para-aminophenol
4-hydroxyaniline
Identification
| Name | para-aminophenol |
| IUPAC | 4-aminophenol |
| CAS Number | 123-30-8 |
| EINECS | 204-616-2 |
| FDA UNII | R7P8FRP05V |
| Molecular Formula | C6 H7 N O |
| Molecular Weight | 109.12799000 |
| MDL Number | MFCD00007869 |
| Nikkaji Number | J3.620J |
| Beilstein | 385836 |
Regulatory
Physical Properties
| Appearance | colorless crystals (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 187.50 °C. @ 760.00 mm Hg |
| Boiling Point | 284.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 0.002000 mmHg @ 25.00 °C. (est) |
| Flash Point | 256.00 °F. TCC ( 124.30 °C. ) (est) |
| logP (o/w) | 0.040 |
| Soluble in | water, 1.60E+04 mg/L @ 25 °C (exp) |
Cosmetic Information
| CosIng | ['cosmetic data2', 'cosmetic data'] |
| Cosmetic Uses | hair dyeing agents |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-bird - wild LD50 56200 ug/kg |
| Dermal Toxicity | subcutaneous-cat LDLo 37 mg/kg |
| Inhalation Toxicity | inhalation-rat LC50 > 5 mg/m3/1H |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | hair dyeing agents |
| Recommendation for para-aminophenol usage levels up to | not for fragrance use. |
| Recommendation for para-aminophenol flavor usage levels up to | not for flavor use. |
Glentham Life Sciences Ltd
The Chemical, Biochemical & Research Essentials Supplier
Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK.
Penta International Corporation
Chemistry innovation
At Penta, our products and services help businesses do business better.
Potential Uses
Natural Occurrence
Synonyms
activol
4-
amino-1-hydroxybenzene
1-
amino-4-hydroxybenzene
4-
amino-phenol
p-
aminobenzenol
4-
aminophenol
p-
aminophenol
p-
aminophenol [UN2512] [Poison]
aminophenol, p-
benzofur P
c.i. 76550
C.I. oxidation base 6
certinal
ci 76550
citol
durafur brown RB
energol
fouramine P
fourrine 84
fourrine P base
4-
hydroxyaniline
nako brown R
paranol
pelagol grey P base
pelagol P base
phenol, 4-amino-
phenol, p-amino-
renal AC
rodinal
tertral P base
ursol P
zoba brown P base
PubMed:
Gold nanocatalyst-based immunosensing strategy accompanying catalytic reduction of 4-nitrophenol for sensitive monitoring of chloramphenicol residue.
PubMed:
Sensitive bi-enzymatic biosensor based on polyphenoloxidases-gold nanoparticles-chitosan hybrid film-graphene doped carbon paste electrode for carbamates detection.
PubMed:
N-Acetyl-4-aminophenol (paracetamol), N-acetyl-2-aminophenol and acetanilide in urine samples from the general population, individuals exposed to aniline and paracetamol users.
PubMed:
Attenuation of uremia by orally feeding alpha-lipoic acid on acetaminophen induced uremic rats.
PubMed:
Biosensor based on multi-walled carbon nanotubes paste electrode modified with laccase for pirimicarb pesticide quantification.
PubMed:
Laccase-Prussian blue film-graphene doped carbon paste modified electrode for carbamate pesticides quantification.
PubMed:
Ultra sensitive microfluidic immunosensor for determination of clenbuterol in bovine hair samples using electrodeposited gold nanoparticles and magnetic micro particles as bio-affinity platform.
PubMed:
Effects and mechanisms of rifampin on hepatotoxicity of acetaminophen in mice.
PubMed:
Selective determination of catechin among phenolic antioxidants with the use of a novel optical fiber reflectance sensor based on indophenol dye formation on nano-sized TiOâ.
PubMed:
Simultaneous analysis of acetaminophen, p-aminophenol and aspirin metabolites by hydrophilic interaction and strong anion exchange capillary liquid chromatography coupled to amperometric detection.
PubMed:
A novel strategy for ultra-sensitive electrochemical immunoassay of biomarkers by coupling multifunctional iridium oxide (IrO(x)) nanospheres with catalytic recycling of self-produced reactants.
PubMed:
A graphene-based Au(111) platform for electrochemical biosensing based catalytic recycling of products on gold nanoflowers.
PubMed:
Enzyme-free electrochemical immunoassay with catalytic reduction of p-nitrophenol and recycling of p-aminophenol using gold nanoparticles-coated carbon nanotubes as nanocatalysts.
PubMed:
The therapeutic applications of and risks associated with acetaminophen use: a review and update.
PubMed:
Acute toxicity and mutagenesis of three metabolites mixture of nitrobenzene in mice.
PubMed:
Reproductive and developmental toxicity screening study of 4-aminophenol in rats.
PubMed:
Enzymatic recycling-based amperometric immunosensor for the ultrasensitive detection of okadaic acid in shellfish.
PubMed:
Structure analysis of aromatic medicines containing nitrogen using near-infrared spectroscopy and generalized two-dimensional correlation spectroscopy.
PubMed:
Generation of quinoneimine intermediates in the bioactivation of 3-(N-phenylamino)alanine (PAA) by human liver microsomes: a potential link between eosinophilia-myalgia syndrome and toxic oil syndrome.
PubMed:
Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice.
PubMed:
Electrochemical detection of cardiac troponin I using a microchip with the surface-functionalized poly(dimethylsiloxane) channel.
PubMed:
Synthesis and stability studies of the glutathione and N-acetylcysteine adducts of an iminoquinone reactive intermediate generated in the biotransformation of 3-(N-phenylamino)propane-1,2-diol: implications for toxic oil syndrome.
PubMed:
Plasma/blood pharmacokinetics and metabolism after dermal exposure to para-aminophenol or para-phenylenediamine.
PubMed:
Amperometric determination of live Escherichia coli using antibody-coated paramagnetic beads.
PubMed:
Preventive effect of Thea sinensis melanin against acetaminophen-induced hepatic injury in mice.
PubMed:
Toxicity and human health risk of hair dyes.
PubMed:
Metabolism of (R)- and (S)-3-(phenylamino)propane-1,2-diol in C57BL/6- and A/J-strain mice. Identification of new metabolites with potential toxicological significance to the toxic oil syndrome.
PubMed:
Analysis of the metabolites of the sodium salt of 6-hydroxy-5-(phenylazo)-2-naphthalenesulfonic acid in Sprague-Dawley rat urine.
PubMed:
Small volume bead assay for ovalbumin with electrochemical detection.
PubMed:
Effect of dietary 2(3)-tert-butyl-4-hydroxyanisole on the metabolism and action of estradiol and estrone in female CD-1 mice.
PubMed:
Increased renal drug metabolism in treadmill-exercised Fischer-344 male rats.
PubMed:
Hydroxyurea and p-aminophenol are the suicide inhibitors of ascorbate peroxidase.
PubMed:
The toxicity of p-aminophenol in the Sprague-Dawley rat: effects on growth, reproduction and foetal development.
PubMed:
Metabolic activation and nucleic acid binding of acetaminophen and related arylamine substrates by the respiratory burst of human granulocytes.
PubMed:
Multigeneration reproduction and carcinogenicity studies in Sprague-Dawley rats exposed topically to oxidative hair-colouring formulations containing p-phenylenediamine and other aromatic amines.
PubMed:
The influence of nutrition and inducers on mechanisms of toxicity in humans and animals.
PubMed:
Hemiglobin formation in vitro induced by azo dyes and their metabolites.
PubMed:
[Experimental studies of the semiquantitative determination of parathion methyl residues in food with thin layer chromatography (after reduction to p-aminophenol)].
PubMed:
Chemotherapy of fascioliasis. I. Derivatives of di-(p-aminophenyl) methane and p-aminophenol.