7-ethoxycoumarin
7-ethoxy-2H-chromen-2-one
Identification
| Name | 7-ethoxycoumarin |
| IUPAC | 7-ethoxychromen-2-one |
| CAS Number | 31005-02-4 |
| EINECS | 250-429-4 |
| FDA UNII | C8K66XCQ6L |
| Molecular Formula | C11 H10 O3 |
| Molecular Weight | 190.19830000 |
| MDL Number | MFCD00006877 |
| Nikkaji Number | J315H |
| Beilstein | 146200 |
| XlogP3 | 2.30 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 345.00 °C. @ 760.00 mm Hg (est) |
| Flash Point | 290.00 °F. TCC ( 143.10 °C. ) (est) |
| logP (o/w) | 2.310 (est) |
| Soluble in | water, 813.1 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for 7-ethoxycoumarin usage levels up to | not for fragrance use. |
| Recommendation for 7-ethoxycoumarin flavor usage levels up to | not for flavor use. |
BOC Sciences
Best of Chemicals Supplier
Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...
Potential Uses
Natural Occurrence
Synonyms
2H-1-
benzopyran-2-one, 7-ethoxy-
7-
ethoxy-1-benzopyran-2-one
7-
ethoxy-2H-1-benzopyran-2-one
7-
ethoxy-2H-chromen-2-one
7-
ethoxychromen-2-one
PubMed:
Metabolism of 7-ethoxycoumarin, safrole, flavanone and hydroxyflavanone by cytochrome P450 2A6 variants.
PubMed:
Influence of cigarette smoke on the L-ascorbic acid metabolism and the activities of drug-metabolizing enzyme in rats.
PubMed:
Thyme (Thymus vulgaris L.) leaves and its constituents increase the activities of xenobiotic-metabolizing enzymes in mouse liver.
PubMed:
Allogeneic cell therapy for the treatment of liver disease.
PubMed:
Inhibition of cytochrome p450 enzymes by enrofloxacin in the sea bass (Dicentrarchus labrax).
PubMed:
Antimutagenicity of ethanol extracts of bee glue against environmental mutagens.
PubMed:
Beta2-agonist abuse in food producing animals: use of in vitro liver preparations to assess biotransformation and potential target residues for surveillance.
PubMed:
Modulation of cytochrome P-450-dependent monooxygenases, glutathione and glutathione S-transferase in rat liver by geniposide from Gardenia jasminoides.
PubMed:
Use of fresh and cryopreserved hepatocytes to study the metabolism of pesticides in food-producing animals and rats.
PubMed:
Metabolism of [ring-U-14C] agaritine by precision-cut rat, mouse and human liver and lung slices.
PubMed:
Comparison of the metabolism of 7-ethoxycoumarin and coumarin in precision-cut rat liver and lung slices.
PubMed:
Effect of swimming exercise and ethanol on rat liver P450-dependent monooxygenases.
PubMed:
Influence of metabolism in skin on dosimetry after topical exposure.
PubMed:
Comparison of maturation of drug-metabolizing enzymes in calves with functioning or nonfunctioning rumen.
PubMed:
Food restriction and stimulation of monooxygenation of p-nitroanisole in perfused rat liver.
PubMed:
Studies on the acute effects of coumarin and some coumarin derivatives in the rat.
PubMed:
Induction of cytochrome P-450-dependent enzyme activities in cultured rat liver slices.
PubMed:
Effects of soya bean flakes and liquorice root extract on enzyme induction and toxicity in B6C3F1 mice.
PubMed:
Enzyme induction of the early chick embryo by airborne particulate extracts.
PubMed:
Suppression of benzo[a]pyrene metabolism by accumulation of triacylglycerols in rat hepatocytes: effect of high-fat and food-restricted diets.
PubMed:
Enzyme activities associated with carcinogen metabolism in liver and nonhepatic tissues of rats maintained on high fat and food-restricted diets.
PubMed:
Maturational development of drug-metabolizing enzymes in sheep.
PubMed:
Maturational development of drug-metabolizing enzymes in dogs.
PubMed:
Dietary selenium protects against acute toxicity of T-2 toxin in rats.
PubMed:
Metabolism of xenobiotics during percutaneous penetration: role of absorption rate and cutaneous enzyme activity.
PubMed:
Studies of cytotoxicity and metabolic competence with the rat intestinal cell line IEC-17.
PubMed:
Mechanisms of anti-carcinogenesis by indole-3-carbinol. Studies of enzyme induction, electrophile-scavenging, and inhibition of aflatoxin B1 activation.
PubMed:
Interactions of heterocyclic Maillard products with the hepatic microsomal monooxygenase system.
PubMed:
Effects of the fungicide prochloraz on xenobiotic metabolism in rainbow trout: in vivo induction.
PubMed:
Difference between species in response to a 3,5-dichloropyridyloxyphenoxy compound: induction of cytochrome P-450 and/or peroxisome proliferation.
PubMed:
Effects of dietary Schizandra chinensis, brussels sprouts and Illicium verum extracts on carcinogen metabolism systems in mouse liver.
PubMed:
Comparison of the effects of various flavonoids on ethoxycoumarin deethylase activity of rat intestinal and hepatic microsomes.
PubMed:
Potent induction of human placental mono-oxygenase activity by previous dietary exposure to polychlorinated biphenyls and their thermal degradation products.
PubMed:
Effects of semisynthetic diets on xenobiotic metabolizing enzyme activity and morphology of small intestinal mucosa in humans.
PubMed:
Adipose tissue content as a modifier of the tissue distribution, biological effects, and excretion of a hexachlorobiphenyl in C57BL/6J and DBA/JBOMf mice.
PubMed:
Hepatic biotransformation in farmed blue fox and raccoon dog.
PubMed:
Drug-oxidizing mono-oxygenase system in liver microsomes of goldfish (Carassius auratus).