7-hydroxy-4-methyl coumarin

4-methylumbelliferone

CAS: 90-33-5 C10 H8 O3 MW: 176.17136000

Identification

Name7-hydroxy-4-methyl coumarin
IUPAC7-hydroxy-4-methylchromen-2-one
CAS Number90-33-5
EINECS201-986-7
FDA UNII3T5NG4Q468
Molecular FormulaC10 H8 O3
Molecular Weight176.17136000
MDL NumberMFCD00006866
Nikkaji NumberJ3.914D
Beilstein0142217
XlogP31.90 (est)

Regulatory

Physical Properties

Appearance colorless crystals (est)
Food Chemicals Codex Listed No
Boiling Point 377.40 °C. @ 760.00 mm Hg (est)
Flash Point 346.00 °F. TCC ( 174.40 °C. ) (est)
logP (o/w) 2.370 (est)
Soluble in water, 5210 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for 7-hydroxy-4-methyl coumarin usage levels up tonot for fragrance use.
Recommendation for 7-hydroxy-4-methyl coumarin flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

found in nature

Synonyms

7- hydroxy-4-methyl-2H-1-benzopyran-2-one hymecromone beta- methyl unbelliferone 4- methyl-7-hydroxycoumarin 7- hydroxy-4-methylcoumarin coumarin, 7-hydroxy-4-methyl- 4- methylumbelliferone 7- hydroxy-4-methylchromen-2-one PubMed: Long-term supplementation of umbelliferone and 4-methylumbelliferone alleviates high-fat diet induced hypertriglyceridemia and hyperglycemia in mice. PubMed: Acitretin exhibits inhibitory effects towards UDP-glucuronosyltransferase (UGT)1A9-mediated 4-methylumbelliferone (4-MU) and propofol glucuronidation reaction. PubMed: Comparative biological study of roots, stems, leaves, and seeds of Angelica shikokiana Makino. PubMed: 4-methylumbelliferone inhibits angiogenesis in vitro and in vivo. PubMed: Deglycosylation of liquiritin strongly enhances its inhibitory potential towards UDP-glucuronosyltransferase (UGT) isoforms. PubMed: Modulation of root branching by a coumarin derivative. PubMed: Expression of active recombinant human gastric lipase in Nicotiana benthamiana using the CPMV-HT transient expression system. PubMed: Phospholipase A2 and antioxidant enzyme activities in normal and PSE pork. PubMed: Hypolipidemic effect of Pleurotus eryngii extract in fat-loaded mice. PubMed: Light emitting diode induced chemiluminescence and its application as a detector for high performance liquid chromatography. PubMed: Serogroup distribution and virulence characteristics of sorbitol-negative Escherichia coli from food and cattle stool. PubMed: Determination of viable Escherichia coli using antibody-coated paramagnetic beads with fluorescence detection. PubMed: Deficient UDP-glucuronosyltransferase detoxification enzyme activity in the small intestinal mucosa of patients with coeliac disease. PubMed: Efficient enzymatic synthesis of 4-methylumbelliferyl N-acetyllactosaminide and 4-methylumbelliferyl sialyl N-acetyllactosaminides employing beta-D-galactosidase and sialyltransferases. PubMed: Study of beta-glucosidase production by wine-related yeasts during alcoholic fermentation. A new rapid fluorimetric method to determine enzymatic activity. PubMed: Hydrolase and glycosynthase activity of endo-1,3-beta-glucanase from the thermophile Pyrococcus furiosus. PubMed: Overexpression and characterization of a novel chitinase from Trichoderma atroviride strain P1. PubMed: A medium for the presumptive detection of Enterobacter sakazakii in infant formula: interlaboratory study. PubMed: Polar organic solvent added to an aqueous solution changes hydrolytic property of lipase. PubMed: Kinetic studies on the hydrolysis of N-acetylated and N-deacetylated derivatives of 4-methylumbelliferyl chitobioside by the family 18 chitinases ChiA and ChiB from Serratia marcescens. PubMed: Cloning and characterization of two alpha-glucosidases from Bifidobacterium adolescentis DSM20083. PubMed: Utilization of fluorogenic assay for rapid detection of Escherichia coli in acidic fruit juice. PubMed: A colorimetric and fluorometric microplate assay for the detection of microcystin-LR in drinking water without preconcentration. PubMed: An alternative approach for enumeration of Escherichia coli in foods. PubMed: Rapid methods to enumerate Escherichia coli in foods using 4-methylumbelliferyl-beta-D-glucuronide. PubMed: Screening of non-Saccharomyces wine yeasts for the production of beta-D-xylosidase activity. PubMed: False-positive fluorescence by pink salmon tissue and staphylococci in a rapid test for Escherichia coli. PubMed: An evaluation of the use of 4-methylumbelliferyl-beta-D-glucuronide (MUG) in different solid media for the detection and enumeration of Escherichia coli in foods. PubMed: Comparison of commercially available kits with standard methods for the detection of coliforms and Escherichia coli in foods. PubMed: Enzyme capture assay for rapid identification of Escherichia coli in blood cultures. PubMed: A rapid method for detection of N-acetylglucosaminidase-type chitinase activity in crossed immunoelectrophoresis and sodium dodecyl sulfate-polyacrylamide gel electrophoresis gels using 4-methylumbelliferyl-N-acetyl-D-glucosaminide as substrate. PubMed: A highly sensitive and fast nonradioactive method for detection of polymerase chain reaction products. PubMed: Evaluation of a rapid fluorogenic method for the detection of Escherichia coli in dairy products. PubMed: [Use of methylumbelliferylglucuronide (MUG) for the rapid identification of E. coli in food microbiology]. PubMed: Glucuronidase assay in a rapid MPN determination for recovery of Escherichia coli from selected foods. PubMed: Fluorogenic assay for rapid detection of Escherichia coli in food. PubMed: [Detection of low lipase activities in food]. PubMed: Monensin-based medium for determination of total gram-negative bacteria and Escherichia coli. PubMed: Evaluation of a fluorogenic assay for detection of Escherichia coli in foods. PubMed: Fluorogenic selective and differential medium for isolation of fecal streptococci. PubMed: Fluorogenic assays for immediate confirmation of Escherichia coli. PubMed: [Total blood bile acid concentration after meal-test in acute and chronic liver disorders: influence of a choleretic agent. Preventive note].