tioxolone
1,3-benzoxathiol-2-one, 6-hydroxy-
Identification
| Name | tioxolone |
| IUPAC | 6-hydroxy-1,3-benzoxathiol-2-one |
| CAS Number | 4991-65-5 |
| EINECS | 225-653-0 |
| FDA UNII | S0FAJ1R9CD |
| Molecular Formula | C7 H4 O3 S |
| Molecular Weight | 168.17148000 |
| MDL Number | MFCD00005859 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 160.00 °C. @ 760.00 mm Hg |
| Boiling Point | 377.80 °C. @ 760.00 mm Hg (est) |
| Flash Point | 360.00 °F. TCC ( 182.30 °C. ) (est) |
| logP (o/w) | 1.770 (est) |
| Soluble in | water, 9005 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | astringents |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-rat LD50 633 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | inhalation-rat LC50 3710 mg/m3 |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | astringents |
| Recommendation for tioxolone usage levels up to | not for fragrance use. |
| Recommendation for tioxolone flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
1,3-
benzoxathiol-2-one, 6-hydroxy-
6-
hydroxy-1,3-benzoxathiol-2-one
thioxolone
PubMed:
Synchrotron Radiation Provides a Plausible Explanation for the Generation of a Free Radical Adduct of Thioxolone in Mutant Carbonic Anhydrase II.
PubMed:
Benzothioxalone derivatives as novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferases (MurA and MurZ).
PubMed:
Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors?
PubMed:
Inhibition of carbonic anhydrase II by thioxolone: a mechanistic and structural study.
PubMed:
Inhibition profiling of human carbonic anhydrase II by high-throughput screening of structurally diverse, biologically active compounds.
PubMed:
The supramolecular structure of 6-hydroxy-1,3-benzoxathiol-2-one (tioxolone).
PubMed:
Contact dermatitis from thioxolone.
PubMed:
Mechanism of allergic cross-reactions--I. Multispecific binding of ligands to a mouse monoclonal anti-DNP IgE antibody.
PubMed:
Contact dermatitis to thioxolone.
PubMed:
Contact dermatitis to thioxolone.
PubMed:
[Local treatment of acne with tioxolone].
PubMed:
[Alcoholized gel of thioxolone in treatment of juvenile acne. Apropos of 36 cases].
PubMed:
[POLAROGRAPHY OF THIOXOLONE DERIVATIVES. 3. DECOMPOSITION OF CHLOROTHIOXOLONE IN ALKALINE SOLUTION].
PubMed:
[POLAROGRAPHY OF THIOXOLONE DERIVATIVES. II. DETERMINATION OF THIOXOLONE IN THE DRUGS].
PubMed:
[POLAROGRAPHY OF THIOXOLONE DERIVATIVES. I. DECOMPOSITION OF THIOXOLONE IN ALKALINE SOLUTION].
PubMed:
[STUDIES ON CHEMOTHERAPEUTICAL DRUGS. I. STUDIES ON THIOXOLONE DERIVATIVES].