5-methoxysalicylic acid
benzoic acid, 2-hydroxy-5-methoxy-
Identification
| Name | 5-methoxysalicylic acid |
| IUPAC | 2-hydroxy-5-methoxybenzoic acid |
| CAS Number | 2612-02-4 |
| EINECS | 220-037-8 |
| FDA UNII | Search |
| Molecular Formula | C8 H8 O4 |
| Molecular Weight | 168.14856000 |
| MDL Number | MFCD00002459 |
| Nikkaji Number | J26.970K |
| Beilstein | 2209647 |
| XlogP3 | 2.50 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 347.00 °C. @ 760.00 mm Hg (est) |
| Flash Point | 296.00 °F. TCC ( 146.50 °C. ) (est) |
| logP (o/w) | 2.100 (est) |
| Soluble in | water, 2463 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for 5-methoxysalicylic acid usage levels up to | not for fragrance use. |
| Recommendation for 5-methoxysalicylic acid flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
m-
anisic acid, 6-hydroxy-
benzoic acid, 2-hydroxy-5-methoxy-
2-
hydroxy-5-methoxybenzoic acid
5-
methoxy-2-hydroxybenzoic acid
PubMed:
5-Methoxysalicylic Acid Matrix for Ganglioside Analysis with Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry.
PubMed:
A thiophene-containing compound as a matrix for matrix-assisted laser desorption/ ionization mass spectrometry and the electrical conductivity of matrix crystals.
PubMed:
In vitro anti-platelet effects of simple plant-derived phenolic compounds are only found at high, non-physiological concentrations.
PubMed:
DFT, FT-Raman and FT-IR investigations of 5-methoxysalicylic acid.
PubMed:
Biochemical assays of immobilized oligonucleotides with mass spectrometry.
PubMed:
Laser spectroscopic investigation of salicylic acids hydrogen bonded with water in supersonic jets: Microsolvation effects for excited state proton dislocation.
PubMed:
Fast excited-state intramolecular proton transfer and subnanosecond dynamic stokes shift of time-resolved fluorescence spectra of the 5-methoxysalicylic acid/diethyl ether complex.
PubMed:
Structural characterization of Mycobacterium tuberculosis lipoarabinomannans by the combination of capillary electrophoresis and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
PubMed:
5-Methoxysalicylic acid and spermine: a new matrix for the matrix-assisted laser desorption/ionization mass spectrometry analysis of oligonucleotides.
PubMed:
Direct quantitative analysis of peptides using matrix assisted laser desorption ionization.
PubMed:
Metabolism of Hydroxydibenzofurans, Methoxydibenzofurans, Acetoxydibenzofurans, and Nitrodibenzofurans by Sphingomonas sp. Strain HH69.
PubMed:
Tryptic mapping of recombinant proteins by matrix-assisted laser desorption/ionization mass spectrometry.
PubMed:
Pheromonal activity of single castoreum constituents in beaver,Castor canadensis.
PubMed:
[Intestinal absorption of insulin with a new telemetric shuttle in dogs].
PubMed:
Effects of sodium 5-methoxysalicylate on macromolecule absorption and mucosal morphology in a vascularly perfused rat gut preparation in vivo.
PubMed:
Inhibition of gluconeogenesis by salicylate and 5-methoxysalicylate in liver of normal and alloxan-diabetic rats.
PubMed:
High-performance liquid chromatographic determination of certain salicylates and their major metabolites in plasma following topical administration of a liniment to healthy subjects.
PubMed:
Lymphatic transport of sodium cefoxitin in the presence of sodium 5-methoxysalicylate after injection into rat rectal connective tissue, femoral muscle and femoral vein.
PubMed:
Effect of adjuvants on the rectal absorption and lymphatic uptake of pepleomycin in rats.
PubMed:
Possible mechanism of uptake for several compounds in ionized form through human erythrocyte membrane.
PubMed:
Salicylate-promoted permeation of cefoxitin, insulin and phenylalanine across red cell membrane. Possible mechanism.
PubMed:
Enhancement of rectal absorption of insulin using salicylates in dogs.
PubMed:
Enhanced small intestinal absorption of cefmetazole and cefoxitin in rats in the presence of non-surfactant adjuvants.
PubMed:
Enhanced rectal bioavailability of polypeptides using sodium 5-methoxysalicylate as an absorption promoter.
PubMed:
Enhanced intestinal absorption of insulin in rats in the presence of sodium 5-methoxysalicylate.