5-chlorosalicylic acid

benzoic acid, 5-chloro-2-hydroxy-

CAS: 321-14-2 C7 H5 Cl O3 MW: 172.56645000

Identification

Name5-chlorosalicylic acid
IUPAC5-chloro-2-hydroxybenzoic acid
CAS Number321-14-2
EINECS206-283-9
FDA UNIIJ2YFG68VCZ
Molecular FormulaC7 H5 Cl O3
Molecular Weight172.56645000
MDL NumberMFCD00002457
Nikkaji NumberJ26.969G
Beilstein2046665
XlogP33.10 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 171.50 °C. @ 760.00 mm Hg
Boiling Point 320.50 °C. @ 760.00 mm Hg (est)
Flash Point 298.00 °F. TCC ( 147.60 °C. ) (est)
logP (o/w) 3.090
Soluble in water, 1.00E+04 mg/L @ 20 °C (exp)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesskin conditioning

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintraperitoneal-mouse LDLo 250 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic ingredient for skin conditioning
Recommendation for 5-chlorosalicylic acid usage levels up tonot for fragrance use.
Recommendation for 5-chlorosalicylic acid flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

benzoic acid, 5-chloro-2-hydroxy- 5- chloro salicylic acid 5- chloro-2-hydroxybenzoic acid 5- chloro-2-hydroxybenzoicacid 5- chlorosalicyclic acid chlorosalicylic acid 5- chlorosalicylicacid 2- hydroxy-5-chlorobenzoic acid salicylic acid, 5-chloro- PubMed: Salicylic acid and some of its derivatives as antibacterial agents for viscose fabric. PubMed: Effect of biological confinement on the photophysics and dynamics of a proton-transfer phototautomer: an exploration of excitation and emission wavelength-dependent photophysics of the protein-bound drug. PubMed: Fluorescence-based high-throughput screening assay for drug interactions with UGT1A6. PubMed: On the photophysics of 3,5,6-Trichlorosalicylic acid: spectroscopic study combined with Hartree-Fock and Density Functional Theory calculations. PubMed: Bismuth(III) complexes derived from non-steroidal anti-inflammatory drugs and their activity against Helicobacter pylori. PubMed: Deciphering the photophysics of 5-chlorosalicylic acid: evidence for excited-state intramolecular proton transfer. PubMed: In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II. PubMed: Transport evaluation of salicylic acid and structurally related compounds across Caco-2 cell monolayers and artificial PAMPA membranes. PubMed: Two angular dioxygenases contribute to the metabolic versatility of dibenzofuran-degrading Rhodococcus sp. strain HA01. PubMed: Guest-controlling effects on ER behaviors of beta-cyclodextrin polymer. PubMed: Effect of ion-exchange fiber structure on the binding and release of model salicylates. PubMed: New bacterial pathway for 4- and 5-chlorosalicylate degradation via 4-chlorocatechol and maleylacetate in Pseudomonas sp. strain MT1. PubMed: Degradation of chlorinated dibenzofurans and dibenzo-p-dioxins by two types of bacteria having angular dioxygenases with different features. PubMed: Synthesis and biological activity of new diarylalkenes. PubMed: Biodegradation pathway of 2-chlorodibenzo-p-dioxin and 2-chlorodibenzofuran in the biphenyl-utilising strain JB1. PubMed: Defense Responses in Infected and Elicited Cucumber (Cucumis sativus L.) Hypocotyl Segments Exhibiting Acquired Resistance. PubMed: Pretreatment of Parsley (Petroselinum crispum L.) Suspension Cultures with Methyl Jasmonate Enhances Elicitation of Activated Oxygen Species. PubMed: Structure-activity studies in E. coli strains on ochratoxin A (OTA) and its analogues implicate a genotoxic free radical and a cytotoxic thiol derivative as reactive metabolites. PubMed: Conditioning of Parsley (Petroselinum crispum L.) Suspension Cells Increases Elicitor-Induced Incorporation of Cell Wall Phenolics. PubMed: Mutagenic activity of 2-chloro-4-nitroaniline and 5-chlorosalicylic acid in Salmonella typhimurium: two possible metabolites of niclosamide. PubMed: Genotoxicity of ochratoxin A and structurally related compounds in Escherichia coli strains: studies on their mode of action. PubMed: Microbial metabolism of chlorosalicylates: effect of prolonged subcultivation on constructed strains. PubMed: Microbial metabolism of chlorosalicylates: accelerated evolution by natural genetic exchange. PubMed: Comparative gastric ulcerogenic effects of meseclazone, 5-chlorosalicylic acid and other nonsteroidal anti-inflammatory drugs following acute and repeated oral administration to rats. PubMed: Meseclazone, 5-chlorosalicylic acid and acetylsalicylic acid. Comparison of their effects on in vitro and ex vivo platelet aggregation. PubMed: Comparative antiphlogistic activity of meseclazone, 5-chlorosalicylic acid, acetylsalicylic acid, phenylbutazone, indomethacin and hydrocortisone in various rat paw edema models. PubMed: [Chronic toxicity of 4-chloroanilide of 5-chlorosalicylic acid (Arylide)]. PubMed: Alteration of Hepatic microsomal enzyme systems and the lethal action of non-steroidal anti-arthritic drugs in acute and chronic models of inflammation. PubMed: Comparative anti-inflammatory, analgesic, and antipyretic activities of 7-chloro-3,3a-dihydro-2-methyl-2H,9H-isoxazolo-(3,2-b)(1,3)-benzoxazin-9-one and 5-chlorosalicylic acid in rats. PubMed: Absorption, distribution, and metabolic fate of 7-chloro-3,3a-dihydro-2-methyl-2H,9H-isoxazolo-(3,2-b)(1,3)-benzoxazin-9-one in rats, dogs, and humans. PubMed: [Bactericidal effect of streptomycin on acid-fast bacilli in the presence of 4-chloroanilid of 5-chlorosalicylic acid]. PubMed: [Some pharmacological properties of 4-chloroanilide of 5-chlorosalicylic acid]. PubMed: [Binding of 4-chloroanilide of 5-chlorosalicylic acid by blood serum proteins and other protein substances. I. Qualitative methods for determination of the binding of arylid by protein substances]. PubMed: Structural studies on complexes. IV. Crystal structure of a 1:1 5-chlorosalicylic acid and theophylline complex. PubMed: [Toxicity of 4-chloroanilid of 5-chlorosalicylic acid (arylid) for various species of laboratory animals]. PubMed: [Effect of 5-chlorosalicylic acid, 4-chloroanilide on tubercle bacilli]. PubMed: [Effect of 4-chloroanilid of 5-chlorosalicylic acid on the viability of tubercle bacilli in vitro]. PubMed: [Effect of 4-chloroanilid of 5-chlorosalicylic acid on experimental tuberculosis in guinea pigs]. PubMed: [Effect of the 4-chloroanilide of 5-chlorosalicylic acid on the respiration of tubercle bacilli]. PubMed: [Effect of 4-chloroanilide of 5-chlorosalicylic acid in experimental tuberculosis of white mice]. PubMed: [EFFECT OF 4-CHLOROANILIDE OF 5-CHLOROSALICYLIC ACID ON MYCOBACTERIUM TUBERCULOSIS IN VITRO]. PubMed: [Treatment of epidermophytosis with the 2'-chloroanilide of 5-chlorosalicylic acid].