4-hexyl resorcinol

4-hexyl-1,3-benzenediol

CAS: 136-77-6 C12 H18 O2 MW: 194.27386000

Identification

Name4-hexyl resorcinol
IUPAC4-hexylbenzene-1,3-diol
CAS Number136-77-6
EINECS205-257-4
FDA UNIIR9QTB5E82N
Molecular FormulaC12 H18 O2
Molecular Weight194.27386000
MDL NumberMFCD00002284
Nikkaji NumberJ2.020F
Beilstein2048312
XlogP33.50 (est)

Regulatory

JECFA Food Additive4-Hexylresorcinol
DG SANTE Food Additives4-hexylresorcinol

Physical Properties

Appearance white powder (est)
Assay 98.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 68.00 °C. @ 760.00 mm Hg
Boiling Point 334.00 °C. @ 760.00 mm Hg
Vapor Pressure 0.000092 mmHg @ 25.00 °C. (est)
Flash Point 311.00 °F. TCC ( 155.20 °C. ) (est)
logP (o/w) 3.450
Soluble in acetone

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantimicrobial agents

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-rat LD50 550 mg/kg
Dermal Toxicitysubcutaneous-mouse LDLo 750 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryantioxidants
Recommendation for 4-hexyl resorcinol usage levels up tonot for fragrance use.
Recommendation for 4-hexyl resorcinol flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

benzenediol, 4-hexyl- 1,3- benzenediol, 4-hexyl- caprokol 1,3- dihydroxy-4-hexyl benzene gelovermin hexyl resorcinol 4- hexyl-1,3-benzenediol 4- hexyl-1,3-dihydroxybenzene 4- hexyl-benzene-1,3-diol 4- hexylbenzene-1,3-diol 4- hexylbenzol-1,3-diol hexylresorcin 4- hexylresorcine 4- hexylresorcinol 4-N- hexylresorcinol p- hexylresorcinol sucrets worm-agen PubMed: Silk fibroin and 4-hexylresorcinol incorporation membrane for guided bone regeneration. PubMed: 4-hexylresorcinol exerts antitumor effects via suppression of calcium oscillation and its antitumor effects are inhibited by calcium channel blockers. PubMed: Cisplatin and 4-hexylresorcinol synergise to decrease metastasis and increase survival rate in an oral mucosal melanoma xenograft model: a preliminary study. PubMed: 4-n-butylresorcinol, a highly effective tyrosinase inhibitor for the topical treatment of hyperpigmentation. PubMed: 4-hexylresorcinol stimulates the differentiation of SCC-9 cells through the suppression of E2F2, E2F3 and Sp3 expression and the promotion of Sp1 expression. PubMed: Comparison of the simple cyclic voltammetry (CV) and DPPH assays for the determination of antioxidant capacity of active principles. PubMed: 4-hexylresorcinol inhibits NF-κB phosphorylation and has a synergistic effect with cisplatin in KB cells. PubMed: Aerosol deposition of hydroxyapatite and 4-hexylresorcinol coatings on titanium alloys for dental implants. PubMed: Differential tissue distribution and specificity of phenoloxidases from the Pacific oyster Crassostrea gigas. PubMed: A measurement of the unstirred aqueous boundary layer in a Franz diffusion cell. PubMed: Edible mushroom (Flammulina velutipes) extract inhibits melanosis in Kuruma shrimp (Marsupenaeus japonicus). PubMed: [Effect of chemical chaperones on properties of lysozyme and the reaction center protein from Rhodobacter sphaeroides]. PubMed: 4-Hexylresorcinol inhibits transglutaminase-2 activity and has synergistic effects along with cisplatin in KB cells. PubMed: First evidence of laccase activity in the Pacific oyster Crassostrea gigas. PubMed: Variations in IC(50) values with purity of mushroom tyrosinase. PubMed: Effect of natural antibrowning agents on color and related enzymes in fresh-cut Fuji apples as an alternative to the use of ascorbic acid. PubMed: Identification of xenoestrogens in food additives by an integrated in silico and in vitro approach. PubMed: Effect of pyrophosphate and 4-hexylresorcinol pretreatment on quality of refrigerated white shrimp (Litopenaeus vannamei) kept under modified atmosphere packaging. PubMed: Solvent effects on the spectroscopic properties of 4-hexylresorcinol. PubMed: Browning prevention by ascorbic acid and 4-hexylresorcinol: different mechanisms of action on polyphenol oxidase in the presence and in the absence of substrates. PubMed: Ascorbic acid and 4-hexylresorcinol effects on pear PPO and PPO catalyzed browning reaction. PubMed: Oxyresveratrol as an antibrowning agent for cloudy apple juices and fresh-cut apples. PubMed: Use of experimental design methodology to prepare Maillard reaction products from glucose and cysteine inhibitors of polyphenol oxidase from eggplant (Solanum melongena). PubMed: [Determination of 4-hexylresorcinol residues in prawns and crabs]. PubMed: Role of sulfites and 4-hexylresorcinol in microbial growth and melanosis prevention of deepwater pink shrimp (Parapenaeus longirostris) using a controlled atmosphere. PubMed: Effects of resveratrol and 4-hexylresorcinol on hydrogen peroxide-induced oxidative DNA damage in human lymphocytes. PubMed: Polyphenol oxidases from latex of Hevea brasiliensis: purification and characterization. PubMed: Maintaining quality of fresh-cut mangoes using antibrowning agents and modified atmosphere packaging. PubMed: Cytokine release and cytotoxicity in human keratinocytes and fibroblasts induced by phenols and sodium dodecyl sulfate. PubMed: Characterization of catecholase and cresolase activities of eggplant polyphenol oxidase. PubMed: Determination of 4-hexylresorcinol in shrimp by liquid chromatography with fluorescence detection. PubMed: Influence of pH, benzoic acid, glutathione, EDTA, 4-hexylresorcinol, and sodium chloride on the pressure inactivation kinetics of mushroom polyphenol oxidase. PubMed: Oxidation of the flavonol quercetin by polyphenol oxidase. PubMed: Extending storage life of fresh-cut apples using natural products and their derivatives. PubMed: Oxidation of the flavonol fisetin by polyphenol oxidase. PubMed: 4-Hexylresorcinol as inhibitor of shrimp melanosis: efficacy and residues studies; evaluation of possible toxic effect in a human intestinal in vitro model (Caco-2); preliminary safety assessment. PubMed: Determination of 4-hexylresorcinol in crab meat. PubMed: Liquid chromatographic determination of the processing aid 4-hexylresorcinol in shrimp. PubMed: Generally recognized as safe (GRAS) evaluation of 4-hexylresorcinol for use as a processing aid for prevention of melanosis in shrimp. PubMed: Does everything "cause" cancer: an alternative interpretation of the "carcinogenesis" bioassay. PubMed: Development and validation of a cellular transplant model for leukemia in Fischer rats: a short-term assay for potential anti-leukemic chemicals. PubMed: Inhibition of some spontaneous tumors by 4-hexylresorcinol in F344/N rats and B6C3F1 mice. PubMed: NTP Toxicology and Carcinogenesis Studies of 4-Hexylresorcinol (CAS No. 136-77-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies). PubMed: Genotoxicity of amebicide and anthelmintic drugs in Escherichia coli pol A+/pol A-. PubMed: Prediction of solubility in nonideal multicomponent systems using the UNIFAC group contribution model. PubMed: Mutagenicity of antiamebic and anthelmintic drugs in the Salmonella typhimurium microsomal test system. PubMed: Solubility behavior of phenolic compounds in hexane-ethyl acetate, hexane-ethyl myristate, and hexane-ethyl pivalate cosolvent systems. PubMed: Effect of complex formation between 4-hexylresorcinol and ethyl myristate on release rate of 4-hexylresorcinol from petrolatum base. PubMed: Review of the 4-hexylresorcinol procedure for acrolein analysis. PubMed: [Determination of acrolein in the air by means of its reaction with 4-hexylresorcinol]. PubMed: The use of acid dissociation constants in selecting buffers to effect the electrophoretic separation of bithionol, fenticlor, hexachlorophene, bromchlorophene, dichlorophene, tetrachlorophene and 4-hexylresorcinol. PubMed: [Experimental anticancer studies. II. On the anti-tumor effect of 6-(2'-hydroxy-3', 5'-dihalophenylazo)-4-hexylresorcinol and related compounds on Yoshida sarcoma and Ehrlich ascites carcinoma in vivo]. PubMed: Experimental anticancer studies. I. The preparation of 6-(2'-hydroxy-3', 5'-dibromophenylazo)-4-hexylresorcinol and related compounds, with brief reference to their anticancer activity.