4-(tert-octyl) phenol
phenol, 4-(1,1,3,3-tetramethylbutyl)-
Identification
| Name | 4-(tert-octyl) phenol |
| IUPAC | 4-(2,4,4-trimethylpentan-2-yl)phenol |
| CAS Number | 140-66-9 |
| EINECS | 205-426-2 |
| FDA UNII | IOY9FVU3J3 |
| Molecular Formula | C14 H22 O |
| Molecular Weight | 206.32854000 |
| MDL Number | MFCD00002368 |
| Nikkaji Number | J1.190H |
| Beilstein | 0513992 |
| XlogP3 | 5.00 (est) |
Regulatory
| FDA Mainterm (SATF) | 140-66-9 ; ALPHA-{P-(1,1,3,3-TETRAMETHYLBUTYL)PHENYL}-OMEGA-HYDROXYPOLY(OXYETHYLENE) |
| FDA Regulation | FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION |
Physical Properties
| Food Chemicals Codex Listed | No |
| Melting Point | 84.00 to 85.00 °C. @ 760.00 mm Hg |
| Boiling Point | 282.30 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 0.002000 mmHg @ 25.00 °C. (est) |
| Flash Point | 299.00 °F. TCC ( 148.30 °C. ) (est) |
| logP (o/w) | 5.180 (est) |
| Soluble in | water, 4.821 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-rat LD50 4600 mg/kg |
| Dermal Toxicity | skin-rabbit LD50 1880 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | adjuvants for pesticide use dilutions |
| Recommendation for 4-(tert-octyl) phenol usage levels up to | not for fragrance use. |
| Recommendation for 4-(tert-octyl) phenol flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
4-t-
octylphenol
4-tert-
octylphenol
p-tert-
octylphenol
phenol, 4-(1,1,3,3-tetramethylbutyl)-
phenol, p-(1,1,3,3-tetramethylbutyl)-
phenol, p-(tert-octyl)-
4-(1,1,3,3-
tetramethyl butyl) phenol
4-(1,1,3,3-
tetramethyl-butyl)-phenol
4-(1,1,3,3-
tetramethyl-butyl)phenol
4-(1,1,3,3-
tetramethylbutyl)phenol
p-(1,1,3,3-
tetramethylbutyl)phenol
4-(2,4,4-
trimethyl-2-pentanyl)phenol
4-(2,4,4-
trimethylpentan-2-yl)phenol
PubMed:
A novel fatty-acid-based in-tube dispersive liquid-liquid microextraction technique for the rapid determination of nonylphenol and 4-tert-octylphenol in aqueous samples using high-performance liquid chromatography-ultraviolet detection.
PubMed:
Ameliorating effect of chicory (Chichorium intybus L.) fruit extract against 4-tert-octylphenol induced liver injury and oxidative stress in male rats.
PubMed:
Complete feminization of catfish by feeding Limnodilus, an annelid worm collected in contaminated streams.
PubMed:
Bisphenol A, 4-tert-octylphenol, and 4-nonylphenol in the Gulf of GdaÅsk (Southern Baltic).
PubMed:
Real-time growth kinetics measuring hormone mimicry for ToxCast chemicals in T-47D human ductal carcinoma cells.
PubMed:
Binding of the endocrine disruptors 4-tert-octylphenol and 4-nonylphenol to human serum albumin.
PubMed:
Determination of alkylphenols and phthalate esters in vegetables and migration studies from their packages by means of stir bar sorptive extraction coupled to gas chromatography-mass spectrometry.
PubMed:
Alkylphenols in human milk and their relations to dietary habits in central Taiwan.
PubMed:
Oral p-tert-octylphenol exposures induce minimal toxic or estrogenic effects in adult female Sprague-Dawley rats.
PubMed:
Analysis of phenolic xenoestrogens by pressurized CEC with amperometric detection.
PubMed:
Determination and residual characteristic of alkylphenols in household food detergents of Taiwan.
PubMed:
Plastic components affect the activation of the aryl hydrocarbon and the androgen receptor.
PubMed:
Determination of alkylphenol residues in baby-food purees by steam distillation extraction and gas chromatography-mass spectrometry.
PubMed:
Occurrence of alkylphenolic substances in a Great Lakes coastal marsh, Cootes Paradise, ON, Canada.
PubMed:
The toxic effects of 4-tert-octylphenol on the reproductive system of male rats.
PubMed:
[Estimation of daily intake of phenols in hospital meal samples].
PubMed:
Effects of 4-tert-octylphenol given in drinking water for 4 months on the male reproductive system of Fischer 344 rats.
PubMed:
Male reproductive effects of octylphenol and estradiol in Fischer and Wistar rats.
PubMed:
Determination of 4-octylphenol and 4-nonylphenol congeners in composite foods.
PubMed:
Effects of estrogenic and antiandrogenic compounds on the testis structure of the adult guppy (Poecilia reticulata).
PubMed:
Alkylphenol and bisphenol A levels in rubber products.
PubMed:
Evaluation of 4-nonylphenols and 4-tert-octylphenol contamination of fish in rivers by laboratory accumulation and excretion experiments.
PubMed:
Effects of 4-tert-octylphenol on initiation and maintenance of pregnancy following oral administration during early pregnancy in rats.
PubMed:
Endocrine disrupting compounds: effect of octylphenol on reproduction over three generations.
PubMed:
Identification and quantification of estrogenic compounds in recycled and virgin paper for household use as determined by an in vitro yeast estrogen screen and chemical analysis.
PubMed:
Chronic administration of the environmental pollutant 4-tert-octylphenol to adult male rats interferes with the secretion of luteinizing hormone, follicle-stimulating hormone, prolactin, and testosterone.