4-bromomethyl-7-methoxycoumarin
4-bromomethyl-7-methoxy-2-oxo-2H-benzopyran
Identification
| Name | 4-bromomethyl-7-methoxycoumarin |
| IUPAC | 4-(bromomethyl)-7-methoxychromen-2-one |
| CAS Number | 35231-44-8 |
| EINECS | 252-448-3 |
| FDA UNII | Search |
| Molecular Formula | C11 H9 Br O3 |
| Molecular Weight | 269.09433000 |
| MDL Number | MFCD00006869 |
| Nikkaji Number | J207.993C |
| Beilstein | 0187211 |
| XlogP3 | 2.40 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 385.30 °C. @ 760.00 mm Hg (est) |
| Flash Point | 368.00 °F. TCC ( 186.80 °C. ) (est) |
| logP (o/w) | 2.730 (est) |
| Soluble in | water, 139.7 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | information only not used for fragrances or flavors |
| Recommendation for 4-bromomethyl-7-methoxycoumarin usage levels up to | not for fragrance use. |
| Recommendation for 4-bromomethyl-7-methoxycoumarin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
4-
bromomethyl-7-methoxy-2-oxo-2H-benzopyran
4-(
bromomethyl)-7-methoxychromen-2-one
PubMed:
Critical practical aspects in the application of liquid chromatography-mass spectrometric studies for the characterization of impurities and degradation products.
PubMed:
Determination of tegafur, 5-fluorouracil, gimeracil and oxonic acid in human plasma using liquid chromatography-tandem mass spectrometry.
PubMed:
Simultaneous determination of 6-methylcoumarin and 7-methoxycoumarin in cosmetics using three-dimensional excitation-emission matrix fluorescence coupled with second-order calibration methods.
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Determination of sodium monofluoroacetate (1080) in biological samples as its 4-bromomethyl-7-methoxycoumarin derivative by RP-HPLC.
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Identification of lipid binders in old oil paintings by separation of 4-bromomethyl-7-methoxycoumarin derivatives of fatty acids by liquid chromatography with fluorescence detection.
PubMed:
Steviol quantification at the picomole level by high-performance liquid chromatography.
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Uracil in human DNA from subjects with normal and impaired folate status as determined by high-performance liquid chromatography-tandem mass spectrometry.
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The validity of two HPLC methods and a colorimetric PP2A assay related to the mouse bioassay in quantification of diarrhetic toxins in blue mussels (Mytilus edulis).
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The repeatability of two HPLC methods and the PP2A assay in the quantification of diarrhetic toxins in blue mussels (Mytilus edulis).
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Fluorescent-labeled ligands for the benzodiazepine receptor. Part 1: Synthesis and characterization of fluorescent-labeled benzodiazepines.
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Synthesis, photochemistry and application of (7-methoxycoumarin-4-yl)methyl-caged 8-bromoadenosine cyclic 3',5'-monophosphate and 8-bromoguanosine cyclic 3',5'-monophosphate photolyzed in the nanosecond time region.
PubMed:
Derivatization of thymine and thymine photodimers with 4-bromomethyl-7-methoxycoumarin for fluorescence detection in high-performance liquid chromatography.
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Chemical synthesis and biological properties of novel fluorescent antifolates in Pgp- and MRP-overexpressing tumour cell lines.
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Derivatization of 5-fluorouracil with 4-bromomethyl-7-methoxycoumarin for determination by liquid chromatography-mass spectrometry.
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Sensitive high-performance liquid chromatographic assay for pilocarpine in biological fluids using fluorescence derivatisation.
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Fatty acids in erythrocytes measured by isocratic HPLC.
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Fluorescent derivatives of thromboxane B(2): Synthesis, spectroscopic and immunologic properties.
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A procedure for the determination of 5-fluorouracil in tissue using microbore HPLC and fluorescence detection.
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Investigation of derivatization reagents for the analysis of diarrhetic shellfish poisoning toxins by liquid chromatography with fluorescence detection.
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Labeling of immunoglobulins with bifunctional, sulfhydryl-selective, and photoreactive coumarins.
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High performance liquid chromatographic determination of free and conjugated bile acids in serum, liver biopsies, bile, gastric juice and feces by fluorescence labeling.
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Determination of fatty acids in fish oil dietary supplements by capillary chromatography with laser-induced fluorescence detection.
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Determination of free valproic acid: evaluation of the Centrifree system and comparison between high-performance liquid chromatography and enzyme immunoassay.
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Phycotoxins in seafood--toxicological and chromatographic aspects.
PubMed:
Determination of valproic acid by high-performance liquid chromatography with photodiode-array and fluorescence detection.
PubMed:
4-Bromomethyl-7-methoxycoumarin and analogues as derivatization agents for high-performance liquid chromatography determinations: a review.
PubMed:
Measurement of incorporation of bromodeoxyuridine into DNA by high performance liquid chromatography using a novel fluorescent labelling technique.
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New fluorescent derivatives of cyclosporin for use in immunoassays.
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Selective high-performance liquid chromatographic method for the determination of glycyrrhizin and glycyrrhetic acid-3-O-glucuronide in biological fluids: application of ion-pair extraction and fluorescence labelling agent.
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Clean-up and determination of sodium valproate in serum by high-performance liquid chromatography with fluorimetric detection.
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High-performance liquid chromatography with chemiluminescence detection of serum levels of pre-column derivatized fluoropyrimidine compounds.
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Determination of individual bile acids in serum by high performance liquid chromatography.
PubMed:
Improved automated precolumn derivatization reaction of fatty acids with bromomethylmethoxycoumarin as label.
PubMed:
Analysis of 5-fluorouracil in plasma by precolumn derivatization with 4-bromomethyl-7-methoxycoumarin, followed by multi-dimensional high-performance liquid chromatography.
PubMed:
Automated analysis procedure for valproic acid in blood, serum and brain dialysate by high-performance liquid chromatography with bromomethylmethoxycoumarin as fluorescent label.
PubMed:
Conformational change of the L-shaped tRNA(Phe) molecule.
PubMed:
High-performance liquid chromatography of 5-fluorouracil after derivatization with 4-bromomethyl-7-methoxycoumarin. Characterization of the derivative and the use of column switching for the improvement of resolution and the enhancement of sensitivity.
PubMed:
High-performance liquid chromatographic determination of valproic acid in plasma using a micelle-mediated pre-column derivatization.
PubMed:
High-performance liquid chromatographic analysis of glucuronic acid conjugates after derivatization with 4-bromomethyl-7-methoxycoumarin.
PubMed:
Simultaneous determination of imidazoleacetic acid and N tau- and N pi-methylimidazoleacetic acids in human urine by high-performance liquid chromatography with fluorescence detection.
PubMed:
Use of 4-bromomethyl-7-methoxycoumarin for derivatization of pyrimidine compounds in serum analysed by high-performance liquid chromatography with fluorimetric detection.
PubMed:
High-performance liquid chromatography with fluorimetric detection in biological tissues of the 4-bromomethyl-7-methoxycoumarin ester derivative of 5-pyrrolidone-2-carboxylic acid.
PubMed:
Fluorescence determination of 5-fluorouracil and 1-(tetrahydro-2-furanyl)-5-fluorouracil in blood serum by high-performance liquid chromatography.
PubMed:
Prostaglandin determination with fluorescent reagents.
PubMed:
Determination by hplc of trifluoroacetate levels in plasma and urine of patients anaesthetized with halothane.
PubMed:
Determination of trace levels of fatty acid metal salts by high-performance liquid chromatography with fluorescence prelabeling.
PubMed:
Fluorescence labelling of pyrimidine nucleobases and their related compounds for high-performance liquid chromatography.
PubMed:
Conformational study of low molecular weight RNAs in solution by fluorescent probe.
PubMed:
[Assay of 2-phenylbutyric acid in plasma with gas and liquid chromatography].
PubMed:
[Labeling of 5-fluorouracil and pyrimidine nucleosides with 4-bromomethyl-7-methoxycoumarin for fluorimetric detection in high performance liquid chromatography].
PubMed:
Quantitative high-pressure liquid chromatography-fluorescence determination of some important lower Fatty acids in lake sediments.
PubMed:
Partial melting of the segment around pseudouridine in yeast 5S RNA.
PubMed:
Thermal and Mg2+ dependent behavior of pseudouridines at 39th and 55th of yeast tRNAPhe.
PubMed:
Fluorescence labelling in trace analysis of biological samples: simultaneous determination of free fatty acids and related carboxylic compounds.
PubMed:
Fluorescent derivatives of prostaglandins and thromboxanes for liquid chromatography.
PubMed:
4-Bromomethyl-7-methoxycoumarin as a new fluorescence label for fatty acids.