monobenzone

hydroquinone monobenzyl ether

CAS: 103-16-2 C13 H12 O2 MW: 200.23704000

Identification

Namemonobenzone
IUPAC4-phenylmethoxyphenol
CAS Number103-16-2
EINECS203-083-3
FDA UNII9L2KA76MG5
Molecular FormulaC13 H12 O2
Molecular Weight200.23704000
MDL NumberMFCD00002333
Nikkaji NumberJ5.012A
Beilstein1958305
XlogP33.40 (est)

Regulatory

FDA Mainterm (IAUFC)103-16-2 ; HYDROQUINONE MONOBENZYL ETHER
FDA RegulationFDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS

Physical Properties

Appearance white crystalline powder (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 122.50 °C. @ 760.00 mm Hg
Boiling Point 359.00 to 360.00 °C. @ 760.00 mm Hg (est)
Flash Point 416.00 °F. TCC ( 213.40 °C. ) (est)
logP (o/w) 2.651 (est)
Soluble in water, 251.4 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintraperitoneal-rat LD50 4500 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypreservatives
Recommendation for monobenzone usage levels up tonot for fragrance use.
Recommendation for monobenzone flavor usage levels up tonot for flavor use.

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

View All Website 1-631-485-4226 account@bocsci.com

Glentham Life Sciences Ltd

The Chemical, Biochemical & Research Essentials Supplier

Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK.

View All Website +44 (0) 1225 667798 info@glentham.com

Jiangyin Healthway International Trade Co., Ltd

Independent Ingredients Supplier

We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.

View All Website 86-510-86023169 info@healthwaychem.com

TCI AMERICA

Moving Your Chemistry Forward

We continuously strive to advance our technology.

View All Website 1-800-423-8616 Sales-US@TCIchemicals.com;

Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

agerite alba p- benzoxyphenol para- benzoxyphenol 4-( benzyl oxy) phenol benzyl p-hydroxyphenyl ether benzyl para-hydroxyphenyl ether 4-( benzyl-oxy)phenol 4- benzyloxy phenol 4- benzyloxy-phenol p-( benzyloxy) phenol 4-( benzyloxy)benzolol 4-( benzyloxy)phenol p-( benzyloxy)phenol 4-( benzyloxyl)phenol 4- benzyloxyphenol p- benzyloxyphenol hydroquinone monobenzyl ether p- hydroxyphenyl benzyl ether phenol, 4-(phenylmethoxy)- phenol, 4-benzyloxy- phenol, p-(benzyloxy)- 4-( phenylmethoxy)phenol 4- phenylmethoxyphenol PubMed: Different effects of five depigmentary compounds, rhododendrol, raspberry ketone, monobenzone, rucinol and AP736 on melanogenesis and viability of human epidermal melanocytes. PubMed: A mouse model of vitiligo induced by monobenzone. PubMed: Monobenzone-induced depigmentation: from enzymatic blockade to autoimmunity. PubMed: Successful treatment of extensive vitiligo with monobenzone. PubMed: Skin-depigmenting agent monobenzone induces potent T-cell autoimmunity toward pigmented cells by tyrosinase haptenation and melanosome autophagy. PubMed: The therapeutic effects of EGCG on vitiligo. PubMed: Effective melanoma immunotherapy in mice by the skin-depigmenting agent monobenzone and the adjuvants imiquimod and CpG. PubMed: Pre-clinical evidences of Pyrostegia venusta in the treatment of vitiligo. PubMed: A reactive ortho-quinone generated by tyrosinase-catalyzed oxidation of the skin depigmenting agent monobenzone: self-coupling and thiol-conjugation reactions and possible implications for melanocyte toxicity. PubMed: Corneal and conjunctival effects of monobenzone in patients with vitiligo. PubMed: Monobenzone, Superfade, vitiligo and confetti-like depigmentation. PubMed: Dermatitis produced by applications of monobenzone in patients with active vitiligo. PubMed: Diffuse leukoderma following use of monobenzone. PubMed: MONOBENZONE. PubMed: Evaluation of monobenzone. PubMed: Enhanced bleaching treatment: opportunities for immune-assisted melanocyte suicide in vitiligo. PubMed: Breaking immunological tolerance to melanocyte differentiation antigens by hypopigmenting agents: a new means for melanoma immunotherapy? PubMed: Targeting melanocyte and melanoma stem cells by 8-hydroxy-2-dipropylaminotetralin. PubMed: Accelerating bleaching in vitiligo: balancing benefits versus risks. PubMed: Preferential secretion of inducible HSP70 by vitiligo melanocytes under stress. PubMed: Vitiligo-inducing phenols activate the unfolded protein response in melanocytes resulting in upregulation of IL6 and IL8. PubMed: Depigmentation therapies for normal skin in vitiligo universalis. PubMed: The development of guidelines for the treatment of vitiligo. Clinical Epidemiology Unit of the Istituto Dermopatico dell'Immacolata-Istituto di Recovero e Cura a Carattere Scientifico (IDI-IRCCS) and the Archives of Dermatology. PubMed: How we treat vitiligo. PubMed: Monobenzyl ether of hydroquinone and 4-tertiary butyl phenol activate markedly different physiological responses in melanocytes: relevance to skin depigmentation. PubMed: New and experimental treatments of vitiligo and other hypomelanoses. PubMed: Retinoic acid synergistically enhances the melanocytotoxic and depigmenting effects of monobenzylether of hydroquinone in black guinea pig skin. PubMed: Footwear depigmentation. PubMed: Rapid repigmentation after depigmentation therapy: vitiligo treated with monobenzyl ether of hydroquinone. PubMed: Achromic patch test from hydroquinone monobenzyl ether. PubMed: The Seiji memorial lecture. Pigment stories: from vitiligo to melanomas and points in between. PubMed: Contact depigmentation of the breast. PubMed: Should vitiligo be treated? PubMed: [Leukomelanodermia areata (dyschromia "en confetti") caused by the application of monobenzylether of hydroquinone (author's transl)]. PubMed: [Irreversible toxic depigmentation. Observations following use of hydroquinonemonobenzylether-containing skin bleaching preparations]. PubMed: Contact hypersensitivity to monobenzyl ether of hydroquinone used to treat vitiligo. PubMed: Dyschromatosis. PubMed: A case report of extensive vitiligo. PubMed: Treatment of nonhairy melanocytic macules by dermabrasion and topical application of 5% hydroquinone monobenzyl ether cream. PubMed: Hearing aid depigmentation. PubMed: Influence of depigmenting chemical agents on hair and skin color in yellow (pheomelanic) and black (eumelanic) mice. PubMed: [Confetti-like dyschromia caused by a bleaching cream containing hydroquinone in racially pigmented patients]. PubMed: Modulation of the population density of identifiable epidermal Langerhans cells associated with enhancement or suppression of cutaneous immune reactivity. PubMed: [Treatment of vitiligo]. PubMed: [Therapy of melanin-induced pigment anomalies]. PubMed: Sensitization to hydroquinone and the monobenzyl ether of hydroquinone. PubMed: [Acquired leukomelanoderma caused by topical depigmenting agents]. PubMed: Screening of depigmenting compounds for the development of an alternate method of branding beef cattle. PubMed: [Eye diseases attributable to dermatologic therapy]. PubMed: Vitiligo: a manifestation of apoptosis? PubMed: Vitiligo. PubMed: Cutaneous reactions to topical application of hydroquinone. Results of a 6-year investigation.