aminophylline
1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione - 1,2-ethanediamine (2:1)
Identification
| Name | aminophylline |
| IUPAC | 1,3-dimethyl-7H-purine-2,6-dione;ethane-1,2-diamine |
| CAS Number | 317-34-0 |
| EINECS | 206-264-5 |
| FDA UNII | 27Y3KJK423 |
| Molecular Formula | C16 H24 N10 O4 |
| Molecular Weight | 420.43408000 |
| MDL Number | MFCD00013221 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 454.10 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 0.000000 mmHg @ 25.00 °C. (est) |
| Flash Point | 443.00 °F. TCC ( 228.40 °C. ) (est) |
| logP (o/w) | -0.175 (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | skin conditioning |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intravenous-dog LDLo 150 mg/kg |
| Dermal Toxicity | subcutaneous-guinea pig LD50 222 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | pharmaceuticals / chemical synthisis |
| Recommendation for aminophylline usage levels up to | not for fragrance use. |
| Recommendation for aminophylline flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
aminocardol
aminodur
cardiofilina
cardiomin
cardophylin
cardophyllin
carena
carine
cariomin
cidophylline
diaphilline
diaphylline
3,7-
dihydro-1,3-dimethyl-1H-purine-2,6-dione compd. with 1,2-ethanediamine (2:1)
3,7-
dihydro-1,3-dimethyl-1H-purine-2,6-dione, cmpd. with 1,2-ethanediamine (2:1)
1,3-
dimethyl-3,7-dihydro-1H-purine-2,6-dione - 1,2-ethanediamine (2:1)
1,3-
dimethyl-3,7-dihydro-1H-purine-2,6-dione - ethane-1,2-diamine (2:1)
1,3-
dimethyl-3,9-dihydro-1H-purine-2,6-dione - ethane-1,2-diamine (2:1)
1,3-
dimethyl-7H-purine-2,6-dione;ethane-1,2-diamine
diophyllin
1,2-
ethanediamine compd. with 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione (1:2)
etilen-xantisan
genophyllin
inophylline
lasodex
metaphyllin
novophyllin
novphyllin
pecram
phyllocontin-350
1H-
purine-2,6-dione, 3,9-dihydro-1,3-dimethyl-, compd. with 1,2-ethanediamine (2:1)
somophyllin-O
tefamin
theodrox
variaphylline LA
PubMed:
Salivary peptide tyrosine-tyrosine 3-36 modulates ingestive behavior without inducing taste aversion.
PubMed:
Asthma and other recurrent wheezing disorders in children (acute).
PubMed:
Acute kidney injury.
PubMed:
Acute renal failure.
PubMed:
Pharmacokinetics of theophylline in Guinea pig tears.
PubMed:
Cardiovascular effects of ginger aqueous extract and its phenolic constituents are mediated through multiple pathways.
PubMed:
Study on the effect of food on the absorption of theophylline.
PubMed:
Prediction of plasma concentration-time curve of orally administered theophylline based on a scintigraphic monitoring of gastrointestinal transit in human volunteers.
PubMed:
A double-blind placebo-controlled study on prophylactic use of cisapride on feed intolerance and gastric emptying in preterm neonates.
PubMed:
Restoration of spontaneous circulation from asystole with aminophylline.
PubMed:
Reversal of propranolol blockade of adrenergic receptors and related toxicity with drugs that increase cyclic AMP.
PubMed:
Asthma treatment during pregnancy. What can be safely taken?
PubMed:
Aminophylline stability in total parenteral nutrition admixtures.
PubMed:
Revised FDA labeling guideline for theophylline oral dosage forms.
PubMed:
Enhancement of acute myocardial lesions by asthma drugs in rats.
PubMed:
Kinetics of absorption of a new once-a-day formulation of theophylline in the presence and absence of food.
PubMed:
Circadian rhythms in theophylline disposition: simulations and observations in the dog.
PubMed:
Lack of effect of a high-fat meal on the volume of distribution of theophylline in humans.
PubMed:
The allergy management of bronchial asthma in children in Surabaya.
PubMed:
Enhancement of maximal thermogenesis by reducing endogenous adenosine activity in the rat.
PubMed:
The beagle dog as an animal model for a bioavailability study of controlled-release theophylline under the influence of food.
PubMed:
Effect of retrograde aminophylline administration on calcium and phosphate solubility in neonatal total parenteral nutrient solutions.
PubMed:
Metabolic effects of aminophylline in rats.
PubMed:
Adenosine plays a role in food-induced jejunal hyperemia.
PubMed:
The clinical significance of food-induced changes in the absorption of theophylline from Uniphyl tablets.
PubMed:
The effect of food on the absorption of controlled-release theophylline in mini-swine.
PubMed:
[Use of euphylline and zaditen in the treatment of obstructive syndrome in children with allergic diathesis under ambulatory care].
PubMed:
Anaphylaxis. Why it happens and what to do about it.
PubMed:
Food intake of domestic fowl injected with adrenergic agonists and antagonists into the hepatic portal vein.
PubMed:
Chronobiology and asthma. II. Body-time-dependent differences in the kinetics and effects of bronchodilator medications.
PubMed:
The Contin delivery system: dosing considerations.
PubMed:
Inadequacy of FDA dosing guidelines for theophylline use in neonates.
PubMed:
Ontogeny of food deprivation effects on ornithine decarboxylase: ornithine decarboxylase induction by alpha and beta agonists.
PubMed:
Food-induced changes in theophylline absorption from controlled-release formulations. Part I. Substantial increased and decreased absorption with Uniphyl tablets and Theo-Dur Sprinkle.
PubMed:
Hepatic cyclic AMP generation and ornithine decarboxylase induction by glucagon and beta adrenergic agonists.
PubMed:
Time-dependent absorption of theophylline in man.
PubMed:
Necrotizing enterocolitis: factors affecting mortality in 101 surgical cases.
PubMed:
Food does not effect in bioavailability of theophylline from Theolin Retard.
PubMed:
Comparison of aminophylline and theophylline sustained-release formulations by their bioavailability and steady-state serum levels.
PubMed:
Chronic methylxanthine treatment in rats: a comparison of Wistar and Fischer 344 strains.
PubMed:
Evaluation of two methods for estimating theophylline clearance prior to achieving steady state.
PubMed:
Pharmacokinetics and bioavailability of prednisone and prednisolone in healthy volunteers and patients: a review.
PubMed:
Drugs altering insulin secretion: effects on plasma and brain concentrations of aromatic amino acids and on brain 5-hydroxytryptamine turnover.
PubMed:
Cyclic AMP and central noradrenaline receptors: failure to activate diencephalic adrenergic feeding pathways.
PubMed:
Effects on plasma and brain tryptophan in the rat of drugs and hormones that influence the concentration of unesterified fatty acid in the plasma.
PubMed:
Drugs influencing plasma and brain tryptophan.
PubMed:
Asthma in childhood.
PubMed:
Genetic obesity in rats. II. The effect of food restriction on the metabolism of adipose tissue.
PubMed:
Nuclear magnetic resonance analysis of pharmaceuticals-VII Determination of aminophylline in tablets.
PubMed:
Anaphylaxis.
PubMed:
The effect of fasting, diet, and actinomycin D on insulin secretion in the rat.
PubMed:
Bronchial asthma in infants and children due to food and inhalant allergies.
PubMed:
MANAGEMENT OF CHILDHOOD ASTHMA. THE IMPORTANCE OF VIGOROUS THERAPY.
PubMed:
The effect of diuretics on the water excretion of protein deficient rats.