acetamidocaproic acid
6-acetaminocaproic acid
Identification
| Name | acetamidocaproic acid |
| IUPAC | 6-acetamidohexanoic acid |
| CAS Number | 57-08-9 |
| EINECS | 200-310-8 |
| FDA UNII | 7IC4BO7D3R |
| Molecular Formula | C8 H15 N O3 |
| Molecular Weight | 173.21215000 |
| Nikkaji Number | J4.575F |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 104.50 °C. @ 760.00 mm Hg |
| Boiling Point | 404.50 °C. @ 760.00 mm Hg (est) |
| Flash Point | 389.00 °F. TCC ( 198.40 °C. ) (est) |
| logP (o/w) | -0.500 (est) |
| Soluble in | water, 2.125e+004 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | antioxidants |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | antioxidants |
| Recommendation for acetamidocaproic acid usage levels up to | not for fragrance use. |
| Recommendation for acetamidocaproic acid flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
6-
acetamidocaproic acid
6-
acetamidohexanoic acid
acetaminocaproic acid
6-
acetaminocaproic acid
N-
acetyl-6-aminohexanoic acid
6-(
acetylamino)hexanoic acid
6-
acetylaminocaproic acid
6-
acetymidohexanoic acid
hexanoic acid, 6-(acetylamino)-
hexanoic acid, 6-(acetylamino)- (9CI)
hexanoic acid, 6-acetamido- (8CI)
plastenan
PubMed:
Induction of differentiation of human promyelocytic leukemia cells (HL60) by metabolites of hexamethylene bisacetamide
PubMed:
Reduced clearance of î-acetamidocaproic acid in rats with acute renal failure induced by uranyl nitrate
PubMed:
î-Acetamidocaproic acid pharmacokinetics in rats with gastric ulcer or small bowel inflammation
PubMed:
A Bioluminescent Probe for Simultaneously Imaging Esterase and Histone Deacetylase Activity in a Tumor
PubMed:
Quantification of neurotransmitters in mouse brain tissue by using liquid chromatography coupled electrospray tandem mass spectrometry
PubMed:
Pharmacokinetic interaction between ?-acetamidocaproic acid (AACA) and cimetidine in indomethacin-induced acute gastric ulcer and control rats: inhibition of active renal secreti
PubMed:
Phase I bioavailability and pharmacokinetic study of hexamethylene bisacetamide (NSC 95580) administered via nasogastric tube
PubMed:
Identification of metabolites of the cell-differentiating agent hexamethylene bisacetamide in humans
PubMed:
Alkylamides as inducers of human leukemia cell differentiation: a quantitative structure-activity relationship study using comparative molecular field analysis
PubMed:
Development and Validation of a Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of î-Acetamidocaproic Acid in Rat Plasma
PubMed:
Involvement of monoamine oxidase and diamine oxidase in the metabolism of the cell differentiating agent hexamethylene bisacetamide (HMBA)
PubMed:
An active, aldehydic metabolite of the cell-differentiating agent hexamethylene bisacetamide
PubMed:
Pharmacokinetics and first-pass effects of epsilon-acetamidocaproic acid after administration of zinc acexamate in rats
PubMed:
Direct detection of tetrahydrobiopterin (BH4) and dopamine in rat brain using liquid chromatography coupled electrospray tandem mass spectrometry
PubMed:
Plasma pharmacokinetics and urinary excretion of hexamethylene bisacetamide metabolites
PubMed:
Performance of human immunostimulating agents in the improvement of fish cytogenetic preparations
PubMed:
Metabolism of hexamethylene bisacetamide and its metabolites in leukemic cells
PubMed:
The effect of the monoamine oxidase inhibitor isocarboxazid on the canine metabolism of the cell-differentiating agent hexamethylene bisacetamide
PubMed:
Effects of the monoamine oxidase inhibitor, tranylcypromine, on induction of HL60 cell differentiation by hexamethylene bisacetamide and N-acetyl-1,6-diaminohexane
PubMed:
Deacetylation of alpha-keto-epsilon-acetamidocaproic acid by epsilon-lysine acylase
PubMed:
Simultaneous measurement of the cell-differentiating agent hexamethylene bisacetamide and its metabolites by gas chromatography