alpha-naphthoflavone

7,8- benzoflavone 4H- naphtho(1,2-b)pyran-4-one, 2-phenyl- 4H- naphtho[1, 2-b]pyran-4-one, 2-phenyl- 4H- naphtho[1,2-b]pyran-4-one, 2-phenyl- a- naphthoflavone a- naphthylflavone 2- phenyl-4H-benzo[h]chromen-4-one 2- phenyl-4H-naphtho(1,2-b)pyran-4-one 2- phenyl-4H-naphtho[1,2-b]pyran-4-one 2- phenyl-4H-naphthol(1,2-b)pyran-4-one 2- phenyl-benzo[h]chromen-4-one 2- phenylbenzo(h)chromen-4-one 2- phenylbenzo[h]chromen-4-one PubMed: Effect of dihydromyricetin on benzo[a]pyrene activation in rats. PubMed: α-Naphthoflavone modulates inflammatory response in adipocytes-macrophages interaction through NFκB signaling. PubMed: Metabolism of chamaechromone in vitro with human liver microsomes and recombinant human drug-metabolizing enzymes. PubMed: Synergistic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and N-nitrosodiethylamine on cell malignant transformation. PubMed: α-Naphthoflavone inhibits 3T3-L1 pre-adipocytes differentiation via modulating p38MAPK signaling. PubMed: Hepatic cytochrome P450s attenuate the cytotoxicity induced by leflunomide and its active metabolite A77 1726 in primary cultured rat hepatocytes. PubMed: Inhibition of cytochrome P450 2A participating in coumarin 7-hydroxylation in pig liver microsomes. PubMed: In vitro biotransformation and investigation of metabolic enzymes possibly responsible for the metabolism of bisdesoxyolaquindox in the liver fractions of rats, chicken, and pigs. PubMed: Mutagenic activation and detoxification of benzo[a]pyrene in vitro by hepatic cytochrome P450 1A1 and phase II enzymes in three meat-producing animals. PubMed: Metabolites of galangin by 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P450 1A1 in human intestinal epithelial Caco-2 cells and their antagonistic activity toward aryl hydrocarbon receptor. PubMed: Validation of cytochrome P450 time-dependent inhibition assays: a two-time point IC50 shift approach facilitates kinact assay design. PubMed: EROD and MROD as Markers of Cytochrome P450 1A Activities in Hepatic Microsomes from Entire and Castrated Male Pigs. PubMed: A human intervention study with foods containing natural Ah-receptor agonists does not significantly show AhR-mediated effects as measured in blood cells and urine. PubMed: Human cytochrome p450 enzyme specificity for the bioactivation of estragole and related alkenylbenzenes. PubMed: Estrogen receptor alpha as a target for indole-3-carbinol. PubMed: alpha-Naphthoflavone, a potent antiplatelet flavonoid, is mediated through inhibition of phospholipase C activity and stimulation of cyclic GMP formation. PubMed: Intestinal metabolism of PAH: in vitro demonstration and study of its impact on PAH transfer through the intestinal epithelium. PubMed: Protection by quercetin against cooking oil fumes-induced DNA damage in human lung adenocarcinoma CL-3 cells: role of COX-2. PubMed: Induction of cytochrome P4501A1 by autoclavable culture medium change in HepG2 cells. PubMed: Human intestinal Caco-2 cells display active transport of benzo[a]pyrene metabolites. PubMed: Differential response of cultured human umbilical vein and artery endothelial cells to Ah receptor agonist treatment: CYP-dependent activation of food and environmental mutagens. PubMed: Antioxidant protection against PCB-mediated endothelial cell activation. PubMed: Inhibition of mouse and human CYP 1A- and 2E1-dependent substrate metabolism by the isoflavonoids genistein and equol. PubMed: The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies. PubMed: Carbaryl induces CYP1A1 gene expression in HepG2 and HaCaT cells but is not a ligand of the human hepatic Ah receptor. PubMed: Metabolism of the aryl hydrocarbon receptor agonist 3,3',4,4'-tetrachlorobiphenyl by the marine fish scup (Stenotomus chrysops) in vivo and in vitro. PubMed: Metabolism of 2-amino-alpha-carboline. A food-borne heterocyclic amine mutagen and carcinogen by human and rodent liver microsomes and by human cytochrome P4501A2. PubMed: The metabolism and DNA binding of the cooked-food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in precision-cut rat liver slices. PubMed: Inhibition of in vitro aflatoxin B1-DNA binding in rainbow trout by CYP1A inhibitors: alpha-naphthoflavone, beta-naphthoflavone and trout CYP1A1 peptide antibody. PubMed: Metabolic activation of the food mutagen 3-amino-1,4-dimethyl-5H-pyrido-[4,3-b]indole (Trp-P-1) in endothelial cells of cytochrome P-450-induced mice. PubMed: Metabolic activation of the food mutagen Trp-P-1 in endothelial cells of heart and kidney in cytochrome P450-induced mice. PubMed: The role of sulfation and/or acetylation in the metabolism of the cooked-food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Salmonella typhimurium and isolated rat hepatocytes. PubMed: Flavonoid inhibition of aromatase enzyme activity in human preadipocytes. PubMed: Cytochrome P450 forms in the rodent lung involved in the metabolic activation of food-derived heterocyclic amines. PubMed: Metabolism of food-derived heterocyclic amines in human and rabbit tissues by P4503A proteins in the presence of flavonoids. PubMed: Covalent binding of food carcinogens MeIQx, MeIQ and IQ to DNA and protein in microsomal incubations and isolated rat hepatocytes. PubMed: Cytochrome P4501A2 constitutively expressed from transduced DNA mediates metabolic activation and DNA-adduct formation of aromatic amine carcinogens in NIH 3T3 cells. PubMed: Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450. PubMed: Differential rates of metabolic activation and detoxication of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by different cytochrome P450 enzymes. PubMed: 4-(2-amino-1-methylimidazo[4,5-b]pyrid-6-yl)phenyl sulfate--a major metabolite of the food mutagen 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine (PhIP) in the rat. PubMed: Genotoxicity of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): formation of 2-hydroxamino-PhIP, a directly acting genotoxic metabolite. PubMed: Activation of the food-derived mutagen 2-amino-3-methylimidazo[4, 5-f]quinoline by human-liver microsomes. PubMed: Modulation of the mutagenic effects of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) in bacteria with rat-liver 9000 x g supernatant or monolayers of rat hepatocytes as an activation system. PubMed: Correlation of placental microsomal activities with protein detected by antibodies to rabbit cytochrome P-450 isozyme 6 in preparations from humans exposed to polychlorinated biphenyls, quaterphenyls, and dibenzofurans. PubMed: Effects of dietary constituents on the metabolism of chemical carcinogens.