4-methyl pyrazole

1H-pyrazole, 4-methyl-

CAS: 7554-65-6 C4 H6 N2 MW: 82.10582000

Identification

Name4-methyl pyrazole
IUPAC4-methyl-1H-pyrazole
CAS Number7554-65-6
EINECS231-445-0
FDA UNII83LCM6L2BY
Molecular FormulaC4 H6 N2
Molecular Weight82.10582000
MDL NumberMFCD00005245
Nikkaji NumberJ35.396E
Beilstein0105204
XlogP31.40 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 0.99300 @ 25.00 °C.
Boiling Point 206.00 °C. @ 760.00 mm Hg
Vapor Pressure 0.050000 mmHg @ 25.00 °C. (est)
Flash Point 205.00 °F. TCC ( 96.11 °C. )
logP (o/w) 1.097 (est)
Soluble in water, 3.937e+004 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintravenous-mouse LD50 310 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for 4-methyl pyrazole usage levels up tonot for fragrance use.
Recommendation for 4-methyl pyrazole flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

antizol fomepizole 4- methyl-1H-pyrazole 4- methylpyrazole 4- MP 1H- pyrazole, 4-methyl- PubMed: Identification of trans,trans-2,4-decadienal metabolites in mouse and human cells using liquid chromatography-mass spectrometry. PubMed: The involvement of several enzymes in methanol detoxification in Drosophila melanogaster adults. PubMed: The involvement of cytochrome P450 monooxygenases in methanol elimination in Drosophila melanogaster larvae. PubMed: The endogenous cannabinoid 2-arachidonoylglycerol is intravenously self-administered by squirrel monkeys. PubMed: Para-nitrophenol hydroxylation by fish liver microsomes: kinetics and effect of selective cytochrome P450 inhibitors. PubMed: In vitro biotransformation and investigation of metabolic enzymes possibly responsible for the metabolism of bisdesoxyolaquindox in the liver fractions of rats, chicken, and pigs. PubMed: Effect of lycopene on caspase-3 enzyme activation in liver of methanol-intoxicated rats: comparison with fomepizole. PubMed: [Application in veterinary and human clinical toxicology]. PubMed: Fomepizole: a critical assessment of current dosing recommendations. PubMed: Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole--LH 21. PubMed: Potential modulation of plasma ghrelin and glucagon-like peptide-1 by anorexigenic cannabinoid compounds, SR141716A (rimonabant) and oleoylethanolamide. PubMed: Endocannabinoids link feeding state and auditory perception-related gene expression. PubMed: Consumption of high carbohydrate, high fat, and normal chow is equally suppressed by a cannabinoid receptor antagonist in non-deprived rats. PubMed: Antidote review: fomepizole for methanol poisoning. PubMed: A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding. PubMed: Pretreatment of CD-1 mice with 4-methylpyrazole blocks toxicity from the gamma-hydroxybutyrate precursor, 1,4-butanediol. PubMed: Reversal of delta 9-THC hyperphagia by SR141716 and naloxone but not dexfenfluramine. PubMed: Treatment of the alcohol intoxications: ethylene glycol, methanol and isopropanol. PubMed: The role of alcohols as solvents in the genotoxicity testing of alpha,beta-unsaturated ketones in the SOS chromotest. PubMed: Constitutive and inducible expression of hepatic CYP2E1 in leptin-deficient ob/ob mice. PubMed: American Academy of Clinical Toxicology Practice Guidelines on the Treatment of Ethylene Glycol Poisoning. Ad Hoc Committee. PubMed: Retinoic acid reverses ethanol-induced cardiovascular abnormalities in quail embryos. PubMed: Therapeutic lessons from traditional Oriental medicine to contemporary Occidental pharmacology. PubMed: Ethyl carbamate metabolism: in vivo inhibitors and in vitro enzymatic systems. PubMed: In vivo inhibition of N-nitrosodimethylamine metabolism by 4-methylpyrazole: a model for endogenous nitrosation. PubMed: Acute inhibition by ethanol of intestinal absorption of glucose and hepatic glycogen synthesis on glucose refeeding after starvation in the rat. PubMed: An experimental model of self-intoxication in C57 mice. PubMed: Voluntary consumption of ethanol and its consequences in C57 mice treated with 4-methylpyrazole. PubMed: Uninterrupted prolonged ethanol oxidation as a main pathogenetic factor of alcoholic liver damage: evidence from a new liquid diet animal model. PubMed: Aldehyde dehydrogenase inhibitors and voluntary ethanol drinking by rats.