one 4- hydroxy-1-beta-D-ribofuranosyl-2(1H)-pyridinone 4- hydroxy-1-beta-D-ribofuranosyl-2(1H)-pyridone 2(1H)- pyridinone, 4-hydroxy-1-b-D-ribofuranosyl- 2(1H)- pyridinone, 4-hydroxy-1-beta-D-ribofuranosyl- PubMed: Constitutive activation of the ATM/BRCA1 pathway prevents DNA damage-induced apoptosis in 5-azacytidine-resistant cell lines. PubMed: Discovery of novel ribonucleoside analogs with activity against human immunodeficiency virus type 1. PubMed: Synthesis of C3-arylated-3-deazauridine derivatives with potent anti-HSV-1 activities. PubMed: Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway. PubMed: 3-Deazauridine enhances the antileukemic action of 5-aza-2'-deoxycytidine and targets drug-resistance due to deficiency in deoxycytidine kinase. PubMed: Synthesis and biological evaluation of 3,3-difluoropyridine-2,4(1H,3H)-dione and 3-deaza-3-fluorouracil base and nucleoside derivatives. PubMed: Synthesis of methylene- and difluoromethylenephosphonate analogues of uridine-4-phosphate and 3-deazauridine-4-phosphate. PubMed: The 1.48 A resolution crystal structure of the homotetrameric cytidine deaminase from mouse. PubMed: Electrophysiological characterization and modeling of the structure activity relationship of the human concentrative nucleoside transporter 3 (hCNT3). PubMed: 3-Deazauridine triggers dose-dependent apoptosis in myeloid leukemia cells and enhances retinoic acid-induced granulocytic differentiation of HL-60 cells. PubMed: Correlation of nucleoside and nucleobase transporter gene expression with antimetabolite drug cytotoxicity. PubMed: Potentiation of the anti-HIV activity of zalcitabine and lamivudine by a CTP synthase inhibitor, 3-deazauridine. PubMed: Role of antimetabolites of purine and pyrimidine nucleotide metabolism in tumor cell differentiation. PubMed: Possible involvement of DNA methylation in 5-azacytidine-induced neuronal cell apoptosis. PubMed: The IMP dehydrogenase inhibitor mycophenolic acid antagonizes the CTP synthetase inhibitor 3-deazauridine in MOLT-3 human leukemia cells: a central role for phosphoribosyl pyrophosphate. PubMed: Gemcitabine: a modulator of intracellular nucleotide and deoxynucleotide metabolism. PubMed: Antiviral studies of feline infectious peritonitis virus in vitro. PubMed: Inhibition of CTP synthetase induces differentiation of HL-60 cells and down-regulation of the c-myc oncogene. PubMed: Enhancement of anti-neoplastic activity of cytosine arabinoside against human HL-60 myeloid leukemic cells by 3-deazauridine. PubMed: Biological activity of 3-deazauridine nucleoside analogue: a theoretical study. PubMed: Modulation of cytosine arabinoside toxicity by 3-deazauridine in a murine leukemia model. PubMed: Synthesis of two cyclopentenyl-3-deazapyrimidine carbocyclic nucleosides related to cytidine and uridine. PubMed: Synthesis, antitumor activity, and antiviral activity of 3-substituted 3-deazacytidines and 3-substituted 3-deazauridines. PubMed: Antiviral and cytotoxicity evaluation of 3-nitro-3-deazauridine. PubMed: Inhibitory effect of selected antiviral compounds on measles (SSPE) virus replication in vitro. PubMed: Dual effects of pyrazofurin and 3-deazauridine upon pyrimidine and purine biosynthesis in mouse L1210 leukemia. PubMed: Chemotherapy of L1210 and L1210/ARA-C leukemia with 5-aza-2'-deoxycytidine and 3-deazauridine. PubMed: A newly developed immunofluorescent assay for determining the Pichinde virus-inhibitory effects of selected nucleoside analogues. PubMed: Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties. PubMed: 2',3'-Dideoxycytidine: regulation of its metabolism and anti-retroviral potency by natural pyrimidine nucleosides and by inhibitors of pyrimidine nucleotide synthesis. PubMed: Inhibitory effects of antiviral compounds on respiratory syncytial virus replication in vitro. PubMed: Synergistic activity of purine metabolism inhibitors in cultured human tumor cells. PubMed: Role of uridine triphosphate in the phosphorylation of 1-beta-D-arabinofuranosylcytosine by Ehrlich ascites tumor cells. PubMed: Effect of deoxycytidine on the in vitro response of human leukemia cells to inhibitors of de novo pyrimidine biosynthesis. PubMed: Homogeneous uridine kinase from Ehrlich ascites tumor: substrate specificity and inhibition by bisubstrate analogs. PubMed: The effect of 3-deazauridine and dipyridamole on uridine utilization by mice. PubMed: Approaches to overcome in vivo anti-cancer drug resistance. PubMed: 3-Deazauridine (NSC 126849): an interesting modulator of biochemical response. PubMed: Analysis of candidate anticancer drugs by thermospray high-performance liquid chromatography-mass spectrometry and by high-resolution mass spectrometry. PubMed: Uridine kinase from Ehrlich ascites carcinoma. Purification and properties of homogeneous enzyme. PubMed: Effects of pyrimidine antagonists on sialic acid regeneration in HL-60 cells. PubMed: Synthesis of optically active beta-lactams using the photochemical reaction of 3-deazauridines. PubMed: Effect of uridine on response of 5-azacytidine-resistant human leukemic cells to inhibitors of de novo pyrimidine synthesis. PubMed: Regulation of pyrimidine biosynthesis in cultured L1210 cells by 3-deazauridine. PubMed: Pleiotropic mutants of Chinese hamster cells with altered cytidine 5'-triphosphate synthetase. PubMed: Cytotoxic and biochemical effects of thymidine and 3-deazauridine on human tumor cells. PubMed: Specificity and sodium dependence of the active nucleoside transport system in choroid plexus. PubMed: Transport of uridine and 3-deazauridine in cultured human lymphoblastoid cells. PubMed: Quantitative determination of nucleosides and their phosphate esters--1. The acidic nucleosides, 3-deazauridine and 6-azauridine. PubMed: Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications. PubMed: Labelling of the thymidine and deoxycytidine bases of DNA by [2-14C]deoxycytidine in cultured L1210 cells. PubMed: Effect of 3-deazauridine on the metabolism, toxicity, and antitumor activity of azacitidine in mice bearing L1210 leukemia sensitive and resistant to cytarabine. PubMed: Kinetics of deamination of 5-aza-2'-deoxycytidine and cytosine arabinoside by human liver cytidine deaminase and its inhibition by 3-deazauridine, thymidine or uracil arabinoside. PubMed: Hemodynamic effects of potentially useful antineoplastic agents. PubMed: Synthesis of diazaphenoxathiin nucleosides from 3-deazauridine and their chemical properties. PubMed: Sample preparation and estimation of plasma concentration of 3-deazauridine by high-performance liquid chromatography. PubMed: Synthesis of pyridazine analogues of the naturally occurring nucleosides cytidine, uridine, deoxycytidine, and deoxyuridine. PubMed: Phase II study of 3-deazauridine in advanced colorectal adenocarcinoma. PubMed: Synthetic studies on 3-deazauridine derivatives. PubMed: Drug control of Ara-C-resistant tumor cells. PubMed: Phase I trial and pharmacokinetics of a daily x 5 schedule of 3-deazauridine. PubMed: Inhibition of rotaviruses by selected antiviral substances: mechanisms of viral inhibition and in vivo activity. PubMed: Optical activity and electronic absorption spectra of some simple nucleosides related to cytidine and uridine: all-valence-shell molecular orbital calculations. PubMed: Induction of differentiation of human promyelocytic leukemia cells (HL-60) by nucleosides and methotrexate. PubMed: Inhibition of bluetongue and Colorado tick fever orbiviruses by selected antiviral substances. PubMed: Cell cycle arrest as a basis of enhancement of 1-beta-D-arabinofuranosylcytosine anabolism in human lymphoblastoid RPMI 6410 cells cultured with 3-deazauridine. PubMed: Phase I--II study of 3-deazauridine in adults with acute leukemia. PubMed: In vivo cellular kinetic and pharmacological studies of 1-beta-D-arabinofuranosylcytosine and 3-deazauridine chemotherapy for relapsing acute leukemia. PubMed: Simultaneous determination of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate and 3-deazauridine 5'-triphosphate in human leukemia cells by high-performance liquid chromatography. PubMed: Altered 5-azacytidine metabolism following 3-deazauridine treatment of L5178Y and human myeloblasts. PubMed: Phosphorylation of nucleosides catalyzed by a mammalian enzyme other than uridine-cytidine kinase. PubMed: Molecular orbital studies on the structure of nucleoside analogs. III. Conformation of 3-deazapyrimidine nucleosides. PubMed: Cytidine and deoxycytidylate deaminase inhibition by uridine analogs. PubMed: Phase I study of 3-deazauridine in the treatment of adults with solid tumors. PubMed: Intracellular nucleotide pools and their significance in antimetabolite therapy. PubMed: Penetration of 3-deazauridine into human brain, intracerebral tumor, and cerebrospinal fluid. PubMed: Synergistic action of 5-aza-2'-deoxycytidine and 3-deazauridine on L1210 leukemic cells and EMT6 tumor cells. PubMed: Drug sequence-dependent toxicity and small bowel mucosal injury in mice treated with low doses of 3-deazauridine and 1-beta-D-arabinofuranosylcytosine. PubMed: Enzyme pattern-directed chemotherapy. Effects of antipyrimidine combinations on the ribonucleotide content of hepatomas. PubMed: Biochemical and pharmacological effects of the fermentation-derived antitumor agent, (alphaS,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125). PubMed: High-pressure liquid chromatographic analysis of 3-deazauridine-5'-triphosphate in human cancer cells. PubMed: Pharmacokinetics and disposition of 3-deazauridine in humans. PubMed: Ara-C metabolism: implications for drug resistance and drug interactions. PubMed: The regulation of thymidylate biosynthesis in Novikoff hepatoma cells and the effects of amethopterin, 5-fluorodeoxyuridine, and 3-deazauridine. PubMed: Conformation of pyridazine nucleosides: the molecular structure of 4-hydroxy-1-(beta-D-ribofuranosyl)pyridazin-6-one (3-deaza-6-azauridine). PubMed: Formation of 1-beta-D-arabinofuranosylcytosine diphosphate choline in neoplastic and normal cells. PubMed: Formation of 1-beta-D-arabinofuranosylcytosine diphosphate choline in cultured human leukemic RPMI 6410 cells. PubMed: The disposition of 3-deazauridine in mice. PubMed: Toxicity of combinations of arabinosylcytosine and 3-deazauridine toward neoplastic cells in culture. PubMed: Multiple basis of combination chemotherapy. PubMed: Selective inhibition of RNA tumor virus replication in vitro and evaluation of candidate antiviral agents in vivo. PubMed: Effects of 2-deoxy-D-glucose and 3 deazauridine individually and in combination on the replication of Japanese B encephalitis virus. PubMed: Enzyme pattern-directed chemotherapy: synergistic interaction of 3-deazauridine with D-galactosamine. PubMed: Nucleic acid related compounds. 17.3-Deazuridine. Stannous chloride catalysis of cis-diol vs. phenolic base methylation with diazomethane. PubMed: The effects of nucleoside analogs on cutaneous neoplasms. PubMed: The mechanism of action of 3-deazauridine in tumor cells sensitive and resistant to arabinosylcytosine. PubMed: The structure of nucleosides in relation to their biological and and biochemical activity: a summary. PubMed: Synthesis and biological activity of 4-beta-Iribofuranosyl-1,3-dihydroxybenzene ("1,3-dideazauridine"). PubMed: Cytidine 5'-triphosphate synthetase as a target for inhibition by the antitumor agent 3-deazauridine. PubMed: Prevention by testosterone of the intestinal toxicity caused by the antitumor agent 3-deazauridine. PubMed: Inhibition of gross leukemia virus-induced plaque formation in XC cells by 3-deazauridine. PubMed: 3-Deazauridine: inhibition of ribonucleic acid virus-induced cytopathogenic effects in vitro. PubMed: 3-Deazauridine: crystal structure and conformation. PubMed: Codon-anticodon interaction studied with oligonucleotides containing 3 -deazauridine, 4 -deoxyuridine or 3 -deaza- 4 -deoxyuridine. II. Ribosome binding of oligonucleotides and phenylalanyl-tRNA. PubMed: Codon-anticodon interaction studied with oligonucleotides containing 3 -deazauridine, 4 -deoxyuridine or 3 -deaza- 4 -deoxyuridine. I. Synthesis by primer-dependent polynucleotide phosphorylase of oligonucleotides containing modofied nucleosides. PubMed: Inhibition of RNA virus replication in vitro by 3-deazacytidine and 3-deazauridine. PubMed: Studies on the mode of action of 3-deazapyrimidines. 1. Metabolism of 3-deazauridine and 3-deazacytidine in microbial and tumor cells.