aminophylline

1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione - 1,2-ethanediamine (2:1)

CAS: 317-34-0 C16 H24 N10 O4 MW: 420.43408000

Identification

Nameaminophylline
IUPAC1,3-dimethyl-7H-purine-2,6-dione;ethane-1,2-diamine
CAS Number317-34-0
EINECS206-264-5
FDA UNII27Y3KJK423
Molecular FormulaC16 H24 N10 O4
Molecular Weight420.43408000
MDL NumberMFCD00013221

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 454.10 °C. @ 760.00 mm Hg (est)
Vapor Pressure 0.000000 mmHg @ 25.00 °C. (est)
Flash Point 443.00 °F. TCC ( 228.40 °C. ) (est)
logP (o/w) -0.175 (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesskin conditioning

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintravenous-dog LDLo 150 mg/kg
Dermal Toxicitysubcutaneous-guinea pig LD50 222 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for aminophylline usage levels up tonot for fragrance use.
Recommendation for aminophylline flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

aminocardol aminodur cardiofilina cardiomin cardophylin cardophyllin carena carine cariomin cidophylline diaphilline diaphylline 3,7- dihydro-1,3-dimethyl-1H-purine-2,6-dione compd. with 1,2-ethanediamine (2:1) 3,7- dihydro-1,3-dimethyl-1H-purine-2,6-dione, cmpd. with 1,2-ethanediamine (2:1) 1,3- dimethyl-3,7-dihydro-1H-purine-2,6-dione - 1,2-ethanediamine (2:1) 1,3- dimethyl-3,7-dihydro-1H-purine-2,6-dione - ethane-1,2-diamine (2:1) 1,3- dimethyl-3,9-dihydro-1H-purine-2,6-dione - ethane-1,2-diamine (2:1) 1,3- dimethyl-7H-purine-2,6-dione;ethane-1,2-diamine diophyllin 1,2- ethanediamine compd. with 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione (1:2) etilen-xantisan genophyllin inophylline lasodex metaphyllin novophyllin novphyllin pecram phyllocontin-350 1H- purine-2,6-dione, 3,9-dihydro-1,3-dimethyl-, compd. with 1,2-ethanediamine (2:1) somophyllin-O tefamin theodrox variaphylline LA PubMed: Salivary peptide tyrosine-tyrosine 3-36 modulates ingestive behavior without inducing taste aversion. PubMed: Asthma and other recurrent wheezing disorders in children (acute). PubMed: Acute kidney injury. PubMed: Acute renal failure. PubMed: Pharmacokinetics of theophylline in Guinea pig tears. PubMed: Cardiovascular effects of ginger aqueous extract and its phenolic constituents are mediated through multiple pathways. PubMed: Study on the effect of food on the absorption of theophylline. PubMed: Prediction of plasma concentration-time curve of orally administered theophylline based on a scintigraphic monitoring of gastrointestinal transit in human volunteers. PubMed: A double-blind placebo-controlled study on prophylactic use of cisapride on feed intolerance and gastric emptying in preterm neonates. PubMed: Restoration of spontaneous circulation from asystole with aminophylline. PubMed: Reversal of propranolol blockade of adrenergic receptors and related toxicity with drugs that increase cyclic AMP. PubMed: Asthma treatment during pregnancy. What can be safely taken? PubMed: Aminophylline stability in total parenteral nutrition admixtures. PubMed: Revised FDA labeling guideline for theophylline oral dosage forms. PubMed: Enhancement of acute myocardial lesions by asthma drugs in rats. PubMed: Kinetics of absorption of a new once-a-day formulation of theophylline in the presence and absence of food. PubMed: Circadian rhythms in theophylline disposition: simulations and observations in the dog. PubMed: Lack of effect of a high-fat meal on the volume of distribution of theophylline in humans. PubMed: The allergy management of bronchial asthma in children in Surabaya. PubMed: Enhancement of maximal thermogenesis by reducing endogenous adenosine activity in the rat. PubMed: The beagle dog as an animal model for a bioavailability study of controlled-release theophylline under the influence of food. PubMed: Effect of retrograde aminophylline administration on calcium and phosphate solubility in neonatal total parenteral nutrient solutions. PubMed: Metabolic effects of aminophylline in rats. PubMed: Adenosine plays a role in food-induced jejunal hyperemia. PubMed: The clinical significance of food-induced changes in the absorption of theophylline from Uniphyl tablets. PubMed: The effect of food on the absorption of controlled-release theophylline in mini-swine. PubMed: [Use of euphylline and zaditen in the treatment of obstructive syndrome in children with allergic diathesis under ambulatory care]. PubMed: Anaphylaxis. Why it happens and what to do about it. PubMed: Food intake of domestic fowl injected with adrenergic agonists and antagonists into the hepatic portal vein. PubMed: Chronobiology and asthma. II. Body-time-dependent differences in the kinetics and effects of bronchodilator medications. PubMed: The Contin delivery system: dosing considerations. PubMed: Inadequacy of FDA dosing guidelines for theophylline use in neonates. PubMed: Ontogeny of food deprivation effects on ornithine decarboxylase: ornithine decarboxylase induction by alpha and beta agonists. PubMed: Food-induced changes in theophylline absorption from controlled-release formulations. Part I. Substantial increased and decreased absorption with Uniphyl tablets and Theo-Dur Sprinkle. PubMed: Hepatic cyclic AMP generation and ornithine decarboxylase induction by glucagon and beta adrenergic agonists. PubMed: Time-dependent absorption of theophylline in man. PubMed: Necrotizing enterocolitis: factors affecting mortality in 101 surgical cases. PubMed: Food does not effect in bioavailability of theophylline from Theolin Retard. PubMed: Comparison of aminophylline and theophylline sustained-release formulations by their bioavailability and steady-state serum levels. PubMed: Chronic methylxanthine treatment in rats: a comparison of Wistar and Fischer 344 strains. PubMed: Evaluation of two methods for estimating theophylline clearance prior to achieving steady state. PubMed: Pharmacokinetics and bioavailability of prednisone and prednisolone in healthy volunteers and patients: a review. PubMed: Drugs altering insulin secretion: effects on plasma and brain concentrations of aromatic amino acids and on brain 5-hydroxytryptamine turnover. PubMed: Cyclic AMP and central noradrenaline receptors: failure to activate diencephalic adrenergic feeding pathways. PubMed: Effects on plasma and brain tryptophan in the rat of drugs and hormones that influence the concentration of unesterified fatty acid in the plasma. PubMed: Drugs influencing plasma and brain tryptophan. PubMed: Asthma in childhood. PubMed: Genetic obesity in rats. II. The effect of food restriction on the metabolism of adipose tissue. PubMed: Nuclear magnetic resonance analysis of pharmaceuticals-VII Determination of aminophylline in tablets. PubMed: Anaphylaxis. PubMed: The effect of fasting, diet, and actinomycin D on insulin secretion in the rat. PubMed: Bronchial asthma in infants and children due to food and inhalant allergies. PubMed: MANAGEMENT OF CHILDHOOD ASTHMA. THE IMPORTANCE OF VIGOROUS THERAPY. PubMed: The effect of diuretics on the water excretion of protein deficient rats.