para-aminophenol

4-hydroxyaniline

CAS: 123-30-8 C6 H7 N O MW: 109.12799000

Identification

Namepara-aminophenol
IUPAC4-aminophenol
CAS Number123-30-8
EINECS204-616-2
FDA UNIIR7P8FRP05V
Molecular FormulaC6 H7 N O
Molecular Weight109.12799000
MDL NumberMFCD00007869
Nikkaji NumberJ3.620J
Beilstein385836

Regulatory

Physical Properties

Appearance colorless crystals (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 187.50 °C. @ 760.00 mm Hg
Boiling Point 284.00 °C. @ 760.00 mm Hg
Vapor Pressure 0.002000 mmHg @ 25.00 °C. (est)
Flash Point 256.00 °F. TCC ( 124.30 °C. ) (est)
logP (o/w) 0.040
Soluble in water, 1.60E+04 mg/L @ 25 °C (exp)

Cosmetic Information

CosIng['cosmetic data2', 'cosmetic data']
Cosmetic Useshair dyeing agents

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-bird - wild LD50 56200 ug/kg
Dermal Toxicitysubcutaneous-cat LDLo 37 mg/kg
Inhalation Toxicityinhalation-rat LC50 > 5 mg/m3/1H

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryhair dyeing agents
Recommendation for para-aminophenol usage levels up tonot for fragrance use.
Recommendation for para-aminophenol flavor usage levels up tonot for flavor use.

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Penta International Corporation

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Potential Uses

hair dyeing agents

Natural Occurrence

not found in nature

Synonyms

activol 4- amino-1-hydroxybenzene 1- amino-4-hydroxybenzene 4- amino-phenol p- aminobenzenol 4- aminophenol p- aminophenol p- aminophenol [UN2512] [Poison] aminophenol, p- benzofur P c.i. 76550 C.I. oxidation base 6 certinal ci 76550 citol durafur brown RB energol fouramine P fourrine 84 fourrine P base 4- hydroxyaniline nako brown R paranol pelagol grey P base pelagol P base phenol, 4-amino- phenol, p-amino- renal AC rodinal tertral P base ursol P zoba brown P base PubMed: Gold nanocatalyst-based immunosensing strategy accompanying catalytic reduction of 4-nitrophenol for sensitive monitoring of chloramphenicol residue. PubMed: Sensitive bi-enzymatic biosensor based on polyphenoloxidases-gold nanoparticles-chitosan hybrid film-graphene doped carbon paste electrode for carbamates detection. PubMed: N-Acetyl-4-aminophenol (paracetamol), N-acetyl-2-aminophenol and acetanilide in urine samples from the general population, individuals exposed to aniline and paracetamol users. PubMed: Attenuation of uremia by orally feeding alpha-lipoic acid on acetaminophen induced uremic rats. PubMed: Biosensor based on multi-walled carbon nanotubes paste electrode modified with laccase for pirimicarb pesticide quantification. PubMed: Laccase-Prussian blue film-graphene doped carbon paste modified electrode for carbamate pesticides quantification. PubMed: Ultra sensitive microfluidic immunosensor for determination of clenbuterol in bovine hair samples using electrodeposited gold nanoparticles and magnetic micro particles as bio-affinity platform. PubMed: Effects and mechanisms of rifampin on hepatotoxicity of acetaminophen in mice. PubMed: Selective determination of catechin among phenolic antioxidants with the use of a novel optical fiber reflectance sensor based on indophenol dye formation on nano-sized TiO₂. PubMed: Simultaneous analysis of acetaminophen, p-aminophenol and aspirin metabolites by hydrophilic interaction and strong anion exchange capillary liquid chromatography coupled to amperometric detection. PubMed: A novel strategy for ultra-sensitive electrochemical immunoassay of biomarkers by coupling multifunctional iridium oxide (IrO(x)) nanospheres with catalytic recycling of self-produced reactants. PubMed: A graphene-based Au(111) platform for electrochemical biosensing based catalytic recycling of products on gold nanoflowers. PubMed: Enzyme-free electrochemical immunoassay with catalytic reduction of p-nitrophenol and recycling of p-aminophenol using gold nanoparticles-coated carbon nanotubes as nanocatalysts. PubMed: The therapeutic applications of and risks associated with acetaminophen use: a review and update. PubMed: Acute toxicity and mutagenesis of three metabolites mixture of nitrobenzene in mice. PubMed: Reproductive and developmental toxicity screening study of 4-aminophenol in rats. PubMed: Enzymatic recycling-based amperometric immunosensor for the ultrasensitive detection of okadaic acid in shellfish. PubMed: Structure analysis of aromatic medicines containing nitrogen using near-infrared spectroscopy and generalized two-dimensional correlation spectroscopy. PubMed: Generation of quinoneimine intermediates in the bioactivation of 3-(N-phenylamino)alanine (PAA) by human liver microsomes: a potential link between eosinophilia-myalgia syndrome and toxic oil syndrome. PubMed: Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice. PubMed: Electrochemical detection of cardiac troponin I using a microchip with the surface-functionalized poly(dimethylsiloxane) channel. PubMed: Synthesis and stability studies of the glutathione and N-acetylcysteine adducts of an iminoquinone reactive intermediate generated in the biotransformation of 3-(N-phenylamino)propane-1,2-diol: implications for toxic oil syndrome. PubMed: Plasma/blood pharmacokinetics and metabolism after dermal exposure to para-aminophenol or para-phenylenediamine. PubMed: Amperometric determination of live Escherichia coli using antibody-coated paramagnetic beads. PubMed: Preventive effect of Thea sinensis melanin against acetaminophen-induced hepatic injury in mice. PubMed: Toxicity and human health risk of hair dyes. PubMed: Metabolism of (R)- and (S)-3-(phenylamino)propane-1,2-diol in C57BL/6- and A/J-strain mice. Identification of new metabolites with potential toxicological significance to the toxic oil syndrome. PubMed: Analysis of the metabolites of the sodium salt of 6-hydroxy-5-(phenylazo)-2-naphthalenesulfonic acid in Sprague-Dawley rat urine. PubMed: Small volume bead assay for ovalbumin with electrochemical detection. PubMed: Effect of dietary 2(3)-tert-butyl-4-hydroxyanisole on the metabolism and action of estradiol and estrone in female CD-1 mice. PubMed: Increased renal drug metabolism in treadmill-exercised Fischer-344 male rats. PubMed: Hydroxyurea and p-aminophenol are the suicide inhibitors of ascorbate peroxidase. PubMed: The toxicity of p-aminophenol in the Sprague-Dawley rat: effects on growth, reproduction and foetal development. PubMed: Metabolic activation and nucleic acid binding of acetaminophen and related arylamine substrates by the respiratory burst of human granulocytes. PubMed: Multigeneration reproduction and carcinogenicity studies in Sprague-Dawley rats exposed topically to oxidative hair-colouring formulations containing p-phenylenediamine and other aromatic amines. PubMed: The influence of nutrition and inducers on mechanisms of toxicity in humans and animals. PubMed: Hemiglobin formation in vitro induced by azo dyes and their metabolites. PubMed: [Experimental studies of the semiquantitative determination of parathion methyl residues in food with thin layer chromatography (after reduction to p-aminophenol)]. PubMed: Chemotherapy of fascioliasis. I. Derivatives of di-(p-aminophenyl) methane and p-aminophenol.