5-methoxysalicylic acid

benzoic acid, 2-hydroxy-5-methoxy-

CAS: 2612-02-4 C8 H8 O4 MW: 168.14856000

Identification

Name5-methoxysalicylic acid
IUPAC2-hydroxy-5-methoxybenzoic acid
CAS Number2612-02-4
EINECS220-037-8
FDA UNIISearch
Molecular FormulaC8 H8 O4
Molecular Weight168.14856000
MDL NumberMFCD00002459
Nikkaji NumberJ26.970K
Beilstein2209647
XlogP32.50 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 347.00 °C. @ 760.00 mm Hg (est)
Flash Point 296.00 °F. TCC ( 146.50 °C. ) (est)
logP (o/w) 2.100 (est)
Soluble in water, 2463 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for 5-methoxysalicylic acid usage levels up tonot for fragrance use.
Recommendation for 5-methoxysalicylic acid flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

castoreum PMC primula veris

Synonyms

m- anisic acid, 6-hydroxy- benzoic acid, 2-hydroxy-5-methoxy- 2- hydroxy-5-methoxybenzoic acid 5- methoxy-2-hydroxybenzoic acid PubMed: 5-Methoxysalicylic Acid Matrix for Ganglioside Analysis with Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry. PubMed: A thiophene-containing compound as a matrix for matrix-assisted laser desorption/ ionization mass spectrometry and the electrical conductivity of matrix crystals. PubMed: In vitro anti-platelet effects of simple plant-derived phenolic compounds are only found at high, non-physiological concentrations. PubMed: DFT, FT-Raman and FT-IR investigations of 5-methoxysalicylic acid. PubMed: Biochemical assays of immobilized oligonucleotides with mass spectrometry. PubMed: Laser spectroscopic investigation of salicylic acids hydrogen bonded with water in supersonic jets: Microsolvation effects for excited state proton dislocation. PubMed: Fast excited-state intramolecular proton transfer and subnanosecond dynamic stokes shift of time-resolved fluorescence spectra of the 5-methoxysalicylic acid/diethyl ether complex. PubMed: Structural characterization of Mycobacterium tuberculosis lipoarabinomannans by the combination of capillary electrophoresis and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. PubMed: 5-Methoxysalicylic acid and spermine: a new matrix for the matrix-assisted laser desorption/ionization mass spectrometry analysis of oligonucleotides. PubMed: Direct quantitative analysis of peptides using matrix assisted laser desorption ionization. PubMed: Metabolism of Hydroxydibenzofurans, Methoxydibenzofurans, Acetoxydibenzofurans, and Nitrodibenzofurans by Sphingomonas sp. Strain HH69. PubMed: Tryptic mapping of recombinant proteins by matrix-assisted laser desorption/ionization mass spectrometry. PubMed: Pheromonal activity of single castoreum constituents in beaver,Castor canadensis. PubMed: [Intestinal absorption of insulin with a new telemetric shuttle in dogs]. PubMed: Effects of sodium 5-methoxysalicylate on macromolecule absorption and mucosal morphology in a vascularly perfused rat gut preparation in vivo. PubMed: Inhibition of gluconeogenesis by salicylate and 5-methoxysalicylate in liver of normal and alloxan-diabetic rats. PubMed: High-performance liquid chromatographic determination of certain salicylates and their major metabolites in plasma following topical administration of a liniment to healthy subjects. PubMed: Lymphatic transport of sodium cefoxitin in the presence of sodium 5-methoxysalicylate after injection into rat rectal connective tissue, femoral muscle and femoral vein. PubMed: Effect of adjuvants on the rectal absorption and lymphatic uptake of pepleomycin in rats. PubMed: Possible mechanism of uptake for several compounds in ionized form through human erythrocyte membrane. PubMed: Salicylate-promoted permeation of cefoxitin, insulin and phenylalanine across red cell membrane. Possible mechanism. PubMed: Enhancement of rectal absorption of insulin using salicylates in dogs. PubMed: Enhanced small intestinal absorption of cefmetazole and cefoxitin in rats in the presence of non-surfactant adjuvants. PubMed: Enhanced rectal bioavailability of polypeptides using sodium 5-methoxysalicylate as an absorption promoter. PubMed: Enhanced intestinal absorption of insulin in rats in the presence of sodium 5-methoxysalicylate.