7-hydroxy-4-methyl coumarin
4-methylumbelliferone
Identification
| Name | 7-hydroxy-4-methyl coumarin |
| IUPAC | 7-hydroxy-4-methylchromen-2-one |
| CAS Number | 90-33-5 |
| EINECS | 201-986-7 |
| FDA UNII | 3T5NG4Q468 |
| Molecular Formula | C10 H8 O3 |
| Molecular Weight | 176.17136000 |
| MDL Number | MFCD00006866 |
| Nikkaji Number | J3.914D |
| Beilstein | 0142217 |
| XlogP3 | 1.90 (est) |
Regulatory
Physical Properties
| Appearance | colorless crystals (est) |
| Food Chemicals Codex Listed | No |
| Boiling Point | 377.40 °C. @ 760.00 mm Hg (est) |
| Flash Point | 346.00 °F. TCC ( 174.40 °C. ) (est) |
| logP (o/w) | 2.370 (est) |
| Soluble in | water, 5210 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for 7-hydroxy-4-methyl coumarin usage levels up to | not for fragrance use. |
| Recommendation for 7-hydroxy-4-methyl coumarin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
7-
hydroxy-4-methyl-2H-1-benzopyran-2-one
hymecromone
beta-
methyl unbelliferone
4-
methyl-7-hydroxycoumarin
7-
hydroxy-4-methylcoumarin
coumarin, 7-hydroxy-4-methyl-
4-
methylumbelliferone
7-
hydroxy-4-methylchromen-2-one
PubMed:
Long-term supplementation of umbelliferone and 4-methylumbelliferone alleviates high-fat diet induced hypertriglyceridemia and hyperglycemia in mice.
PubMed:
Acitretin exhibits inhibitory effects towards UDP-glucuronosyltransferase (UGT)1A9-mediated 4-methylumbelliferone (4-MU) and propofol glucuronidation reaction.
PubMed:
Comparative biological study of roots, stems, leaves, and seeds of Angelica shikokiana Makino.
PubMed:
4-methylumbelliferone inhibits angiogenesis in vitro and in vivo.
PubMed:
Deglycosylation of liquiritin strongly enhances its inhibitory potential towards UDP-glucuronosyltransferase (UGT) isoforms.
PubMed:
Modulation of root branching by a coumarin derivative.
PubMed:
Expression of active recombinant human gastric lipase in Nicotiana benthamiana using the CPMV-HT transient expression system.
PubMed:
Phospholipase A2 and antioxidant enzyme activities in normal and PSE pork.
PubMed:
Hypolipidemic effect of Pleurotus eryngii extract in fat-loaded mice.
PubMed:
Light emitting diode induced chemiluminescence and its application as a detector for high performance liquid chromatography.
PubMed:
Serogroup distribution and virulence characteristics of sorbitol-negative Escherichia coli from food and cattle stool.
PubMed:
Determination of viable Escherichia coli using antibody-coated paramagnetic beads with fluorescence detection.
PubMed:
Deficient UDP-glucuronosyltransferase detoxification enzyme activity in the small intestinal mucosa of patients with coeliac disease.
PubMed:
Efficient enzymatic synthesis of 4-methylumbelliferyl N-acetyllactosaminide and 4-methylumbelliferyl sialyl N-acetyllactosaminides employing beta-D-galactosidase and sialyltransferases.
PubMed:
Study of beta-glucosidase production by wine-related yeasts during alcoholic fermentation. A new rapid fluorimetric method to determine enzymatic activity.
PubMed:
Hydrolase and glycosynthase activity of endo-1,3-beta-glucanase from the thermophile Pyrococcus furiosus.
PubMed:
Overexpression and characterization of a novel chitinase from Trichoderma atroviride strain P1.
PubMed:
A medium for the presumptive detection of Enterobacter sakazakii in infant formula: interlaboratory study.
PubMed:
Polar organic solvent added to an aqueous solution changes hydrolytic property of lipase.
PubMed:
Kinetic studies on the hydrolysis of N-acetylated and N-deacetylated derivatives of 4-methylumbelliferyl chitobioside by the family 18 chitinases ChiA and ChiB from Serratia marcescens.
PubMed:
Cloning and characterization of two alpha-glucosidases from Bifidobacterium adolescentis DSM20083.
PubMed:
Utilization of fluorogenic assay for rapid detection of Escherichia coli in acidic fruit juice.
PubMed:
A colorimetric and fluorometric microplate assay for the detection of microcystin-LR in drinking water without preconcentration.
PubMed:
An alternative approach for enumeration of Escherichia coli in foods.
PubMed:
Rapid methods to enumerate Escherichia coli in foods using 4-methylumbelliferyl-beta-D-glucuronide.
PubMed:
Screening of non-Saccharomyces wine yeasts for the production of beta-D-xylosidase activity.
PubMed:
False-positive fluorescence by pink salmon tissue and staphylococci in a rapid test for Escherichia coli.
PubMed:
An evaluation of the use of 4-methylumbelliferyl-beta-D-glucuronide (MUG) in different solid media for the detection and enumeration of Escherichia coli in foods.
PubMed:
Comparison of commercially available kits with standard methods for the detection of coliforms and Escherichia coli in foods.
PubMed:
Enzyme capture assay for rapid identification of Escherichia coli in blood cultures.
PubMed:
A rapid method for detection of N-acetylglucosaminidase-type chitinase activity in crossed immunoelectrophoresis and sodium dodecyl sulfate-polyacrylamide gel electrophoresis gels using 4-methylumbelliferyl-N-acetyl-D-glucosaminide as substrate.
PubMed:
A highly sensitive and fast nonradioactive method for detection of polymerase chain reaction products.
PubMed:
Evaluation of a rapid fluorogenic method for the detection of Escherichia coli in dairy products.
PubMed:
[Use of methylumbelliferylglucuronide (MUG) for the rapid identification of E. coli in food microbiology].
PubMed:
Glucuronidase assay in a rapid MPN determination for recovery of Escherichia coli from selected foods.
PubMed:
Fluorogenic assay for rapid detection of Escherichia coli in food.
PubMed:
[Detection of low lipase activities in food].
PubMed:
Monensin-based medium for determination of total gram-negative bacteria and Escherichia coli.
PubMed:
Evaluation of a fluorogenic assay for detection of Escherichia coli in foods.
PubMed:
Fluorogenic selective and differential medium for isolation of fecal streptococci.
PubMed:
Fluorogenic assays for immediate confirmation of Escherichia coli.
PubMed:
[Total blood bile acid concentration after meal-test in acute and chronic liver disorders: influence of a choleretic agent. Preventive note].