alpha-chymotrypsin
Identification
| Name | alpha-chymotrypsin |
| CAS Number | 9004-07-3 |
| FDA UNII | Search |
| MDL Number | MFCD00130481 |
Regulatory
| FDA/DG SANTE Petitions, Reviews, Notices | GRN 564 |
Physical Properties
| Food Chemicals Codex Listed | No |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-rat LD50 > 4000 mg/kg |
| Dermal Toxicity | subcutaneous-rat LD50 250 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | enzyme preparations and microorganisms |
| Recommendation for alpha-chymotrypsin usage levels up to | not for fragrance use. |
| Recommendation for alpha-chymotrypsin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
alfapsin
avazyme
chimotripsina
chymolase
chymotrypsin A
chymotrypsin, alpha-, type II, from bovine pancreas
chymotrypsine
chymozym
protease from bacillus licheniformis
quimotrase
zolyse
PubMed:
Lactobacillus gasseri requires peptides, not proteins or free amino acids, for growth in milk.
PubMed:
Purification, characterization and immunoreactivity of β'-component, a major allergen from the roe of large yellow croaker (Pseudosciaena crocea).
PubMed:
Purification and characterisation of plantaricin ZJ008, a novel bacteriocin against Staphylococcus spp. from Lactobacillus plantarum ZJ008.
PubMed:
Structural identification and proteolytic effects of the hatching enzyme from starfish Asterias amurensis.
PubMed:
Fractionation of protein hydrolysates of fish and chicken using membrane ultrafiltration: investigation of antioxidant activity.
PubMed:
Purification and characterization of a novel fibrinolytic α chymotrypsin like serine metalloprotease from the edible mushroom, Lyophyllum shimeji.
PubMed:
Bioavailability of the anti-clostridial bacteriocin thuricin CD in gastrointestinal tract.
PubMed:
Effect of limited enzymatic hydrolysis on linoleic acid binding properties of β-lactoglobulin.
PubMed:
Hemolytic activity of venom from crown-of-thorns starfish Acanthaster planci spines.
PubMed:
A selective artificial enzyme inhibitor based on nanoparticle-enzyme interactions and molecular imprinting.
PubMed:
Reduction of major peanut allergens Ara h 1 and Ara h 2, in roasted peanuts by ultrasound assisted enzymatic treatment.
PubMed:
Characterization of a fibrinolytic enzyme secreted by Bacillus amyloliquefaciens CB1 and its gene cloning.
PubMed:
Nutritional and antinutritional evaluation of raw and processed Australian wattle (Acacia saligna) seeds.
PubMed:
Chymotrypsin selectively digests β-lactoglobulin in whey protein isolate away from enzyme optimal conditions: potential for native α-lactalbumin purification.
PubMed:
Screening for lactic acid bacteria capable of inhibiting Campylobacter jejuni in in vitro simulations of the broiler chicken caecal environment.
PubMed:
Isolation and characterization of an agarase-producing bacterial strain, Alteromonas sp. GNUM-1, from the West Sea, Korea.
PubMed:
In vitro study on digestion of pumpkin oil cake protein hydrolysate: evaluation of impact on bioactive properties.
PubMed:
Screening of whey protein isolate hydrolysates for their dual functionality: influence of heat pre-treatment and enzyme specificity.
PubMed:
Purification and determination of two novel antioxidant peptides from flounder fish (Paralichthys olivaceus) using digestive proteases.
PubMed:
Antioxidant effects of ovotransferrin and its hydrolysates.
PubMed:
Production of bacteriocin by Leuconostoc mesenteroides 406 isolated from Mongolian fermented mare's milk, airag.
PubMed:
A hemocyte-derived Kunitz-BPTI-type chymotrypsin inhibitor, HlChI, from the ixodid tick Haemaphysalis longicornis, plays regulatory functions in tick blood-feeding processes.
PubMed:
Purification and characterization of a novel angiotensin I-converting enzyme inhibitory peptide derived from an enzymatic hydrolysate of duck skin byproducts.
PubMed:
Solvent selection and optimization of α-chymotrypsin-catalyzed synthesis of N-Ac-Phe-Tyr-NH2 using mixture design and response surface methodology.
PubMed:
Identification of a new IgE-binding epitope of peanut oleosin that cross-reacts with buckwheat.
PubMed:
The interaction of α-chymotrypsin with one persistent organic pollutant (dicofol): spectroscope and molecular modeling identification.
PubMed:
Protective effect of a novel antioxidative peptide purified from a marine Chlorella ellipsoidea protein against free radical-induced oxidative stress.
PubMed:
Stability of milk fat globule membrane proteins toward human enzymatic gastrointestinal digestion.
PubMed:
Thermophysical characterization of tilapia myosin and its subfragments.
PubMed:
Thermal denaturation of tilapia myosin and its subunits as affected by constantly increasing temperature.
PubMed:
In vitro gastric and intestinal digestions of pulsed light-treated shrimp extracts.
PubMed:
A Novel endo-1,4-β-mannanase from Bispora antennata with good adaptation and stability over a broad pH range.
PubMed:
Purification of a novel angiotensin I-converting enzyme (ACE) inhibitory peptide with an antihypertensive effect from loach (Misgurnus anguillicaudatus).
PubMed:
Purification and characterization of a major fibrinolytic enzyme from Bacillus amyloliquefaciens MJ5-41 isolated from Meju.
PubMed:
Free radical scavenging and angiotensin-I converting enzyme inhibitory peptides from Pacific cod (Gadus macrocephalus) skin gelatin.
PubMed:
Biochemical activities of Brochothrix thermosphacta.
PubMed:
Characterization of two safe Enterococcus strains producing enterocins isolated from Egyptian dairy products.
PubMed:
Enzymatic treatment of peanut kernels to reduce allergen levels.
PubMed:
Purification, amino acid sequence and characterization of the class IIa bacteriocin weissellin A, produced by Weissella paramesenteroides DX.
PubMed:
Gut proteases target Yersinia invasin in vivo.
PubMed:
Oxidation of sarcoplasmic proteins during processing of Cantonese sausage in relation to their aggregation behaviour and in vitro digestibility.
PubMed:
Paenibacillus polymyxa JB05-01-1 and its perspectives for food conservation and medical applications.
PubMed:
Isolation of bacteriocin-like substances producing bacteria from finished cattle-manure compost and activity evaluation against some food-borne pathogenic and spoilage bacteria.
PubMed:
Enhanced thermal and ultrasonic stability of a fungal protease encapsulated within biomimetically generated silicate nanospheres.
PubMed:
Toxicity of hydrolyzed vicilins toward Callosobruchus maculatus and phytopathogenic fungi.
PubMed:
Gene cloning, overexpression, and characterization of a xylanase from Penicillium sp. CGMCC 1669.
PubMed:
Purification and characterization of a Kunitz-type trypsin inhibitor from Acacia victoriae Bentham seeds.
PubMed:
Optimal alpha-chymotrypsin-catalyzed synthesis of N-Ac-Phe-Gly-NH(2).
PubMed:
Characterization of porcine plasma protein-based films as affected by pretreatment and cross-linking agents.
PubMed:
Purification and antioxidant properties of bigeye tuna (Thunnus obesus) dark muscle peptide on free radical-mediated oxidative systems.
PubMed:
Characterization of antilisterial bacteriocins produced by Enterococcus faecium and Enterococcus durans isolates from Hispanic-style cheeses.
PubMed:
Incidence of nisin Z production in Lactococcus lactis subsp. lactis TFF 221 isolated from Thai fermented foods.
PubMed:
In vitro evaluation of the probiotic properties of human intestinal Bifidobacterium species and selection of new probiotic candidates.
PubMed:
Effect of meat cooking on physicochemical state and in vitro digestibility of myofibrillar proteins.
PubMed:
Physicochemical and bitterness properties of enzymatic pea protein hydrolysates.
PubMed:
Subtractive screening for probiotic properties of lactobacillus species from the human gastrointestinal tract in the search for new probiotics.
PubMed:
Antihypertensive effect of angiotensin i converting enzyme-inhibitory peptide from hydrolysates of Bigeye tuna dark muscle, Thunnus obesus.
PubMed:
Fate of the two-component lantibiotic lacticin 3147 in the gastrointestinal tract.
PubMed:
Effect of oxidation on in vitro digestibility of skeletal muscle myofibrillar proteins.
PubMed:
Changes in allergenicity and digestibility of squid tropomyosin during the Maillard reaction with ribose.
PubMed:
In vitro fermentation studies for selection and evaluation of Bacillus strains as starter cultures for the production of okpehe, a traditional African fermented condiment.
PubMed:
Purification and characterization of two bacteriocins produced by lactic acid bacteria isolated from Mongolian airag.
PubMed:
Inhibition of Vibrio parahaemolyticus by a bacteriocin-like inhibitory substance (BLIS) produced by Vibrio mediterranei 1.
PubMed:
Studies on kinetics and thermostability of a novel acid invertase from Fusarium solani.
PubMed:
Food-protein enzymatic hydrolysates possess both antimicrobial and immunostimulatory activities: a "cause and effect" theory of bifunctionality.
PubMed:
Purification, characterization and amino acid sequencing of divergicin M35: a novel class IIa bacteriocin produced by Carnobacterium divergens M35.
PubMed:
Effects of protein engineering of canola procruciferin on its physicochemical and functional properties.
PubMed:
Effects of designed sulfhydryl groups and disulfide bonds into soybean proglycinin on its structural stability and heat-induced gelation.
PubMed:
Kinetic study on the changes in the susceptibility of egg white proteins to enzymatic hydrolysis induced by heat and high hydrostatic pressure pretreatment.
PubMed:
Purification and properties of proteinaceous trypsin inhibitors in the skin mucus of pufferfish Takifugu pardalis.
PubMed:
Characterization of thoeniicin 447, a bacteriocin isolated from Propionibacterium thoenii strain 447.
PubMed:
Enzyme activity of alpha-chymotrypsin after derivatization with phenolic compounds.
PubMed:
Heat-induced changes in the susceptibility of egg white proteins to enzymatic hydrolysis: a kinetic study.
PubMed:
Epsilon-polylysine inhibits pancreatic lipase activity and suppresses postprandial hypertriacylglyceridemia in rats.
PubMed:
Inhibitory specificity change of the ovomucoid third domain of the silver pheasant upon introduction of an engineered Cys14-Cys39 bond.
PubMed:
Isolation of nisin-producing Lactococcus lactis WNC 20 strain from nham, a traditional Thai fermented sausage.
PubMed:
Deodorization of soybean proteins by enzymatic and physicochemical treatments.
PubMed:
Aspartame optical biosensor with bienzyme-immobilized eggshell membrane and oxygen-sensitive optode membrane.
PubMed:
Bacteriocin-producing lactic Acid bacteria isolated from traditional fermented food.
PubMed:
(S)-Thiirancarboxylic acid as a reactive building block for a new class of cysteine protease inhibitors.
PubMed:
Mechanism and characteristics of protein release from lactitol-based cross-linked hydrogel.
PubMed:
Physicochemical properties and susceptibility to proteolytic digestion of myoglobin-phenol derivatives.
PubMed:
Bactericidal action of egg yolk phosvitin against Escherichia coliunder thermal stress.
PubMed:
Enzymatic hydrolysis, grease permeation, and water barrier properties of zein isolate coated paper.
PubMed:
Occurrence of nisin Z production in Lactococcus lactis BFE 1500 isolated from wara, a traditional Nigerian cheese product.
PubMed:
Isolation of peptides from an enzymatic hydrolysate of food proteins and characterization of their taste properties.
PubMed:
Isolation, purification and partial characterization of plantaricin 423, a bacteriocin produced by Lactobacillus plantarum.
PubMed:
Characterization and antimicrobial spectrum of bifidocin B, a bacteriocin produced by Bifidobacterium bifidum NCFB 1454.
PubMed:
Detection and characterization of a bacteriocin produced by Lactococcus lactis subsp. cremoris R isolated from radish.
PubMed:
Improving the thermostability of Bacillus stearothermophilus neutral protease by introducing proline into the active site helix.
PubMed:
Isolation and amino acid sequences of two Kunitz-type protease inhibitors from the sea anemone Anthopleura aff. xanthogrammica.
PubMed:
Botulinum neurotoxin type A: limited proteolysis by endoproteinase Glu-C and alpha-chymotrypsin enhanced following reduction; identification of the cleaved sites and fragments.
PubMed:
Amperometric bienzymic sensor for aspartame.
PubMed:
Anti-aflatoxigenic activity of Lactobacillus casei pseudoplantarum.
PubMed:
Simultaneous measurement of metabolic flux in portally-drained viscera, liver, spleen, kidney and hindquarter in the conscious pig.
PubMed:
The primary structure and characterization of carbohydrate chains of the extracellular glycoprotein proteinase inhibitor from latex of Carica papaya.
PubMed:
Production and characterization of enterocin 900, a bacteriocin produced by Enterococcus faecium BFE 900 from black olives.
PubMed:
Behavior of Listeria monocytogenes in Mozzarella cheese in presence of Lactococcus lactis.
PubMed:
Bacteriocin production by Carnobacterium piscicola LV 61.
PubMed:
Continuous enzymatic production of oligopeptides: synthesis of an enkephalin pentapeptide in a multistage bioreactor.
PubMed:
Molecular cloning of silkworm (Bombyx mori) antichymotrypsin. A new member of the serpin superfamily of proteins from insects.
PubMed:
Identification and characterization of two bacteriocin-producing strains of Lactococcus lactis isolated from vegetables.
PubMed:
Effect of different proteolytic enzymes on the nature of subunit composition of arachins from groundnut (Arachis hypogaea L.).
PubMed:
The nature of the unhydrolysed fraction of alpha-globulin, the major protein component of Sesamum indicum L. hydrolysed by alpha-chymotrypsin.
PubMed:
Production of an Amylase-Sensitive Bacteriocin by an Atypical Leuconostoc paramesenteroides Strain.
PubMed:
Patchwork-structure serpins from silkworm (Bombyx mori) larval hemolymph.
PubMed:
[Analysis of food and feed by partial sequences of characteristic protein components (carrier peptides). 1. Isolation and structural determination of wheat-specific peptides from chymotryptic hydrolysates of gliadin].
PubMed:
Continuous synthesis of a tripeptide by successive condensation and transesterification catalyzed by two immobilized proteinases in organic solvent.
PubMed:
Enzymic method for the spectrophotometric determination of aspartame in beverages.
PubMed:
Enzymatic synthesis of the precursor of Leu-enkephalin in water-immiscible organic solvent systems.
PubMed:
Biochemical characteristics of trypsin inhibitor from wheat grain, beta variety.
PubMed:
Limited proteolysis of silkworm antitrypsin by several proteinases.
PubMed:
Resistance of alpha-globulin from Sesamum indicum L. to proteases in relationship to its structure.
PubMed:
Gelation of the heat-induced complex between kappa-casein and alpha-lactalbumin.
PubMed:
Characterization and mode of action of a purified bacteriocin from the oral bacterium Streptococcus mutans RM-10.
PubMed:
[Chemical composition of seeds from Cucumeropsis mannii Naudin and their suitability as food].
PubMed:
The effects of pregnancy and lactation on the activities of trypsin and alpha-chymotrypsin in the rat pancreas.
PubMed:
Effect of reductive alkylation of the epsilon-amino group of lysyl redsidues of casein on its nutritive value in rats.
PubMed:
Immobilized enzymes on chitosan columns: alpha-chymotrypsin and acid phosphatase.