azacitidine

4- amino-1-(b-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one 4- amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one 4- amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-1,3,5-triazin-2(1H)-one 4- amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,3,5-triazin-2(1H)-one 4- amino-1-b-D-ribofuranosyl-1,3,5-triazin-2(1H)-one azacitidinum azacytidine 5-aza cytidine aza cytidine, 5- 1-[(4S,2R,3R,5R)-3,4- dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-amino-1,3,5-triazin-2-one ladakamycin mylosar 1,3,5- triazin-2(1H)-one, 4-amino-1-b-D-ribofuranosyl- PubMed: Pharmacokinetics of different formulations of oral azacitidine (CC-486) and the effect of food and modified gastric pH on pharmacokinetics in subjects with hematologic malignancies. PubMed: Blastic plasmacytoid dendritic cell neoplasm: the first report of two cases treated by 5-azacytidine. PubMed: Efficacy and tolerability of treatment with azacitidine for 5 days in elderly patients with acute myeloid leukemia. PubMed: Azacitidine in the management of patients with myelodysplastic syndromes. PubMed: FDA drug approval summary: azacitidine (5-azacytidine, Vidaza) for injectable suspension. PubMed: Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias. PubMed: Induction of proto-oncogene BRF2 in breast cancer cells by the dietary soybean isoflavone daidzein. PubMed: Chronic myelomonocytic leukemia: 2013 update on diagnosis, risk stratification, and management. PubMed: The demethylating agent 5-Aza reduces the growth, invasiveness, and clonogenicity of uveal and cutaneous melanoma. PubMed: Lower gastric secretion and higher incorporation of orotic acid into liver RNA in rats treated with 5-azacytidine and cycloheximide. PubMed: Subchronic oral toxicity study of decitabine in combination with tetrahydrouridine in CD-1 mice. PubMed: Vitamin A and beta-carotene inhibitory effect during 1,2-dimethylhydrazine induced hepatocarcinogenesis potentiated by 5-azacytidine. PubMed: Inhibition of aflatoxin metabolism and growth of Aspergillus flavus in liquid culture by a DNA methylation inhibitor. PubMed: Decitabine induces delayed reactive oxygen species (ROS) accumulation in leukemia cells and induces the expression of ROS generating enzymes. PubMed: Epigenetic action of decitabine (5-aza-2'-deoxycytidine) is more effective against acute myeloid leukemia than cytotoxic action of cytarabine (ARA-C). PubMed: Can hypomethylating agents provide a platform for curative therapy in myelodysplastic syndromes? PubMed: Chemical induction of endogenous retrovirus particles from the vero cell line of African green monkeys. PubMed: Approval summary: azacitidine for treatment of myelodysplastic syndrome subtypes. PubMed: Development of phenotypic screening assays for γ-globin induction using primary human bone marrow day 7 erythroid progenitor cells. PubMed: Activity of decitabine in patients with myelodysplastic syndrome previously treated with azacitidine. PubMed: Advances in myelodysplastic syndrome: nursing implications of azacitidine. PubMed: Boulevard of broken dreams: drug approval for older adults with acute myeloid leukemia. PubMed: Chronic myelomonocytic leukemia: 2012 update on diagnosis, risk stratification, and management. PubMed: Reexpression of tumor suppressor, sFRP1, leads to antitumor synergy of combined HDAC and methyltransferase inhibitors in chemoresistant cancers. PubMed: Azacitidine-associated hyperthermia and interstitial pneumonitis in a patient with myelodysplastic syndrome. PubMed: Reprogramming of pig dermal fibroblast into insulin secreting cells by a brief exposure to 5-aza-cytidine. PubMed: The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor genes. PubMed: Colon cancer cell apoptosis is induced by combined exposure to the n-3 fatty acid docosahexaenoic acid and butyrate through promoter methylation. PubMed: DNA demethylation and invasive cancer: implications for therapeutics. PubMed: Epigenetic potentiation of NY-ESO-1 vaccine therapy in human ovarian cancer. PubMed: Folate deficiency induces dysfunctional long and short telomeres; both states are associated with hypomethylation and DNA damage in human WIL2-NS cells. PubMed: Economic analysis of decitabine versus best supportive care in the treatment of intermediate- and high-risk myelodysplastic syndromes from a US payer perspective. PubMed: Discovery of drugs that possess activity against feline leukemia virus. PubMed: Expression and immunotherapeutic targeting of the SSX family of cancer-testis antigens in prostate cancer. 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PubMed: DNA methylation and soy phytoestrogens: quantitative study in DU-145 and PC-3 human prostate cancer cell lines. PubMed: Character of the stimulatory response of uridine kinase in rat livers to cycloheximide treatment. PubMed: Multicenter study of decitabine administered daily for 5 days every 4 weeks to adults with myelodysplastic syndromes: the alternative dosing for outpatient treatment (ADOPT) trial. PubMed: Early detection of endogenous retroviruses in chemically induced mouse cells. PubMed: Epigenetic regulation of reelin and brain-derived neurotrophic factor genes in long-term potentiation in rat medial prefrontal cortex. PubMed: DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation. PubMed: Effects of specific DNMT gene depletion on cancer cell transformation and breast cancer cell invasion; toward selective DNMT inhibitors. 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