4-benzoyl pyridine

pyridine, 4-benzoyl-

CAS: 14548-46-0 C12 H9 N O MW: 183.20993000 astringent

Identification

Name4-benzoyl pyridine
IUPACphenyl(pyridin-4-yl)methanone
CAS Number14548-46-0
EINECS238-586-7
FDA UNII524YQ3O21T
Molecular FormulaC12 H9 N O
Molecular Weight183.20993000
MDL NumberMFCD00006430
Nikkaji NumberJ15.003G
Beilstein0003864
XlogP32.00 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 72.00 °C. @ 760.00 mm Hg
Boiling Point 315.00 °C. @ 760.00 mm Hg, 130.00 to 131.00 °C. @ 1.00 mm Hg
Flash Point 302.00 °F. TCC ( 150.00 °C. )
logP (o/w) 1.980
Soluble in alcohol
Insoluble in water

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintraperitoneal-mouse LD50 520 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryinformation only not used for fragrances or flavors
Recommendation for 4-benzoyl pyridine usage levels up tonot for fragrance use.
Recommendation for 4-benzoyl pyridine flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

gamma- benzoyl pyridine 4- benzoylpyridine gamma- benzoylpyridine ketone, phenyl 4-pyridyl methanone, phenyl-4-pyridinyl- phenyl (4-pyridinyl) methanone phenyl 4-pyridyl ketone phenyl-4-pyridinylmethanone phenyl-pyridin-4-yl-methanone phenyl(4-pyridinyl)methanone phenyl(pyridin-4-yl)methanone pyridine, 4-benzoyl- 4- pyridyl phenyl ketone US Patents: 3,952,024 - Furfurylthioacetone PubMed: Photoinduced Oxidation of Secondary Alcohols Using 4-Benzoylpyridine as an Oxidant. US Patents: Certain 2,5-dimethyl-3-thiopyrazines PubMed: Generation of free oxygen atoms O((3)P) in solution by photolysis of 4-benzoylpyridine N-oxide. PubMed: Synthesis, structure, spectral, thermal and first-order molecular hyperpolarizability of 4-benzoylpyridine isonicotinyl hydrazone monohydrate single crystals. PubMed: Two copper(II) complexes with 4-benzoylpyridine ligand: synthesis, crystal structure and luminescent properties. PubMed: Comparative inhibition of tetrameric carbonyl reductase activity in pig heart cytosol by alkyl 4-pyridyl ketones. PubMed: S-nitrosoglutathione covalently modifies cysteine residues of human carbonyl reductase 1 and affects its activity. PubMed: Studies on the 4-benzoylpyridine-3-carboxamide entity as a fragment model of the Isoniazid-NAD adduct. PubMed: Stereoselective reduction of 4-benzoylpyridine in the heart of vertebrates. PubMed: 9,10-phenanthrenequinone, a component of diesel exhaust particles, inhibits the reduction of 4-benzoylpyridine and all-trans-retinal and mediates superoxide formation through its redox cycling in pig heart. PubMed: Towards the chemical control of molecular packing: syntheses and crystal structures of three trans-[NiL4(NCS)2] complexes. PubMed: Possible mechanism of superoxide formation through redox cycling of plumbagin in pig heart. PubMed: Different topologies in three manganese-μ-azido 1D compounds: magnetic behavior and DFT-quantum Monte Carlo calculations. PubMed: Rhenium-to-benzoylpyridine and rhenium-to-bipyridine MLCT excited states of fac-[Re(Cl)(4-benzoylpyridine)(2)(CO)(3)] and fac-[Re(4-benzoylpyridine)(CO)(3)(bpy)](+): a time-resolved spectroscopic and spectroelectrochemical study. PubMed: Two new one-dimensional compounds with end-to-end dicyanamide as a bridging ligand: syntheses and structural characterization of trans-[Mn(4-bzpy)2(N(CN)2)2]n and cis-[Mn(Bpy)(N(CN)2)2]n, (4-bzpy = 4-benzoylpyridine; bpy = 2,2'-bipyridyl). PubMed: Excited-state characteristics of tetracyanidonitridorhenium(V) and -technetium(V) complexes with N-heteroaromatic ligands. PubMed: Interindividual variability of carbonyl reductase levels in human livers. PubMed: Involvement of carbonyl reductase in superoxide formation through redox cycling of adrenochrome and 9,10-phenanthrenequinone in pig heart. PubMed: Inhibitory effects of flavonoids on rabbit heart carbonyl reductase. PubMed: Purification and catalytic properties of a tetrameric carbonyl reductase from rabbit heart. PubMed: Immunohistochemical localization and physiological regulation of carbonyl reductase in immature rat ovary. PubMed: Structural combination of established 5-HT(2A) receptor ligands: new aspects of the binding mode. PubMed: [Structure and function of peroxisomal tetrameric carbonyl reductase]. PubMed: Luminescence ranging from red to blue: a series of copper(I)-halide complexes having rhombic {Cu2(mu-X)2} (X = Br and I) units with N-heteroaromatic ligands. PubMed: Inhibition of rabbit heart carbonyl reductase by fatty acids. PubMed: Characterization of multiple forms of carbonyl reductase from chicken liver. PubMed: Effects of antiestrogens on ovarian aldo-keto reductase in relation to ovulation in rats. PubMed: Regulation of ovarian carbonyl reductase mediated by estrogen receptor in immature rats. PubMed: Carbonyl reductases from rat testis and vas deferens. Purification, properties and localization. PubMed: Different functions between human monomeric carbonyl reductase 3 and carbonyl reductase 1. PubMed: Inhibition of carbonyl reductase activity in pig heart by alkyl phenyl ketones. PubMed: Differences in catalytic activity between rat testicular and ovarian carbonyl reductases are due to two amino acids. PubMed: Characterization of multiple Chinese hamster carbonyl reductases. PubMed: Pre- and post-ovulatory changes in carbonyl reductase in ovarian follicles and corpora lutea in rats. PubMed: Carbonyl reductase activity exhibited by pig testicular 20 beta-hydroxysteroid dehydrogenase. PubMed: Inhibition of pink color development in cooked, uncured ground turkey through the binding of non-pink generating ligands to muscle pigments. PubMed: Effects of psychotropic drugs on aldo-keto reductase activity in rat ovary and adrenal gland. PubMed: Purification and characterization of 5 alpha-dihydrotestosterone 3 beta-hydroxysteroid dehydrogenase from mature pig testicular cytosol. PubMed: Structural requirements for the induction of hepatic microsomal cytochrome P450 by imidazole- and pyridine-containing compounds in rats. PubMed: Changes and localization of ovarian carbonyl reductase during pseudopregnancy and pregnancy in rats. PubMed: Physiological role of ovarian carbonyl reductase and effect of antiestrogen on its activity in rats. PubMed: Kinetic mechanisms in the reduction of aldehydes and ketones catalyzed by rabbit liver aldehyde reductases and hydroxysteroid dehydrogenases.