7-ethoxycoumarin

7-ethoxy-2H-chromen-2-one

CAS: 31005-02-4 C11 H10 O3 MW: 190.19830000

Identification

Name7-ethoxycoumarin
IUPAC7-ethoxychromen-2-one
CAS Number31005-02-4
EINECS250-429-4
FDA UNIIC8K66XCQ6L
Molecular FormulaC11 H10 O3
Molecular Weight190.19830000
MDL NumberMFCD00006877
Nikkaji NumberJ315H
Beilstein146200
XlogP32.30 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 345.00 °C. @ 760.00 mm Hg (est)
Flash Point 290.00 °F. TCC ( 143.10 °C. ) (est)
logP (o/w) 2.310 (est)
Soluble in water, 813.1 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for 7-ethoxycoumarin usage levels up tonot for fragrance use.
Recommendation for 7-ethoxycoumarin flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

found in nature

Synonyms

2H-1- benzopyran-2-one, 7-ethoxy- 7- ethoxy-1-benzopyran-2-one 7- ethoxy-2H-1-benzopyran-2-one 7- ethoxy-2H-chromen-2-one 7- ethoxychromen-2-one PubMed: Metabolism of 7-ethoxycoumarin, safrole, flavanone and hydroxyflavanone by cytochrome P450 2A6 variants. PubMed: Influence of cigarette smoke on the L-ascorbic acid metabolism and the activities of drug-metabolizing enzyme in rats. PubMed: Thyme (Thymus vulgaris L.) leaves and its constituents increase the activities of xenobiotic-metabolizing enzymes in mouse liver. PubMed: Allogeneic cell therapy for the treatment of liver disease. PubMed: Inhibition of cytochrome p450 enzymes by enrofloxacin in the sea bass (Dicentrarchus labrax). PubMed: Antimutagenicity of ethanol extracts of bee glue against environmental mutagens. PubMed: Beta2-agonist abuse in food producing animals: use of in vitro liver preparations to assess biotransformation and potential target residues for surveillance. PubMed: Modulation of cytochrome P-450-dependent monooxygenases, glutathione and glutathione S-transferase in rat liver by geniposide from Gardenia jasminoides. PubMed: Use of fresh and cryopreserved hepatocytes to study the metabolism of pesticides in food-producing animals and rats. PubMed: Metabolism of [ring-U-14C] agaritine by precision-cut rat, mouse and human liver and lung slices. PubMed: Comparison of the metabolism of 7-ethoxycoumarin and coumarin in precision-cut rat liver and lung slices. PubMed: Effect of swimming exercise and ethanol on rat liver P450-dependent monooxygenases. PubMed: Influence of metabolism in skin on dosimetry after topical exposure. PubMed: Comparison of maturation of drug-metabolizing enzymes in calves with functioning or nonfunctioning rumen. PubMed: Food restriction and stimulation of monooxygenation of p-nitroanisole in perfused rat liver. PubMed: Studies on the acute effects of coumarin and some coumarin derivatives in the rat. PubMed: Induction of cytochrome P-450-dependent enzyme activities in cultured rat liver slices. PubMed: Effects of soya bean flakes and liquorice root extract on enzyme induction and toxicity in B6C3F1 mice. PubMed: Enzyme induction of the early chick embryo by airborne particulate extracts. PubMed: Suppression of benzo[a]pyrene metabolism by accumulation of triacylglycerols in rat hepatocytes: effect of high-fat and food-restricted diets. PubMed: Enzyme activities associated with carcinogen metabolism in liver and nonhepatic tissues of rats maintained on high fat and food-restricted diets. PubMed: Maturational development of drug-metabolizing enzymes in sheep. PubMed: Maturational development of drug-metabolizing enzymes in dogs. PubMed: Dietary selenium protects against acute toxicity of T-2 toxin in rats. PubMed: Metabolism of xenobiotics during percutaneous penetration: role of absorption rate and cutaneous enzyme activity. PubMed: Studies of cytotoxicity and metabolic competence with the rat intestinal cell line IEC-17. PubMed: Mechanisms of anti-carcinogenesis by indole-3-carbinol. Studies of enzyme induction, electrophile-scavenging, and inhibition of aflatoxin B1 activation. PubMed: Interactions of heterocyclic Maillard products with the hepatic microsomal monooxygenase system. PubMed: Effects of the fungicide prochloraz on xenobiotic metabolism in rainbow trout: in vivo induction. PubMed: Difference between species in response to a 3,5-dichloropyridyloxyphenoxy compound: induction of cytochrome P-450 and/or peroxisome proliferation. PubMed: Effects of dietary Schizandra chinensis, brussels sprouts and Illicium verum extracts on carcinogen metabolism systems in mouse liver. PubMed: Comparison of the effects of various flavonoids on ethoxycoumarin deethylase activity of rat intestinal and hepatic microsomes. PubMed: Potent induction of human placental mono-oxygenase activity by previous dietary exposure to polychlorinated biphenyls and their thermal degradation products. PubMed: Effects of semisynthetic diets on xenobiotic metabolizing enzyme activity and morphology of small intestinal mucosa in humans. PubMed: Adipose tissue content as a modifier of the tissue distribution, biological effects, and excretion of a hexachlorobiphenyl in C57BL/6J and DBA/JBOMf mice. PubMed: Hepatic biotransformation in farmed blue fox and raccoon dog. PubMed: Drug-oxidizing mono-oxygenase system in liver microsomes of goldfish (Carassius auratus).