4-hexyl resorcinol
4-hexyl-1,3-benzenediol
Identification
| Name | 4-hexyl resorcinol |
| IUPAC | 4-hexylbenzene-1,3-diol |
| CAS Number | 136-77-6 |
| EINECS | 205-257-4 |
| FDA UNII | R9QTB5E82N |
| Molecular Formula | C12 H18 O2 |
| Molecular Weight | 194.27386000 |
| MDL Number | MFCD00002284 |
| Nikkaji Number | J2.020F |
| Beilstein | 2048312 |
| XlogP3 | 3.50 (est) |
Regulatory
| JECFA Food Additive | 4-Hexylresorcinol |
| DG SANTE Food Additives | 4-hexylresorcinol |
Physical Properties
| Appearance | white powder (est) |
| Assay | 98.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 68.00 °C. @ 760.00 mm Hg |
| Boiling Point | 334.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 0.000092 mmHg @ 25.00 °C. (est) |
| Flash Point | 311.00 °F. TCC ( 155.20 °C. ) (est) |
| logP (o/w) | 3.450 |
| Soluble in | acetone |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | antimicrobial agents |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-rat LD50 550 mg/kg |
| Dermal Toxicity | subcutaneous-mouse LDLo 750 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | antioxidants |
| Recommendation for 4-hexyl resorcinol usage levels up to | not for fragrance use. |
| Recommendation for 4-hexyl resorcinol flavor usage levels up to | not for flavor use. |
BOC Sciences
Best of Chemicals Supplier
Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...
Penta International Corporation
Chemistry innovation
At Penta, our products and services help businesses do business better.
R C Treatt and Co Ltd
Innovative ingredient solutions
World-leading innovative ingredient solutions provider for the flavour, fragrance and FMCG industries.
Potential Uses
Natural Occurrence
Synonyms
benzenediol, 4-hexyl-
1,3-
benzenediol, 4-hexyl-
caprokol
1,3-
dihydroxy-4-hexyl benzene
gelovermin
hexyl resorcinol
4-
hexyl-1,3-benzenediol
4-
hexyl-1,3-dihydroxybenzene
4-
hexyl-benzene-1,3-diol
4-
hexylbenzene-1,3-diol
4-
hexylbenzol-1,3-diol
hexylresorcin
4-
hexylresorcine
4-
hexylresorcinol
4-N-
hexylresorcinol
p-
hexylresorcinol
sucrets
worm-agen
PubMed:
Silk fibroin and 4-hexylresorcinol incorporation membrane for guided bone regeneration.
PubMed:
4-hexylresorcinol exerts antitumor effects via suppression of calcium oscillation and its antitumor effects are inhibited by calcium channel blockers.
PubMed:
Cisplatin and 4-hexylresorcinol synergise to decrease metastasis and increase survival rate in an oral mucosal melanoma xenograft model: a preliminary study.
PubMed:
4-n-butylresorcinol, a highly effective tyrosinase inhibitor for the topical treatment of hyperpigmentation.
PubMed:
4-hexylresorcinol stimulates the differentiation of SCC-9 cells through the suppression of E2F2, E2F3 and Sp3 expression and the promotion of Sp1 expression.
PubMed:
Comparison of the simple cyclic voltammetry (CV) and DPPH assays for the determination of antioxidant capacity of active principles.
PubMed:
4-hexylresorcinol inhibits NF-κB phosphorylation and has a synergistic effect with cisplatin in KB cells.
PubMed:
Aerosol deposition of hydroxyapatite and 4-hexylresorcinol coatings on titanium alloys for dental implants.
PubMed:
Differential tissue distribution and specificity of phenoloxidases from the Pacific oyster Crassostrea gigas.
PubMed:
A measurement of the unstirred aqueous boundary layer in a Franz diffusion cell.
PubMed:
Edible mushroom (Flammulina velutipes) extract inhibits melanosis in Kuruma shrimp (Marsupenaeus japonicus).
PubMed:
[Effect of chemical chaperones on properties of lysozyme and the reaction center protein from Rhodobacter sphaeroides].
PubMed:
4-Hexylresorcinol inhibits transglutaminase-2 activity and has synergistic effects along with cisplatin in KB cells.
PubMed:
First evidence of laccase activity in the Pacific oyster Crassostrea gigas.
PubMed:
Variations in IC(50) values with purity of mushroom tyrosinase.
PubMed:
Effect of natural antibrowning agents on color and related enzymes in fresh-cut Fuji apples as an alternative to the use of ascorbic acid.
PubMed:
Identification of xenoestrogens in food additives by an integrated in silico and in vitro approach.
PubMed:
Effect of pyrophosphate and 4-hexylresorcinol pretreatment on quality of refrigerated white shrimp (Litopenaeus vannamei) kept under modified atmosphere packaging.
PubMed:
Solvent effects on the spectroscopic properties of 4-hexylresorcinol.
PubMed:
Browning prevention by ascorbic acid and 4-hexylresorcinol: different mechanisms of action on polyphenol oxidase in the presence and in the absence of substrates.
PubMed:
Ascorbic acid and 4-hexylresorcinol effects on pear PPO and PPO catalyzed browning reaction.
PubMed:
Oxyresveratrol as an antibrowning agent for cloudy apple juices and fresh-cut apples.
PubMed:
Use of experimental design methodology to prepare Maillard reaction products from glucose and cysteine inhibitors of polyphenol oxidase from eggplant (Solanum melongena).
PubMed:
[Determination of 4-hexylresorcinol residues in prawns and crabs].
PubMed:
Role of sulfites and 4-hexylresorcinol in microbial growth and melanosis prevention of deepwater pink shrimp (Parapenaeus longirostris) using a controlled atmosphere.
PubMed:
Effects of resveratrol and 4-hexylresorcinol on hydrogen peroxide-induced oxidative DNA damage in human lymphocytes.
PubMed:
Polyphenol oxidases from latex of Hevea brasiliensis: purification and characterization.
PubMed:
Maintaining quality of fresh-cut mangoes using antibrowning agents and modified atmosphere packaging.
PubMed:
Cytokine release and cytotoxicity in human keratinocytes and fibroblasts induced by phenols and sodium dodecyl sulfate.
PubMed:
Characterization of catecholase and cresolase activities of eggplant polyphenol oxidase.
PubMed:
Determination of 4-hexylresorcinol in shrimp by liquid chromatography with fluorescence detection.
PubMed:
Influence of pH, benzoic acid, glutathione, EDTA, 4-hexylresorcinol, and sodium chloride on the pressure inactivation kinetics of mushroom polyphenol oxidase.
PubMed:
Oxidation of the flavonol quercetin by polyphenol oxidase.
PubMed:
Extending storage life of fresh-cut apples using natural products and their derivatives.
PubMed:
Oxidation of the flavonol fisetin by polyphenol oxidase.
PubMed:
4-Hexylresorcinol as inhibitor of shrimp melanosis: efficacy and residues studies; evaluation of possible toxic effect in a human intestinal in vitro model (Caco-2); preliminary safety assessment.
PubMed:
Determination of 4-hexylresorcinol in crab meat.
PubMed:
Liquid chromatographic determination of the processing aid 4-hexylresorcinol in shrimp.
PubMed:
Generally recognized as safe (GRAS) evaluation of 4-hexylresorcinol for use as a processing aid for prevention of melanosis in shrimp.
PubMed:
Does everything "cause" cancer: an alternative interpretation of the "carcinogenesis" bioassay.
PubMed:
Development and validation of a cellular transplant model for leukemia in Fischer rats: a short-term assay for potential anti-leukemic chemicals.
PubMed:
Inhibition of some spontaneous tumors by 4-hexylresorcinol in F344/N rats and B6C3F1 mice.
PubMed:
NTP Toxicology and Carcinogenesis Studies of 4-Hexylresorcinol (CAS No. 136-77-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies).
PubMed:
Genotoxicity of amebicide and anthelmintic drugs in Escherichia coli pol A+/pol A-.
PubMed:
Prediction of solubility in nonideal multicomponent systems using the UNIFAC group contribution model.
PubMed:
Mutagenicity of antiamebic and anthelmintic drugs in the Salmonella typhimurium microsomal test system.
PubMed:
Solubility behavior of phenolic compounds in hexane-ethyl acetate, hexane-ethyl myristate, and hexane-ethyl pivalate cosolvent systems.
PubMed:
Effect of complex formation between 4-hexylresorcinol and ethyl myristate on release rate of 4-hexylresorcinol from petrolatum base.
PubMed:
Review of the 4-hexylresorcinol procedure for acrolein analysis.
PubMed:
[Determination of acrolein in the air by means of its reaction with 4-hexylresorcinol].
PubMed:
The use of acid dissociation constants in selecting buffers to effect the electrophoretic separation of bithionol, fenticlor, hexachlorophene, bromchlorophene, dichlorophene, tetrachlorophene and 4-hexylresorcinol.
PubMed:
[Experimental anticancer studies. II. On the anti-tumor effect of 6-(2'-hydroxy-3', 5'-dihalophenylazo)-4-hexylresorcinol and related compounds on Yoshida sarcoma and Ehrlich ascites carcinoma in vivo].
PubMed:
Experimental anticancer studies. I. The preparation of 6-(2'-hydroxy-3', 5'-dibromophenylazo)-4-hexylresorcinol and related compounds, with brief reference to their anticancer activity.