5-chlorosalicylic acid
benzoic acid, 5-chloro-2-hydroxy-
Identification
| Name | 5-chlorosalicylic acid |
| IUPAC | 5-chloro-2-hydroxybenzoic acid |
| CAS Number | 321-14-2 |
| EINECS | 206-283-9 |
| FDA UNII | J2YFG68VCZ |
| Molecular Formula | C7 H5 Cl O3 |
| Molecular Weight | 172.56645000 |
| MDL Number | MFCD00002457 |
| Nikkaji Number | J26.969G |
| Beilstein | 2046665 |
| XlogP3 | 3.10 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 171.50 °C. @ 760.00 mm Hg |
| Boiling Point | 320.50 °C. @ 760.00 mm Hg (est) |
| Flash Point | 298.00 °F. TCC ( 147.60 °C. ) (est) |
| logP (o/w) | 3.090 |
| Soluble in | water, 1.00E+04 mg/L @ 20 °C (exp) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | skin conditioning |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intraperitoneal-mouse LDLo 250 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic ingredient for skin conditioning |
| Recommendation for 5-chlorosalicylic acid usage levels up to | not for fragrance use. |
| Recommendation for 5-chlorosalicylic acid flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
benzoic acid, 5-chloro-2-hydroxy-
5-
chloro salicylic acid
5-
chloro-2-hydroxybenzoic acid
5-
chloro-2-hydroxybenzoicacid
5-
chlorosalicyclic acid
chlorosalicylic acid
5-
chlorosalicylicacid
2-
hydroxy-5-chlorobenzoic acid
salicylic acid, 5-chloro-
PubMed:
Salicylic acid and some of its derivatives as antibacterial agents for viscose fabric.
PubMed:
Effect of biological confinement on the photophysics and dynamics of a proton-transfer phototautomer: an exploration of excitation and emission wavelength-dependent photophysics of the protein-bound drug.
PubMed:
Fluorescence-based high-throughput screening assay for drug interactions with UGT1A6.
PubMed:
On the photophysics of 3,5,6-Trichlorosalicylic acid: spectroscopic study combined with Hartree-Fock and Density Functional Theory calculations.
PubMed:
Bismuth(III) complexes derived from non-steroidal anti-inflammatory drugs and their activity against Helicobacter pylori.
PubMed:
Deciphering the photophysics of 5-chlorosalicylic acid: evidence for excited-state intramolecular proton transfer.
PubMed:
In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II.
PubMed:
Transport evaluation of salicylic acid and structurally related compounds across Caco-2 cell monolayers and artificial PAMPA membranes.
PubMed:
Two angular dioxygenases contribute to the metabolic versatility of dibenzofuran-degrading Rhodococcus sp. strain HA01.
PubMed:
Guest-controlling effects on ER behaviors of beta-cyclodextrin polymer.
PubMed:
Effect of ion-exchange fiber structure on the binding and release of model salicylates.
PubMed:
New bacterial pathway for 4- and 5-chlorosalicylate degradation via 4-chlorocatechol and maleylacetate in Pseudomonas sp. strain MT1.
PubMed:
Degradation of chlorinated dibenzofurans and dibenzo-p-dioxins by two types of bacteria having angular dioxygenases with different features.
PubMed:
Synthesis and biological activity of new diarylalkenes.
PubMed:
Biodegradation pathway of 2-chlorodibenzo-p-dioxin and 2-chlorodibenzofuran in the biphenyl-utilising strain JB1.
PubMed:
Defense Responses in Infected and Elicited Cucumber (Cucumis sativus L.) Hypocotyl Segments Exhibiting Acquired Resistance.
PubMed:
Pretreatment of Parsley (Petroselinum crispum L.) Suspension Cultures with Methyl Jasmonate Enhances Elicitation of Activated Oxygen Species.
PubMed:
Structure-activity studies in E. coli strains on ochratoxin A (OTA) and its analogues implicate a genotoxic free radical and a cytotoxic thiol derivative as reactive metabolites.
PubMed:
Conditioning of Parsley (Petroselinum crispum L.) Suspension Cells Increases Elicitor-Induced Incorporation of Cell Wall Phenolics.
PubMed:
Mutagenic activity of 2-chloro-4-nitroaniline and 5-chlorosalicylic acid in Salmonella typhimurium: two possible metabolites of niclosamide.
PubMed:
Genotoxicity of ochratoxin A and structurally related compounds in Escherichia coli strains: studies on their mode of action.
PubMed:
Microbial metabolism of chlorosalicylates: effect of prolonged subcultivation on constructed strains.
PubMed:
Microbial metabolism of chlorosalicylates: accelerated evolution by natural genetic exchange.
PubMed:
Comparative gastric ulcerogenic effects of meseclazone, 5-chlorosalicylic acid and other nonsteroidal anti-inflammatory drugs following acute and repeated oral administration to rats.
PubMed:
Meseclazone, 5-chlorosalicylic acid and acetylsalicylic acid. Comparison of their effects on in vitro and ex vivo platelet aggregation.
PubMed:
Comparative antiphlogistic activity of meseclazone, 5-chlorosalicylic acid, acetylsalicylic acid, phenylbutazone, indomethacin and hydrocortisone in various rat paw edema models.
PubMed:
[Chronic toxicity of 4-chloroanilide of 5-chlorosalicylic acid (Arylide)].
PubMed:
Alteration of Hepatic microsomal enzyme systems and the lethal action of non-steroidal anti-arthritic drugs in acute and chronic models of inflammation.
PubMed:
Comparative anti-inflammatory, analgesic, and antipyretic activities of 7-chloro-3,3a-dihydro-2-methyl-2H,9H-isoxazolo-(3,2-b)(1,3)-benzoxazin-9-one and 5-chlorosalicylic acid in rats.
PubMed:
Absorption, distribution, and metabolic fate of 7-chloro-3,3a-dihydro-2-methyl-2H,9H-isoxazolo-(3,2-b)(1,3)-benzoxazin-9-one in rats, dogs, and humans.
PubMed:
[Bactericidal effect of streptomycin on acid-fast bacilli in the presence of 4-chloroanilid of 5-chlorosalicylic acid].
PubMed:
[Some pharmacological properties of 4-chloroanilide of 5-chlorosalicylic acid].
PubMed:
[Binding of 4-chloroanilide of 5-chlorosalicylic acid by blood serum proteins and other protein substances. I. Qualitative methods for determination of the binding of arylid by protein substances].
PubMed:
Structural studies on complexes. IV. Crystal structure of a 1:1 5-chlorosalicylic acid and theophylline complex.
PubMed:
[Toxicity of 4-chloroanilid of 5-chlorosalicylic acid (arylid) for various species of laboratory animals].
PubMed:
[Effect of 5-chlorosalicylic acid, 4-chloroanilide on tubercle bacilli].
PubMed:
[Effect of 4-chloroanilid of 5-chlorosalicylic acid on the viability of tubercle bacilli in vitro].
PubMed:
[Effect of 4-chloroanilid of 5-chlorosalicylic acid on experimental tuberculosis in guinea pigs].
PubMed:
[Effect of the 4-chloroanilide of 5-chlorosalicylic acid on the respiration of tubercle bacilli].
PubMed:
[Effect of 4-chloroanilide of 5-chlorosalicylic acid in experimental tuberculosis of white mice].
PubMed:
[EFFECT OF 4-CHLOROANILIDE OF 5-CHLOROSALICYLIC ACID ON MYCOBACTERIUM TUBERCULOSIS IN VITRO].
PubMed:
[Treatment of epidermophytosis with the 2'-chloroanilide of 5-chlorosalicylic acid].